866 research outputs found

    Forschende und ihre Daten. Ergebnisse einer österreichweiten Befragung - Report 2015

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    This report provides an overview of the Austria-wide survey for research data, which was carried out within the framework of the project e-Infrastructures Austria at the beginning of 2015. This survey was directed at the scientific and artistic-scientific personnel of 20 public universities and three extramural research institutions in Austria

    Forschende und ihre Daten. Ergebnisse einer österreichweiten Befragung - Report 2015

    Get PDF
    This report provides an overview of the Austria-wide survey for research data, which was carried out within the framework of the project e-Infrastructures Austria at the beginning of 2015. This survey was directed at the scientific and artistic-scientific personnel of 20 public universities and three extramural research institutions in Austria

    Forschende und ihre Daten. Ergebnisse einer österreichweiten Befragung - Report 2015

    Get PDF
    This report provides an overview of the Austria-wide survey for research data, which was carried out within the framework of the project e-Infrastructures Austria at the beginning of 2015. This survey was directed at the scientific and artistic-scientific personnel of 20 public universities and three extramural research institutions in Austria

    Recommendations for the Visibility of Open Access Publications in the Search Engine of the Austrian Library Network: Report of the OBV Working Group “Repositories in the Network”

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    Im vorliegenden Beitrag werden die Ergebnisse der OBV-Arbeitsgruppe „Repositorien im Verbund“ prĂ€sentiert. Die AG verfolgte das Ziel, einen Leitfaden fĂŒr die Erfassung von Metadaten fĂŒr Objekte in Repositorien, der dazu beitrĂ€gt, einheitliche Standards in dieser Hinsicht zu entwickeln, mit dessen Hilfe es in weiterer Folge ermöglicht werden soll, RepositorienbestĂ€nde ohne Erzeugung von Dubletten in Alma bzw. im Verbundkatalog nachzuweisen. Weitere Ziele waren die Erarbeitung von Empfehlungen fĂŒr eine zentrale Bereitstellung von Metadaten von Open Access-Publikationen zur Vereinfachung der lokalen Workflows (analog zum DFG-geförderten Projekt DeepGreen) mittels Teilautomatisierung sowie von Empfehlungen fĂŒr eine Etablierung eines Reiters fĂŒr Open Access-Materialien in der Suchmaschine des Österreichischen Bibliothekenverbundes (analog zu den Reitern „Fachliteratur“, „Hochschulschriften“ und „NachlĂ€sse / Handschriften“).This paper presents the results of the OBV working group “Repositories in the Austrian Library Network”. The aim of the working group was to develop a guideline for the registration of metadata for objects in repositories, which would contribute to the development of uniform standards in this regard, and with the help of which it should subsequently be possible to identify repository holdings in Alma or in the Austrian Union Catalogue without creating duplicates. Further goals were the development of recommendations for a central provision of metadata of open access publications to simplify local workflows (analogous to the DFG-funded project DeepGreen) by means of partial automation, as well as recommendations for establishing a tab for open access materials in the search engine of the Austrian Library Network (analogous to the tabs “Literature”, “Theses and Dissertations” and “Bequests / Autographs”)

    PATRIC, the bacterial bioinformatics database and analysis resource

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    The Pathosystems Resource Integration Center (PATRIC) is the all-bacterial Bioinformatics Resource Center (BRC) (http://www.patricbrc.org). A joint effort by two of the original National Institute of Allergy and Infectious Diseases-funded BRCs, PATRIC provides researchers with an online resource that stores and integrates a variety of data types [e.g. genomics, transcriptomics, protein-protein interactions (PPIs), three-dimensional protein structures and sequence typing data] and associated metadata. Datatypes are summarized for individual genomes and across taxonomic levels. All genomes in PATRIC, currently more than 10 000, are consistently annotated using RAST, the Rapid Annotations using Subsystems Technology. Summaries of different data types are also provided for individual genes, where comparisons of different annotations are available, and also include available transcriptomic data. PATRIC provides a variety of ways for researchers to find data of interest and a private workspace where they can store both genomic and gene associations, and their own private data. Both private and public data can be analyzed together using a suite of tools to perform comparative genomic or transcriptomic analysis. PATRIC also includes integrated information related to disease and PPIs. All the data and integrated analysis and visualization tools are freely available. This manuscript describes updates to the PATRIC since its initial report in the 2007 NAR Database Issu

    The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning

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    We present a loss-of-function study using antisense morpholino (MO) reagents for the organizer-specific gene Goosecoid (Gsc) and the ventral genes Vent1 and Vent2. Unlike in the mouse Gsc is required in Xenopus for mesodermal patterning during gastrulation, causing phenotypes ranging from reduction of head structures—including cyclopia and holoprosencephaly—to expansion of ventral tissues in MO-injected embryos. The overexpression effects of Gsc mRNA require the expression of the BMP antagonist Chordin, a downstream target of Gsc. Combined Vent1 and Vent2 MOs strongly dorsalized the embryo. Unexpectedly, simultaneous depletion of all three genes led to a rescue of almost normal development in a variety of embryological assays. Thus, the phenotypic effects of depleting Gsc or Vent1/2 are caused by the transcriptional upregulation of their opposing counterparts. A principal function of Gsc and Vent1/2 homeobox genes might be to mediate a self-adjusting mechanism that restores the basic body plan when deviations from the norm occur, rather than generating individual cell types. The results may shed light on the molecular mechanisms of genetic redundancy

    A New Heterobinuclear FeIIICuII Complex with a Single Terminal FeIII–O(phenolate) Bond. Relevance to Purple Acid Phosphatases and Nucleases

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    A novel heterobinuclear mixed valence complex [Fe^IIICu^II(BPBPMP)(OAc)_2]ClO_4, 1, with the unsymmetrical N_5O_2 donor ligand 2-bis[{(2-pyridylmethyl)aminomethyl}-6-{(2-hydroxybenzyl)(2-pyridylmethyl)} aminomethyl]-4-methylphenol (H_2BPBPMP) has been synthesized and characterized. A combination of data from mass spectrometry, potentiometric titrations, X-ray absorption and electron paramagnetic resonance spectroscopy, as well as kinetics measurements indicates that in ethanol/water solutions an [Fe^III-(nu)OH-Cu^IIOH_2]+ species is generated which is the likely catalyst for 2,4-bis(dinitrophenyl)phosphate and DNA hydrolysis. Insofar as the data are consistent with the presence of an Fe_III-bound hydroxide acting as a nucleophile during catalysis, 1 presents a suitable mimic for the hydrolytic enzyme purple acid phosphatase. Notably, 1 is significantly more reactive than its isostructural homologues with different metal composition (Fe^IIIM^II, where M^II is Zn^II, Mn^II, Ni^II,or Fe^II). Of particular interest is the observation that cleavage of double-stranded plasmid DNA occurs even at very low concentrations of 1 (2.5 nuM), under physiological conditions (optimum pH of 7.0), with a rate enhancement of 2.7 x 10^7 over the uncatalyzed reaction. Thus, 1 is one of the most effective model complexes to date, mimicking the function of nucleases

    PESFOR-W: Improving the design and environmental effectiveness of woodlands for water Payments for Ecosystem Services

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    ABSTRACT: The EU Water Framework Directive aims to ensure restoration of Europe?s water bodies to ?good ecological status? by 2027. Many Member States will struggle to meet this target, with around half of EU river catchments currently reporting below standard water quality. Diffuse pollution from agriculture represents a major pressure, affecting over 90% of river basins. Accumulating evidence shows that recent improvements to agricultural practices are benefiting water quality but in many cases will be insufficient to achieve WFD objectives. There is growing support for land use change to help bridge the gap, with a particular focus on targeted tree planting to intercept and reduce the delivery of diffuse pollutants to water. This form of integrated catchment management offers multiple benefits to society but a significant cost to landowners and managers. New economic instruments, in combination with spatial targeting, need to be developed to ensure cost effective solutions - including tree planting for water benefits - are realised. Payments for Ecosystem Services (PES) are flexible, incentive-based mechanisms that could play an important role in promoting land use change to deliver water quality targets. The PESFOR-W COST Action will consolidate learning from existing woodlands for water PES schemes in Europe and help standardize approaches to evaluating the environmental effectiveness and cost-effectiveness of woodland measures. It will also create a European network through which PES schemes can be facilitated, extended and improved, for example by incorporating other ecosystem services linking with aims of the wider forestscarbon policy nexus
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