3-(2,4-Dichloro­phen­oxy)-1-(4-meth­oxy­phen­yl)-4-(3-nitro­phen­yl)azetidin-2-one

In the title compound, C22H16Cl2N2O5, the nearly planar four-membered β-lactam ring [maximum deviations of 0.011 (2) for the N atom] makes dihedral angles of 68.34 (13), 83.04 (13) and 3.37 (13)° with the dichloro-, nitro- and meth­oxy­phenyl rings, respectively. The crystal structure is stabilized by C—H⋯O hydrogen-bond inter­actions. In addition, a π–π stacking inter­action [centroid–centroid distance = 3.6622 (12) Å] is observed between the β-lactam and nitro­phenyl rings

Synthesis and biological evaluation of bile acid dimers linked with 1,2,3-triazole and bis-β-lactam

We report herein the synthesis and biological evaluation of bile acid dimers 11-18 linked through 1,2,3-triazole and bis-β-lactam. The dimers 11-18 were synthesized using 1,3-dipolar cycloaddition reaction of diazido bis-β-lactams 3, 4 and terminal alkynes 7-10 derived from cholic acid/deoxycholic acid in the presence of Cu(I) catalyst (click chemistry). These novel molecules were evaluated in vitro for their antifungal and antibacterial activity. Most of the compounds exhibited significant antifungal as well as antibacterial activity against all the tested fungal and bacterial strains. Moreover, their in vitro cytotoxicities towards HEK-293 and MCF-7cells were also established