Aasen

Abaci

Agha

Ahmed

Al-Awar

American Diabetes Association

Amoh

Annette Graham

Ansell

Baltzis

Bielefeld

Bilousova

Blaber

Brouwer

Burkart

Burnett

Buta

Buth

Catherine S. Wright

Ceder

Chan

Chen

Chichagova

Cory

Davidson

Drawnel

Erin M. O’Shaughnessy

Faller

Faniku

Frank

Fujikura

Gerami-Naini

Girard

Gledhill

Golebiewska

Griscelli

Groeber

Gurdon

Harvey

Hattersley

Hewitt

Hirsch

Hosokawa

Ianitti

Itoh

Kandyba

Kogut

Kong

Kwak

Laakso

Lapasset

Levitsky

Lotte

Maherali

Maione

Mansbridge

Marion

Marro

Martin

Martinez-Santamaria

Matsubara

McCormick

Mewes

Mirza

Mori

Morran

Nissan

Nunan

Pane

Park

Patni

Patricia E. Martin

Paull

Peloso

Pennarossa

Peppa

Petrova

Pollok

Prigione

Prodinger

Pugliese

English

Zaccardi

Schonberger

Stagi

Sugimoto

Sacks

Salvotelli

Tsourdi

Zhang

Zomer

Young

Wicks

Wright

Wiegland

Roquet

Steinberg

Yazdanpanah

Sharpe

Rittie

Shanmugam

Takahashi

Wallet

Shtrichman

Steinle

Singh

Siller

Seah

Yang

Crossref

The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro

Impaired wound healing and ulceration caused by diabetes mellitus, is a significant healthcare burden, markedly impairs quality of life for patients, and is the major cause of amputation worldwide. Current experimental approaches used to investigate the complex wound healing process often involve cultures of fibroblasts and/or keratinocytes in vitro, which can be limited in terms of complexity and capacity, or utilisation of rodent models in which the mechanisms of wound repair differ substantively from that in humans. However, advances in tissue engineering, and the discovery of strategies to reprogramme adult somatic cells to pluripotency, has led to the possibility of developing models of human skin on a large scale. Generation of induced pluripotent stem cells (iPSCs) from tissues donated by diabetic patients allows the (epi)genetic background of this disease to be studied, and the ability to differentiate iPSCs to multiple cell types found within the skin may facilitate the development of more complex skin models; these advances offer key opportunities for improving modelling of wound healing in diabetes, and the development of effective therapeutics for treatment of chronic wounds

The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro

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