Facile Synthesis of N α -Protected Amino/Peptide Hydroxamic Acids Mediated by Comu

One-pot preparation of N α -protected amino/peptide hydroxamic acids from corresponding carboxylic acids is described using uronium-type coupling reagent COMU. The present protocol is simple and mild conditions are used. Thus the resulting hydroxamic acids are obtained in good yields without racemization

Facile Synthesis of N (alpha) -Protected Amino/Peptide Hydroxamic Acids Mediated by COMU

One-pot preparation of N (alpha) -protected amino/peptide hydroxamic acids from corresponding carboxylic acids is described using uronium-type coupling reagent COMU. The present protocol is simple and mild conditions are used. Thus the resulting hydroxamic acids are obtained in good yields without racemization

T3P® (propylphosphonic anhydride) Mediated Conversion of Carboxylic Acids into Acid Azides and one-pot Synthesis of Ureidopeptides

A general, mild, efficient, and environmentally benign protocol, which makes use of T3P® as an acid activating agent for the direct synthesis of acid azides from carboxylic acids is described. Further, the protocol is employed for the one-pot synthesis of α-ureidopeptides starting from N-protected α-amino acids

A straight forward synthesis of cyanoguanidines tethered dipeptidomimetics

1131-1135This work describes a simple and straight forward route for the synthesis of cyanoguanidine tethered dipeptidomimetics. The protocol is simple and uses thioureidopeptides as starting materials. HgCl2 serve as an effective desulphurizing agent in affording the desired products in good yields