42 research outputs found
Art Criticism and Gender
La crítica de arte desde la perspectiva de género acorta la distancia con las audiencias. El presente estado de la cuestión analiza a través de once proposiciones cuatro círculos concéntricos: la renovación de la historiografía artística; la erosión del canon y del criterio neutro de calidad; la infiltración de la perspectiva de género en la crítica del arte contemporáneo; y el estado de la crítica feminista en el presente.Gendered art criticism shorts the gap with audiences. This status of the issue paper analyzes through eleven proposals four concentric circles: renovation of art historiography; erosion of canon and neutral criteria; gender infiltration on contemporary art criticism; and the estate of feminist criticism at present
A new cerkl mouse model generated by CRISPR-Cas9 shows progressive retinal degeneration and altered morphological and electrophysiological phenotype
Purpose: Close to 100 genes cause retinitis pigmentosa, a Mendelian rare disease that affects 1 out of 4000 people worldwide. Mutations in the ceramide kinase-like gene (CERKL) are a prevalent cause of autosomal recessive cause retinitis pigmentosa and cone-rod dystrophy, but the functional role of this gene in the retina has yet to be fully determined. We aimed to generate a mouse model that resembles the phenotypic traits of patients carrying CERKL mutations to undertake functional studies and assay therapeutic approaches. Methods: The Cerkl locus has been deleted (around 97 kb of genomic DNA) by gene editing using the CRISPR-Cas9 D10A nickase. Because the deletion of the Cerkl locus is lethal in mice in homozygosis, a double heterozygote mouse model with less than 10% residual Cerkl expression has been generated. The phenotypic alterations of the retina of this new model have been characterized at the morphological and electrophysiological levels. Results: This CerklKD/KO model shows retinal degeneration, with a decreased number of cones and progressive photoreceptor loss, poorly stacked photoreceptor outer segment membranes, defective retinal pigment epithelium phagocytosis, and altered electrophysiological recordings in aged retinas. Conclusions: To our knowledge, this is the first Cerkl mouse model to mimic many of the phenotypic traits, including the slow but progressive retinal degeneration, shown by human patients carrying CERKL mutations. This useful model will provide unprecedented insights into the retinal molecular pathways altered in these patients and will contribute to the design of effective treatments
Prevalence of eating disorders in college students and associated factors: uniHcos Project
Introducción:
Los trastornos de la conducta alimentaria
(TCA) son especialmente frecuentes en los jóvenes.
Objeti
-
vo
: Determinar la prevalencia de TCA en jóvenes universi
-
tarios y sus factores asociados.
Metodología:
Estudio de prevalencia en jóvenes univer
-
sitarios españoles del proyecto uniHcos. Mediante regre
-
sión logística no condicional se determinó la magnitud de
la asociación entre los factores de riesgo asociados al estilo
de vida y padecer un TCA medido mediante el cuestionario
Sick, Control, One, Fat, Food (SCOFF).
Resultados:
La prevalencia de TCA fue del 19,5%, sien
-
do mayor en mujeres (ORa=1,59; p=0,006). En los chicos,
tener criterios de padecer TCA se asoció con vivir en cole
-
gios mayores, con realizar “binge drinking”, y uso proble
-
mático de internet. En las mujeres el estudiar titulaciones
diferentes a las ciencias de la salud (ORa=1,50) y el uso pro
-
blemático de internet (ORa=2,33). Aquellas mujeres con
riesgo de TCA presentaban con mayor frecuencia depre
-
sión (ORa=2,02), dolores menstruales (ORa=1,81) y mala
salud percibida (ORa=1,70). En los hombres, aquellos con
riesgo de TCA presentaban con mayor frecuencia una mala
salud percibida (ORa=2,42).
Conclusiones:
El riesgo de obtener resultados positivos
en el SCOFF en nuestro estudio es similar a lo publicado
para otras poblaciones de estudiantes, así como su asocia
-
ción con determinadas adicciones y problemas de salud. Se
observaron diferencias en función del sexo que precisan
atención en el diseño de estrategias de prevención y control.Introduction:
eating disorders (ED) are particularly
common in young people. Objective: To determine the
prevalence of eating disorders in college students and its
associated factors.
Methods
: Study of prevalence in young Spanish university
uniHcos project. Using unconditional logistic regression
have determined the magnitude of the association between
the risk factors associated with lifestyle and ED measured
by questionnaire Sick, Control, One, Fat, Food (SCOFF).
Results:
The prevalence of ED was 19.5%, being higher
in women (ORa=1.59; p=0.006). In boys, have criteria of
developing an eating disorder was associated with living
in halls of residence, “binge drinking” and problematic
Internet use. In women studying different courses at
Health Sciences (ORa=1.50) and problematic Internet use
(ORa=2.33). Those women at risk of ED more frequently
had depression (ORa=2.02), menstrual pains (ORa=1.81)
and perceived poor health (ORa=1.70). In men, those
at risk for eating disorders more frequently had poor
perceived health (ORa=2.42).
Conclusions:
The risk of a positive outcome in the scoff
in our study is similar to that reported for other populations
of students as well as their association with certain health
problems and addictions. By gender differences that need
attention in the design of prevention and control strategies
were observed.Este proyecto se ha financiado gracias a la Delegación del Gobierno para el Plan Nacional Sobre Drogas (Códigos: 2010|145 y
2013|034)
Consumo de drogas ilegales, apoyo familiar y factores relacionadosen estudiantes universitarios. Un estudio transversal basado en datosdel Proyecto uniHcos
Objective: To assess the prevalence of illegal drug use in college students on any previous occasion, duringthe previous year and the previous month, and to analyze the relationship between illegal drug use andfamily support and other factors.Methods: A cross-sectional study using data from students participating in the uniHcos project (n = 3767)was conducted. The prevalence and age of onset of consumption of cannabis, non-prescription sedatives,stimulants and depressants was evaluated. Polyconsumption was also assessed. The independent vari-ables were: family support, age, residence, and employment status. To determine the factors related todrug use multivariate logistic regression models stratified by gender were fitted.Results: Differences between men and women in prevalence of illegal drug use except non-prescriptionsedatives were observed. In both genders, less family support was associated with higher consumptionof all drugs, except depressants, and with polyconsumption. To be studying and looking for work wasrelated to cannabis and stimulant use and to polyconsumption among women, but only to cannabis useamong men.Conclusions: These results support the notion that the start of university studies is a particularly relevantstage in the onset of illegal drug use and its prevention, and that consumption may be especially associatedwith family support.Objetivo: Evaluar la prevalencia del consumo de drogas ilegales en estudiantes universitarios y analizarla relación entre dicho consumo, el apoyo familiar y otros factores.Método: Se realizó un dise?no transversal basado en datos de participantes en el proyecto uniHcos (n =3767). Se evaluaron la prevalencia y la edad de inicio del consumo de cannabis, tranquilizantes sin receta,estimulantes y depresores, y el policonsumo. Como variables independientes se consideraron el apoyofamiliar, la edad, la residencia y la situación laboral. Para la determinación de los factores asociados alconsumo de drogas se ajustaron modelos de regresión logística estratificados por sexo.Resultados: Se observaron diferencias entre hombres y mujeres en la prevalencia del consumo de todaslas drogas ilegales, excepto tranquilizantes sin receta. En ambos sexos, cuanto peor apoyo familiar, mayorconsumo de todas las drogas, excepto depresores y policonsumo. Encontrarse estudiando y buscandotrabajo se relacionó con el consumo de cannabis, estimulantes y policonsumo en las mujeres, y solo concannabis en los hombres.Conclusiones: Los resultados de este estudio aportan nueva evidencia a favor de que el inicio de la etapauniversitaria es un momento de especial relevancia en el inicio del consumo de drogas ilegales y suprevención, pudiendo este consumo estar especialmente relacionado con el apoyo familiar
Psychological Distress, Family Support and Employment Status in First-Year University Students in Spain
Mental disorders are consistently and closely related to psychological distress. At the start of the university period, the relationship between a student's psychological distress, family support, and employment status is not well-known. The aims of this study were: To determine the prevalence of psychological distress in first-year university students and to analyze its relationship with family support and the student's employment status. Data from 4166 first-year university students from nine universities across Spain were considered. The prevalence of psychological distress was obtained using the GHQ-12, a valid and reliable screening tool to detect poor mental health. To analyze the relationship between psychological distress, family support, and employment status, logistic regression models were fitted. Regarding the prevalence found, 46.9% of men and 54.2% of women had psychological distress. In both genders, psychological distress levels increased as family support decreased. Among women, psychological distress was associated with their employment status. The prevalence of psychological distress among first-year university students in Spain is high. In addition, family support, and employment status for women, could be factors to take into account when developing psychological distress prevention strategies at the beginning of the university period.This study was funded by the National Drug Plan from the Ministry of Health, Social Services and Equality of Spain (Codes: 2010|145 and 2013|034)
Associated factors for mortality in a COVID-19 colombian cohort : is the third wave relevant when Mu variant was predominant epidemiologically?
Q1Q1Pacientes con COVID-19Objectives:
To evaluate the association between Colombia's third wave when the Mu variant was predominant epidemiologically (until 75%) in Colombia and COVID-19 all-cause in-hospital mortality.
Methods:
In this retrospective cohort, we included hospitalized patients ≥18 years with SARS-CoV-2 infection between March 2020 to September 2021 in ten hospitals from three cities in Colombia. Description analysis, survival, and multivariate Cox regression analyses were performed to evaluate the association between the third epidemic wave and in-hospital mortality.
Results:
A total of 25,371 patients were included. The age-stratified time-to-mortality curves showed differences according to epidemic waves in patients ≥75 years (log-rank test p = 0.012). In the multivariate Cox analysis, the third wave was not associated with increased mortality relative to the first wave (aHR 0.95; 95%CI 0.84–1.08), but there was an interaction between age ≥75 years and the third wave finding a lower HR for mortality (aHR 0.56, 95%CI 0.36–0.86).
Conclusions:
We did not find an increase in in-hospital mortality during the third epidemic wave in which the Mu variant was predominant in Colombia. The reduced hazard in mortality in patients ≥75 years hospitalized in the third wave could be explained by the high coverage of SARS-CoV-2 vaccination in this population and patients with underlying conditions.https://orcid.org/0000-0003-1833-1599https://orcid.org/0000-0001-5363-5729https://orcid.org/0000-0001-6964-2229https://orcid.org/0000-0003-3975-2835https://orcid.org/0000-0001-9441-4375Revista Internacional - IndexadaA1N
Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design
Introduction: We present the protocol of a large population-based case-control study of 5 common tumors
in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors.
Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary
care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer,
1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic
lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age,
sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and
from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic
factors, environmental exposures, occupation, medication, lifestyle, and personal and family
medical history. In addition, participants completed a self-administered food-frequency questionnaire
and telephone interviews. Blood samples were collected from 76% of participants while saliva samples
were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded
for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals.
Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple
analyses are planned to assess the association of environmental, personal and genetic risk factors
for each tumor and to identify pleiotropic effects.
Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology
& Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers
and will promote cancer research and prevention in Spain.The study was partially funded by the “Accion Transversal
del Cancer”, approved on the Spanish Ministry Council on the
11th October 2007, by the Instituto de Salud Carlos III-FEDER
(PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286,
PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889,
PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265,
PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués
de Valdecilla (API 10/09), by the ICGC International Cancer Genome
Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by
the Consejería de Salud of the Junta de Andalucía (PI-0571), by the
Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10),
by the Recercaixa (2010ACUP 00310), by the Regional Government
of the Basque Country by European Commission grants FOOD-CT-
2006-036224-HIWATE, by the Spanish Association Against Cancer
(AECC) Scientific Foundation, by the The Catalan Government
DURSI grant 2009SGR1489
Leer en comunidad: creación de clubes de lectura de literatura escrita por mujeres en la universidad
Depto. de Lengua Española y Teoría de la LiteraturaFac. de FilologíaFALSEUniversidad Complutense de Madridsubmitte
Miradas y voces de la investigación educativa I
Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Calneggia, María Isabel. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Di Francesco, Adriana Carlota. Universidad Católica de Córdoba. Facultad de Educación; Argentin