Plataforma Moodle de la Universidad Católica Silva Henríquez (UCSH): experiencias de docentes y estudiantes de la carrera de Pedagogía en Educación Diferencial

Treballs finals del Màster d'Entorns d’Ensenyament i Aprenentatge amb Tecnologies Digitals, Facultat de Pedagogia, Universitat de Barcelona, Curs: 2015-2016, Tutora: Pilar Folgueiras BertomeuLa incorporación de las tecnologías de información y la comunicación han generado diferentes y variadas propuestas educativas, entre ellas la plataforma Moodle. Sistema digital que contiene herramientas de comunicación de tipo sincrónica y asincrónica que contribuye a generar nuevas formas de pensar, actuar, relacionarse y aprender. El propósito de este estudio es analizar las experiencias de docentes y estudiantes de la carrera de Pedagogía en Educación Diferencial de la Universidad Católica Silva Henríquez, sobre el uso y funcionamiento de la plataforma Moodle. En términos metodológicos, la investigación se enmarca dentro de un enfoque cualitativo, en tanto que pretende comprender la realidad de forma holística por intermedio de la interpretación de los actores: docentes y estudiantes. Se considera como diseño el estudio instrumental de casos. La recogida de información, busca conocer las experiencias de profesores y estudiantes, comprender las estrategias de innovación docente y reconocer las posibilidades y limitaciones en el uso de la plataforma virtual de la UCSH. Las técnicas de recogida de información que se utilizan para ello son la entrevista y focus group. Los informantes son el profesorado y los estudiantes. Se realiza un análisis de contenido a partir de la triangulación de técnicas e informantes..

Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9)

International audienceBackground : ASAP is a newly characterized microtubule-associated protein (MAP) essential for propercell-cycling. We have previously shown that expression deregulation of human ASAP results in profounddefects in mitotic spindle formation and mitotic progression leading to aneuploidy, cytokinesis defects and/or cell death. In the present work we analyze the structure and evolution of the ASAP gene, as well as thedomain composition of the encoded protein. Mouse and Xenopus cDNAs were cloned, the tissueexpression characterized and the overexpression profile analyzed. Results : Bona fide ASAP orthologs are found in vertebrates with more distantly related potentialorthologs in invertebrates. This single-copy gene is conserved in mammals where it maps to syntenicchromosomal regions, but is also clearly identified in bird, fish and frog. The human gene is stronglyexpressed in brain and testis as a 2.6 Kb transcript encoding a ~110 KDa protein. The protein containsMAP, MIT-like and THY domains in the C-terminal part indicative of microtubule interaction, while the N-terminal part is more divergent. ASAP is composed of ~42% alpha helical structures, and two main coiled-coil regions have been identified. Different sequence features may suggest a role in DNA damage response. As with human ASAP, the mouse and Xenopus proteins localize to the microtubule network in interphaseand to the mitotic spindle during mitosis. Overexpression of the mouse protein induces mitotic defectssimilar to those observed in human. In situ hybridization in testis localized ASAP to the germ cells, whereasin culture neurons ASAP localized to the cell body and growing neurites. Conclusion : The conservation of ASAP indicated in our results reflects an essential function invertebrates. We have cloned the ASAP orthologs in mouse and Xenopus, two valuable models to studythe function of ASAP. Tissue expression of ASAP revealed a high expression in brain and testis, two tissuesrich in microtubules. ASAP associates to the mitotic spindle and cytoplasmic microtubules, and representsa key factor of mitosis with possible involvement in other cell cycle processes. It may have a role inspermatogenesis and also represents a potential new target for antitumoral drugs. Possible involvement inneuron dynamics also highlights ASAP as a candidate target in neurodegenerative disease

A dietary supplementation with leucine and antioxidants is capable to accelerate muscle mass recovery after immobilization in adult rats

Prolonged inactivity induces muscle loss due to an activation of proteolysis and decreased protein synthesis; the latter is also involved in the recovery of muscle mass. The aim of the present work was to explore the evolution of muscle mass and protein metabolism during immobilization and recovery and assess the effect of a nutritional strategy for counteracting muscle loss and facilitating recovery. Adult rats (6-8 months) were subjected to unilateral hindlimb casting for 8 days (10-18) and then permitted to recover for 10 to 40 days (R10-R40). They were fed a Control or Experimental diet supplemented with antioxidants/polyphenols (AOX) (10 to 18), AOX and leucine (AOX + LEU) (18 to R15) and LEU alone (R15 to R40). Muscle mass, absolute protein synthesis rate and proteasome activities were measured in gastrocnemius muscle in casted and non-casted legs in post prandial (PP) and post absorptive (PA) states at each time point. Immobilized gastrocnemius protein content was similarly reduced (-37%) in both diets compared to the non-casted leg. Muscle mass recovery was accelerated by the AOX and LEU supplementation (+6% AOX+LEU vs. Control, P<0.05 at R40) due to a higher protein synthesis both in PA and PP states (+23% and 31% respectively, Experimental vs. Control diets, P<0.05, R40) without difference in trypsin-and chymotrypsin-like activities between diets. Thus, this nutritional supplementation accelerated the recovery of muscle mass via a stimulation of protein synthesis throughout the entire day (in the PP and PA states) and could be a promising strategy to be tested during recovery from bed rest in humans

The Carbon-Rich Gas in the Beta Pictoris Circumstellar Disk

The edge-on disk surrounding the nearby young star Beta Pictoris is the archetype of the "debris disks", which are composed of dust and gas produced by collisions and evaporation of planetesimals, analogues of Solar System comets and asteroids. These disks provide a window on the formation and early evolution of terrestrial planets. Previous observations of Beta Pic concluded that the disk gas has roughly solar abundances of elements [1], but this poses a problem because such gas should be rapidly blown away from the star, contrary to observations of a stable gas disk in Keplerian rotation [1, 2]. Here we report the detection of singly and doubly ionized carbon (CII, CIII) and neutral atomic oxygen (OI) gas in the Beta Pic disk; measurement of these abundant volatile species permits a much more complete gas inventory. Carbon is extremely overabundant relative to every other measured element. This appears to solve the problem of the stable gas disk, since the carbon overabundance should keep the gas disk in Keplerian rotation [3]. New questions arise, however, since the overabundance may indicate the gas is produced from material more carbon-rich than the expected Solar System analogues.Comment: Accepted for publication in Nature. PDF document, 12 pages. Supplementary information may be found at http://www.dtm.ciw.edu/akir/Documents/roberge_supp.pdf *** Version 2 : Removed extraneous publication information, per instructions from the Nature editor. No other changes mad

Telemac3D for aquatic ecological modelling: calibration of the coupled ecological library AED2

HydrodynamicsAbstrac

North Atlantic Midlatitude Surface-Circulation Changes Through the Plio-Pleistocene Intensification of Northern Hemisphere Glaciation

The North Atlantic Current (NAC) transports warm salty water to high northern latitudes, with important repercussions for ocean circulation and global climate. A southward displacement of the NAC and Subarctic Front, which separate subpolar and subtropical water masses, is widely suggested for the Last Glacial Maximum (LGM) and may have acted as a positive feedback in glacial expansion at this time. However, the role of the NAC during the intensification of Northern Hemisphere glaciation (iNHG) at ~3.5 to 2.5 Ma is less clear. Here we present new records from Integrated Ocean Drilling Program Site U1313 (41°N) spanning ~2.8–2.4 Ma to trace the influence of Subarctic Front waters above this mid‐latitude site. We reconstruct surface and permanent pycnocline temperatures and seawater δ18O using paired Mg/Ca‐δ18O measurements on the planktic foraminifers Globigerinoides ruber and Globorotalia crassaformis and determine abundances of the subpolar foraminifer Neogloboquadrina atlantica. We find that the first significant glacial incursions of Subarctic Front surface waters above Site U1313 did not occur until ~2.6 Ma. At no time during our study interval was (sub)surface reorganization in the midlatitude North Atlantic analogous to the LGM. Our findings suggest that LGM‐like processes sensu stricto cannot be invoked to explain interglacial‐glacial cycle amplification during iNHG. They also imply that increased glacial productivity at Site U1313 during iNHG was not only driven by southward deflections of the Subarctic Front. We suggest that nutrient injection from cold‐core eddies and enhanced glacial dust delivery may have played additional roles in increasing export productivity in the midlatitude North Atlantic from 2.7 Ma.t. Funding for this research was provided by IODP France (C. T. B.) and the German Research Foundation (DFG) (grant OF 2544/2 to O. F.). I. B. is grateful to the UK IODP for financial support for shipboard and post-cruise participation in IODP Exp. 306. C. T. B., K. T., T. D. G., L. V., C. S., and M. E. acknowledge OSU Pythéas. M. M. R. acknowledges support by the USGS Land Change Science Program

Fundamentos de una educación divertida para la integración de las artes ciencias y tecnología en las clases de matemática y ciencias naturales

The objective of the study is to favor the practices of a fun education through the relationship between arts, science and technology in mathematics and natural science classes for third year elementary school students in mathematics and natural science classes. The methodology was based on a mixed approach and a sequential exploratory design, supported by documentary, descriptive and explanatory research. The population consisted of 256 students and 59 teachers. The purposive sample consisted of 34 students and 1 teacher. The data collection techniques were the pedagogical test and the interview. Descriptive and inferential statistics and content analysis were used for data analysis. The results show that there is little relationship between the official curriculum and educational practice in the classroom. It was shown that there are significant differences (Wilcoxon test, p-value: .000) between the initial and final evaluation in the area of mathematics and natural sciences, evidencing the substantial improvement in student learning. In conclusion, it is argued that fun education is a viable proposal in the classroom and promotes developmental, creative, critical and motivating learning.El estudio tiene como objetivo favorecer las prácticas de una educación divertida, a través de las relaciones entre las artes, ciencias y tecnología en las clases de matemática y ciencias naturales para estudiantes tercer año de educación primaria en las clases de matemática y ciencias naturales. La metodología se basó en un enfoque mixto y un diseño exploratorio secuencial, apoyado de la investigación documental, descriptiva y explicativa. La población estuvo conformada por 256 estudiantes y 59 docentes. La muestra intencional quedó determinada por 34 estudiantes y 1 docente Las técnicas de recogida de datos fueron la prueba pedagógica y la entrevista. Para el análisis de los datos se utilizó la estadística descriptiva e inferencial y el análisis de contenido. Los resultados demuestran que existe poca relación entre el currículo oficial y la práctica educativa dentro del aula de clases. Se demostró que existen diferencias significativas (prueba de Wilcoxon, p-valor: .000) entre la evaluación inicial y final en el área de matemática y ciencias naturales, evidenciando la mejora sustancial en el aprendizaje de los estudiantes. En conclusión, se argumenta que la educación divertida es una propuesta viable en las aulas de clases y promueve un aprendizaje desarrollador, creativo, crítico y motivante

Identifying toxic impacts of metals potentially released during deep-sea mining - a synthesis of the challenges to quantifying risk

In January 2017, the International Seabed Authority released a discussion paper on the development of Environmental Regulations for deep-sea mining (DSM) within the Area Beyond National Jurisdiction (the "Area"). With the release of this paper, the prospect for commercial mining in the Area within the next decade has become very real. Moreover, within nations' Exclusive Economic Zones, the exploitation of deep-sea mineral ore resources could take place on very much shorter time scales and, indeed, may have already started. However, potentially toxic metal mixtures may be released at sea during different stages of the mining process and in different physical phases (dissolved or particulate). As toxicants, metals can disrupt organism physiology and performance, and therefore may impact whole populations, leading to ecosystem scale effects. A challenge to the prediction of toxicity is that deep-sea ore deposits include complex mixtures of minerals, including potentially toxic metals such as copper, cadmium, zinc, and lead, as well as rare earth elements. Whereas the individual toxicity of some of these dissolved metals has been established in laboratory studies, the complex and variable mineral composition of seabed resources makes the a priori prediction of the toxic risk of DSM extremely challenging. Furthermore, although extensive data quantify the toxicity of metals in solution in shallow-water organisms, these may not be representative of the toxicity in deep-sea organisms, which may differ biochemically and physiologically and which will experience those toxicants under conditions of low temperature, high hydrostatic pressure, and potentially altered pH. In this synthesis, we present a summation of recent advances in our understanding of the potential toxic impacts of metal exposure to deep-sea meio- to megafauna at low temperature and high pressure, and consider the limitation of deriving lethal limits based on the paradigm of exposure to single metals in solution. We consider the potential for long-term and far-field impacts to key benthic invertebrates, including the very real prospect of sub-lethal impacts and behavioral perturbation of exposed species. In conclusion, we advocate the adoption of an existing practical framework for characterizing bulk resource toxicity in advance of exploitation

The Genome of Borrelia recurrentis, the Agent of Deadly Louse-Borne Relapsing Fever, Is a Degraded Subset of Tick-Borne Borrelia duttonii

In an effort to understand how a tick-borne pathogen adapts to the body louse, we sequenced and compared the genomes of the recurrent fever agents Borrelia recurrentis and B. duttonii. The 1,242,163–1,574,910-bp fragmented genomes of B. recurrentis and B. duttonii contain a unique 23-kb linear plasmid. This linear plasmid exhibits a large polyT track within the promoter region of an intact variable large protein gene and a telomere resolvase that is unique to Borrelia. The genome content is characterized by several repeat families, including antigenic lipoproteins. B. recurrentis exhibited a 20.4% genome size reduction and appeared to be a strain of B. duttonii, with a decaying genome, possibly due to the accumulation of genomic errors induced by the loss of recA and mutS. Accompanying this were increases in the number of impaired genes and a reduction in coding capacity, including surface-exposed lipoproteins and putative virulence factors. Analysis of the reconstructed ancestral sequence compared to B. duttonii and B. recurrentis was consistent with the accelerated evolution observed in B. recurrentis. Vector specialization of louse-borne pathogens responsible for major epidemics was associated with rapid genome reduction. The correlation between gene loss and increased virulence of B. recurrentis parallels that of Rickettsia prowazekii, with both species being genomic subsets of less-virulent strains