3,356 research outputs found
Effect of glycerol and dimethyl sulfoxide on the phase behavior of lysozyme: Theory and experiments
Salt, glycerol and dimethyl sulfoxide (DMSO) are used to modify the
properties of protein solutions. We experimentally determined the effect of
these additives on the phase behavior of lysozyme solutions. Upon the addition
of glycerol and DMSO, the fluid-solid transition and the gas-liquid coexistence
curve (binodal) shift to lower temperatures and the gap between them increases.
The experimentally observed trends are consistent with our theoretical
predictions based on the thermodynamic perturbation theory (TPT) and the
Derjaguin-Landau-Verwey-Overbeek (DLVO) model for the lysozyme-lysozyme pair
interactions. The values of the parameters describing the interactions, namely
the refractive indices, dielectric constants, Hamaker constant and cut-off
length, are extracted from literature or are experimentally determined by
independent experiments, including static light scattering to determine the
second virial coefficient. We observe that both, glycerol and DMSO, render the
potential more repulsive, while sodium chloride reduces the repulsion.Comment: Manuscript accepted for publication in The Journal of Chemical
Physic
Academic team formation as evolving hypergraphs
This paper quantitatively explores the social and socio-semantic patterns of
constitution of academic collaboration teams. To this end, we broadly underline
two critical features of social networks of knowledge-based collaboration:
first, they essentially consist of group-level interactions which call for
team-centered approaches. Formally, this induces the use of hypergraphs and
n-adic interactions, rather than traditional dyadic frameworks of interaction
such as graphs, binding only pairs of agents. Second, we advocate the joint
consideration of structural and semantic features, as collaborations are
allegedly constrained by both of them. Considering these provisions, we propose
a framework which principally enables us to empirically test a series of
hypotheses related to academic team formation patterns. In particular, we
exhibit and characterize the influence of an implicit group structure driving
recurrent team formation processes. On the whole, innovative production does
not appear to be correlated with more original teams, while a polarization
appears between groups composed of experts only or non-experts only, altogether
corresponding to collectives with a high rate of repeated interactions
Collaboration in sensor network research: an in-depth longitudinal analysis of assortative mixing patterns
Many investigations of scientific collaboration are based on statistical
analyses of large networks constructed from bibliographic repositories. These
investigations often rely on a wealth of bibliographic data, but very little or
no other information about the individuals in the network, and thus, fail to
illustrate the broader social and academic landscape in which collaboration
takes place. In this article, we perform an in-depth longitudinal analysis of a
relatively small network of scientific collaboration (N = 291) constructed from
the bibliographic record of a research center involved in the development and
application of sensor network and wireless technologies. We perform a
preliminary analysis of selected structural properties of the network,
computing its range, configuration and topology. We then support our
preliminary statistical analysis with an in-depth temporal investigation of the
assortative mixing of selected node characteristics, unveiling the researchers'
propensity to collaborate preferentially with others with a similar academic
profile. Our qualitative analysis of mixing patterns offers clues as to the
nature of the scientific community being modeled in relation to its
organizational, disciplinary, institutional, and international arrangements of
collaboration.Comment: Scientometrics (In press
Elevated level of inhibin-α subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer
The biological function of inhibin-α subunit (INHα) in prostate cancer (PCa) is currently unclear. A recent study associated elevated levels of INHα in PCa patients with a higher risk of recurrence. This prompted us to use clinical specimens and functional studies to investigate the pro-tumourigenic and pro-metastatic function of INHα. We conducted a cross-sectional study to determine a link between INHα expression and a number of clinicopathological parameters including Gleason score, surgical margin, extracapsular spread, lymph node status and vascular endothelial growth factor receptor-3 expression, which are well-established prognostic factors of PCa. In addition, using two human PCa cell lines (LNCaP and PC3) representing androgen-dependent and -independent PCa respectively, we investigated the biological function of elevated levels of INHα in advanced cancer. Elevated expression of INHα in primary PCa tissues showed a higher risk of PCa patients being positive for clinicopathological parameters outlined above. Over-expressing INHα in LNCaP and PC3 cells demonstrated two different and cell-type-specific responses. INHα-positive LNCaP demonstrated reduced tumour growth whereas INHα-positive PC3 cells demonstrated increased tumour growth and metastasis through the process of lymphangiogenesis. This study is the first to demonstrate a pro-tumourigenic and pro-metastatic function for INHα associated with androgen-independent stage of metastatic prostate disease. Our results also suggest that INHα expression in the primary prostate tumour can be used as a predictive factor for prognosis of PCa
Measurements of Flavour Dependent Fragmentation Functions in Z^0 -> qq(bar) Events
Fragmentation functions for charged particles in Z -> qq(bar) events have
been measured for bottom (b), charm (c) and light (uds) quarks as well as for
all flavours together. The results are based on data recorded between 1990 and
1995 using the OPAL detector at LEP. Event samples with different flavour
compositions were formed using reconstructed D* mesons and secondary vertices.
The \xi_p = ln(1/x_E) distributions and the position of their maxima \xi_max
are also presented separately for uds, c and b quark events. The fragmentation
function for b quarks is significantly softer than for uds quarks.Comment: 29 pages, LaTeX, 5 eps figures (and colour figs) included, submitted
to Eur. Phys. J.
Bose-Einstein Correlations of Three Charged Pions in Hadronic Z^0 Decays
Bose-Einstein Correlations (BEC) of three identical charged pions were
studied in 4 x 10^6 hadronic Z^0 decays recorded with the OPAL detector at LEP.
The genuine three-pion correlations, corrected for the Coulomb effect, were
separated from the known two-pion correlations by a new subtraction procedure.
A significant genuine three-pion BEC enhancement near threshold was observed
having an emitter source radius of r_3 = 0.580 +/- 0.004 (stat.) +/- 0.029
(syst.) fm and a strength of \lambda_3 = 0.504 +/- 0.010 (stat.) +/- 0.041
(syst.). The Coulomb correction was found to increase the \lambda_3 value by
\~9% and to reduce r_3 by ~6%. The measured \lambda_3 corresponds to a value of
0.707 +/- 0.014 (stat.) +/- 0.078 (syst.) when one takes into account the
three-pion sample purity. A relation between the two-pion and the three-pion
source parameters is discussed.Comment: 19 pages, LaTeX, 5 eps figures included, accepted by Eur. Phys. J.
Bose-Einstein Correlations in e+e- to W+W- at 172 and 183 GeV
Bose-Einstein correlations between like-charge pions are studied in hadronic
final states produced by e+e- annihilations at center-of-mass energies of 172
and 183 GeV. Three event samples are studied, each dominated by one of the
processes W+W- to qqlnu, W+W- to qqqq, or (Z/g)* to qq. After demonstrating the
existence of Bose-Einstein correlations in W decays, an attempt is made to
determine Bose-Einstein correlations for pions originating from the same W
boson and from different W bosons, as well as for pions from (Z/g)* to qq
events. The following results are obtained for the individual chaoticity
parameters lambda assuming a common source radius R: lambda_same = 0.63 +- 0.19
+- 0.14, lambda_diff = 0.22 +- 0.53 +- 0.14, lambda_Z = 0.47 +- 0.11 +- 0.08, R
= 0.92 +- 0.09 +- 0.09. In each case, the first error is statistical and the
second is systematic. At the current level of statistical precision it is not
established whether Bose-Einstein correlations, between pions from different W
bosons exist or not.Comment: 24 pages, LaTeX, including 6 eps figures, submitted to European
Physical Journal
Search for Neutral Higgs Bosons in e+e- Collisions at sqrt(s) ~189GeV
A search for neutral Higgs bosons has been performed with the OPAL detector
at LEP, using approximately 170 pb-1 of e+e- collision data collected at
sqrt(s)~189GeV. Searches have been performed for the Standard Model (SM)
process e+e- to H0Z0 and the MSSM processes e+e- to H0Z0, A0h0. The searches
are sensitive to the b b-bar and tau antitau decay modes of the Higgs bosons,
and also to the MSSM decay mode h0 to A0A0. OPAL search results at lower
centre-of-mass energies have been incorporated in the limits we set, which are
valid at the 95% confidence level. For the SM Higgs boson, we obtain a lower
mass bound of 91.0 GeV. In the MSSM, our limits are mh>74.8GeV and mA>76.5GeV,
assuming tan(beta)>1, that the mixing of the scalar top quarks is either zero
or maximal, and that the soft SUSY-breaking masses are 1 TeV. For the case of
zero scalar top mixing, we exclude values of tan(beta) between 0.72 and 2.19.Comment: 38 pages, 15 figures, submitted Euro. Phys. J.
W+W- production and triple gauge boson couplings at LEP energies up to 183 GeV
A study of W-pair production in e+e- annihilations at Lep2 is presented,
based on 877 W+W- candidates corresponding to an integrated luminosity of 57
pb-1 at sqrt(s) = 183 GeV. Assuming that the angular distributions of the
W-pair production and decay, as well as their branching fractions, are
described by the Standard Model, the W-pair production cross-section is
measured to be 15.43 +- 0.61 (stat.) +- 0.26 (syst.) pb. Assuming lepton
universality and combining with our results from lower centre-of-mass energies,
the W branching fraction to hadrons is determined to be 67.9 +- 1.2 (stat.) +-
0.5 (syst.)%. The number of W-pair candidates and the angular distributions for
each final state (qqlnu,qqqq,lnulnu) are used to determine the triple gauge
boson couplings. After combining these values with our results from lower
centre-of-mass energies we obtain D(kappa_g)=0.11+0.52-0.37,
D(g^z_1)=0.01+0.13-0.12 and lambda=-0.10+0.13-0.12, where the errors include
both statistical and systematic uncertainties and each coupling is determined
setting the other two couplings to the Standard Model value. The fraction of W
bosons produced with a longitudinal polarisation is measured to be
0.242+-0.091(stat.)+-0.023(syst.). All these measurements are consistent with
the Standard Model expectations.Comment: 48 pages, LaTeX, including 13 eps or ps figures, submitted to
European Physical Journal
A Measurement of Rb using a Double Tagging Method
The fraction of Z to bbbar events in hadronic Z decays has been measured by
the OPAL experiment using the data collected at LEP between 1992 and 1995. The
Z to bbbar decays were tagged using displaced secondary vertices, and high
momentum electrons and muons. Systematic uncertainties were reduced by
measuring the b-tagging efficiency using a double tagging technique. Efficiency
correlations between opposite hemispheres of an event are small, and are well
understood through comparisons between real and simulated data samples. A value
of Rb = 0.2178 +- 0.0011 +- 0.0013 was obtained, where the first error is
statistical and the second systematic. The uncertainty on Rc, the fraction of Z
to ccbar events in hadronic Z decays, is not included in the errors. The
dependence on Rc is Delta(Rb)/Rb = -0.056*Delta(Rc)/Rc where Delta(Rc) is the
deviation of Rc from the value 0.172 predicted by the Standard Model. The
result for Rb agrees with the value of 0.2155 +- 0.0003 predicted by the
Standard Model.Comment: 42 pages, LaTeX, 14 eps figures included, submitted to European
Physical Journal
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