Influence of ABO locus on PFA-100 collagen-ADP closure time is not totally dependent on the von willebrand factor. Results of a GWAS on gait-2 project phenotypes

(1) Background: In a previous study, we found that two phenotypes related to platelet reactivity, measured with the PFA-100 system, were highly heritable. The aim of the present study was to identify genetic determinants that influence the variability of these phenotypes: Closure time of collagen-ADP (Col-ADP) and of collagen-epinephrine (Col-Epi). (2) Methods: As part of the GAIT-2 (Genetic Analysis of Idiopathic Thrombophilia (2) Project, 935 individuals from 35 large Spanish families were studied. A genome-wide association study (GWAS) with ≈ 10 M single nucleotide polymorphisms (SNPs) was carried out with Col-ADP and Col-Epi phenotypes. (3) Results: The study yielded significant genetic signals that mapped to the ABO locus. After adjusting both phenotypes for the ABO genotype, these signals disappeared. After adjusting for von Willebrand factor (VWF) or for coagulation factor VIII (FVIII), the significant signals disappeared totally for Col-Epi phenotype but only partially for Col-ADP phenotype. (4) Conclusion: Our results suggest that the ABO locus exerts the main genetic influence on PFA-100 phenotypes. However, while the effect of the ABO locus on Col-Epi phenotype is mediated through VWF and/or FVIII, the effect of the ABO locus on Col-ADP phenotype is partly produced through VWF and/or FVIII, and partly through other mechanisms

Diffraction effects and inelastic electron transport in angle-resolved microscopic imaging applications

We analyze the signal formation process for scanning electron microscopic imaging applications on crystalline specimens. In accordance with previous investigations, we find nontrivial effects of incident beam diffraction on the backscattered electron distribution in energy and momentum. Specifically, incident beam diffraction causes angular changes of the backscattered electron distribution which we identify as the dominant mechanism underlying pseudocolor orientation imaging using multiple, angle-resolving detectors. Consequently, diffraction effects of the incident beam and their impact on the subsequent coherent and incoherent electron transport need to be taken into account for an in-depth theoretical modeling of the energy and momentum distribution of electrons backscattered from crystalline sample regions. Our findings have implications for the level of theoretical detail that can be necessary for the interpretation of complex imaging modalities such as electron channeling contrast imaging (ECCI) of defects in crystals. If the solid angle of detection is limited to specific regions of the backscattered electron momentum distribution, the image contrast that is observed in ECCI and similar applications can be strongly affected by incident beam diffraction and topographic effects from the sample surface. As an application, we demonstrate characteristic changes in the resulting images if different properties of the backscattered electron distribution are used for the analysis of a GaN thin film sample containing dislocations

The all-sky GEOS RR Lyr survey with the TAROT telescopes. Analysis of the Blazhko effect

We used the GEOS database to study the Blazhko effect of galactic RRab stars. The database is continuously enriched by maxima supplied by amateur astronomers and by a dedicated survey by means of the two TAROT robotic telescopes. The same value of the Blazhko period is observed at different values of the pulsation periods and different values of the Blazhko periods are observed at the same value of the pulsation period. There are clues suggesting that the Blazhko effect is changing from one cycle to the next. The secular changes in the pulsation and Blazhko periods of Z CVn are anticorrelated. The diagrams of magnitudes against phases of the maxima clearly show that the light curves of Blazhko variables can be explained as modulated signals, both in amplitude and in frequency. The closed curves describing the Blazhko cycles in such diagrams have different shapes, reflecting the phase shifts between the epochs of the brightest maximum and the maximum O-C. Our sample shows that both clockwise and anticlockwise directions are possible for similar shapes. The improved observational knowledge of the Blazhko effect, in addition to some peculiarities of the light curves, have still to be explained by a satisfactory physical mechanism.Comment: 13 pages, 12 figures, accepted for publication in Astronomical Journa

Leaf economics and plant hydraulics drive leaf : wood area ratios

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this recordData accessibility: All data are archived and are available from the TRY plant trait data base: www.try-db.org (https://doi.org/10.1111/j.1365-2486.2011.02451.x).Biomass and area ratios between leaves, stems and roots regulate many physiological and ecological processes. The Huber value Hv (sapwood area/leaf area ratio) is central to plant water balance and drought responses. However, its coordination with key plant functional traits is poorly understood, which prevents developing trait-based prediction models. Based on theoretical arguments, we hypothesise that global patterns in Hv of terminal woody branches can be predicted from variables related to plant trait spectra, i.e., plant hydraulics and size and leaf economics. Using a global compilation of 1135 species-averaged Hv , we show that Hv varies over 3 orders of magnitude. Higher Hv are seen in short small-leaved low-SLA shrubs with low Ks in arid relative to tall large-leaved high-SLA trees with high Ks in moist environments. All traits depend on climate but climatic correlations are stronger for explanatory traits than Hv . Negative isometry is found between Hv and Ks , suggesting a compensation to maintain hydraulic supply to leaves across species. This work identifies the major global drivers of branch sapwood/leaf area ratios. Our approach based on widely available traits facilitates the development of accurate models of aboveground biomass allocation and helps predict vegetation responses to drought.Spanish Ministry of Economy and Competitiveness (MINECO)University of NottinghamSwedish Research Council Forma

Valoración de los ángulos del cuello del aneurisma de aorta abdominal. Estudio en 507 pacientes

Angulation in different planes of the neck of abdominal aortic aneurysms may be considered a limiting factor in the implantation of different prostheses in the treatment of this pathology. It is necessary to make an assessment of the angles in different planes in routine studies prior to the planning of the procedures and especially by AngioTAC. The study evaluated the measurement of 507 patients with abdominal aortic aneurysms and treated endovascular procedures and of whom the complete information was available at the level of neck angulations. In a prospective and descriptive study the situation of this aortic sector was evaluated, contributing information about the tendency in the morphological presentation of the aorta in patients with this aetiolog

Knee osteoarthritis and periarticular structure quantified by ultrasound. A case-control study

Background Assessment of pain and physical function is complex in patients with knee osteoarthritis (OA), as standard criteria are lacking.A previous study examining correlations between functional capacity and pain (WOMAC) and anthropometric characteristics and periarticular knee structure (quantified by ultrasound imaging) in females with knee OA found increased quadriceps muscle density was associated with higher functional disability and pain scores, suggesting that not only joint wear and symptom severity are involved and more objective measures are necessary..

Study of angulations of visceral abdominals arteries in their abdominal aorta emergency

Recently, fenestrated, branched and stent grafts have been developed in order to treat endovascular aneurysmal pathology at the level of the aorta in the emergence of the visceral arteries. For the implantation of stents, it is necessary to have a precise planimetry of the origin and orientation of the visceral branches in order firstly to perform the correct manufacture of the endoprosthesis and secondly the placement with precision of the same. The knowledge of the emergency of the vessels of the aortic wall and its orientation knowing the angle of emergency. The data obtained for the planning of the endovascular treatment of 37 patients in order to obtain data from the descriptive point of view of this sector

On the possibility of magneto-structural correlations: detailed studies of di-nickel carboxylate complexes

A series of water-bridged dinickel complexes of the general formula [Ni<sub>2</sub>(μ<sub>2</sub>-OH<sub>2</sub>)(μ2- O<sub>2</sub>C<sup>t</sup>Bu)<sub>2</sub>(O<sub>2</sub>C<sup>t</sup>Bu)2(L)(L0)] (L = HO<sub>2</sub>C<sup>t</sup>Bu, L0 = HO<sub>2</sub>C<sup>t</sup>Bu (1), pyridine (2), 3-methylpyridine (4); L = L0 = pyridine (3), 3-methylpyridine (5)) has been synthesized and structurally characterized by X-ray crystallography. The magnetic properties have been probed by magnetometry and EPR spectroscopy, and detailed measurements show that the axial zero-field splitting, D, of the nickel(ii) ions is on the same order as the isotropic exchange interaction, J, between the nickel sites. The isotropic exchange interaction can be related to the angle between the nickel centers and the bridging water molecule, while the magnitude of D can be related to the coordination sphere at the nickel sites