Comprehensive Assessment of Maize Aflatoxin Levels in Eastern Kenya, 2005–2007

Background: Aflatoxin, a potent fungal toxin, contaminates 25% of crops worldwide. Since 2004, 477 aflatoxin poisonings associated with eating contaminated maize have been documented in Eastern Kenya, with a case-fatality rate of 40%

Investigating Childhood Leukemia in Churchill County, Nevada

BACKGROUND: Sixteen children diagnosed with acute leukemia between 1997 and 2002 lived in Churchill County, Nevada, at the time of or before their illness. Considering the county population and statewide cancer rate, fewer than two cases would be expected. OBJECTIVES: In March 2001, the Centers for Disease Control and Prevention led federal, state, and local agencies in a cross-sectional, case-comparison study to determine if ongoing environmental exposures posed a health risk to residents and to compare levels of contaminants in environmental and biologic samples collected from participating families. METHODS: Surveys with more than 500 variables were administered to 205 people in 69 families. Blood, urine, and cheek cell samples were collected and analyzed for 139 chemicals, eight viral markers, and several genetic polymorphisms. Air, water, soil, and dust samples were collected from almost 80 homes to measure more than 200 chemicals. RESULTS: The scope of this cancer cluster investigation exceeded any previous study of pediatric leukemia. Nonetheless, no exposure consistent with leukemia risk was identified. Overall, tungsten and arsenic levels in urine and water samples were significantly higher than national comparison values; however, levels were similar among case and comparison groups. CONCLUSIONS: Although the cases in this cancer cluster may in fact have a common etiology, their small number and the length of time between diagnosis and our exposure assessment lessen the ability to find an association between leukemia and environmental exposures. Given the limitations of individual cancer cluster investigations, it may prove more efficient to pool laboratory and questionnaire data from similar leukemia clusters

Intra aortic balloon pump: literature review of risk factors related to complications of the intraaortic balloon pump

The increasing use of the intra aortic balloon pump is attributed to the relatively easy percutaneous insertion and the low threshold of use over the past few years, especially in elderly patients with multi-vessel diseases and an affected ejection fraction

Sediment source fingerprinting: benchmarking recent outputs, remaining challenges and emerging themes

Abstract: Purpose: This review of sediment source fingerprinting assesses the current state-of-the-art, remaining challenges and emerging themes. It combines inputs from international scientists either with track records in the approach or with expertise relevant to progressing the science. Methods: Web of Science and Google Scholar were used to review published papers spanning the period 2013–2019, inclusive, to confirm publication trends in quantities of papers by study area country and the types of tracers used. The most recent (2018–2019, inclusive) papers were also benchmarked using a methodological decision-tree published in 2017. Scope: Areas requiring further research and international consensus on methodological detail are reviewed, and these comprise spatial variability in tracers and corresponding sampling implications for end-members, temporal variability in tracers and sampling implications for end-members and target sediment, tracer conservation and knowledge-based pre-selection, the physico-chemical basis for source discrimination and dissemination of fingerprinting results to stakeholders. Emerging themes are also discussed: novel tracers, concentration-dependence for biomarkers, combining sediment fingerprinting and age-dating, applications to sediment-bound pollutants, incorporation of supportive spatial information to augment discrimination and modelling, aeolian sediment source fingerprinting, integration with process-based models and development of open-access software tools for data processing. Conclusions: The popularity of sediment source fingerprinting continues on an upward trend globally, but with this growth comes issues surrounding lack of standardisation and procedural diversity. Nonetheless, the last 2 years have also evidenced growing uptake of critical requirements for robust applications and this review is intended to signpost investigators, both old and new, towards these benchmarks and remaining research challenges for, and emerging options for different applications of, the fingerprinting approach

Chronology of sediment deposition in Upper Klamath Lake, Oregon

A combination of tephrochronology and 14C, 210Pb, and 137Cs measurements provides a robust chronology for sedimentation in Upper Klamath Lake during the last 45 000 years. Mixing of surficial sediments and possible mobility of the radio-isotopes limit the usefulness of the 137Cs and 210Pb data, but 210Pb profiles provide reasonable average sediment accumulation rates for the last 100–150 years. Radiocarbon ages near the top of the core are somewhat erratic and are too old, probably as a result of detrital organic carbon, which may have become a more common component in recent times as surrounding marshes were drained. Below the tops of the cores, radiocarbon ages in the center of the basin appear to be about 400 years too old, while those on the margin appear to be accurate, based on comparisons with tephra layers of known age. Taken together, the data can be combined into reasonable age models for each site. Sediments have accumulated at site K1, near the center of the basin, about 2 times faster than at site CM2, on the margin of the lake. The rates are about 0.10 and 0.05 cm/yr, respectively. The chronological data also indicate that accumulation rates were slower during the early to middle Holocene than during the late Holocene, consistent with increasing wetness in the late Holocene

Stratigraphy and palaeoclimatic significance of Late Quaternary loess–palaeosol sequences of the Last Interglacial–Glacial cycle in central Alaska

Loess is one of the most widespread subaerialdeposits in Alaska and adjacent Yukon Territory and may have a history that goes back 3 Ma. Based on mineralogy and major and trace element chemistry, central Alaskan loess has a composition that is distinctive from other loess bodies of the world, although it is quartz-dominated. Central Alaskan loess was probably derived from a variety of rock types, including granites, metabasalts and schists. Detailed stratigraphic data and pedologic criteria indicate that, contrary to early studies, many palaeosols are present in central Alaskan loess sections. The buried soils indicate that loess sedimentation was episodic, or at least rates of deposition decreased to the point where pedogenesis could keep ahead of aeolian input. As in China, loess deposition and pedogenesis are likely competing processes and neither stops completely during either phase of the loess/soil formation cycle. Loess deposition in central Alaska took place before, and probably during the last interglacial period, during stadials of the mid-Wisconsin period, during the last glacial period and during the Holocene. An unexpected result of our geochronological studies is that only moderate loess deposition took place during the last glacial period. Our studies lead us to conclude that vegetation plays a key role in loess accumulation in Alaska. Factors favouring loess production are enhanced during glacial periods but factors that favour loess accumulation are diminished during glacial periods. The most important of these is vegetation; boreal forest serves as an effective loess trap, but sparsely distributed herb tundra does not. Thus, thick accumulations of loess should not be expected where tundra vegetation was dominant and this is borne out by modern studies near the treeline in central Alaska. Much of the stratigraphic diversity of North American loess, including that found in the Central Lowlands, the Great Plains, and Alaska is explained by a new model that emphasizes the relative importance of loess production factors versus loess accumulation factors