Congenital cystic adenomatoid malformation: case report

Congenital cystic adenomatoid malformation of the lung is a rare lesion that typically manifests as severe progressive respiratory distress in the neonate secondary to expansion of the affected lung. We present a neonate in whom this condition was diagnosed and managed at the Aga Khan University Hospital. In presenting this patient, we hope to highlight the radiological aspects of this condition which, with prompt recognition and management and in the absence of pulmonary hypoplasia, foetal hydrops or other congenital anomalies, has a favourable prognosis

Congenital cystic adenomatoid malformation: case report

Congenital cystic adenomatoid malformation of the lung is a rare lesion that typically manifests as severe progressive respiratory distress in the neonate secondary to expansion of the affected lung. We present a neonate in whom this condition was diagnosed and managed at the Aga Khan University Hospital. In presenting this patient, we hope to highlight the radiological aspects of this condition which, with prompt recognition and management and in the absence of pulmonary hypoplasia, foetal hydrops or other congenital anomalies, has a favourable prognosis

Global hypoellipticity and global solvability for vector fields on compact Lie groups

We present necessary and sufficient conditions to have global hypoellipticity and global solvability for a class of vector fields defined on a product of compact Lie groups. In view of Greenfield's and Wallach's conjecture, about the non-existence of globally hypoelliptic vector fields on compact manifolds different from tori, we also investigate different notions of regularity weaker than global hypoellipticity and describe completely the global hypoellipticity and global solvability of zero-order perturbations of our vector fields. We also present a class of vector fields with variable coefficients whose operators can be reduced to a normal form, and we prove that the study of the global properties of such operators is equivalent to the study of the respective properties for their normal forms.Comment: 43 page

Het archeologisch vooronderzoek aan de Beskensstraat te Zonhoven

Dit rapport werd ingediend bij het agentschap samen met een aantal afzonderlijke digitale bijlagen. Een aantal van deze bijlagen zijn niet inbegrepen in dit pdf document en zijn niet online beschikbaar. Sommige bijlagen (grondplannen, fotos, spoorbeschrijvingen, enz.) kunnen van belang zijn voor een betere lezing en interpretatie van dit rapport. Indien u deze bijlagen wenst te raadplegen kan u daarvoor contact opnemen met: [email protected]

The Free-Radical Copolymerization of Difurylmethane with Maleic Anhydride

The copolymerization of difurylmethane with maleic anhydride in the presence of azobisisobutyronitrile as an initiator has been investigated at 65 ºC, 72 ºC and 85 ºC in different solvents. Reaction feeds containing 85 mol % and higher of difurylmethane yielded a soluble alternating copolymer in which the furan residue entrained in the polymer chain formed 2,5 linkages and had 3,4 unsaturation. The 1:1 difurylmethane- maleic anhydride adduct was readily prepared, and at the above temperatures and in the presence of the radical initiator partially underwent retro-Diels-Alder reaction. Copolymerization of the difurylmethane and maleic anhydride thus formed yielded the unsaturated alternating copolymer. Copolymers prepared from reaction feeds with proportions of difurylmethane lower than 85 mol % had higher cross-link density and exhibited higher thermodecomposition temperatures. South African Journal of Chemistry Vol.55 2002: 1-1

Implementasi Peraturan Menteri Pemberdayaan Perempuan dan Perlindungan Anak Republik Indonesia Nomor 11 Tahun 2011 Tentang Kebijakan Pengembangan Kota Layak Anak (Studi di Desa Kuala Gading Kecamatan Batang Cenaku Kabupaten Indragiri Hulu)

Kata Kunci: Implementasi, Kebijakan, Kota Layak Anak Penelitian ini bertujuan untuk mengetahui bagaimana Implementasi Peraturan Menteri Pemberdayaan Perempuan dan Perlindungan Anak Republik Indonesia Nomor 11 Tahun 2011 tentang Kebijakan Pengembangan Kabupaten/Kota Layak Anak (Studi di Desa Kuala Gading Kecamatan Batang Cenaku Kabupaten Indragiri Hulu). Indikator penilaian implementasi yang dipergunakan meliputi komunikasi, sumber daya, sikap/disposisi, dan struktur birokrasi. Hipotesis dalam penelitian ini adalah adanya dugaan program Kota Layak Anak yang selanjutnya disebut Desa Layak Anak di Desa Kuala Gading belum terlaksana secara efektif. Tipe penelitian yang berlokasi di Desa Kuala Gading Kecamatan Batang Cenaku Kabupaten Indragiri Hulu adalah teknik survei deskriptif dengan metode penelitian kualitatif dan kuantitatif. Besaran sampel yang ditetapkan dari kedua kelompok populasi ini adalah 9 dan 80 orang. Teknik yang digunakan dalam menentukan individu sampel pada kelompok populasi pertama yaitu teknik sensus terdiri dari Dinas Pemberdayaan Perempuan dan Perlindungan Anak Bidang Perlindungan Anak, Kepala Desa, dan 7 tim gugus tugas. Selanjutnya pada populasi keduanya menggunakan teknik purposive sampling yaitu terdiri dari sejumlah kepala keluarga dengan jumlah anaknya banyak. Jenis dan teknik pengumpulan data menggunakan data primer yang dikumpulkan dengan menggunakan teknik daftar kuisioner dan wawancara serta data sekunder yang dikumpulkan menggunakan teknik observasi. Sementara teknik analisis data yang dipergunakan adalah teknik statistik. Berdasarkan teknik analisis ini peneliti menilai dan menyimpulkan bahwa Implementasi Peraturan Menteri Pemberdayaan Perempuan dan Perlindungan Anak Republik Indonesia Nomor 11 Tahun 2011 Tentang Kebijakan Pengembangan Kabupaten/Kota Layak Anak (studi di Desa Kuala Gading Kecamatan Batang Cenaku Kabupaten Indragiri Hulu) pada interval cukup baik. Rekomendasi yang perlu dipertimbangkan berkenaan dengan komunikasi, yaitu pada sosialisasi dan penyampaian informasi baik pada tim gugus tugas maupun kepada masyarakat agar lebih memahami pemenuhan hak-hak anak secara maksimal

Factors that enhance the ability of Pseudomonas aeruginosa to resist the action of antibiotics

P.aeruginosa is one of the most important pathogens in nosocomial infections and fails to respond to standard treatment, particularly in the case of patients subjected to prolong antibiotic treatment. To generate a more comprehensive understanding of the failure of antimicrobial treatment, focusing especially on the adaptive resistance could be the key area that the bacterium develops in this phenomenon. Most studies on antibiotic resistance in P.aeruginosa have focused upon genotypic studies. This study set out to develop an in vitro model to examine the effect of continual exposure of P.aeruginosa PA01 to the antibiotics studied. Experiments were initially conducted to consider the factors that having a significant influence on antibiotic susceptibility using a novel fluorescence based assay (OxoPlate® system). P.aeruginosa was subjected to the action of tobramycin, amikacin and colistin under various environmental factors. The results of the in vitro analysis showed that, from among the three antibiotics used, amikacin was the antibiotic where resistance was most readily developed. From these results, chemostat studies were designed to examine prolonged exposure of the antibiotic to planktonic cells. Chemostat cultures were exposed to amikacin at sub-inhibitory concentrations using Evans defined synthetic medium at different dilution rates (D) under glucose limitation. Both cultures grown at 0.025h-1 and 0.06h-1 developed the following characteristics i. low-level amikacin resistance, which exhibited an increase in the MIC 4-fold. ii. a clear development of phenotypic resistance and this resistance was not acquired as evidenced by the loss of resistance on culture into fresh medium lacking antibiotic. iii. adaptive resistance to amikacin conferred low-level resistance to other aminoglycosides such as tobramycin and antibiotics with different modes of action such as colistin. Low oxygen availability was seen in the cultures grown at 0.099 h-1 and 0.125 h-1, which lead to i. the appearance of the so called “persister” phenotype. These persisters are sub populations of cells that showed a reduction in bacterial cell size as evidenced from the flow cytometry output as well as being slow growing and resistant ii. extracellular polymeric fibrils were produced in the cells derived after 72h incubation time. In all cases, continual exposure resulted in phenotypically distinct mucoid and non- mucoid colony morphotypes, which were clearly observed on amikacin-free nutrient agar. Some of these selected morphotypes showed from the MIC and MBC data a high-level resistance to the antibiotic when left without antibiotics. The biological responses resulting from these studies offer valuable clues underlying unsuccessful treatment. Conducting experiments using robust systems renders this project extremely novel in the field of microbiology and this will contribute to the development of viable treatment options and ultimately the reduction of the emergence of antibiotic resistance