37 research outputs found
The effects of gonadectomy on sex- and age-typical responses to novelty and ethanol-induced social inhibition in adult male and female Sprague-Dawley rats
Differences in sensitivity to ethanol-induced conditioned taste aversions emerge after pre- or post-pubertal gonadectomy in male and female rats
Evidence for suppressant effects of testosterone on sex-typical ethanol intake in male Sprague-Dawley rats
The Effects of Gonadectomy on Age- and Sex-Typical Patterns of Ethanol Consumption in Sprague-Dawley Rats
Age-related differences in the appetitive and aversive motivational effects of alcohol
Alcohol drinking behaviors occur very early in life and shape trajectories of alcohol use that can eventually lead to alcohol use disorders. This chapter focuses on age-related differences in sensitivity to the appetitive, andaversive motivational effects, of alcohol in rodent studies. Alcohol-induced conditioned aversion is difficult to detect up to postnatal days 810 and is significantly lower in adolescent than in adult subjects. Conversely, compared with adult counterparts, infant and adolescent rats are significantly more prone to the expression of conditioned preferences for exteroceptive stimuli (e.g., textures or distinctive chambers) that are paired with alcohol.The results suggest that immature subjects (i.e., infants and adolescents) exhibit differential sensitivity to alcohol?smotivational effects, which may explain their propensity to engage in, and escalate, alcohol intake. Futurestudies should focus on the ways in which the apparent reward-sensitive phenotype of late infancy and adolescenceis modulated by environmental and genetic factors.Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de InvestigaciĂłn MĂ©dica Mercedes y MartĂn Ferreyra. Universidad Nacional de CĂłrdoba. Instituto de InvestigaciĂłn MĂ©dica Mercedes y MartĂn Ferreyra; Argentin