9 research outputs found
Exposure to N-Ethyl-N-Nitrosourea in Adult Mice Alters Structural and Functional Integrity of Neurogenic Sites
- Author
- A Acevedo-Arozena
- A Alvarez-Buylla
- A Briancon-Marjollet
- A Ferragud
- A Garthe
- A Kikuchi
- A Koestner
- AH Luo
- Antonio Ferragud
- B Seri
- B Seri
- B Sunyer
- BJ Nagel
- C Agustin-Pavon
- C Lois
- C Zhao
- Christine Jasoni
- D Soewarto
- DN Abrous
- E Drapeau
- E Enwere
- EF Yamasaki
- EL Jones
- F Doetsch
- F Doetsch
- F Lazarini
- FE Harrison
- G Gheusi
- G Winocur
- GF Pilkington
- GJ Pilkington
- GR Sareddy
- H Bartsch
- H Eichenbaum
- I Driscoll
- I Imayoshi
- J Haorah
- J Mukherjee
- J Raber
- JE Malberg
- JL Mayer
- JM Revest
- JM Wojtowicz
- Jose Manuel Garcia-Verdugo
- JR Leonard
- JS Snyder
- Juan Jose Canales
- K Shimazu
- L Petreanu
- Luis Bonet-Ponce
- M Sirerol-Piquer
- MC Cook
- MD Saxe
- MS Fanselow
- MT Valley
- N Burgess
- N Ghebranious
- N Sanai
- PL Lantos
- PM Lledo
- R Belvindrah
- R Rola
- RC Schothorst
- RF Barth
- S Gil-Perotin
- S Jessberger
- S Preston-Martin
- Sara Gil-Perotin
- SM Hong
- SS Hecht
- SS Mirvish
- ST Bland
- T Bilzer
- T Jang
- V Breton-Provencher
- V Capilla-Gonzalez
- V Capilla-Gonzalez
- V Hernandez-Rabaza
- V Lemaire
- VA Anderson
- Vivian Capilla-Gonzalez
- W Altkofer
- W Slikker 3rd
- W Zhao
- Y Sakuraba
- YC Ho
- Publication venue
- Public Library of Science
- Publication date
- 04/01/2012
- Field of study
BACKGROUND: Previous studies have shown that prenatal exposure to the mutagen N-ethyl-N-nitrosourea (ENU), a N-nitroso compound (NOC) found in the environment, disrupts developmental neurogenesis and alters memory formation. Previously, we showed that postnatal ENU treatment induced lasting deficits in proliferation of neural progenitors in the subventricular zone (SVZ), the main neurogenic region in the adult mouse brain. The present study is aimed to examine, in mice exposed to ENU, both the structural features of adult neurogenic sites, incorporating the dentate gyrus (DG), and the behavioral performance in tasks sensitive to manipulations of adult neurogenesis. METHODOLOGY/PRINCIPAL FINDINGS: 2-month old mice received 5 doses of ENU and were sacrificed 45 days after treatment. Then, an ultrastructural analysis of the SVZ and DG was performed to determine cellular composition in these regions, confirming a significant alteration. After bromodeoxyuridine injections, an S-phase exogenous marker, the immunohistochemical analysis revealed a deficit in proliferation and a decreased recruitment of newly generated cells in neurogenic areas of ENU-treated animals. Behavioral effects were also detected after ENU-exposure, observing impairment in odor discrimination task (habituation-dishabituation test) and a deficit in spatial memory (Barnes maze performance), two functions primarily related to the SVZ and the DG regions, respectively. CONCLUSIONS/SIGNIFICANCE: The results demonstrate that postnatal exposure to ENU produces severe disruption of adult neurogenesis in the SVZ and DG, as well as strong behavioral impairments. These findings highlight the potential risk of environmental NOC-exposure for the development of neural and behavioral deficits
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
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- Aimoniotou-Georgiou E
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- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
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- Zamudio D
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- Zhao L
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- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Linfoma de Hodkin en Chile: Experiencia de 15 años del Programa Nacional de Cáncer del Adulto
- Author
- Publication venue
- 'SciELO Agencia Nacional de Investigacion y Desarrollo (ANID)'
- Publication date
- Field of study
Fixated on Ability
- Author
- Alarcón Norma
- Alcoff Linda Martín
- Anzaldúa Gloria E
- Anzaldúa Gloria E
- Anzaldúa Gloria E
- Babbitt Susan
- Beauvoir Simone de
- Beth A. Ferri
- Blee Kathleen M
- Boler Megan
- Brueggemann Brenda Jo
- Butler Judith
- Carbado Devon W
- Cerevenak Sarah J
- Cervantes Lorna Dee
- Christian Barbara
- Cleaver Kathleen Neal
- Code Lorraine
- Collins Patricia Hill
- Crutchfield Susan
- Darke Paul
- Davis Lennard
- DuCille Ann
- Duncan James
- Elia Nada
- Ferri Beth A
- Franks Beth
- Grewal Inderpal
- Grillo Trina
- Guattari Félix
- Harding Sandra
- Hardy Aiken Susan
- hooks bell
- Hull Gloria T
- Jamila Shani
- Joseph Miranda
- Keith Lois
- Kleege Georgina
- Lee Rachel
- Linton Simi
- Lugones María
- Mairs Nancy
- Martin Biddy
- Martínez Erica Gonzalez
- Mascia-Lees Frances E
- May Vivian M
- May Vivian M
- Mitchell David T
- Morrison Toni
- Ng Roxana
- Norden Martin F
- Oliver Kelly
- Pratt Geraldine
- Reid DKim
- Sandoval Chela
- Sasaki Betty
- Segrest Mab
- Shildrick Margrit
- Smith Barbara
- Smith Valerie
- Spelman Elizabeth V
- Trinh T Minh-ha
- Truth Sojourner
- Vivian M. May
- Wiegman Robyn
- Wing Adrien Katherine
- Yellin Jean Fagan
- Young Iris Marion
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Asymmetric architecture is non-random and repeatable in a bird’s nests
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- Aberg Cobo B.
- Abrego Veizaga V.
- Acosta H.
- Acosta M.
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- Aguilar J.
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- Albuerne I.
- Alcaraz M.
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- Alonso P.
- Alterino D.
- Alvarez de Quevedo M.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 09/05/2022
- Field of study
Kuluttajabarometri maakunnittain 2000, 2. neljännes
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
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- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
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- Amstrup-Hansen L
- Anagnou A
- Andersen C
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- Anderson P
- Andreadaki E
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- Andreou P
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- Angermair S
- Angus K
- Anillo V
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- Apostolou K
- Applewhaite C
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- Arkalaki E
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- Yeh E
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- Yuan F
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- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
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- Zhao L
- Zhao L
- Zhao S
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- Zhao W
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- Zhong Y
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- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
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- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- Tilastokeskus
- Publication date
- 11/07/2000
- Field of study
Suomen virallinen tilasto (SVT
Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
- Bates S
- Batista HD
- Bauchmuller K
- Bauer M
- Baumgarten G
- Baxter L
- Beaton C
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- Zamudio D
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2017
- Field of study
This was an investigator-initiated study funded by Nestle Health Sciences through an unrestricted research grant and by a National Institute for Health Research (UK) Professorship held by R.P. The study was sponsored by Queen Mary University of London
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- Accountability
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- Aggarwal Pramila
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- Applegate Bill
- Arax Mark
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- Ashton Geoffrey C
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Progression of Geographic Atrophy in Age-related Macular Degeneration
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- Jorge Rodriguez
- Jose Carrion
- Jose Rebimbas
- Jose S. Pulido
- Joseph Civantos
- Joseph Coney
- Joseph F. Fisher
- Joseph Fan
- Joseph Googe
- Joseph Maguire
- Joseph Morales
- Joshua Dunaief
- Joshua Udoetek
- Joy Bankert
- Joy L. Meier
- Juan Grunwald
- Judy Belt
- Judy Brower
- Judy E. Kim
- Judy Flanders
- Judy Liu
- Julia Haller
- Julia Teatsworth
- Julianne Hall
- Julie Hammersley
- Julio Sierra
- Julissa Diaz
- Justin Brown
- Justin Davis
- Justin L. Gottlieb
- Justin Langdon
- Justin Townsend
- K.V. Chalam
- Kamella Lau Zimmerman
- Kara Rollins Halsey
- Karen Aletter
- Karen Duignan
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- Karin Berg
- Karishma Chandra
- Karl Olsen
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- Katherine Hall Shimel
- Kathleen Carlton
- Kathryn Burke
- Kathy Glander
- Kathy Selchert
- Katie Kilgo
- Katrina Jones
- Katy W. Tai
- Kawa
- Kayla Williams
- Kean Oh
- Keith McBroom
- Kekul B. Shah
- Kellianne Marfisi
- Kelly Sholtis
- Kelly Stalford
- Ken Carnevale
- Kenneth Fong
- Kenneth Huff
- Kevin J. Blinder
- Khanifar
- Kia Rookard
- Kiersten Nelson
- Kim Drury
- Kim DuBois
- Kim Walther
- Kimberley Wegner
- Kimberly A. Neely
- Kimberly Drenser
- Kimberly Stepian
- Kimberly Yeckel
- Kirk Krogstad
- Kirk Packo
- Kit Morehead
- Klein
- Klein
- Klein
- Komal Desai
- Kourous Rezaei
- Krissa Packard
- Krista Bayer
- Krista Rosenberg
- Kristin Lipka
- Kristina Oliver
- Kristine Dietzman
- Kristine Johnson
- Kristy Keller
- Kumar Thotapally
- Kylie Mendez
- Lacy Stover
- Larry D. Hubbard
- Laura Holm
- Laura McPoland
- Laura Sladoje
- Laura Walter
- Laurel Weeney
- Lauren B. Fox
- Lauren Welch
- Lawrence Halperin
- Lawrence Ho
- Lawrence Morse
- Lawrence Singerman
- Lawrence Ulanski
- Lawrence Yannuzzi
- Lea Doll Raymer
- Leanne Labriola
- Lee Jampol
- Lenise Myers
- Leslie Ellorin
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- Levy
- Levy
- Linda Curtis
- Linda Manor
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- Lindblad
- Lindsay Williams
- Lisa Ferguson
- Lisa Grande
- Lisa Hawkins
- Lisa Hogue
- Lisa Preston
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- Liza Jarrett Beaudette
- Lizette Lopez
- Lloyd Clark
- Logan Hitchcock
- Lois Swafford
- Loraine Clark
- Lori E. Coors
- Lori Kaminski
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- Lori Revella
- Lorraine Sherlin
- Lucia Sobrin
- Lucy Young
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- Lynn Schueckler
- Lynn Swartz
- Lynn Watson
- Lynnette F. Lambert
- M. Gilbert Grand
- Madison Slusher
- Mallie Taylor
- Mandeep Dhalla
- Manfred A. von Fricken
- Manjot Gill
- Marc Levy
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- Marcia Grillo
- Marcia Kopfer
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- Marco Zarbin
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- Margaret Graham
- Margaret Padilla
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- Mark Clark
- Mark Clark
- Mark Harrod
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- Mark Peters
- Mark Prybylski
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- Mark Sneath
- Marlene Rico
- Marriner Skelly
- Marshall Tyler
- Martin Thomley
- Mary Ann Nguyen
- Mary B. Lansing
- Mary Beth Shannon
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- Mary Ilc
- Mary Jill Palmer
- Mary Lamy
- Mary Monk
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- Maurice B. Landers
- Megan Rakes
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- Melanie Bailey
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- Melina Mazurek
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- Michael Albert
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- Odette M. Houghton
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- Ong
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- Paul A. Edwards
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- Paula Morris
- Paula Price
- Peggy Allchin
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- Peggy Miller
- Peter MacDowell
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- Philip J. Rosenfeld
- Philip Laird
- Philip Rosenfeld
- Pouya Dayani
- Qin Zhou
- R. Joseph Logan
- R. Scott Varner
- Rachel Grunhaus Hollar
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- Rafael L. Ufret-Vincenty
- Rajendra Apte
- Rajiv Anand
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- Ramin Sarrafizadeh
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- Rebecca Lee
- Rebecca Nielsen
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- Ricky D. Isernhagen
- Rinki Ratnapriya
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- Rita Denbow
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- Riva Adamovsky
- Rob Richmond
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- Robert A. Liss
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- Robert Frantz
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- Roisman
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- Rosa Rodriguez
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- Sadda
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- Sandeep Grover
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- Sashi Kaur
- Schaal
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- Schmitz-Valckenberg
- Scott Anagnoste
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- Scott Savage
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- Sean Grout
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- Sharon Solomon
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- Shelly Fulbright
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- Sherrie Schenning
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- Shree Kurup
- Silvia Linares
- Sleiman
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- Sohail Hasan
- Sonia Mehta
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- Steven Bennett
- Steven H. Sherman
- Steven Lin
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- Steven Spencer
- Steven T. Bailey
- Steven Truong
- Steven Yeh
- Suber Huang
- Sue Pope
- Suk Jin Moon
- Sun
- Sunir Garg
- Sunness
- Sunness
- Sunness
- Suresh Chandra
- Susan Allman
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- Susie Chang
- Swaroop
- Sylvia Ramos
- T. Michael Nork
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- Tammy Brink
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- Tammy Gasparyan
- Tammy Walker
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- Tanya Alexander Snowden
- Tanya Tracy Marsh
- Tara Farmer
- Tara Raphael
- Tara Young McCannel
- Tarek S. Hassan
- Tatiana Mikheyav
- Teresa Coffey
- Teresa Slagle
- Tereza Conway
- Theresa Cain
- Theresa Goddard
- Thomas B. Connor
- Thomas Blondo
- Thomas Friberg
- Thomas G. Chu
- Thomas J. Hwang
- Thomas Link
- Thomas R. Pheasant
- Thomas S. Stevens
- Thomas W. Stone
- Tiana Gonzales
- Tiarnan D. Keenan
- Tien Pei Wong
- Tiffanie Keaton
- Tiffany Swinford
- Tim Odem
- Timothy Bennett
- Timothy Olsen
- Tina Bell
- Tina Scheufele Cleary
- Tod A. McMillan
- Todd E. Schneiderman
- Tom Treuter
- Tony Adkins
- Torsten Wiegand
- Tracey Caldwell
- Tracey Martin
- Traci Clemons
- Traci E. Clemons
- Tracy Emond
- Tracy Kaczanowski
- Tracy Murray
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- Travis Meredith
- Trexler Topping
- Trina Nitzsche
- Uma Balasubramaniam
- Ursula Lord Bator
- Valerie Davis
- Valerie Watson
- Vanessa Bergman
- Vanessa Denny
- Vanessa Hoelscher
- Vera Dilts
- Veronica Sneed
- Vesper Williams
- Vicki Barwick
- Victoria Donaldson
- Vinad Voleti
- Virginia Therrien
- Vivian Tanner
- W. Copley McLean
- W. Scott Thompson
- W. Zachery Bridges
- Wai T. Wong
- Wai T. Wong
- Waldemar Torres
- Walter Holland
- Wanda Carrasquillo-Boyd
- Wang
- Wayne A. Solley
- Wendy McBee
- Wenhua Li
- Willia Ingram
- William Anderson
- William Deegan
- William J. Wirostko
- William J. Wood
- William Kiernan
- William Rosenthal
- William Tasman
- Yaspan
- Yehoshua
- Yehoshua
- Yehoshua
- Yehoshua
- Yesenia Ovando
- Yesmin Urias
- Yin Chen
- Yolanda Konior
- Yu
- Yu-Guang He
- Zayna Nahas
- Zbigniew Krason
- Zlatan Sadikovic
- Zohar Yehoshua
- Zuzanna Rozenbajgier
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