Hypertrophic Cardiomyopathy - Past, Present and Future

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy with a prevalence of 1 in 500 in the general population. Since the first pathological case series at post mortem in 1957, we have come a long way in its understanding, diagnosis and management. Here, we will describe the history of our understanding of HCM including the initial disease findings, diagnostic methods and treatment options. We will review the current guidelines for the diagnosis and management of HCM, current gaps in the evidence base and discuss the new and promising developments in this field

More than sense of place? Exploring the emotional dimension of rural tourism experiences

It is widely suggested that participation in rural tourism is underpinned by a sense of rural place or “rurality”. However, although nature and the countryside have long been recognised as a source of spiritual or emotional fulfilment, few have explored the extent to which tourism, itself often claimed to be a sacred experience, offers an emotional/spiritual dimension in the rural context. This paper addresses that literature gap. Using in-depth interviews with rural tourists in the English Lake District, it explores the extent to which, within respondents’ individual understanding of spirituality, a relationship exists between sense of place and deeper, emotional experiences and, especially, whether participation in rural tourism may induce spiritual or emotional responses. The research revealed that all respondents felt a strong attachment to the Lake District; similarly, and irrespective of their openness to spirituality, engaging in rural tourism activities resulted in highly emotive experiences for all respondents, the description/interpretation of such experiences being determined by individual “beliefs”. However, sense of place was not a prerequisite to emotional or spiritual experiences. Being in and engaging with the landscape � effectively becoming part of it � especially through physical activity is fundamental to emotional responses

Opinião e conhecimento de docentes de uma instituição de ensino superior em saúde sobre prontuário eletrônico do paciente

O objetivo do trabalho foi avaliar a opinião e o conhecimento de docentes de educação superior sobre o prontuário eletrônico do paciente (PEP) e identificar fatores que interferem em sua utilização. Consiste em um estudo transversal com 67 docentes de uma faculdade de saúde inseridos em ambiente de assistência ao paciente. Foram coletados dados epidemiológicos e relacionados a opinião/conhecimento sobre o PEP, por meio de formulário. As variáveis contínuas foram apresentadas como medidas de tendência central e de dispersão e as categóricas, apresentadas em forma de frequência. O projeto foi aprovado pelo Comitê de Ética em Pesquisas. Os achados apontam que a maioria dos docentes: possui um bom conhecimento sobre o PEP; considera-o uma ferramenta benéfica na assistência à saúde; sente-se preparada para aplicar as ferramentas em seu trabalho, porém, relata alguma dificuldade em seu manuseio.O objetivo do trabalho foi avaliar a opinião e o conhecimento de docentes de educação superior sobre o prontuário eletrônico do paciente (PEP) e identificar fatores que interferem em sua utilização. Consiste em um estudo transversal com 67 docentes de uma faculdade de saúde inseridos em ambiente de assistência ao paciente. Foram coletados dados epidemiológicos e relacionados a opinião/conhecimento sobre o PEP, por meio de formulário. As variáveis contínuas foram apresentadas como medidas de tendência central e de dispersão e as categóricas, apresentadas em forma de frequência. O projeto foi aprovado pelo Comitê de Ética em Pesquisas. Os achados apontam que a maioria dos docentes: possui um bom conhecimento sobre o PEP; considera-o uma ferramenta benéfica na assistência à saúde; sente-se preparada para aplicar as ferramentas em seu trabalho, porém, relata alguma dificuldade em seu manuseio

Historical controversies about the thalamus: from etymology to function

The authors report on and discuss the historical evolution of the 3 intellectual and scientific domains essential for the current understanding of the function of the human thalamus: 1) the identification of the thalamus as a distinct anatomical and functional entity, 2) the subdivision of thalamic gray matter into functionally homogeneous units (the thalamic nuclei) and relative disputes about nuclei nomenclature, and 3) experimental physiology and its limitations.Galen was allegedly the first to identify the thalamus. The etymology of the term remains unknown although it is hypothesized that Galen may have wanted to recall the thalamus of Odysseus. Burdach was the first to clearly and systematically define the thalamus and its macroscopic anatomy, which paved the way to understanding its internal microarchitecture. This structure in turn was studied in both nonhuman primates (Friedemann) and humans (Vogt and Vogt), leading to several discrepancies in the findings because of interspecies differences. As a consequence, two main nomenclatures developed, generating sometimes inconsistent (or nonreproducible) anatomo-functional correlations. Recently, considerable effort has been aimed at producing a unified nomenclature, based mainly on functional data, which is indispensable for future developments. The development of knowledge about macro- and microscopic anatomy has allowed a shift from the first galenic speculations about thalamic function (the "thalamus opticorum nervorum") to more detailed insights into the sensory and motor function of the thalamus in the 19th and 20th centuries. This progress is mostly the result of lesion and tracing studies. Direct evidence of the in vivo function of the human thalamus, however, originates from awake stereotactic procedures only.Our current knowledge about the function of the human thalamus is the result of a long process that occurred over several centuries and has been inextricably intermingled with the increasing accumulation of data about thalamic macro- and microscopic anatomy. Although the thalamic anatomy can currently be considered well understood, further studies are still needed to gain a deeper insight into the function of the human thalamus in vivo

Photochimie de derives benzoyles du cyclohexene : cinetique et mecanisme de la photoisomerisation du dibenzoyl-4,5 dimethyl-1,2 cyclohexene trans

SIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Physionomie agraire et orientation politique dans le département des Côtes-du Nord.

De Vulpian Alain. Physionomie agraire et orientation politique dans le département des Côtes-du Nord.. In: Revue française de science politique, 1ᵉ année, n°1-2, 1951. pp. 110-132

14. Laboratoire de pathologie expérimentale à la Faculté de médecine de Paris

Vulpian , Bochefontaine . 14. Laboratoire de pathologie expérimentale à la Faculté de médecine de Paris. In: Rapport sur l'École pratique des hautes études, 1876-1877. 1876. pp. 104-108

Laboratoire de Pathologie expérimentale à la faculté de médecine

Vulpian . Laboratoire de Pathologie expérimentale à la faculté de médecine. In: Rapport sur l'École pratique des hautes études, 1872-1873. 1872. pp. 70-71

Laboratoire de Pathologie expérimentale à la Faculté de médecine de Paris

Vulpian . Laboratoire de Pathologie expérimentale à la Faculté de médecine de Paris. In: Rapport sur l'École pratique des hautes études, 1874-1875. 1874. pp. 101-103