275 research outputs found
Een systeem ter berekening van huisvestingskosten:opzet voor een systeem ter berekening van de kosten van de gebouwen en huisvesting in economisch en materieel beheer bij het Ministerie van Landbouw, Natuurbeheer en Visserij
Gene expression profiling identifies tumour markers potentially playing a role in uveal melanoma development
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7βRILPβp150Glued and late endosome positioning
Late endosomes (LEs) have characteristic intracellular distributions determined by their interactions with various motor proteins. Motor proteins associated to the dynactin subunit p150Glued bind to LEs via the Rab7 effector Rab7-interacting lysosomal protein (RILP) in association with the oxysterol-binding protein ORP1L. We found that cholesterol levels in LEs are sensed by ORP1L and are lower in peripheral vesicles. Under low cholesterol conditions, ORP1L conformation induces the formation of endoplasmic reticulum (ER)βLE membrane contact sites. At these sites, the ER protein VAP (VAMP [vesicle-associated membrane protein]-associated ER protein) can interact in trans with the Rab7βRILP complex to remove p150Glued and associated motors. LEs then move to the microtubule plus end. Under high cholesterol conditions, as in Niemann-Pick type C disease, this process is prevented, and LEs accumulate at the microtubule minus end as the result of dynein motor activity. These data explain how the ER and cholesterol control the association of LEs with motor proteins and their positioning in cells
Advances and Insights into Neurological Practice 2016-17
Papers published by the European Journal of Neurology reflect the broad interest of practicing neurologists in advances in the aetiology, diagnosis and management of neurological disorders. As a general journal, the proportion of papers in the different subject areas reasonably reflects the case load of a practising neurologist. Stroke represents the largest proportion of papers published, including those on pathophysiology (1-23), acute stroke management (24-47) and the outcome of patients who have suffered stroke (48-72). This article is protected by copyright. All rights reserved
A post-microsomal fraction from rat liver: isolation, characterization and function
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mmubn000001_248018132.pdf (publisher's version ) (Open Access)Promotor : H. Bloemendal
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