On Perception and Consciousness in HPPD:A Systematic Review

Hallucinogen-persisting perception disorder (HPPD) features as a diagnostic category in the DSM-5, ICD-11, and other major classifications, but our knowledge of the phenomenology of the perceptual symptoms involved and the changes in consciousness during the characteristic “flashbacks” is limited. We systematically evaluated original case reports and case series on HPPD to define its phenomenology, associated (psycho)pathology, and course. Our search of PubMed and Embase yielded 66 relevant publications that described 97 people who, together, experienced 64 unique symptoms of HPPD. Of these, 76% concerned symptoms characteristic of Alice in Wonderland syndrome, over 50% non-visual symptoms, and 38% perceptual symptoms not clearly linked to prior intoxication states. This is in contrast with the DSM-5 diagnostic criteria for HPPD. Even though less than half of the patients showed a protracted disease course of over a year, a third achieved remission. However, in patients with co-occurring depression (with or without anxiety) HPPD symptoms persisted longer and treatment outcomes were more often negative. Thus, unlike the acute stages of psychedelic drug intoxication, which may be accompanied by altered states of consciousness, HPPD is rather characterized by changes in the content of consciousness and an attentional shift from exogenous to endogenous phenomena. Since HPPD is a more encompassing nosological entity than suggested in the DSM-5, we recommend expanding its diagnostic criteria. In addition, we make recommendations for clinical practice and future research

Molecular cytogenetic analysis of prostatic adenocarcinomas from screening studies : early cancers may contain aggressive genetic features

No objective parameters have been found so far that can predict the biological behavior of early stages of prostatic cancer, which are encountered frequently nowadays due to surveillance and screening programs. We have applied comparative genomic hybridization to routinely processed, paraffin-embedded radical prostatectomy specimens derived from patients who participated in the European Randomized Study of Screening for Prostate Cancer. We defined a panel consisting of 36 early cancer specimens: 13 small (total tumor volume (Tv) < 0.5 ml) carcinomas and 23 intermediate (Tv between 0.5-1.0 ml) tumors. These samples were compared with a set of 16 locally advanced, large (Tv > 2.0 ml) tumor samples, not derived from the European Randomized Study of Screening for Prostate Cancer. Chromosome arms that frequently (ie, > or = 15%) showed loss in the small tumors included 13q (31%), 6q (23%), and Y (15%), whereas frequent (ie, > or = 15%) gain was seen of 20q (15%). In the intermediate cancers, loss was detected of 8p (35%), 16q (30%), 5q (26%), Y (22%), 6q, and 18q (both 17%). No consistent gains were found i

Late onset of new conduction disturbances requiring permanent pacemaker implantation following TAVI

Background: The timing of onset and associated predictors of late new conduction disturbances (CDs) leading to permanent pacemaker implantation (PPI) following transcatheter aortic valve implantation (TAVI) are still unknown, however, essential for an early and safe discharge. This study aimed to investigate the timing of onset and associated predictors of late onset CDs in patients requiring PPI (LCP) following TAVI. Methods and results: We performed retrospective analysis of prospectively collected data from five large volume centres in Europe. Post-TAVI electrocardiograms and telemetry data were evaluated in patients with a PPI post-TAVI to identify the onset of new advanced CDs. Early onset CDs were defined as within 48 hours after procedure, and late onset CDs as after 48 hours. A total of 2804 patients were included for analysis. The PPI rate was 12%, of which 18% was due to late onset CDs (>48 hours). Independent predictors for LCP were pre-existing non-specific intraventricular conduction delay, pre-existing right bundle branch block, self-expandable valves and predilation. At least one of these risk factors was present in 98% of patients with LCP. Patients with a balloon-expandable valve without predilation did not develop CDs requiring PPI after 48 hours. Conclusions: Safe early discharge might be feasible in patients without CDs in the first 48 hours after TAVI if no risk factors for LCP are present

The causes of the red sequence, the blue cloud, the green valley, and the green mountain

The galaxies found in optical surveys fall in two distinct regions of a diagram of optical colour versus absolute magnitude: the red sequence and the blue cloud with the green valley in between. We show that the galaxies found in a submillimetre survey have almost the opposite distribution in this diagram, forming a `green mountain'. We show that these distinctive distributions follow naturally from a single, continuous, curved Galaxy Sequence in a diagram of specific star-formation rate versus stellar mass without there being the need for a separate star-forming galaxy Main Sequence and region of passive galaxies. The cause of the red sequence and the blue cloud is the geometric mapping between stellar mass/specific star-formation rate and absolute magnitude/colour, which distorts a continuous Galaxy Sequence in the diagram of intrinsic properties into a bimodal distribution in the diagram of observed properties. The cause of the green mountain is Malmquist bias in the submillimetre waveband, with submillimetre surveys tending to select galaxies on the curve of the Galaxy Sequence, which have the highest ratios of submillimetre-to-optical luminosity. This effect, working in reverse, causes galaxies on the curve of the Galaxy Sequence to be underrepresented in optical samples, deepening the green valley. The green valley is therefore not evidence (1) for there being two distinct populations of galaxies, (2) for galaxies in this region evolving more quickly than galaxies in the blue cloud and the red sequence, (c) for rapid quenching processes in the galaxy population

FDR4ATMOS (Task A): Improving SCIAMACHY Level 1 and add calibrated lunar data

The project FDR4ATMOS (Fundamental Data Records in the domain of satellite Atmospheric Composition) has been initiated by the European Space Agency (ESA). Task A of the project covers the improvement of the SCIAMACHY Level 1b degradation correction, with the aim to remove ozone trends from the SCIAMACHY Level 2 data set that were introduced during the development of baseline version 9 (both data sets not released). We will also, for the first time, add calibrated lunar data to Level 1, covering the whole spectral range of SCIAMACHY and the full mission time. The SCIAMACHY processing chain for better Ozone total column data: After the full re-processing of the SCIAMACHY mission with the updated processor versions, the validation showed that the total Ozone column drifted downward by nearly 2% over the mission lifetime. This drift is likely caused by changes in the degradation correction in the Level 1 processor, that led to subtle changes in the spectral structures. These are misinterpreted as an atmospheric signature. We updated the Level 0-1 processor accordingly and a full mission re-processing was done. As a major improvement we additionally incorporated calibrated lunar data in the SCIAMACHY Level 1b product. In the new Level 1b product we will provide the individual scans of the moon as well as disk integrated and calibrated lunar irradiance and reflectance. The instrument performed regular lunar observations building up a unique 10 year data set of lunar spectra from the UV to the SWIR with moderately high spectral resolution. SCIAMACHY scanned the full lunar disk and over the ten year mission time made 1123 observations of the moon. Most satellites can only observe the moon under very specific geometries due to instrument-viewing and orbit restrictions. SCIAMACHY, however, with a two mirror pointing system was much less constrained and was able to observe the moon under an extreme large variation of geometries (especially during dedicated lunar observation campaigns), allowing it thus potentially to tie different satellites and geometry observations together. During the individual lunar observations, SCIAMACHY only saw a small slice of the Moon and scanned over the moon in order to obtain data for the full disk. We combined the individual calibrated scans, correcting for scan speed and the fact the Moon does not fill the entire slit length. The calculation of distance-normalized lunar reflectances did not require an external solar spectrum, but used solar measurements of SCIAMACHY itself. This version of Level 1 will also be the first one that replaces the ENVISAT byte stream format with the netCDF format that is aligned with the product format of other atmospheric sensors like the Sentinels The paper will present the improvements of the Level 1 product, the results of the quality control and validation

The causes of the red sequence, the blue cloud, the green valley, and the green mountain

The galaxies found in optical surveys fall in two distinct regions of a diagram of optical colour versus absolute magnitude: the red sequence and the blue cloud, with the green valley in between. We show that the galaxies found in a submillimetre survey have almost the opposite distribution in this diagram, forming a \u27green mountain\u27. We show that these distinctive distributions follow naturally from a single, continuous, curved Galaxy Sequence in a diagram of specific star formation rate versus stellar mass, without there being the need for a separate star-forming galaxy main sequence and region of passive galaxies. The cause of the red sequence and the blue cloud is the geometric mapping between stellar mass/specific star formation rate and absolute magnitude/colour, which distorts a continuous Galaxy Sequence in the diagram of intrinsic properties into a bimodal distribution in the diagram of observed properties. The cause of the green mountain isMalmquist bias in the submillimetre waveband, with submillimetre surveys tending to select galaxies on the curve of the Galaxy Sequence, which have the highest ratios of submillimetre-to-optical luminosity. This effect, working in reverse, causes galaxies on the curve of the Galaxy Sequence to be underrepresented in optical samples, deepening the green valley. The green valley is therefore not evidence (1) for there being two distinct populations of galaxies, (2) for galaxies in this region evolving more quickly than galaxies in the blue cloud and the red sequence, and (3) for rapid-quenching processes in the galaxy population

ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies

Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of its acquisition and quantification. In a community-wide effort towards robust and reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized analyses across centers and scanners. The procedures used in ExploreASL capitalize on published image processing advancements and address the challenges of multi-center datasets with scanner-specific processing and artifact reduction to limit patient exclusion. ExploreASL is self-contained, written in MATLAB and based on Statistical Parameter Mapping (SPM) and runs on multiple operating systems. To facilitate collaboration and data-exchange, the toolbox follows several standards and recommendations for data structure, provenance, and best analysis practice. ExploreASL was iteratively refined and tested in the analysis of >10,000 ASL scans using different pulse-sequences in a variety of clinical populations, resulting in four processing modules: Import, Structural, ASL, and Population that perform tasks, respectively, for data curation, structural and ASL image processing and quality control, and finally preparing the results for statistical analyses on both single-subject and group level. We illustrate ExploreASL processing results from three cohorts: perinatally HIV-infected children, healthy adults, and elderly at risk for neurodegenerative disease. We show the reproducibility for each cohort when processed at different centers with different operating systems and MATLAB versions, and its effects on the quantification of gray matter cerebral blood flow. ExploreASL facilitates the standardization of image processing and quality control, allowing the pooling of cohorts which may increase statistical power and discover between-group perfusion differences. Ultimately, this workflow may advance ASL for wider adoption in clinical studies, trials, and practice

Tandem Catalysis with Antagonistic Catalysts Compartmentalized in the Dispersed and Continuous Phases of a Pickering Emulsion

Tandem catalysis combines multiple conversion steps, catalysts, and reagents in one reaction medium, offering the potential to reduce waste and time. In this study, Pickering emulsions-emulsions stabilized by solid particles-are used as easy-to-prepare and bioinspired, compartmentalized reaction media for tandem catalysis. Making use of simple and inexpensive acid and base catalysts, the strategy of compartmentalization of two noncompatible catalysts in both phases of the emulsion is demonstrated by using the deacetalization-Knoevenagel condensation reaction of benzaldehyde dimethyl acetal as a probe reaction. In contrast to simple biphasic systems, which do not allow for tandem catalysis and show instantaneous quenching of the acid and base catalysts, the Pickering emulsions show efficient antagonistic tandem catalysis and give the desired product in high yield, as a result of an increased interfacial area and suppressed mutual destruction of the acid and base catalysts