Parental involvement during pandemic times: challenges and opportunities

Due to COVID-19, many countries implemented emergency plans, such as lockdown and school closures. This new situation has significantly affected families, namely, the involvement required to support children's learning at home. The current study aimed to analyze Portuguese parents' perceptions of their home-based parental involvement in their children's learning during the lockdown and school closures in 2020 due to COVID-19. An online survey, using a closed-ended questionnaire, was employed. Variables included parents' sociodemographic and COVID-19 related characteristics; students' sociodemographic characteristics; distance learning context; parental involvement; and students' autonomy. Data were collected from a sample of 21,333 parents with children from elementary school to secondary education, and statistical data analysis was performed using IBM SPSS Statistics 26. Findings revealed that Portuguese parents supported their children during the pandemic mainly through the monitoring of attention in classes and task realization. However, several variables appear to significantly determine parental involvement time, which is higher when students attend public schools, when they are less autonomous and younger, when parents' level of education is lower, when the child is a boy (except in secondary education where gender is not relevant), and when the online school time is higher. Findings highlight the need for a significant investment of time from parents, particularly of primary school children, making it difficult to cohere work or telework with school activities. Implications for policies, schools, families are discussed in order to promote children's learning and success.info:eu-repo/semantics/publishedVersio

Planejamento cultural organizacional: o intercâmbio entre o gestor e a cultura

O objetivo deste estudo é identificar a importância do planejamento cultural para a gestão organizacional. O fator “Cultura” é responsável pelo fracasso de muitos modelos consagrados, ao não considerar as diferenças culturais entre os países. Muitas vezes a teoria não corresponde a prática em países de culturas distintas. Quando a literatura refere-se a uma organização, normalmente existem diversos fatores que incidem sobre o sucesso, a gestão é um dos fatores de maior peso na decisão do sucesso organizacional. E a cultura é um fator preponderante nesta gestão empresarial, uma variável interveniente. Para alcançar este objetivo foi usada a pesquisa exploratória a fim de buscar um modelo que explicasse a cultura na gestão. Foram encontrados 1456 artigos na base de dados Scielo, onde através dos trabalhos observados se revelou o sucesso da gestão através do planejamento da cultura organizacional

AVALIAÇÃO DE DIFERENTES NÍVEIS DE DESBASTE NAS PROPRIEDADES DA MADEIRA E DO CARVÃO VEGETAL DE Eucalyptus grandis x Eucalyptus urophylla

O presente trabalho teve como objetivo avaliar os efeitos de diferentes níveis de desbaste nas propriedades físicas e químicas da madeira e do carvão vegetal de híbrido de Eucalyptus urophylla W. Hill ex Maiden x Eucalyptus grandis S. T. Blake. O experimento foi instalado em um talhão de uma empresa do setor florestal, que foi dividido em quatro faixas, representando os níveis de desbaste de 0, 20, 35 e 50% aplicados ao povoamento aos cinco anos. Foram coletadas 3 árvores de cada tratamento, 62 meses pós-desbaste. Determinou-se densidade básica, poder calorífico superior (PCS) e composição química da madeira, os rendimentos gravimétricos além da densidade aparente, PCS e composição química imediata do carvão vegetal. A madeira apresentou características tecnológicas satisfatórias para produção de carvão vegetal, sob os diferentes níveis de desbaste, porém estes não influenciaram de maneira significativa as propriedades físicas e químicas doccarvão vegetal.This research aimed to evaluate effects of different levels of thinning in the physical and chemical properties of wood and charcoal from a hybrid clone of Eucalyptus urophylla W. Hill ex Maiden x Eucalyptus grandis S. T. Blake. The experiment was conducted in a plot of a forestry company which was divided into four tracks, representing the thinning levels of 0, 20, 35 and 50% applied to five years old plantations. Three trees were collected from each treatment, 62 months after thinning. Basic density, calorific power and chemical composition of wood had been determined, as well as charcoal properties as follows: gravimetric yields, density, chemical immediate composition and calorific power. Wood presented suitable technological characteristics for charcoal production, under different levels of thinning, but these did not influence significantly charcoal physical and chemical properties

Prognostic stratification of adult primary glioblastoma multiforme patients based on their tumor gene amplification profiles

Several classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics. Here we propose a prognostic stratification model for these primary tumors based on tumor gene amplification profiles, that might be easily implemented in routine diagnostics, and potentially improve the patients management. Gene amplification profiles were prospectively evaluated in 80 primary glioblastoma multiforme tumors using single-nucleotide polymorphism arrays and the results obtained validated in publicly available data from 267/347 cases. Gene amplification was detected in 45% of patients, and chromosome 7p11.2 including the EGFR gene, was the most frequently amplified chromosomal region – either alone (18%) or in combination with amplification of DNA sequences in other chromosomal regions (10% of cases). Other frequently amplified DNA sequences included regions in chromosomes 12q(10%), 4q12(7%) and 1q32.1(4%). Based on their gene amplification profiles, glioblastomas were subdivided into: i) tumors with no gene amplification (55%); ii) tumors with chromosome 7p/EGFR gene amplification (with or without amplification of other chromosomal regions) (38%); and iii) glioblastoma multiforme with a single (11%) or multiple (6%) amplified DNA sequences in chromosomal regions other than chromosome 7p. From the prognostic point of view, these amplification profiles showed a significant impact on overall survival of glioblastoma multiforme patients (p>0.001). Based on these gene amplification profiles, a risk-stratification scoring system was built for prognostic stratification of glioblastoma which might be easily implemented in routine diagnostics, and potentially contribute to improved patient management.This work was supported by RETICC RD06/0020/0035, RD06/0020/0059 and RD12/0036/0048 grants from Red Temática de Investigación Cooperativa en Cáncer (RTICC), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, (Madrid, Spain and FONDOS FEDER), AES PI16/000476 (Instituto de Salud Carlos III, Madrid, Spain and FONDOS FEDER), GRS909A14 (JCYL) and CB16/12/00400 grant (CIBERONC, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Madrid, Spain and FONDOS FEDER)

Prognostic stratification of adult primary glioblastoma multiforme patients based on their tumor gene amplification profiles

[EN]everal classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics. Here we propose a prognostic stratification model for these primary tumors based on tumor gene amplification profiles, that might be easily implemented in routine diagnostics, and potentially improve the patients management. Gene amplification profiles were prospectively evaluated in 80 primary glioblastoma multiforme tumors using singlenucleotide polymorphism arrays and the results obtained validated in publicly available data from 267/347 cases. Gene amplification was detected in 45% of patients, and chromosome 7p11.2 including the EGFR gene, was the most frequently amplified chromosomal region - either alone (18%) or in combination with amplification of DNA sequences in other chromosomal regions (10% of cases). Other frequently amplified DNA sequences included regions in chromosomes 12q(10%), 4q12(7%) and 1q32.1(4%). Based on their gene amplification profiles, glioblastomas were subdivided into: i) tumors with no gene amplification (55%); ii) tumors with chromosome 7p/EGFR gene amplification (with or without amplification of other chromosomal regions) (38%); and iii) glioblastoma multiforme with a single (11%) or multiple (6%) amplified DNA sequences in chromosomal regions other than chromosome 7p

Transtorno Bipolar em crianças: análise de revisões sistemáticas entre 2019- 2023

O transtorno bipolar em crianças apresenta desafios diagnósticos, sendo crucial considerar fatores genéticos, sintomas inespecíficos e a sobreposição com outras condições psiquiátricas. O diagnóstico precoce e a avaliação neuropsicológica são essenciais para um tratamento adequado, considerando o impacto nas funções executivas e, por conseguinte, no desenvolvimento global da criança. Este estudo teve como objetivo revisar estudos publicados entre 2019 e 2023 sobre transtorno bipolar em crianças para entender descobertas, lacunas e orientações futuras. Nesse sentido, foi desenvolvida uma revisão sistemática de literatura a partir das bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), o Medical Literature Analysis and Retrieval System Online (MEDLINE) e a Scientific Electronic Library Online (SCIELO). Com a análise e interpretação qualitativa dos resultados, concluiu-se que o estudo abordando o transtorno bipolar em crianças entre 2019 e 2023 evidencia desafios na identificação e tratamento, com destaque para a falta de critérios diagnósticos claros e lacunas no tratamento farmacológico, especialmente em relação ao uso do lítio. A pesquisa também ressalta a complexidade multifatorial do transtorno, envolvendo fatores genéticos, biológicos e ambientais, indicando a necessidade urgente de avanços na compreensão e manejo dessa condição na infância

Prognostic stratification of adult primary glioblastoma multiforme patients based on their tumor gene amplification profiles

Several classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics. Here we propose a prognostic stratification model for these primary tumors based on tumor gene amplification profiles, that might be easily implemented in routine diagnostics, and potentially improve the patients management. Gene amplification profiles were prospectively evaluated in 80 primary glioblastoma multiforme tumors using singlenucleotide polymorphism arrays and the results obtained validated in publicly available data from 267/347 cases. Gene amplification was detected in 45% of pati

The Sensitizers Nickel Sulfate and 2,4-dinitrofluorobenzene Increase CD40 and IL-12 Receptor Expression in a Fetal Skin Dendritic Cell Line

Dendritic cells (DCs) are antigen-presenting cells (APCs) capable of capturing haptens and to process and present them to T lymphocytes. In order to sensitize T cells for contact hypersensitivity (CHS), skin DCs suffer a maturation process with modifications on their surface molecules. The aim of this work was to evaluate changes induced by two contact sensitizers, 2,4-dinitrofluorobenzene (DNFB) and nickel sulfate (NiSO4), and a non-sensitizer 2,4-dichloronitrobenzene (DCNB), on the protein levels of two activation markers, CD40 and IL-12 receptor (IL-12R), in a mouse skin dendritic cell line (FSDC). The expression of CD40 and IL-12R proteins was evaluated by western blot assay and direct immunofluorescence microscopy. The results showed that CD40 and IL-12R expression increased significantly after cell exposure to NiSO4 and DNFB, although DNFB exhibited a stronger activity. There was no effect with DCNB. The epidermal cytokine granulocyte–macrophage colony-stimulating factor (GM-CSF), also used in the experiments, slightly increased the expression of both CD40 and IL-12R and when tested together with the sensitizers the effect was partially additive. The results suggest that the sensitizers DNFB and NiSO4 are directly involved on the changes of the surface markers CD40 and IL-12R in skin DCs, during the sensitization phase of CHS, and this effect may be enhanced by GM-CSF. In contrast, no effect was observed with DCNB