Analysis of Markov processes in team sports modeling

The increasing computational power and automated collection of ever richer data about sporting events have enabled the development of complex analytical models that offer decision makers a competitive advantage in the world of sport. In the thesis we address the problem of automatic extraction of regularities in the sequence of events in sports games and construction of statistical models for generating a plausible simulation of a match between two distinct teams. We model the progression of a sports game as a random walk through the state space. We express the transition matrix of our Markov model as a function of the current state description which includes factors relevant for the further development of events in the match. The main idea of our approach is to incorporate a cascade of models that sequentially (and conditioned to each other) predict the individual components of the next state description. We present a method for automatic construction of a feature space which does not require any expert knowledge about the domain. The attributes are defined as the ratio between the number of entries and exits from higher-level concepts that are identified as groups of similar game events. The similarity between the events is determined by the similarity between probability distributions describing the preceding and following events in the observed sequences of game progression. Experimental evaluation of the proposed methods applied in the basketball domain showed that the models fitted in the automatically generated feature space are of comparable quality to models that use features based on expert knowledge. Statistical analysis of the generated simulations showed that the models successfully capture the dynamics of the game of basketball

Potențialul turismului educațional durabil al Parcului Național Djerdap

Starting from the new education paradigm, which relies on constructivist and contextual approach, this paper will specify the tourism potential of the Djerdap National Park, which should develop young people’s skills for sustainable development. The main objective of this paper is to use the holistic approach, the analysis of tourism resources, their educational potential and types of educational tourism in the Djerdap National Park to emphasize the insufficiently utilized educational potential. This could help children and young people acquire knowledge, skills and develop their personality by promoting learning through experience, direct contact with the things they are learning about, research and project approach. The results of this study indicate the need to create educational programs for all ages, to improve accommodation capacities as well as educational materials, to better educate the guides on how to conduct ambient learning, project and research activities for all age groups. Emphasizing the importance of educational tourism, which could help education for sustainable development, the paper underlines the need for support from state level with promotion, activities, projects and sharing best practices

Dileme moralnog biounaprijeđenja

Ovaj diplomski rad je podijeljen na dva glavna dijela te se temlelji na knjizi Perssona i Savulescu „Unfit for the Future: The Need for Moral Enhancement“. U prvom dijelu diplomskog rada su iznesene osnovne i temeljne teze Perssona i Savulescua koje uključuju tezu da je lakše nanijeti štetu nego dobrobit, zatim se razmatra koncept odgovornosti temeljen na uzročnosti. Druga značajna teza je da su pristranost prema bliskoj budućnosti i indiferentnost prema velikom broju ljudi manjkavost ljudske prirode te zajedno sa liberalnim demokracijama otežavaju rješavanje problema današnjice. Pri tom prvenstveno misle na sve veće mogućnosti zloupotrebe znanosti, manjkavosti liberalnih demokracija te kako se to odražava na ekološke probleme, opasnost od terorističkih napada te društvene probleme našeg doba. Rješenje nalaze u moralnom unaprijeđenju ljudi pomoću lijekova (oksitocin i SSRI) ili genetičkim inžinjeringom te daju svoju definiciju moralnosti koja se temelji na altruizmu i osjećaju pravde. Ove dvije dispozicije prema njima, uvijek dovode do moralno ispravnog ponašanja. Drugi dio diplomskog rada se bavi prigovorima i kritikom, kritizira se stav da su empatija i altruizam ono što dovodi do moralno ispravnog ponašanja, razmatra se problematika emocija nasuprot kognicije u moralnim odlukama i ponašanjima te problematika javnog financiranja projekta moralnog biounaprijeđenja. Zatim slijedi prigovor tezi da je lakše donijeti štetu nego dobrobit drugom, problematika oko samog provođenja moralnog biounaprijeđenja: dobrovoljno ili nametnuto te upitnost same sigurnosti i pouzdanosti takvog projekta.This thesis is divided into two main parts and is based on Persson and Savulescu's book "Unfit for the Future: The Need for Moral Enhancement". The first part of this thesis presents the basic and fundamental facts presented by Persson and Savulescu including the idea that it is easier to harm than to benefit. Subsequently, this thesis looks more closely into the concept of causally based responsibility. Another important assumption that the authors make is that the bias toward the near future and indifference to great numbers of people are one of the main flaws of human nature and together with liberal democracies they hamper the resolution of problems that we are facing today. In this they are primarily refering to the increasing possibilities of misuse/abuse of science, the deficiencies of liberal democracies and its influence on environmental problems, the risk of terrorist attacks and society problems of our contemporary society. The solution they propose is to morally enhance people using drugs (oxytocin and SSRI) or by genetically engineering humans and they give their definition of morality that is based on altruism and a sense of justice. These two dispositions, according to them, always lead to morally correct behavior. The second part of this thesis concernes itself with criticism, particulary on the view that empathy and altruism always lead to morally correct behavior. The issue of emotions and cognition in moral decisions and behaviors are also considered as well as the difficulties of the public financing of the project of moral bio-enhancement. Furthermore, this thesis attempts to challenge the theory that it is easier to harm than benefit, and it is concerned with issues that arise around the implementation of moral bio-enhancement: will the enhancement be voluntary or imposed upon people, the questionability of the safety and reliability of such a project

Dileme moralnog biounaprijeđenja

Ovaj diplomski rad je podijeljen na dva glavna dijela te se temlelji na knjizi Perssona i Savulescu „Unfit for the Future: The Need for Moral Enhancement“. U prvom dijelu diplomskog rada su iznesene osnovne i temeljne teze Perssona i Savulescua koje uključuju tezu da je lakše nanijeti štetu nego dobrobit, zatim se razmatra koncept odgovornosti temeljen na uzročnosti. Druga značajna teza je da su pristranost prema bliskoj budućnosti i indiferentnost prema velikom broju ljudi manjkavost ljudske prirode te zajedno sa liberalnim demokracijama otežavaju rješavanje problema današnjice. Pri tom prvenstveno misle na sve veće mogućnosti zloupotrebe znanosti, manjkavosti liberalnih demokracija te kako se to odražava na ekološke probleme, opasnost od terorističkih napada te društvene probleme našeg doba. Rješenje nalaze u moralnom unaprijeđenju ljudi pomoću lijekova (oksitocin i SSRI) ili genetičkim inžinjeringom te daju svoju definiciju moralnosti koja se temelji na altruizmu i osjećaju pravde. Ove dvije dispozicije prema njima, uvijek dovode do moralno ispravnog ponašanja. Drugi dio diplomskog rada se bavi prigovorima i kritikom, kritizira se stav da su empatija i altruizam ono što dovodi do moralno ispravnog ponašanja, razmatra se problematika emocija nasuprot kognicije u moralnim odlukama i ponašanjima te problematika javnog financiranja projekta moralnog biounaprijeđenja. Zatim slijedi prigovor tezi da je lakše donijeti štetu nego dobrobit drugom, problematika oko samog provođenja moralnog biounaprijeđenja: dobrovoljno ili nametnuto te upitnost same sigurnosti i pouzdanosti takvog projekta.This thesis is divided into two main parts and is based on Persson and Savulescu's book "Unfit for the Future: The Need for Moral Enhancement". The first part of this thesis presents the basic and fundamental facts presented by Persson and Savulescu including the idea that it is easier to harm than to benefit. Subsequently, this thesis looks more closely into the concept of causally based responsibility. Another important assumption that the authors make is that the bias toward the near future and indifference to great numbers of people are one of the main flaws of human nature and together with liberal democracies they hamper the resolution of problems that we are facing today. In this they are primarily refering to the increasing possibilities of misuse/abuse of science, the deficiencies of liberal democracies and its influence on environmental problems, the risk of terrorist attacks and society problems of our contemporary society. The solution they propose is to morally enhance people using drugs (oxytocin and SSRI) or by genetically engineering humans and they give their definition of morality that is based on altruism and a sense of justice. These two dispositions, according to them, always lead to morally correct behavior. The second part of this thesis concernes itself with criticism, particulary on the view that empathy and altruism always lead to morally correct behavior. The issue of emotions and cognition in moral decisions and behaviors are also considered as well as the difficulties of the public financing of the project of moral bio-enhancement. Furthermore, this thesis attempts to challenge the theory that it is easier to harm than benefit, and it is concerned with issues that arise around the implementation of moral bio-enhancement: will the enhancement be voluntary or imposed upon people, the questionability of the safety and reliability of such a project

Phenotypic and genotypic characteristics of Escherichia coli isolated from faeces of dogs

Šiga toksin produkujuće Escherichia coli (STEC) čine jednu od šest grupa dijarejagenih E. coli. Na svjetskom nivou, infekcija izazvana STEC najčešći je uzrok akutne renalne insuficijencije kod djece i starijih osoba. Kako su psi prepoznati kao rezervoari STEC, blizak kontakt ljudi i pasa predstavlja rizik za zoonotsku transmisiju ovih bakterija.  U Republici Srbiji, osim ograničenog broja istraživanja o prisustvu STEC kod domaćih životinja i ljudi nema dostupnih literaturnih podataka o istraživanjima ove grupe E. coli kod pasa. Stoga, cilj ove doktorske disertacije bio je da se dokaže prisustvo i utvrdi prevalencija STEC u populaciji pasa s teritorije grada Novog Sada, izvrši tipizacija i molekulrna karakterizacija sojeva E. coli izolovanih iz fecesa pasa i utvrdi prisustvo rezistentnih sojeva E. coli. U ovo istraživanje bio je uključen 101 pas s teritorije Novog Sada, a kao materijal korišćeni su uzorci fecesa pasa. U cilju izolacije E. coli iz fecesa pasa primijenjeni su standardni bakteriološki metodi izolacije i biohemijske identifikacije, a potvrda pripadnosti vrsti izvršena je korišćenjem  matricom potpomognute laserske desorpcije/jonizacije-vrijeme preleta masene spektrometrije (MALDI-TOF MS). Za utvrđivanje prisustva STEC kod pasa primijenjeni su metodi lateks aglutinacije za serogrupu O157,  direktne aglutinacije za serogrupe “velike šestorke” O26, O45, O103, O111, O121 i O145, test verocitotoksičnosti (VCA), imunoenzimski test (ELISA), kao i lančana reakcija polimeraze (PCR). Antibiotska rezistencija utvrđena je disk difuzionim metodom prema standardima EUCAST i CLSI.  U ovom istraživanju, po prvi put u Republici Srbiji, dokazano je prisustvo STEC u populaciji pasa. Primjenom VCA metoda ustanovljena je prevalencija od 1,98%, dok je primjenom ELISA i PCR metoda ustanovljena prevalencija od 5,94% odnosno 4,95%. Dva izolata E. coli pripadala su nekoj od serogrupa “velike šestorke” STEC, dok prisustvo sojeva iz serogrupe O157 nije utvrđeno. U ispitivanoj populaciji pasa utvrđeno je prisustvo sojeva E. coli rezistentnih na jedan ili više korišćenih antibiotika, kao i jednog multirezistentnog izolata. Najviše izolata E. coli pokazalo je rezistenciju na ampicilin (22,5%), dok nijedan izolat nije pokazao rezistenciju na gentamcin. Pozitivna povezanost utvrđena je između stila života psa i prisustva STEC. Naime, značajno veća prevalencija STEC, u odnosu na vlasničke pse, zabilježena je kod pasa lutalica, što je vjerovatno posljedica neograničene slobode kretanja, a time i češćeg kontakta s kontaminiranom hranom i vodom kao izvorom STEC.  Nalaz STEC i izolata E. coli rezistentnih na antibiotike kod pasa od značaja je kako s aspekta male kliničke prakse tako i s aspekta javnog zdravlja u Republici Srbiji. DatumShiga toxin-producing Escherichia coli (STEC) strains constitute one of six groups of diarrheagenic E. coli. Infection caused by STEC is the most common cause of acute renal failure in young children and elderly people worldwide. As dogs are recognized as a reservoir for STEC, the close contact between humans and dogs poses a risk for zoonotic transmission of these bacteria. Except scarce studies of STEC in humans and domestic animals, there are no available data about this E. coli group in dogs in the Republic of Serbia. Therefore the aim of this doctoral dissertation was to determine the presence and prevalence of STEC in the dog populaton in the area of Novi Sad, to perform typing and molecular characterization of E. coli strains isolated from faeces of dogs,  as well to determine the presence of antibiotic resistant E. coli strains. In total 101 dogs from the area of Novi Sad was included in this research. As the material fecal samples of dogs were used. In order to isolate E. coli strains from faeces standard methods of bacterial isolation and biochemical identification were used, and for the confirmation of species identity matrix-assisted laser desorption/ionization time-offlight mass spectrometry (MALDI-TOF MS) was used. In order to determine the presence of STEC in dogs latex agglutination for the serogroup O157, direct agglutination for “big six” serogroups (O26, O45, O103, O111, O121 and O145), Vero cell cytotoxicity assay (VCA), enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) were used. Antibiotic resistance was determined by disc diffusion method according to the EUCAST and CLSI guidelines. In this research, for the first time in the Republic of Serbia, the presence of STEC has been proven in the dog population. By VCA method the prevalence of 1,98% was determined, while by ELISA and PCR the determined prevalence was 5,94% and 4,95% respectively. Two E. coli isolates belonged to some of the STEC “big six” serogroups, while none of the isolates belonged to O157 serogroup. Furthermore, in the dog population included in this research, the presence of strains resistant to one or more of used antibiotics was determined, as well as the presence of one multiresistant strain. Most of the E coli isolates showed resistance to ampicillin (22,5%), while every of the isolates showed susceptibility to gentamicin. In this research significant association between lifestyle of dogs and STEC harbouring. That is to say, significantly higher STEC prevalence was noticed in stray dogs in comparison to pet dogs, what is likely due to unlimited freedom of movement and thereby more frequent contact with contaminated water and food as sources of STEC. Finding of STEC and E. coli strains resistant to antibiotics in dog population is of importance not just in small animal practice, but also in terms of public health in the Republic of Serbia

Disorders of Thyroid Function in Dogs and Cats

Među bolestima štitnjače koje se javljaju u pasa i mačaka nesumnjivu važnost imaju hipotireoidizam i hipertireoidizam. Kada govorimo o hipotireozi, govorimo o najčešćem endokrinološkom poremećaju u pasa u kojem dolazi do prekomjernog stvaranja hormona štitnjače. Sama terapija pasa usmjerena je dakle na medikamentozno liječenje tj. na nadoknadu hormona štitnjače. Iako je T3 metabolički aktivni oblik hormona štitnjače, nije izbor terapije. Primarna prednost pružanja prohormona T4 je taj da tijelo ima priliku regulirati količinu T3 generirana normalnim fiziološkim mehanizmima. Odgovarajuća T4 terapija rezultira u normalnim koncentracijama T4 i T3. Najprimjenjiviji oblik terapije je oralna terapija sintetskog l-tiroksina u početnoj dozi od 10 μ/kg dva puta dnevno. Kontrolni pregled bi se trebao obaviti za dva mjeseca. Hipotireoidizam je jedna od najzahvalnijih bolesti za liječenje zbog lakoće lijećenja i njenog pozitivnog odgovora na lijećenje. Sa odgovarajućom terapijom i redovitim kontrolnim pregledima svakih pola godine, obično sve promjene povezane sa hipotireoidizmom postanu reverzibilne. Dugoročna prognoza za ovu bolest je odlična. Postoje tri opcije za eliminiranje pretjerane produkcije tiroksina u hipertireotičnih mačaka, a to su kirurška tireodektomija, terapija radioaktivnim jodom te inhibicija sekrecije hormona lijekovima. Za mačke sa hipertireozom koje nisu razvile teške komplikacije poput srčanih i bubrežnih bolesti prognoza za očuvanja zdravlja je odlična nakon uspješne kirurške intervencije. Nakon terapije radioaktivnim jodom prognoza je jednako dobra ili čak i bolja. U većini hipertireotičnih mačaka metamizol ili karbamizol dovode do poboljšanja.Among thyroid diseases that occur in dogs and cats undoubtedly great importance carry hypothyroidism and hyperthyroidism. Hypothyroidism is the most common endocrine disorder in dogs which is marked by excessive secretion of thyroid hormones. The therapy for dogs is therefore focused on drug therapy ie. the compensation of thyroid hormones. Although T3 is the metabolically active thyroid hormone, it is not the supplement of choice. A primary advantage of providing the “prohormone” T4 is that the body is given the oppourtunity to regulate the amount of T3 generated by normal physiologic mechanisms. Appropriate T4 therapy results in normal levels of both T4 and T3. Most commonly oral supplementation with tablets of synthetic l-thyroxine is started at a dose rate of 10 ng/kg twice daily. A follow-up examination is made after two months. Hypothyroidism is one of the most gratifying diseases to treat because of the ease and completeness with which it responds to treatment. With appropriate treatment and follow-up examinations every half year, usually all of the alterations associated with hypothyroidism are reversible. The long term prognosis is excellent. There are three options for eliminating the excess production of T4: surgical thyroidectomy, radioiodine ablation of the thyroid and inhibition of secretion by antithyroid drugs. In cats without severe complicating cardiac or kidney disease the prognosis for restoration of health is excellent after successful surgey. After raioiodine treatment the prognosis is as good or even better. In the great majority of hyperthyroid cats either methimazole or carbimazole is effective

Monitoring of coliform bacteria in river Bednja from 2005. to 2015.

Rijeka Bednja izvire u naselju Bednjica koje se nalazi u podnožju Ravne gore u Hrvatskom zagorju. Sa svoja 133 kilometra najuža je rijeka koja ima izvor i ušće u Hrvatskoj. Porječje obuhvaća 966 km2, a proteže se brežuljkastim krajem sjeverno od Ivančice i Kalnika te Podravskom nizinom. Teče od zapada prema istoku te je jedina od četiri rijeke Hrvatskog zagorja koja se ulijeva u Dravu. Širina rijeke kreće se od 10 do 20 metara, a dubina je 3 metra. Zbog nepročišćenih otpadnih voda koje ispuštaju 5 grada i poveći broj manjih naselja a koje prihvaća duž svojeg cijelog toka, rijeka Bednja spada u najopterećeniji vodotok u Varaždinskoj županiji. U ovom radu obrađena je tema praćenja koliformnih bakterija na mjernim postajama rijeke Bednje. Podaci o praćenju stanja rijeke Bednje dobiveni su od Hrvatskih voda, a uzorci su uzimani na mjernim postajama Lepoglava, Stažnjevec, Tuhovec i Mali Bukovec. Koliformne bakterije spadaju među glavne skupine mikroorganizama kontaminanata površinskih slatkih voda. Izlučuju se fekalijama te dospijevaju u otpadne vode, a preko njih u prirodne vode, recipijente otpadnih voda, u ovom slučaju rijeku Bednju. Koliformne bakterije su primarno nepatogene i normalno obitavaju u donjem intestinalnom traktu toplokrvnih životinja te su odgovorne za pravilnu probavu hrane. Ukoliko su u fekalijama prisutne i patogene bakterije, one će također dospjeti zajedno sa koliformnim bakterijama u otpadne i prirodne vode. Koliformne bakterije i fekalni streptokoki ili enterokoki su najpodobnija grupa indikatorskih bakterija za vrednovanje higijenske kvalitete vode

Uticaj veličine čestica mermera u hrani nosilja i vremena ovipozicije na kvalitet ljuske jaja

Eggshell quality was studied in three groups of Issa Brown hens, from 73 to 78 weeks of age. Group 1 (control) received a basal diet with 3,8 % Ca and 0,35 % available P, in which pulverized limestone (particle size 0,02 mm) was the main source of Ca. The other two groups of hens were fed diets of the same composition but differing in the supplemented limestone particle size. In group 2 and 3 60 % of the pulverized limestone was substituted with a granular form, of particle size 1,10-1,40 mm. and 1,42-2,80 mm respectively. Eggs for examination were collected at three periods of time: 7-9 hours, 11-13 hours and 15-17 hours. There were significant effects of particle size and oviposition time on eggshell quality. Egg mass and shell deformation decreased, while shell breaking force, shell thickness and shell mass increased with increasing oviposition time. At the afternoon period of laying, significantly higher (p (lt) 0,05) breaking force (5,0 kg) and lower shell deformation (21,9μ) were obtained in eggs of hens fed on the diet incorporating the granular form of limestone (particle size 1,10-1,40 mm) than eggs of hens fed only pulverized limestone. It was shown that there are possibilities for improving eggshell quality, in older hens, by a combination of pulverized and granular limestone in the diet, as a source of calcium.Ispitivanje je obavljeno na 90 nosilja Issa Brown, u uzrastu od 73-78 nedelja, podeljenih u tri grupe. Sve grupe su za ishranu dobijale smeše istog sastava, u kojima je glavni izvor kalcijuma bio mleveni mermer. Razlike između grupa su bile u veličini čestica mermera dodatog u hranu. Grupa 1, (kontrola), je dobijala smešu sa praškasto mlevenim mermerom (kreda), veličine čestica 0,02 mm. U smeši za grupu 2 oko 60 % mermera je bilo sa krupnijim česticama (1,10-1,40 mm), a 40 % u obliku krede. U smeši za grupu 3 oko 60 % mermera je bilo sa još krupnijim česticama (1,42-2,80 mm), a 40 % u obliku krede. Za ispitivanje kvaliteta ljuske jaja su sakupljana svakodnevno u tri vremenska intervala (vreme ovipozicije): 7-9 sati, 11-13 sati i 15-17 sati. Ustanovljeno je da sa vremenom ovipozicije opada masa jaja i deformacija ljuske, dok se vrednosti sile loma, debljine i mase ljuske povećavaju. Veličina čestica mermera dodatog u hranu, ispoljila je značajan uticaj na kvalitet ljuske jaja, izražen kroz deformaciju i silu loma. Jaja nosilja iz 2. i 3. grupe (krupnije čestice mermera), snesena popodne, imala su značajno (p (lt) 0,05) manje vrednosti deformacije (21,9 μ; 19,9 μ) i veće vrednosti sile loma ljuske (5,0 kg; 4,6 kg) u odnosu na jaja nosilja iz 1. grupe. U toku prepodnevnog perioda nošenja, jaja nosilja 1. i2. grupe su ispoljila veću silu loma u odnosu na jaja nosilja 3. grupe. Generalno, može se zaključiti da je 2. grupa nosilja (veličina čestica mermera 1,10-1,40 mm) pokazala najbolje rezultate i da je moguće poboljšati čvrstoću ljuske jaja, kod starijih nosilja, dodatkom u hranu izvesne količine mermera krupnijih čestica

Phenotypic and genotypic characteristics of Escherichia coli isolated from faeces of dogs

Šiga toksin produkujuće Escherichia coli (STEC) čine jednu od šest grupa dijarejagenih E. coli. Na svjetskom nivou, infekcija izazvana STEC najčešći je uzrok akutne renalne insuficijencije kod djece i starijih osoba. Kako su psi prepoznati kao rezervoari STEC, blizak kontakt ljudi i pasa predstavlja rizik za zoonotsku transmisiju ovih bakterija.  U Republici Srbiji, osim ograničenog broja istraživanja o prisustvu STEC kod domaćih životinja i ljudi nema dostupnih literaturnih podataka o istraživanjima ove grupe E. coli kod pasa. Stoga, cilj ove doktorske disertacije bio je da se dokaže prisustvo i utvrdi prevalencija STEC u populaciji pasa s teritorije grada Novog Sada, izvrši tipizacija i molekulrna karakterizacija sojeva E. coli izolovanih iz fecesa pasa i utvrdi prisustvo rezistentnih sojeva E. coli. U ovo istraživanje bio je uključen 101 pas s teritorije Novog Sada, a kao materijal korišćeni su uzorci fecesa pasa. U cilju izolacije E. coli iz fecesa pasa primijenjeni su standardni bakteriološki metodi izolacije i biohemijske identifikacije, a potvrda pripadnosti vrsti izvršena je korišćenjem  matricom potpomognute laserske desorpcije/jonizacije-vrijeme preleta masene spektrometrije (MALDI-TOF MS). Za utvrđivanje prisustva STEC kod pasa primijenjeni su metodi lateks aglutinacije za serogrupu O157,  direktne aglutinacije za serogrupe “velike šestorke” O26, O45, O103, O111, O121 i O145, test verocitotoksičnosti (VCA), imunoenzimski test (ELISA), kao i lančana reakcija polimeraze (PCR). Antibiotska rezistencija utvrđena je disk difuzionim metodom prema standardima EUCAST i CLSI.  U ovom istraživanju, po prvi put u Republici Srbiji, dokazano je prisustvo STEC u populaciji pasa. Primjenom VCA metoda ustanovljena je prevalencija od 1,98%, dok je primjenom ELISA i PCR metoda ustanovljena prevalencija od 5,94% odnosno 4,95%. Dva izolata E. coli pripadala su nekoj od serogrupa “velike šestorke” STEC, dok prisustvo sojeva iz serogrupe O157 nije utvrđeno. U ispitivanoj populaciji pasa utvrđeno je prisustvo sojeva E. coli rezistentnih na jedan ili više korišćenih antibiotika, kao i jednog multirezistentnog izolata. Najviše izolata E. coli pokazalo je rezistenciju na ampicilin (22,5%), dok nijedan izolat nije pokazao rezistenciju na gentamcin. Pozitivna povezanost utvrđena je između stila života psa i prisustva STEC. Naime, značajno veća prevalencija STEC, u odnosu na vlasničke pse, zabilježena je kod pasa lutalica, što je vjerovatno posljedica neograničene slobode kretanja, a time i češćeg kontakta s kontaminiranom hranom i vodom kao izvorom STEC.  Nalaz STEC i izolata E. coli rezistentnih na antibiotike kod pasa od značaja je kako s aspekta male kliničke prakse tako i s aspekta javnog zdravlja u Republici Srbiji. DatumShiga toxin-producing Escherichia coli (STEC) strains constitute one of six groups of diarrheagenic E. coli. Infection caused by STEC is the most common cause of acute renal failure in young children and elderly people worldwide. As dogs are recognized as a reservoir for STEC, the close contact between humans and dogs poses a risk for zoonotic transmission of these bacteria. Except scarce studies of STEC in humans and domestic animals, there are no available data about this E. coli group in dogs in the Republic of Serbia. Therefore the aim of this doctoral dissertation was to determine the presence and prevalence of STEC in the dog populaton in the area of Novi Sad, to perform typing and molecular characterization of E. coli strains isolated from faeces of dogs,  as well to determine the presence of antibiotic resistant E. coli strains. In total 101 dogs from the area of Novi Sad was included in this research. As the material fecal samples of dogs were used. In order to isolate E. coli strains from faeces standard methods of bacterial isolation and biochemical identification were used, and for the confirmation of species identity matrix-assisted laser desorption/ionization time-offlight mass spectrometry (MALDI-TOF MS) was used. In order to determine the presence of STEC in dogs latex agglutination for the serogroup O157, direct agglutination for “big six” serogroups (O26, O45, O103, O111, O121 and O145), Vero cell cytotoxicity assay (VCA), enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) were used. Antibiotic resistance was determined by disc diffusion method according to the EUCAST and CLSI guidelines. In this research, for the first time in the Republic of Serbia, the presence of STEC has been proven in the dog population. By VCA method the prevalence of 1,98% was determined, while by ELISA and PCR the determined prevalence was 5,94% and 4,95% respectively. Two E. coli isolates belonged to some of the STEC “big six” serogroups, while none of the isolates belonged to O157 serogroup. Furthermore, in the dog population included in this research, the presence of strains resistant to one or more of used antibiotics was determined, as well as the presence of one multiresistant strain. Most of the E coli isolates showed resistance to ampicillin (22,5%), while every of the isolates showed susceptibility to gentamicin. In this research significant association between lifestyle of dogs and STEC harbouring. That is to say, significantly higher STEC prevalence was noticed in stray dogs in comparison to pet dogs, what is likely due to unlimited freedom of movement and thereby more frequent contact with contaminated water and food as sources of STEC. Finding of STEC and E. coli strains resistant to antibiotics in dog population is of importance not just in small animal practice, but also in terms of public health in the Republic of Serbia