A rare case presentation of large mucinous ovarian cystadenocarcinoma in a young female

Here authors report a case of large ovarian mucinous cystadenocarcinoma in a young female complicating young pregnancy. Ovarian mucinous adenocarcinoma is a rare ovarian tumour that arises from the surface epithelium of the ovary. A 25-year young female, 9 days post-partum presented to the hospital with complain of abdominal distension. USG finding suggesting large solid cystic mass 36 × 14 cm arising from pelvis extending up to epigastrium. MRI pelvis evident of heterogenous hyperintense solid cystic mass lesion giving bunch of grapes appearance with size 24.5 × 25 × 11.5 cms seen in intra peritoneal space extending cranially up to epigastrium and caudally into pelvis giving anterior displacement of uterus.  And posterior displacement of bowel loops. A large part of lesion is cystic with solid component with multiple internal echoes

A randomized controlled trial of endodontic treatment using ultrasonic irrigation and laser activated irrigation to evaluate healing in chronic apical periodontitis

Aim of this trial was to evaluate the combined clinical and radiographic success rate of endodontic treatment using passive ultrasonic irrigation (PUI) and laser activated irrigation (LAI) as compared to conventional syringe irrigation. Permanent incisors and single rooted premolars were assessed for eligibility and 69 patients were randomly divided into three treatment groups (n=23) by allocation concealment method and irrigation was performed in accordance with the allocated group. Teeth were evaluated clinically and radiographically with CBCT after 6 months and 12 months of the treatment. A significant difference was observed in the radiographic healing rates among three groups (?2=12.29, p=0.05). On comparing the final outcome among the three groups (n=19), it was found that 2 (10.5%) cases of group I(Conventional Syringe irrigation), 7 (36.8%) cases of group II (Passive ultrasonic irrigation) and 8 (42.1%) cases of group III(Laser activated irrigation) were healed while under healing category 13 (68.4%) cases of group I, 12 (63.2%) cases of group II and 11 (57.9%) of group III were observed whereas 4 (21.1%) cases were categorised as diseased in group I only. LAI and PUI can increase the predictability of the endodontic treatment success in cases of chronic apical periodontitis

Role of Twagadi Gutika in Pain Management

Pain is any suffering or discomfort, whether physical or mental, brought on by an illness or injury. Regardless of how minor the pain is, it still causes discomfort and interferes with daily activities for the person. Pain is referred to in Ayurveda as the premonitory indicator and as symptoms of various diseases under different names, such as Shool, Ruja, and Vedana. Acharya Sushruta states that Vata Dosha is the primary source of all pain, or "Vatat Rute Nasti Ruja." Even with the latest developments in anaesthesia and pain management, managing pain is still difficult. Vata Dosha is regarded as the root cause of all types of pain. The nervous system and body movements are governed by the Vata Dosha. An imbalance in it can result into difficulty with joint mobility and function, which can exacerbate disorders like arthritis and musculoskeletal pain. Pain associated with Vata Dosha is frequently described as throbbing, aching, or acute in nature. Ayurveda may offer hope in a world where everyone is searching for ways to reduce and eliminate pain by helping people comprehend its true nature and offering fresh approaches to its management. Ayurveda provides a variety of treatment modalities to manage pain, depending on the origin, type, and duration of the condition. The present article aims at throwing light on one of the herbal preparations, Twagadi Gutika, mentioned in Ayurveda Samhita, for Vata dosha disorders and specifically for managing pain

Polyamine-promoted aqueous DEEA for CO2 capture: An experimental analysis

411-417An enormous increase in global energy demand has resulted in the increasing emissions of Carbon dioxide (CO2) throughout the globe, and hence, the refinement of established technologies for the capture of CO2 is of global interest. Currently, the absorption performed with chemical solvents, particularly alkanolamines and their blends, represents the most practical option. In general, the enhancement in absorption and regeneration capacities is targeted via the blending of several alkanolamines consisting of different functionalities to seek the absorption-favoured properties of individual amines. The present work considers blending of a tertiary alkanolamine, N,N-diethylethanolamine (DEEA) with a polyamine, triethylenetetramine (TETA). This blend has been envisaged to combine the high absorption capacity of TETA with high regeneration capacity of DEEA. The concentration of  DEEA and TETA in the blends is varied between 2.5-2.95 M and 0.05-0.5 M, respectively. The performance of these blends has been evaluated using an indigenous wetted-wall contactor. The CO2 partial pressure was varied between 5-15 kPa and its effect on the CO2 loading capacity and absorption flux for different compositions is evaluated in the temperature range of 30-50 . It is found that increasing the concentration of TETA increases the absorption drastically. Besides, the physical properties (density and viscosity) of these solvent systems have also been estimated

Purine-Stabilized Green Fluorescent Gold Nanoclusters for Cell Nuclei Imaging Applications

We report facile one-pot synthesis of water-soluble green fluorescent gold nanoclusters (AuNCs), capped with 8-mercapto-9-propyladenine. The synthesized AuNCs were characterized by Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), ¹H NMR, and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. These nanoclusters show high photostability and biocompatibility. We observed that AuNCs stain cell nuclei with high specificity, where the mechanism of AuNC uptake was established through pathway-specific uptake inhibitors. These studies revealed that cell internalization of AuNCs occurs via a macropinocytosis pathway

Nanotechnology Interventions in the Management of COVID-19: Prevention, Diagnosis and Virus-Like Particle Vaccines

SARS-CoV-2 claimed numerous lives and put nations on high alert. The lack of antiviral medications and the small number of approved vaccines, as well as the recurrence of adverse effects, necessitates the development of novel treatment ways to combat COVID-19. In this context, using databases such as PubMed, Google Scholar, and Science Direct, we gathered information about nanotechnology’s involvement in the prevention, diagnosis and virus-like particle vaccine development. This review revealed that various nanomaterials like gold, polymeric, graphene and poly amino ester with carboxyl group coated magnetic nanoparticles have been explored for the fast detection of SARS-CoV-2. Personal protective equipment fabricated with nanoparticles, such as gloves, masks, clothes, surfactants, and Ag, TiO2 based disinfectants played an essential role in halting COVID-19 transmission. Nanoparticles are used not only in vaccine delivery, such as lipid nanoparticles mediated transport of mRNA-based Pfizer and Moderna vaccines, but also in the development of vaccine as the virus-like particles elicit an immune response. There are now 18 virus-like particle vaccines in pre-clinical development, with one of them, developed by Novavax, reported being in phase 3 trials. Due to the probability of upcoming COVID-19 waves, and the rise of new diseases, the future relevance of virus-like particles is imperative. Furthermore, psychosocial variables linked to vaccine reluctance constitute a critical problem that must be addressed immediately to avert pandemic

Mechanistic Insight into Antimicrobial and Antioxidant Potential of Jasminum Species: A Herbal Approach for Disease Management

Drug resistance among microbial pathogens and oxidative stress caused by reactive oxygen species are two of the most challenging global issues. Firstly, drug-resistant pathogens cause several fatalities every year. Secondly aging and a variety of diseases, such as cardiovascular disease and cancer, are associated with free radical generated oxidative stress. The treatments currently available are limited, ineffective, or less efficient, so there is an immediate need to tackle these issues by looking for new therapies to resolve resistance and neutralize the harmful effects of free radicals. In the 21st century, the best way to save humans from them could be by using plants as well as their bioactive constituents. In this specific context, Jasminum is a major plant genus that is used in the Ayurvedic system of medicine to treat a variety of ailments. The information in this review was gathered from a variety of sources, including books, websites, and databases such as Science Direct, PubMed, and Google Scholar. In this review, a total of 14 species of Jasminum have been found to be efficient and effective against a wide variety of microbial pathogens. In addition, 14 species were found to be active free radical scavengers. The review is also focused on the disorders related to oxidative stress, and it was concluded that Jasminum grandiflorum and J. sambac normalized various parameters that were elevated by free radical generation. Alkaloids, flavonoids (rutoside), terpenes, phenols, and iridoid glucosides are among the main phytoconstituents found in various Jasminum species. Furthermore, this review also provides insight into the mechanistic basis of drug resistance, the generation of free radicals, and the role of Jasminum plants in combating resistance and neutralizing free radicals