Autosuficiencia energética en la vivienda

Resumen Los edificios, junto al transporte suponen más de la mitad del consumo energético actual de combustible y de la contaminación a este asociada, de difícil solución por la dispersión de los procesos de combustión en poblaciones o carreteras. Esta distribución en la edificación de la demanda favorece el uso de energía solar, el recurso renovable más abundante y de fácil acceso sobre la superficie terrestre, especialmente adecuado en nuestro clima. El uso de tecnología solar requiere procesos de acumulación que garanticen la disponibilidad del calor excesivo del verano durante las frías noches de invierno así como la iluminación o las comunicaciones durante la noche en base a la radiación recibida en las horas de radiación solar. El trabajo describe la posibilidad de captura térmica en la cubierta con almacenamiento selectivo en el subsuelo capaz de satisfacer la demanda de energía para climatización de la vivienda a lo largo del año a un coste ,muy bajo. La energía eléctrica de "alta calidad" se genera y acumulé1localmente en forma de hidrógeno para alimentar según demanda mediante una pila de combustible. Con la tecnología actual, aún en pleno desarrollo, el balance es claramente positivo lo que significa la posibilidad de autosuficiencia energética para una parte considerable de las viviendas.El MEC ha financiado el desarrollo de nuevos dispositivos de hidrógeno en el proyecto "Diseño y realización de una nueva Pila de Combustible polimérica de bajo coste y alta eficacia" MCYT- ENE2005-09124-C04-02/ALT. y el CSIC ha financiado la generación de hidrógeno a partir de residuos orgánicos. El P.S.E. INVISO para industrialización de la vivienda sostenible financia el desarrollo integral de estos sistemas.Peer reviewe

Robust Field-level Likelihood-free Inference with Galaxies

© 2023. The Author(s). Published by the American Astronomical Society. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/We train graph neural networks to perform field-level likelihood-free inference using galaxy catalogs from state-of-the-art hydrodynamic simulations of the CAMELS project. Our models are rotational, translational, and permutation invariant and do not impose any cut on scale. From galaxy catalogs that only contain 3D positions and radial velocities of ∼1000 galaxies in tiny (25h−1Mpc)3 volumes our models can infer the value of Ωm with approximately 12% precision. More importantly, by testing the models on galaxy catalogs from thousands of hydrodynamic simulations, each having a different efficiency of supernova and active galactic nucleus feedback, run with five different codes and subgrid models—IllustrisTNG, SIMBA, Astrid, Magneticum, SWIFT-EAGLE—we find that our models are robust to changes in astrophysics, subgrid physics, and subhalo/galaxy finder. Furthermore, we test our models on 1024 simulations that cover a vast region in parameter space—variations in five cosmological and 23 astrophysical parameters—finding that the model extrapolates really well. Our results indicate that the key to building a robust model is the use of both galaxy positions and velocities, suggesting that the network has likely learned an underlying physical relation that does not depend on galaxy formation and is valid on scales larger than ∼10 h −1 kpc.Peer reviewe

Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a life-saving procedure used for the treatment of selected hematological malignancies, inborn errors of metabolism, and bone marrow failures. The role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against infection. However, recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered functions. Accordingly, neutrophils are emerging as highly versatile cells that are able to acquire different, often opposite, functional capacities depending on the microenvironment and their differentiation status. Herein, we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT, from the hematopoietic stem cell (HSC) mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC infusion. We also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versus-host disease (GVHD) prophylaxis. Finally, the potential involvement of neutrophils in alloHSCT-related complications, such as transplant-associated thrombotic microangiopathy (TA-TMA), acute and chronic GVHD, and cytomegalovirus (CMV) reactivation, is also discussed. Based on the data reviewed herein, the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial role. However, much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Vivienda de bajo consumo energético térmico

Trabajo realizado con el soporte del Grupo de Investigación de Energías Renovables del Instituto de Automática Industrial - CSIC.El presente trabajo incide en la demanda de soluciones eficaces para su implementación en la construcción de edificios con la finalidad de obtener un bajo consumo energético térmico. Así, en este trabajo se presenta principalmente el estudio de un cerramiento térmico para ser utilizado en una vivienda de bajo coste energético. Además se presenta brevemente la utilización, en su diseño y construcción, de tres sub-sistemas que integrados entre sí que representan una técnica innovadora en su género. El cerramiento térmico está compuesto por múltiples capas. Las capas exteriores tienen alta conductividad térmica y sirven como intercambiadores de calor tanto con el ambiente exterior como con el interior del edificio. Las capas interiores sirven de aislante y, además, sirven para controlar la conductividad térmica mediante aportaciones de flujos de energía acumulada.Peer reviewe

Energía solar en el subsuelo

Resumen: La temperatura del subsuelo, prácticamente constante a partir de una cierta profundidad, o bajo una capa ligera de aislante, coincide aproximadamente en cada región con la temperatura media anual del aire en la superficie. Esto significa que disponemos de una fuente ingente de calor a coste reducido. Además esta temperatura en nuestro clima está solo unos grados por debajo de la denominada "banda de confort" de los edificios. Por otro lado, frente a una demanda energética de los edificios, que en nuestro clima apenas supera los 100 kWh/m2 año (IDAE), la energía solar recibida en cubierta, es 1.600 kWh/m2 año. Si la Tierra captura el 50% de la -radiación incidente en forma de calor, no resulta técnicamente difícil ni costoso el proceso de captura y almacenamiento en el subsuelo del exceso de energía. Este trabajo describe la técnica, analizando los resultados de diferentes edificios con acumulación geotérmica selectiva que garantizan en nuestro clima un coste energético próximo a cero para calefacción, refrigeración y ACS, el 70% del consumo total de energía. El modelo analítico de flujo térmico entre las superficies de captura directa bajo cubierta al subsuelo y de este a la demanda del edificio se corrobora con los resultados experimentales obtenidos en un edificio prototipo de dos plantas y 200 m2• La gran inercia térmica del subsuelo del edificio ofrece una estabilidad de acumulación plurianual, y una adecuada gestión de la energía reducen drásticamente la demanda de potencia puntual para climatización.Los siguientes proyectos han financiado el desarrollo y prototipos que aquí se resumen: • EXPOAGUA 2008 ZARAGOZA. • MICINN P.S.E INVISO Industrialización de la vivienda sostenible PSE-380000-2008-6. • CSIC PIE Generación de hidrógeno a partir de residuos orgánicos Ref. 2004 8 OE 254. • Diseño y realización de una nueva Pila de Combustible polimérica de bajo coste y alta eficacia". MCYT- ENE2005-09124-C04-02/ALT. • Pila de combustible en una arquitectura inteligente de control para su integración en un sistema energético autosuficiente CICYT-ENE2008-06888-C02-02.Peer reviewe