DC and low-frequency noise analysis for buried SiGe channel metamorphic PMOSFETs with high Ge content, Journal of Telecommunications and Information Technology, 2005, nr 1

Measurements of current drive in p-Si1-xGex MOSFETs, with x = 0.7, 0.8 reveal an enhancement ratio of over 2 times as compared to a Si device at an effective channel length of 0.55 um. They also show a lower knee voltage in the output I-V characteristics while retaining similar values of drain induced barrier lowering, subthreshold swing, and off current for devices with a Sb punch-through stopper. For the first time, we have quantitatively explained the low-frequency noise reduction in metamorphic, high Ge content, SiGe PMOSFETs compared to Si PMOSFETs

Rudolf Echt, Emile Boeswillwald als Denkmalpfleger.

Von Joest Thomas. Rudolf Echt, Emile Boeswillwald als Denkmalpfleger.. In: Bulletin Monumental, tome 144, n°2, année 1986. pp. 190-191

Etude de l’impact cellulaire non autonome de la senescence sur la reprogrammation cellulaire

Cellular senescence is a physiological response to a stress, leading to an irreversible cell cycle arrest. Entry in senescence goes along with a myriad of changes, one of the major being the secretion of various factors gathered under the term Senescence Associated Secretory Phenotype (SASP). Recent studies showed the role of senescent cells in regeneration, in particular through SASP. However, mechanisms enabling senescent cells to influence cellular plasticity in the context of tissue repair remain unknown. The discovery of cellular reprogramming, which allows the transformation of a differentiated cell into an induced pluripotent stem cell (iPSC), highlighted the plasticity of differentiated cells. This major breakthrough generated substantial hopes for regenerative medicine and understanding of diseases. I contributed to decipher the mechanisms by which senescence induces cellular plasticity. As a first step, we showed that injury-induced senescence could lead to the reprogramming of skeletal muscle, in particular by IL-6 secretion. Secondly, I decrypted more precisely how SASP influence the reprogramming in vitro and showed that this process could be IL-6 independent. Finally, I performed a proteomic study to identify factors secreted by senescent cells and to determine new factors that could affect reprogramming. I detected amphiregulin and showed that adding this protein enhanced the SASP effect on reprogramming. Indeed, Amphiregulin promotes reprogramming both in vitro and in vivo. Overall, this study not only allows us to better appreciate how senescence influences cellular plasticity after muscular injury, but also links up a new factor to cellular reprogramming.La sénescence est une réponse suite à un stress qui entraîne l’arrêt permanent du cycle cellulaire. La sénescence s’accompagne de changements, notamment la sécrétion de facteurs réunis sous le terme de SASP (Senescence Associated Secretory Phenotype). Des études ont montré le rôle des cellules sénescentes et du SASP dans la régénération tissulaire. Cependant les mécanismes qui permettent d’influer sur la plasticité cellulaire dans ce contexte sont inconnus. La découverte de la reprogrammation cellulaire qui permet de reprogrammer une cellule différenciée en cellule souche pluripotente induite a mis en évidence la plasticité des cellules différenciées. Utilisant ce système comme une plateforme, nous avons montré que la sénescence induite après blessure permettait la reprogrammation du muscle via l’IL-6, qui est un tissu normalement réfractaire à la reprogrammation. Puis, j’ai montré in vitro que le SASP pouvait augmenter l’efficacité de reprogrammation cellulaire indépendamment de l’IL-6. Enfin, j’ai réalisé une étude protéomique afin d’identifier de nouveaux facteurs du SASP pouvant affecter la reprogrammation. J’ai identifié l’amphiréguline et démontré que son ajout augmente la reprogrammation cellulaire in vitro et in vivo. Ces travaux permettent de mieux comprendre comment la sénescence influe sur la plasticité cellulaire et de lier un nouveau facteur à la reprogrammation

Genomic stability during cellular reprogramming: Mission impossible?

International audienceThe generation of induced pluripotent stem cells (iPSCs) from adult somatic cells is one of the most exciting discoveries in recent biomedical research. It holds tremendous potential in drug discovery and regenerative medicine. However, a series of reports highlighting genomic instability in iPSCs raises concerns about their clinical application. Although the mechanisms cause genomic instability during cellular reprogramming are largely unknown, several potential sources have been suggested. This review summarizes current knowledge on this active research field and discusses the latest efforts to alleviate the genomic insults during cellular reprogramming to generate iPSCs with enhanced quality and safety

Zeitschrift für infektionskrankheiten, parasitäre krankheiten und hygiene der haustiere.

Editors: 1905- Robert Ostertag, Ernst Joest, K. Wolffhügel.Mode of access: Internet.Available online through HathiTrust Emergency Access Service. Click the HathiTrust button on the right and log in to access this book onlin

Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming

International audienceCellular senescence is an irreversible growth arrest with a dynamic secretome, termed the senescence-associatedsecretory phenotype (SASP). Senescence is a cell-intrinsic barrier for reprogramming, whereas theSASP facilitates cell fate conversion in non-senescent cells. However, the mechanisms by which reprogramming-induced senescence regulates cell plasticity are not well understood. Here, we investigate how the heterogeneityof paracrine senescence impacts reprogramming. We show that senescence promotes in vitro reprogrammingin a stress-dependent manner. Unbiased proteomics identifies a catalog of SASP factorsinvolved in the cell fate conversion. Amphiregulin (AREG), frequently secreted by senescent cells, promotesin vitro reprogramming by accelerating proliferation and the mesenchymal-epithelial transition via EGFRsignaling. AREG treatment diminishes the negative effect of donor age on reprogramming. Finally, AREG enhances in vivo reprogramming in skeletal muscle. Hence, various SASP factors can facilitate cellular plasticityto promote reprogramming and tissue repair

Dimensions of delusional experience scale: a psychometric evaluation of a german version

Delusional experience is a fundamental symptom of psychotic illness. Over recent years, a multidimensional perspective has become increasingly important regarding this phenomenon. Several instruments to measure different dimensions of delusions have been constructed. The aims of this study were to examine the reliability and validity of a German version of the Dimensions of Delusional Experience Scale (DDE)