17 research outputs found
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
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- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
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- Fan Eddy
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- Fartoukh Muriel
- Farías Pamela A.
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- Fernandez Adriana M.
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- Floris Leda
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- Formenti Paolo
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- Frigyik Aniko D.
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- Futami Satoru
- Gally Josette
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- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
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- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonz Á Lez Raquel Montiel
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Rojas Manuel A.
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- Goodson Jennifer C.
- Gordo Federico
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- Grijalba Carolina Quintana
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- Gueret Renaud M.
- Gurjar Mohan
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- Guérin Claude
- Gómez Pilar Ricart Aroa
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- Haddad Youssef
- Hadfield Dan
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- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
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- Hraiech Sami
- Hua Ma X.
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- Hunt Anna
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- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
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- Ioannou Nicholas
- Iotti Giorgio A.
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- Ismail Dina
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- Ito Fumihito
- Izawa Masayo
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- Jamaati Hamidreza
- Jarquin-Badiola Yves D.
- Jassal Mandeep
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- Javier-Blanco
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- Jiang Liangyan
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- Judy Claine
- Jurado M. . Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kansuke-Koyama
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch Barrett T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon H.
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- Labarca Eduardo F.
- Laffey John
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- Lamb Keith D.
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- Larsson Anders
- Larsson Niklas
- le Moal Charlene
- Lebbinck Herve
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- Lemiale Virginie
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- Leon Yoshido Hector H.
- Li Bin
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- Wang Chunting
- Wang Hua X.
- Wang Shou H.
- Wang Wei
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- Watanabe Eizo
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- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L.
- Williams Alexandra J.
- Williams Karen E.
- Wise Matt P.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David W.
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Immunocompromised patients with acute respiratory distress syndrome : Secondary analysis of the LUNG SAFE database
- Author
- Abad R.D.
- Abe Toshikazu
- Abroug Fekri
- Adams J.C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguirre Janet S
- Aguirre-Bermeo Hernan
- Aisa T.M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi H.M.
- Al Jabbary A.S.
- Albaiceta G.M.
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- Ñamendys-Silva S.A.
- ünal Necmettin
- Publication venue
- Publication date
- 01/01/2018
- Field of study
The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat
- Aisiku Imo
- Ajetunmobi Olaitan
- Aker Mustafa
- Akyol Onat
- Al Dorzi Hasan M.
- Al Jabbary Ahmed
- Albaiceta Guillermo
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain
- Allan Russell
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier
- Altaf Wahid
- Alvarez António
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo
- Antonelli Massimo
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis
- Azad Raman
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- Villagomez Asisclo J.
- Villamagua Boris
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua
- Wang Shou H.
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- Whitehead Christina
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- Williams Alexandra J.
- Williams Karen E.
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- Woods Paul W.
- Wrathall David
- Wrigge Hermann
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- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis
- Zacharowski Kai
- Zani Gianluca
- Zantua Kim
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao
- Zhu Wei H.
- Zogheib Elie
- Ñamendys-Silva Silvio A.
- ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
- Author
- Abad Ricardo,
- Abe Toshikazu
- Abroug Fekri
- Adams John,
- Adamsson Richard,
- Adolfsson Anne
- Aguilar Ronald,
- Aguirre Janet,
- Aguirre-Bermeo Hernan
- Aisa Tharwat,
- Aisiku Imo
- Ajetunmobi Olaitan,
- Aker Mustafa
- Akyol Onat,
- Al Dorzi Hasan,
- Albaiceta Guillermo,
- Albaiceta Guillermo,
- Albarrak Mohamad,
- Albiero Daniela
- Alda Rosa,
- Alejandro Risso,
- Alexander Peter
- Alfonso Alec,
- Algaba Ángela
- Aliaga Felipe,
- Alisasis Alain,
- Aljabbary Ahmed,
- Allan Russell,
- Allue Raquel,
- Almekhlafi Ghaleb
- Alonso Javier,
- Altaf Wahid
- Alvarez António,
- Alvarez Javier
- Amado-Rodríguez Laura
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn,
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo,
- Antônio Ana,
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen,
- Arabi Yaseen,
- Araujo Ana,
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria,
- Artigas Antonio
- Ascoli Aline
- Avila Luis,
- Azad Raman
- Azevedo Luciano,
- Baboi Loredana
- Badie Julio,
- Bailey Irene,
- Bailey Mathew,
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Bannergoodspeed Valerie,
- Barberet Guillaume
- Baro Rebecca,
- Baronia Arvind,
- Barratt-Due Andreas
- Barros Filipa,
- Barros Nelson,
- Batra Hitesh
- Battle Ceri,
- Bauer Philippe,
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu,
- Beegle Scott,
- Beitler Jeremy,
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel,
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien,
- Bettini Lisandro,
- Beuret Pascal
- Bezzi Marco,
- Bhardwaj Vallish,
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Binhjabul Wahab Ahmad,
- Biondi Rodrigo,
- Biscione Roberto,
- Bisso Mariano,
- Black Colin,
- Blakeman Thomas,
- Blanco Javier
- Bolon Stefan
- Borello Silvina,
- Borotto Erika,
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria,
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy,
- Briquet Anais
- Brito Vania,
- Brizuela Matias
- Brochard Laurent
- Broman Lars,
- Brown Samuel,
- Browne Troy,
- Bruhn Alejandro,
- Brunettini Barbara
- Bruns Monique,
- Buensuseso Juan,
- Bugedo Guillermo
- Buise Marc,
- Bulpa Pierre,
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew,
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis,
- Careless Jon,
- Carpentier Dorothée
- Carreño Nicolás,
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro,
- Castro Silvia
- Catorze Nuno,
- Cazorla-Barranquero Francisca,
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria,
- Cervantes Mavy,
- Cesar Palazon,
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon,
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy,
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna,
- Claraco-Vega Luis,
- Clarkson Kevin
- Clarkson Kevin,
- Claverias Laura
- Cohen Jason,
- Cole Jade,
- Collins Daniel,
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele,
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan,
- Cortegiani Andrea
- Cortez Cesar,
- Coxo Cristina,
- Cracchiolo Andrea,
- Cranshaw Julius,
- Crapelli Giulia
- Crouch Daniel,
- Crouch Daniel,
- Crova Philippe,
- Csabi Peter
- Curley Gerard
- Curto Elena,
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin Cédric
- Daviaud Fabrice
- Davies Kyle,
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael,
- Declercq Pierrelouis,
- Dector Dulce
- Deicas Alberto
- del Carmenlorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt Pieter
- Depuydt Pieter
- Derman Suleyman,
- Di Tomasso Nora,
- Di Yu,
- Diaz Juan,
- Diaz-Rodriguez Esther
- Dive Alain,
- Dixit Subhal,
- Do Vale Fernandes Antero
- Dolva Merete,
- Donnelly Adrian
- Dowling Anna,
- Doyen Denis
- Dres Martin
- Dreyer Kyle,
- Dunne Eimhin,
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia,
- Elkhayari Mina
- Ellis Helen,
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin,
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana,
- Estrella Claudia,
- Ezzouine Hanane
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela,
- Fawkes Danielle,
- Ferguson Andrew
- Ferguson Niall,
- Fernandez Adriana,
- Fernandez Ruben,
- Fierro Jonathan,
- Floris Leda
- Follin Arnaud
- Fontenele Danielle,
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana,
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko,
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan,
- Garcia Patricio,
- Gattinoni Luciano
- Gazenkampf Andrey,
- Gelée Bruno
- George Fernando,
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin,
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan,
- Gomaa Dina
- Gomaa Dina
- Gomes Rui,
- Gomez Pablo,
- Gomez-Flores Saira,
- Gonzalez Daniel,
- Gonzalez Marcos
- González Raquel,
- González-Salamanca Ángela
- Gonçalves Claudio,
- Goodson Jennifer,
- Gordo Federico
- Gosselin Ryan,
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth,
- Grigoriev Evgeny
- Grissom Colin,
- Gritsan Alexey,
- Grubissich Nicolas
- Gueret Renaud,
- Gurjar Mohan
- Guttormsen Anne,
- Guérin Claude
- Gómez Pilar,
- Hacking Danielle,
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha,
- Han Hui
- Han Yi
- Hang Ai,
- Hanlon Gabrielle,
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S,
- Hashemian Seyed,
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge,
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert,
- Heunks Leo,
- Heunks Leo,
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hansbernd,
- Hopkins Phil
- Hormis Anil,
- Hou Peter,
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma,
- Huang Qing,
- Huang Xiao,
- Huerta Francisco,
- Huff Nidhi,
- Humphreys Sally,
- Hunt Anna
- Hurtado Javier
- Hurtado Javier
- Hurtado Javier
- Hutchison Robyn,
- Hutton Paula,
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu,
- Imperio María,
- Insaurralde Carolina,
- Inskip Deborah,
- Ioannou Nicholas
- Iotti Giorgio,
- Irvine Donald,
- Isidro San
- Ismail Dina
- Ismail Maizatul
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola,
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves,
- Jassal Mandeep
- Javeed Areej
- Jha Rajeev,
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio,
- Jimenez Juan,
- Jochmans Sébastien
- Jog Sameer,
- Jovanovic Bojan
- Judy Claine
- Jurado M,
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana,
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez,
- Kimura Hiroyasu
- Kiourtzieva Ellada,
- Kitch Barrett,
- Knapman Karl,
- Knoll Jenny
- Knowles Serena
- Kol Mark,
- Kong Jing
- Koyama Kansuke
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon,
- Laake Jon,
- Labarca Eduardo,
- Laffey John,
- Laffey John,
- Lamb Keith,
- Lanspa Michael,
- Larsson Anders
- Larsson Anders
- Larsson Niklas
- Las Lomas Sanatorio
- Le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana,
- Leonyoshido Hector,
- Li Bin
- Li Qingdong
- Li Qiong,
- Li Wenwen
- Li Xiao,
- Li Xinyu
- Li Yimin
- Li Yuan,
- Li-Xin Zhou
- Liew Kong,
- Ling Long,
- Liu Haitao
- Liu Jian
- Liu Jing,
- Liu Ling
- Llano Iguel
- Lohner Ralph
- Loiacono Flavia,
- Lombardo Andrea
- Lopez Esther,
- Lopez-Delgado Juan,
- Lora Fredy,
- Lora Pilar
- Lorente Jose,
- Losada Elena,
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon,
- Luo Xiaoming
- Lynch Joan,
- López-Messa Juan,
- Maazouzi Wajdi
- Macfadyen Rosaleen
- Macfie Caroline,
- Madotto Fabiana
- Maeyama Hiroki,
- Maghrabi Khalid,
- Magret Monica
- Mahto Heera,
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego,
- Marcu Alexandra
- Marin Julien
- Marin Maria,
- Martinez Felipe,
- Martinho Aurelia,
- Marum Susan,
- Massa Eleni,
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin,
- Mcarthur Colin
- Mcauley Daniel,
- Mcauley Daniel,
- Mcauley Danny
- Mccalman Katie,
- Mckechnie Stuart
- Mckee Raymond
- Mckenna Toni,
- Mcleod Alex
- Mcnamee Lia
- Mcnamee Lia
- Meaney Edel,
- Meco Basak,
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco,
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António,
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca,
- Miller Jennene,
- Miller Russel,
- Mirabella Lucia
- Mizuguchi Ichiko
- Mochizuki Katsunori
- Mohr Nicholas,
- Mojoli Francesco
- Moles Silvia,
- Molin Alexandre
- Montanha Gustavo,
- Monteiro Jorge,
- Montero Laura,
- Monti Giacomo
- Montini Luca,
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni,
- Moya David,
- Mukkera Satyanarayana,
- Mustafa Ghanem,
- Muthuchellappan Radhakrishnan
- Máca Jan
- Nagy Eva,
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Jr Antonio,
- Nasu Michitaka
- Navalpotro Miguel,
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius,
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolas
- Nin Nicolás
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark Kim,
- Nunci Lordian
- Nunes Silvia,
- Nunomiya Shin
- Nutt Christopher
- Nuñez Edgardo
- Nygren Ingela
- Occhipinti Giovanna
- Oetting Trevor,
- Ogino Yasuaki
- Oikonomou Marina,
- Okane Sinead,
- Okuda Nao
- Oldroyd Matthew,
- Olga Moreno,
- Oliveira Bruno,
- Oneill Orla
- Ortiz Claudia,
- Oscanoa Fredy,
- Osman Emilio,
- Oss Peteris
- Ouanes Islem
- Ourailogloy Vasilis
- Owens Robert,
- Ozcelik Menekse
- O’croinin Donall
- O’muircheartaigh Aogan,
- Palaniswamy Vijayanand
- Palma Daniela,
- Palmese Salvatore
- Palo Jose,
- Panarello Giovanna
- Papanikolaou Metaxia,
- Papavasilopoulou Theonymfi,
- Papazian Laurent
- Papurica Marius
- Para Luis,
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim Rossini,
- Patroniti Nicolò
- Pattarino Ilaria
- Pecci Elisabetta
- Pellegrini Carlos,
- Pelletier Nicolas
- Pellicer Ana,
- Penuelas Oscar
- Pereira Carlos,
- Perez Cesar,
- Perez Manuel,
- Persson Linnea
- Pesenti Antonio
- Pham Tài
- Phan Nga,
- Piacentini Enrique,
- Pillai Suresh
- Pintado Maria,
- Piquilloud Lise
- Piras Claudio
- Pittini Gustavo
- Plotnikow Gustavo,
- Poblano Manuel
- Poli Michela,
- Pota Vincenzo
- Pozo Norberto,
- Pozzi Matteo
- Preez Pieter,
- Prietogonzález Miryam
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu,
- Qin Tie,
- Qiu Haibo
- Qiu Haibo
- Raaijmakers Monique
- Rafael Sánchez,
- Raimondi Ferdinando
- Raj Ashok,
- Ramakrishnan Nagarajan
- Ramesh Venkatapura,
- Ramirez-Alfaro Christian,
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton,
- Ranero Jorge,
- Ranieri Marco
- Raponi Francesco
- Recio Noelia,
- Reschreiter Henrik
- Reske Andreas,
- Reuter Danielle
- Reynolds Claire
- Rhayakar Rachana,
- Rialp Gemma
- Richecoeur Jack,
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rinia Myra
- Rios Fernando
- Riss Katharina,
- Rittayamai Nuttapol
- Roberts Brigit,
- Robine Adrien
- Robles Joanne,
- Rochecampo Ferran
- Rodgers Helen,
- Rodriguez Lucia,
- Rodriguez Ruben
- Rodríguez-Garcia Raquel
- Rojas Alejandro
- Rojas Manuel,
- Rosa Jonas,
- Roser Tomas,
- Rossi Anna
- Roux Damien
- Rubenfeld Gordon
- Rugonfalvi Szabolcs
- Ruiz Silvia,
- Ruizaguilar Antonio,
- Rylander Christian,
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal,
- Saenz María,
- Saez Alejandro,
- Sagar Sudha,
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier,
- Sales Vanessa,
- Samkaoui Nacer
- Sanchez Roberto,
- Sanchez-Hurtado Luis,
- Sanchez-Medina Jorge,
- Sandesc Dorel
- Santoli Francesco,
- Santos Cristina
- Sauvadet Elise,
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam,
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen,
- Schuetz Michael
- Schultz Marcus,
- Schäfer Susanne
- Scott Christopher,
- Seasman Colette
- Seethala Raghu
- Sellors Gareth,
- Seoane-Quiroga Leticia
- Serra Carolina
- Serra Isabel,
- Setten Mariano,
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn Iii John,
- Shiozaki Kyoko
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne,
- Sivashanmugavel Mageswaran
- Sjøbø Brit,
- Sklienka Peter
- Slutsky Arthur,
- Smith Mark,
- Smith Oliver
- Soler Juan,
- Solisquesada Jaime,
- Sottiaux Thierry
- Souissi Asma,
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra,
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío,
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tabhan Edgardo,
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tan Beatriz,
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Taylor Thompson B
- Temprano Susana
- Terragni Pierpaolo
- Terzi Nicolas
- Thibault Sandrine
- Thomas Matthew
- Thompson Marlus,
- Tibblin Anna,
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana,
- Toribio Dácil,
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T,
- Trinidad Olivia,
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- van Haren Frank
- van Haren Frank
- van Wezel Hellen,
- Vargas Monica,
- Vascotto Ettore,
- Vasquez Daniela,
- Vega Luis,
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villagomez Asisclo,
- Villamagua Boris,
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles,
- Vitale Michela,
- Volta Carlo,
- Wang Chunting
- Wang Hua,
- Wang Shou,
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg,
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma,
- Williams Alexandra,
- Williams Karen,
- Wittebole Xavier
- Wong Helen,
- Woods Paul,
- Wrathall David,
- Wrigge Hermann
- Wrigge Hermann
- Wu Ya,
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng,
- Yeatts Dale,
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob,
- Yuste Luis,
- Zacharas Giannis,
- Zacharowski Kai,
- Zani Gianluca
- Zantua Charing,
- Zazu Alan
- Zeggwagh Amine,
- Zeggwagh Amine,
- Zein Salem,
- Zender Hervé,
- Zhai Zhe
- Zhang Fan
- Zhang Xing,
- Zhao Huiying
- Zhao Jun
- Zhao Xian,
- Zheng Ruiqiang
- Zhou Fa,
- Zhou Suming
- Zhu Bao,
- Zhu Wei,
- Zogheib Elie,
- Ñamendys-Silva Silvio,
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/12/2022
- Field of study
International audienceBackground: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/ hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmH 2 O, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmH 2 O, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmH 2 O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol OnatO
- Al Dorzi Hasan M.
- Albaiceta
- Albaiceta GuillermoM
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- AlJabbary AhmedS
- Allan Russell M
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amado-Rodríguez Laura
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Arabi YaseenM
- Araujo AnaM
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- BannerGoodspeed Valerie M.
- Barberet Guillaume
- Baro Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj VallishK
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- BinHJAbul Wahab Ahmad Yazid
- Biondi Rodrigo S.
- Biscione RobertoR
- Bisso Mariano Carboni
- Black ColinS
- Blakeman Thomas C.
- Blanco Javier
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Broman Lars M
- Brown SamuelM
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze NunoT
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau SimonK
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega LuisM
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole JadeM
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux DanieleM
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw JuliusH
- Crapelli Giulia
- Crouch Daniel R.
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
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- Villamagua BorisG
- Villar Veronica
- Vinzio Mauricio
- Virgilio CorcolesG
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua X.
- Wang ShouH
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D.
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett EmmaL
- Williams Alexandra J
- Williams Karen E.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David W
- Wrigge Hermann
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts DaleJ
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Charing Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender HervéO
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Background: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmH2O, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmH2O, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmH2O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. Trial registration Clinicaltrials.gov NCT02010073
Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome Insights from the LUNG SAFE Study
- Author
- Abe Toshikazu
- Abroug Fekri
- Abul Wahab Ahmad Yazid Bin HJ
- Adams John C
- Adamsson Richard O
- Adolfsson Anne
- Aguirre Janet S
- Aguirre-Bermeo Hernan
- Aisa Tharwat M
- Aisiku Imo
- Ajetunmobi Olaitan O
- Aker Mustafa
- Akyol Onat O
- Al Dorzi Hasan M
- Al Jabbary Ahmed S
- Albaiceta Guillermo M
- Albarrak Mohamad M
- Albiero Daniela
- Alda Rosa S
- Alejandro Risso
- Alexander Peter
- Alfonso Soler Juan
- Algaba Angela
- Aliaga Felipe A
- Alisasis Alain U
- Allan Russell M
- Almekhlafi Ghaleb
- Alonso Javier G
- Altaf Wahid
- Alvarez Montero Laura
- Alvarez Antonio M
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn H
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Angel Lorente Jose
- Antonelli Massimo M
- Antonio Ana Carolina P
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M
- Araujo Ana M
- Arizmendi Alfons
- Arnal Jean-Michel
- Aroa Gomez Pilar Ricart
- Artiga Maria Jose D
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C
- Bailey Irene M
- Bailey Mathew B
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M
- Barberet Guillaume
- Baron Rebecca M
- Baronia Arvind K
- Barratt-Due Andreas
- Barros Filipa M
- Barros Nelson C
- Batra Hitesh
- Battle Ceri E
- Bauer Philippe R
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H
- Beduneau Gaetan
- Beegle Scott H
- Beitler Jeremy R
- Bellani Giacomo
- Beloncle Francois
- Ben Souissi Asma
- Benslama Abdellatif
- Beraldo Daniel O
- Berghe Caroline
- Berkelmans Frantz
- Bermejo Lopez Esther
- Besset Sebastien L
- Bettini Lisandro R
- Beuret Pascal
- Bezzi Marco G
- Bhardwaj Vallish K
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S
- Biscione Roberto R
- Black Colin S
- Blakeman Thomas C
- Blanco Javier
- Blasco Navalpotro Miguel Angel
- Bolon Stefan
- Borello Silvina A
- Borotto Erika E
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M
- Briquet Anais
- Brito Vania A
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent Jean
- Broman Lars M
- Brown Samuel M
- Browne Troy S
- Bruhn Alejandro R
- Brunettini Barbara
- Bruns Monique M
- Buensuseso Juan A
- Bugedo Guillermo
- Buise Marc P
- Bulpa Pierre A
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J
- Burtin Philippe
- Buzancais Gautier
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Carboni Bisso Mariano
- Cardonnet Luis P
- Careless Jon P
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- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G
- Castro Silvia
- Catorze Nuno T
- Cazorla-Barranquero Francisca G
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalan Johanna E
- Claraco-Vega Luis M
- Clarkson Kevin
- Clarkson Kevin P
- Claverias Laura
- Cohen Jason E
- Cole Jade M
- Collins Daniel
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- Colombo Riccardo
- Combaux Daniele M
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E
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- Csabi Peter
- Curley Gerard
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin Cedric
- Daviaud Fabrice
- Davies Kyle G
- Dawson Heidi
- De Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- De Haro Candelaria
- De Pablo Raul
- de Prost Nicolas
- Dean Michael N
- Declercq Pierre-Louis M
- Dector Dulce
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempaire Gabriel
- Dempsey Ged
- Dendane Tarek
- Depuydt Pieter
- Derman Suleyman S
- Di Tomasso Nora N
- Di Yu D
- Diaz Abad Ricardo
- Diaz-Rodriguez Esther
- Dive Alain M
- Dixit Subhal B
- Dolva Merete S
- Donnelly Adrian
- Dowling Anna T
- Doyen Denis
- Dres Martin
- Dreyer Kyle R
- Dunne Eimhin S
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M
- Elkhayari Mina
- Ellis Helen E
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- Solis-Quesada Jaime E
- Soreide Eldar
- Sotillo Diaz Juan Carlos J
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- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Tabhan Edgardo
- Tabhan Edgardo E
- Tai Pham
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tallet Alfonso Alec A
- Tan Beatriz C
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Temprano Susana
- Teresa Jurado Ma
- Terzi Nicolas
- Thibault Sandrine
- Thomas Matthew
- Thompson B Taylor
- Thompson Marlus M
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana R
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T John
- Trinidad Olivia A
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unal Necmettin
- Unnikrishnan Ramesh
- Uppalapati Aditya
- van Haren Frank
- Van Haren Frank
- Van Wezel Hellen M
- Vargas Monica P
- Vascotto Ettore R
- Vasquez Daniela N
- Vega Luis D
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villagomez Asisclo J
- Villamagua Boris G
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G
- Vitale Michela N
- Volta Carlo A
- Wang Chunting
- Wang Hua X
- Wang Shou H
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L
- Williams Alexandra J
- Williams Karen E
- Wittebole Xavier
- Wong Helen S
- Woods Paul W
- Wrathall David W
- Wrigge Hermann
- Wu Ya Q
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L
- Yeatts Dale J
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S
- Yuste Luis J
- Zacharas Giannis A
- Zacharowski Kai D
- Zani Gianluca
- Zantua Kim S
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Herve O
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y
- Zheng Ruiqiang
- Zhou Fa C
- Zhou Li-Xin
- Zhou Suming
- Zhu Bao H
- Zhu Wei H
- Zogheib Elie H
- Zumaran Aguilar Ronald
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/02/2019
- Field of study
BACKGROUND: Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the most recent definition. Our primary objective was to describe the natural course and the factors associated with worsening and mortality in this population. METHODS: This study analyzed patients from the international prospective Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) who had initial mild acute respiratory distress syndrome in the first day of inclusion. This study defined three groups based on the evolution of severity in the first week: "worsening" if moderate or severe acute respiratory distress syndrome criteria were met, "persisting" if mild acute respiratory distress syndrome criteria were the most severe category, and "improving" if patients did not fulfill acute respiratory distress syndrome criteria any more from day 2. RESULTS: Among 580 patients with initial mild acute respiratory distress syndrome, 18% (103 of 580) continuously improved, 36% (210 of 580) had persisting mild acute respiratory distress syndrome, and 46% (267 of 580) worsened in the first week after acute respiratory distress syndrome onset. Global in-hospital mortality was 30% (172 of 576; specifically 10% [10 of 101], 30% [63 of 210], and 37% [99 of 265] for patients with improving, persisting, and worsening acute respiratory distress syndrome, respectively), and the median (interquartile range) duration of mechanical ventilation was 7 (4, 14) days (specifically 3 [2, 5], 7 [4, 14], and 11 [6, 18] days for patients with improving, persisting, and worsening acute respiratory distress syndrome, respectively). Admissions for trauma or pneumonia, higher nonpulmonary sequential organ failure assessment score, lower partial pressure of alveolar oxygen/fraction of inspired oxygen, and higher peak inspiratory pressure were independently associated with worsening. CONCLUSIONS: Most patients with initial mild acute respiratory distress syndrome continue to fulfill acute respiratory distress syndrome criteria in the first week, and nearly half worsen in severity. Their mortality is high, particularly in patients with worsening acute respiratory distress syndrome, emphasizing the need for close attention to this patient population.status: publishe
Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study (Intensive Care Medicine, (2016), 42, 12, (1865-1876), 10.1007/s00134-016-4571-5)
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aiman Maizatul
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ednan K.
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Blanco Javier
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella G
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Conti Sara
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin Cédric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- De Cima-Iglesias Sara
- De Gordoa Laura Ortiz-Ruiz
- De Haro Candelaria
- De Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- Di Tomasso Nora N.
- Di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- Francois Guy M.
- França Ana G.
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
- Gattinoni Luciano
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
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- Krstevski Amanda
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- Lemiale Virginie
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- Li Qingdong
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- Meersseman Philippe
- Mehta Sangeeta
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- Mellis Clare
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- Máca Jan
- Nagy Eva O.
- Nakamura Tomoyuki
- Namih Miriam
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- Navalpotro Miguel Angel Blasco
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius Ioan
- Newby Lynette
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- Niimi Daisuke
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- Pota Vincenzo
- Pozo Norberto C.
- Pozzi Matteo
- Preez Pieter D.
- Prieto-González Miryam
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu H.
- Qin Tie H.
- Qiu Haibo
- Raaijmakers Monique
- Rabboni Francesca
- Rafael Sánchez I.
- Raimondi Ferdinando
- Raj Ashok S.
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J.
- Ramirez-Alfaro Christian M.
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton M.
- Ranero Jorge Luis
- Ranieri Marco
- Raponi Francesco
- Recio Noelia N.
- Reschreiter Henrik
- Reske Andreas W.
- Reuter Danielle
- Reynolds Claire
- Rhayakar Rachana V.
- Rialp Gemma
- Richecoeur Jack R.
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rinia Myra
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- Riss Katharina C.
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- Rodriguez Lucia L.
- Rodriguez Ruben
- Rosa Jonas I.
- Roser Tomas P.
- Rossi Anna
- Roux Damien
- Rubenfeld Gordon D.
- Rugonfalvi Szabolcs
- Ruiz Silvia Rodriguez
- Ruiz-Aguilar Antonio L.
- Rylander Christian C.
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal D.
- Saenz María G.
- Saez Alejandro A.
- Sagar Sudha V.
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier E.
- Sales Vanessa M.
- Samkaoui Nacer
- Sanchez Roberto Jimenez
- Sanchez-Hurtado Luis A.
- Sanchez-Medina Jorge R.
- Sandesc Dorel
- Santoli Francesco L.
- Santos Cristina
- Sauvadet Elise P.
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam B.
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen A.
- Schuetz Michael
- Schultz Marcus J.
- Schäfer Susanne
- Scott Christopher J.
- Seasman Colette
- Seethala Raghu
- Sellors Gareth P.
- Seoane-Quiroga Leticia
- Serra Carolina
- Serra Isabel M.
- Service Gstt Severe Respiratory Failure
- Setten Mariano G.
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn Iii John O.
- Shiozaki Kyoko
- Silesky Jimenez Juan I.
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne D.
- Sivashanmugavel Mageswaran
- Sjøbø Brit Å.
- Sklienka Peter
- Slutsky Arthur S.
- Smith Mark J.
- Smith Oliver
- Soler Juan Alfonso
- Solis-Quesada Jaime E.
- Sotillo Diaz Juan Carlos J.
- Sottiaux T.
- Souissi Asma Ben
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E.
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío Manzano
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tabhan Edgardo E.
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tallet Alfonso Alec A.
- Tan Beatriz C.
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Temprano Susana
- Terzi Nicolas
- Theresa Uhc Mother
- Thibault Sandrine
- Thompson B. Taylor
- Thompson Marlus M.
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana R.
- Toribio Dácil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinidad Olivia A.
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- van Haren Frank
- Van Wezel Hellen M.
- Vargas Monica P.
- Vascotto Ettore R.
- Vasquez Daniela N.
- Vega Luis D.
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
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- Villagomez Asisclo J.
- Villamagua Boris G.
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua X.
- Wang Shou H.
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D.
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L.
- Williams Alexandra J.
- Williams Karen E.
- Wise Matt P.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David W.
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 14/11/2017
- Field of study
The members of the LUNG SAFE Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for this error
Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Blanco Javier
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Bos Lieuwe D.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin Cédric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- Del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- Di Tomasso Nora N.
- Di Yu
- Diaz Juan Carlos J. Sotillo
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dorzi Hasan M. Al
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana G.
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
- Gattinoni Luciano
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Raquel Montiel
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
- Gosselin Ryan J.
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O.
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K.
- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking Danielle J.
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J.
- Han Hui
- Han Yi
- Hang Ai
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
- Huff Nidhi G.
- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
- Hurtado Javier
- Hurtado Javier
- Hutchison Robyn A.
- Hutton Paula J.
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
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- Monteiro Jorge M.
- Montero Laura Alvarez
- Monti Giacomo
- Montini Luca M.
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
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- Moya David D. Llinares
- Mukkera Satyanarayana Reddy
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- Muthuchellappan Radhakrishnan
- Máca Jan
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- Nakamura Tomoyuki
- Namih Miriam
- Nassar Antonio P.
- Nasu Michitaka
- Navalpotro Miguel Angel Blasco
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius Loan
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolas
- Nin Nicolás
- Nishikawa Erin
- Nitta Kenichi
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- Nunci Lordian
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- Nutt Christopher
- Nuñez Edgardo
- Nygren Ingela
- Occhipinti Giovanna
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- Okuda Nao
- Oldroyd Matthew G.
- Olga Moreno F.
- Oliveira Bruno S.
- Ortiz Claudia A.
- Oscanoa Fredy A. Montes
- Osman Emilio M.
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- Palma Daniela M.
- Palmese Salvatore
- Palo Jose Emmanuel
- Panarello Giovanna
- Papanikolaou Metaxia N.
- Papavasilopoulou Theonymfi G.
- Papazian Laurent
- Papurica Marius
- Para Luis Herrera
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim Rossini Abbie B.
- Patroniti Nicolò
- Pattarino Pierpaolo Terragni Ilaria
- Pecci Elisabetta
- Pellegrini Carlos A.
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- Penuelas Oscar
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- Pittini Gustavo
- Plotnikow Gustavo A.
- Poblano Manuel
- Poli Michela M.
- Pota Vincenzo
- Pozo Norberto C.
- Pozzi Matteo
- Preez Pieter D.
- Prieto-González Miryam
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu H.
- Qin Tie H.
- Qiu Haibo
- Qiu Haibo
- Raaijmakers Monique
- Rafael Sánchez I.
- Raimondi Ferdinando
- Raj Ashok S.
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J.
- Ramirez-Alfaro Christian M.
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton M.
- Ranero Jorge Luis
- Ranieri Marco
- Raponi Francesco
- Recio Noelia N.
- Reschreiter Henrik
- Reske Andreas W.
- Reuter Danielle
- Reynolds Claire
- Rhayakar Rachana V.
- Rialp Gemma
- Richecoeur Jack R.
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rinia Myra
- Rios Fernando
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- Robine Adrien
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- Rodriguez Lucia L.
- Rodriguez Ruben
- Rojas Manuel A. González
- Rosa Jonas I.
- Roser Tomas P.
- Rossi Anna
- Roux Damien
- Rubenfeld Gordon
- Rugonfalvi Szabolcs
- Ruiz Silvia Rodriguez
- Ruiz-Aguilar Antonio L.
- Rylander Christian C.
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal D.
- Saenz María G.
- Saez Alejandro A.
- Sagar Sudha V.
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
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- Samkaoui Nacer
- Sanchez Roberto Jimenez
- Sanchez-Hurtado Luis A.
- Sanchez-Medina Jorge R.
- Sandesc Dorel
- Santoli Francesco L.
- Santos Cristina
- Sauvadet Elise P.
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam B.
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen A.
- Schuetz Michael
- Schultz Marcus J.
- Schäfer Susanne
- Scott Christopher J.
- Seasman Colette
- Seethala Raghu
- Sellors Gareth P.
- Seoane-Quiroga Leticia
- Serra Carolina
- Serra Isabel M.
- Setten Mariano G.
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn John O.
- Shiozaki Kyoko
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne D.
- Simonis Fabienne D.
- Sivashanmugavel Mageswaran
- Sjøbø Brit Å.
- Sklienka Peter
- Slutsky Arthur S.
- Smith Mark J.
- Smith Oliver
- Soler Juan Alfonso
- Solis-Quesada Jaime E.
- Sottiaux T.
- Souissi Asma Ben
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E.
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío Manzano
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tabhan Edgardo E.
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tan Beatriz C.
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Temprano Susana
- Terzi Nicolas
- Thibault Sandrine
- Thomas Rajeev R. Jha Matthew
- Thompson B. Taylor
- Thompson Marlus M.
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana R.
- Toribio Dácil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T. John
- Trinidad Olivia A.
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- van Haren Frank
- van Haren Frank
- van Wezel Hellen M.
- Vargas Monica P.
- Vascotto Ettore R.
- Vasquez Daniela N.
- Vega Luis D.
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villagomez Asisclo J.
- Villamagua Boris G.
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua X.
- Wang Shou H.
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D.
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L.
- Williams Alexandra J.
- Williams Karen E.
- Wise Matt P.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David W.
- Wrigge Hermann
- Wrigge Hermann
- Wu Ya
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale J.
- Yoshido Hector H. Leon
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Purpose: To evaluate patients with resolved versus confirmed ARDS, identify subgroups with substantial mortality risk, and to determine the utility of day 2 ARDS reclassification. Methods: Our primary objective, in this secondary LUNG SAFE analysis, was to compare outcome in patients with resolved versus confirmed ARDS after 24 h. Secondary objectives included identifying factors associated with ARDS persistence and mortality, and the utility of day 2 ARDS reclassification. Results: Of 2377 patients fulfilling the ARDS definition on the first day of ARDS (day 1) and receiving invasive mechanical ventilation, 503 (24%) no longer fulfilled the ARDS definition the next day, 52% of whom initially had moderate or severe ARDS. Higher tidal volume on day 1 of ARDS was associated with confirmed ARDS [OR 1.07 (CI 1.01–1.13), P = 0.035]. Hospital mortality was 38% overall, ranging from 31% in resolved ARDS to 41% in confirmed ARDS, and 57% in confirmed severe ARDS at day 2. In both resolved and confirmed ARDS, age, non-respiratory SOFA score, lower PEEP and P/F ratio, higher peak pressure and respiratory rate were each associated with mortality. In confirmed ARDS, pH and the presence of immunosuppression or neoplasm were also associated with mortality. The increase in area under the receiver operating curve for ARDS reclassification on day 2 was marginal. Conclusions: ARDS, whether resolved or confirmed at day 2, has a high mortality rate. ARDS reclassification at day 2 has limited predictive value for mortality. The substantial mortality risk in severe confirmed ARDS suggests that complex interventions might best be tested in this population. Trial Registration: ClinicalTrials.gov NCT02010073
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis
- Author
- 1amendys-Silva Silvio A
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C
- Adamsson Richard O
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S
- Aguirre-Bermeo Hernan
- Aisa Tharwat M
- Aisiku Imo
- Ajetunmobi Olaitan O
- Aker Mustafa
- Akyol Onat O
- Al Dorzi Hasan M
- Al Jabbary Ahmed S
- Albaiceta Guillermo M
- Albarrak Mohamad M
- Albiero Daniela
- Alda Rosa S
- Alejandro Risso V
- Alexander Peter
- Alfonso Alec A Tallet
- Algaba \uc1ngela
- Aliaga Felipe A
- Alisasis Alain U
- Allan Russell M
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G
- Altaf Wahid
- Alvarez Ant\uf3nio M
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- Ampinelli Adenilton M R
- An Youzhong
- Andersen Finn H
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Ant\uf4nio Ana Carolina P
- Antonelli Massimo M
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M
- Araujo Ana M
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E
- Azad Raman
- Azevedo Luciano C
- B\ue9duneau Gaetan
- Baboi Loredana
- Badie Julio C
- Bailey Irene M
- Bailey Mathew B
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M
- Barberet Guillaume
- Baron Rebecca M
- Baronia Arvind K
- Barratt-Due Andreas
- Barros Filipa M
- Barros Nelson C
- Batra Hitesh
- Battle Ceri E
- Bauer Philippe R
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H
- Beegle Scott H
- Beitler Jeremy R
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Ben Souissi Asma
- Benslama Abdellatif
- Beraldo Daniel O
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L
- Bettini Lisandro R
- Beuret Pascal
- Bezzi Marco G
- Bhardwaj Vallish K
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S
- Biscione Roberto R
- Bisso Mariano Carboni
- Black Colin S
- Blakeman Thomas C
- Blanco Javier
- Blasco Navalpotro Miguel Angel
- Bolon Stefan
- Borello Silvina A
- Borotto Erika E
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M
- Briquet Anais
- Brito Vania A
- Brizuela Matias
- Broman Lars M
- Brown Christine
- Brown Samuel M
- Bruhn Alejandro R
- Brunettini Barbara
- Bruns Monique M
- Buensuseso Juan A
- Bugedo Guillermo
- Buise Marc P
- Bulpa Pierre A
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J
- Burtin Philippe
- Buzancais Gautier
- Calfee Carolyn S
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P
- Careless Jon P
- Carpentier Doroth\ue9e
- Carre\uf1o Nicol\ue1s G
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G
- Castro Silvia
- Catorze Nuno T
- Cazorla-Barranquero Francisca G
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Churpek Matthew
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Cital\ue1n Johanna E
- Claraco-Vega Luis M
- Clarkson Kevin
- Clarkson Kevin P
- Claverias Laura
- cnal Necmettin
- Cohen Jason E
- Cole Jade M
- Collins Daniel V
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E
- Cortegiani Andrea
- Cortez Cesar A
- Cowley R Adams
- Cox Cristina M
- Cracchiolo Andrea N
- Cranshaw Julius H
- Crapelli Giulia
- Crouch Daniel R
- Crova Philippe J
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- D\ue9mpaire Gabriel
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C\ue9dric
- Daviaud Fabrice
- Davies Kyle G
- Dawson Heidi
- De Cima-Iglesias Sara
- De Gordoa Laura Ortiz-Ruiz
- De Haro Candelaria
- De Pablo Raul
- de Prost Nicolas
- Dean Michael N
- Declercq Pierre-Louis M
- Dector Dulce M
- Deicas Alberto
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Delucchi Kevin L
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P
- Depuydt Pieter
- Derman Suleyman S
- Di Tomasso Nora N
- Di Yu D
- Diaz Juan Carlos J Sotillo
- Diaz-Rodriguez Esther
- Dive Alain M
- Dixit Subhal B
- do Vale Fernandes Antero
- Dolva Merete S
- Donnelly Adrian
- Dowling Anna T
- Doyen Denis
- Dres Martin
- Dreyer Kyle R
- Dunne Eimhin S
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M
- Elkhayari Mina
- Ellis Helen E
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M
- Estrella Claudia R
- Eugenio Luis Palazon Sanchez
- Ezzouine Hanane
- Fan Eddy
- Far\uedas Pamela A
- Fartoukh Muriel
- Fawkes Danielle A
- Ferguson Andrew
- Ferguson Niall D
- Fernandez Adriana M
- Fernandez Ruben O
- Fierro Jonathan M
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Fran\ue7a Ana G.
- Franco Nieves
- Francois Guy M
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D
- Fusari Maurizio
- Futami Satoru
- G\uf3mez Pilar Ricart Aroa
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N
- Garcia Patricio H
- Gazenkampf Andrey A
- Gel\ue9e Bruno
- George Fernando G
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C
- Gomaa Dina
- Gomaa Dina
- Gomes Rui M
- Gomez Antonio
- Gomez Pablo E
- Gomez-Flores Saira S
- Gon\ue7alves Claudio H
- Gonz\ue1lez Rojas Manuel A
- Gonz\ue1lez-Salamanca \uc1ngela
- Gonzalez Daniel R
- Gonzalez Marcos
- Goodson Jennifer C
- Gordo Federico
- Gosselin Ryan J
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K
- Gritsan Alexey I
- Grubissich Nicolas
- Gu\ue9rin Claude
- Gueret Renaud M
- Gurjar Mohan
- Guttormsen Anne B
- Hacking Danielle J
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J
- Han Hui
- Han Yi
- Hang Ai Y
- Hanlon Gabrielle C
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M
- Hashida Tomoaki
- He June
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J
- Helleberg Johan
- Henderson Galen
- Hendrickson Carolyn M
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J
- Heunks Leo M
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- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F
- Hopkins Phil
- Hormis Anil P
- Hou Peter C
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- Hraiech Sami
- Hua Ma X
- Huang Qing Q
- Huang Xiao B
- Huerta Francisco P
- Huff Nidhi G
- Humphreys Sally K
- Hunt Anna
- Hurtado Javier
- Hurtado Javier
- Hurtado Javier
- Hutchison Robyn A
- Hutton Paula J
- Iba\uf1ez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P
- Imperio Mar\ueda C
- Insaurralde Carolina S
- Inskip Deborah M
- Ioannou Nicholas
- Iotti Giorgio A
- Irvine Donald A
- Ismail Dina
- Ismail Dk Maizatul Aiman B Pg Hj
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves D
- Jassal Mandeep
- Jauregui Alejandra
- Javeed Areej
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio G
- Jochmans S\ue9bastien
- Jog Sameer A
- Jovanovic Bojan
- Judy Claine
- Jurado M\uaa Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
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- Krstevski Amanda
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- Mirabella Lucia
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- Nielsen Jonas
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- Niimi Daisuke
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- Nu\uf1ez Edgardo
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- Penuelas Oscar
- Pere Cesar P
- Pereira Carlos S
- Perez Cheng Meisy
- Perez Losada Elena
- Perez Manuel P
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- Piacentini Enrique A
- Pillai Suresh
- Pintado Maria C
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- Pittini Gustavo
- Plotnikow Gustavo A
- Poblano Manuel
- Poli Michela M
- Pota Vincenzo
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- Qin Bingyu
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- Rafael S\ue1nchez I
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- Raj Ashok S
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- Ryosuke Sekine
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- Santos Cristina
- Sarma Aartik
- Sauvadet Elise P
- Savioli Monica
- Scafetti Sergio
- Sch\ue4fer Susanne
- Schi\uf6ler Fredrik
- Schiavone Vincenzo
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- Schlichting Adam B
- Schneider Francis
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- Schouten Jeroen A
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- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
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- Shiozaki Kyoko
- Silesky Jimenez Juan I
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne D
- Sinha Pratik
- Sivashanmugave Mageswaran
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- Smith Mark J
- Smith Oliver
- Soler Juan Alfonso
- Solis-Quesada Jaime E
- Sottiaux T
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E
- Stansil Frank
- Staudinger Thomas
- Steinberg Jack
- Stephenson Lorraine
- Stewart Richard
- Stigler William
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- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
- Symmonds Sophie
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- Takada Tadaaki
- Takagi Shunsuke
- Tan Beatriz C
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Temprano Susana
- Terragni Pierpaolo
- Terzi Nicolas
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- Thompson Marlus M
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana R
- Toribio D\ue1cil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T John
- Trinidad Olivia A
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- Van Haren Frank
- Van Wezel Hellen M
- Vargas Monica P
- Vascotto Ettore R
- Vasquez Daniela N
- Vega Luis D
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Vessel Kathryn
- Villagomez Asisclo
- Villagomez Asisclo J
- Villamagua Boris G
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G
- Vitale Michela N
- Volta Carlo A
- Wang Chunting
- Wang Chunxue
- Wang Hua X
- Wang Shou H
- Wang Wei
- Ware Lorraine B
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Wickersham Nancy
- Willett Emma L
- Williams Alexandra J
- Williams Karen E
- Wise Matt P
- Wittebole Xavier
- Wong Helen S
- Woods Paul W
- Wrathall David W
- Wrigge Hermann
- Wu Ya Q
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L
- Yeatts Dale J
- Yoshido Hector H Leon
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S
- Yuste Luis J
- Zacharas Giannis A
- Zacharowski Kai D
- Zani Gianluca
- Zantua Kim S
- Zazu Alan
- Zeggwagh Amine Ali
- Zeggwagh Amine Ali
- Zender Herv\ue9 O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y
- Zhao Huiying
- Zhao Jun
- Zhao Wendi
- Zhao Xian Y
- Zheng Ruiqiang
- Zhou Fa C
- Zhou Suming
- Zhu Bao H
- Zhu Wei H
- Zhuo Hanjing
- Zogheib Elie H
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
International audienceTwo acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and differential treatment responses have been identified using latent class analysis (LCA) in seven individual cohorts. To facilitate bedside identification of subphenotypes, clinical classifier models using readily available clinical variables have been described in four randomised controlled trials. We aimed to assess the performance of these models in observational cohorts of ARDS. Methods: In this observational, multicohort, retrospective study, we validated two machine-learning clinical classifier models for assigning ARDS subphenotypes in two observational cohorts of patients with ARDS: Early Assessment of Renal and Lung Injury (EARLI; n=335) and Validating Acute Lung Injury Markers for Diagnosis (VALID; n=452), with LCA-derived subphenotypes as the gold standard. The primary model comprised only vital signs and laboratory variables, and the secondary model comprised all predictors in the primary model, with the addition of ventilatory variables and demographics. Model performance was assessed by calculating the area under the receiver operating characteristic curve (AUC) and calibration plots, and assigning subphenotypes using a probability cutoff value of 0·5 to determine sensitivity, specificity, and accuracy of the assignments. We also assessed the performance of the primary model in EARLI using data automatically extracted from an electronic health record (EHR; EHR-derived EARLI cohort). In Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE; n=2813), a multinational, observational ARDS cohort, we applied a custom classifier model (with fewer variables than the primary model) to determine the prognostic value of the subphenotypes and tested their interaction with the positive end-expiratory pressure (PEEP) strategy, with 90-day mortality as the dependent variable. Findings: The primary clinical classifier model had an area under receiver operating characteristic curve (AUC) of 0·92 (95% CI 0·90–0·95) in EARLI and 0·88 (0·84–0·91) in VALID. Performance of the primary model was similar when using exclusively EHR-derived predictors compared with manually curated predictors (AUC=0·88 [95% CI 0·81–0·94] vs 0·92 [0·88–0·97]). In LUNG SAFE, 90-day mortality was higher in patients assigned the hyperinflammatory subphenotype than in those with the hypoinflammatory phenotype (414 [57%] of 725 vs 694 [33%] of 2088; p<0·0001). There was a significant treatment interaction with PEEP strategy and ARDS subphenotype (p=0·041), with lower 90-day mortality in the high PEEP group of patients with the hyperinflammatory subphenotype (hyperinflammatory subphenotype: 169 [54%] of 313 patients in the high PEEP group vs 127 [62%] of 205 patients in the low PEEP group; hypoinflammatory subphenotype: 231 [34%] of 675 patients in the high PEEP group vs 233 [32%] of 734 patients in the low PEEP group). Interpretation: Classifier models using clinical variables alone can accurately assign ARDS subphenotypes in observational cohorts. Application of these models can provide valuable prognostic information and could inform management strategies for personalised treatment, including application of PEEP, once prospectively validated. Funding: US National Institutes of Health and European Society of Intensive Care Medicine
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
- Author
- Aage Christiansen
- Aaron Venti
- Abdellatif Benslama
- Adam B Schlichting
- Adenilton M Rampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Ahmad Yazid BinHJAbul Wahab
- AhmedS AlJabbary
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Albaiceta Guillermo M
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alejandro Rojas
- Alek Kumar
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandre Demoule
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alistair Nichol
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amado-Rodríguez Laura
- Amanda Krstevski
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Ana Carolina P Antônio
- Ana G França
- Ana M Pellicer
- Anais Briquet
- AnaM Araujo
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Anders Larsson
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andres Esteban
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- Angela Delsing
- Aniko D Frigyik
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna-Karin Morin
- AnnaT Dowling
- Anne Adolfsson
- AnneB Guttormsen
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio P Nassar Jr
- Antonio Pesenti
- AntonioG Jimenez
- AntonioL RuizAguilar
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arthur S Slutsky
- Arvind K Baronia
- Ashley Schomer
- Ashok S Raj
- Asisclo Villagomez
- AsiscloJ Villagomez
- Asma Ben Souissi
- Aurelia M Martinho
- Aylin Seven
- B Taylor Thompson
- Bao H Zhu
- Barbara Brunettini
- Barrett T Kitch
- Barry Kennedy
- Basak Ceyda Meco
- Beatriz C Tan
- Bellani Giacomo
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- BorisG Villamagua
- Brigit L Roberts
- BritÅ Sjøbø
- Bruno Gelée
- Bruno S Oliveira
- Candelaria De Haro
- Carlo A Volta
- Carlos A Pellegrini
- Carlos S Pereira
- Carolina S Insaurralde
- Carolina Serra
- Caroline Berghe
- Caroline C MacFie
- Catalina Forteza
- Cecilia Carbayo-Gorriz
- Cecilia Hermosa
- Ceri E Battle
- Cesar A Cortez
- CesarP Perez
- Charing Kim S Zantua
- Charlene Bigot
- Charlene Le Moal
- Christian C Rylander
- Christian Dellera
- ChristianM Ramirez-Alfaro
- Christina Whitehead
- Christopher Nutt
- Christopher Tainter
- ChristopherJ Scott
- Chunting Wang
- Claine Judy
- Claire Reynolds
- Clare Mellis
- Claude Guérin
- Claudia A Ortiz
- Claudia R Estrella
- Claudio H Gonçalves
- Claudio Piras
- Colette Seasman
- Colin McArthur
- ColinK Grissom
- ColinS Black
- CorcolesG Virgilio
- Corinne Leemann-Refondini
- Cristina M Coxo
- Cristina Santos
- Cédric Daubin
- Daisuke Niimi
- DaleJ Yeatts
- Damien Roux
- Dan E Corneci
- Dan Hadfield
- Dana R Tomescu
- Daniel O Beraldo
- Daniel R Crouch
- Daniel R Crouch
- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
- Daniela M Palma
- Daniela N Vasquez
- DanieleM Combaux
- DanielF McAuley
- DanielF McAuley
- Danielle A Fawkes
- Danielle C Fontenele
- Danielle Nobrega
- Danielle Reuter
- DanielleJ Hacking
- Danny McAuley
- Dany Goldgran-Toledano
- David D Llinares Moya
- David W Wrathall
- Deborah M Inskip
- Deeban Ganesan
- Denis Doyen
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
- Dina Gomaa
- Dina Ismail
- DonaldA Irvine
- Donall O'Croinin
- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce Dector
- Dácil Parrilla Toribio
- Ed Bajwa
- Edel A Meaney
- Edgardo E Tabhan
- Edgardo Nuñez
- Edgardo Tabhan
- Eduardo Beck
- Eduardo F Labarca
- EimhinS Dunne
- Eizo Watanabe
- Eldar Søreide
- Electra E Stamou
- Elena Frati
- Elena Gallego Curto
- Elena Perez Losada
- Eleni K Mouloudi
- Eleni V Massa
- Elie H Zogheib
- Elisa Estenssoro
- Elisabetta Pecci
- EliseP Sauvadet
- Ellada V Kiourtzieva
- Emilio M Osman
- EmmaL Willett
- Emre Erbabacan
- Enrique A Piacentini
- Enrique Cereijo
- Erika E Borotto
- Erin Nishikawa
- Esther Bermejo Lopez
- Esther Diaz-Rodriguez
- EttoreR Vascotto
- Eva O Nagy
- Evangelos Kalaitzis
- Evgeny Grigoriev
- Ewan C Goligher
- Fa C Zhou
- Fabien Grelon
- Fabienne D Simonis
- Fabio Tarantino
- Fabrice Daviaud
- Fahd Amir
- Fan Zhang
- Fan Eddy
- Farshad Heidari
- Fayez Kheir
- Fayez M Kheir
- Federico Gordo
- Fekri Abroug
- Felipe A Aliaga
- Felipe T Martinez
- Ferdinando Raimondi
- Fernando G George
- Fernando Rios
- Ferran RocheCampo
- Filipa M Barros
- Finn H Andersen
- Flavia A Loiacono
- Francesco Mojoli
- Francesco Raponi
- FrancescoL Santoli
- Francis Schneider
- Francisca G Cazorla-Barranquero
- Francisco Esteve
- Francisco Javier Flores Mejia
- FranciscoP Huerta
- Francois Beloncle
- Frank van Haren
- Frank Van Haren
- Frantz Berkelmans
- Fredrik Schiöler
- Fredy A Montes Oscanoa
- Fredy S Lora
- Fumihito Ito
- Gabriel Démpaire
- Gabrielle C Hanlon
- Gaetan Béduneau
- Galen Henderson
- Garcia M Elisabet
- Gareth P Sellors
- Gautier Buzancais
- Ged Dempsey
- Gemma Rialp
- Gerard Curley
- Ghaleb Almekhlafi
- Ghanem M Mustafa
- Ghassan Kamel
- Giacomo Monti
- Gianluca Zani
- Giannis A Zacharas
- Gilda Cinnella
- Giorgio A Iotti
- Giovanna Occhipinti
- Giovanna Panarello
- Giulia Crapelli
- Giuseppe Foti
- Gonzalo Navarro
- Gordon Rubenfeld
- Guillaume Barberet
- Guillaume Carteaux
- Guillermo Bugedo
- GuillermoM Albaiceta
- Gustavo A Plotnikow
- Gustavo M Montanha
- Gustavo Pittini
- Gyorgy Frendl
- Haibo Qiu
- Haibo Qiu
- Haitao Liu
- Hamidreza Jamaati
- Hanane Ezzouine
- Hans Kedelv
- HansBernd F Hopf
- Hasan M Al Dorzi
- Hector H LeonYoshido
- HeeraL Mahto
- Heidi Dawson
- Hektor Sula
- Helen J Rodgers
- Helen S Wong
- HelenE Ellis
- Helga Ceunen
- Hellen M Van Wezel
- Henrik Appelberg
- Henrik Reschreiter
- Hermann Wrigge
- Hermann Wrigge
- Hernan Aguirre-Bermeo
- Hernan Gianinetto
- Herve Dupont
- Herve Lebbinck
- HervéO Zender
- Hicham Balkhi
- Hiroki N Maeyama
- Hiroshi Imai
- Hiroyasu Kimura
- Hiroyuki Honda
- Hiroyuki Suzuki
- Hiroyuki Tanaka
- Hitesh Batra
- Hua X Wang
- Huanzhang Shao
- Hui Han
- Huiying Zhao
- Ichiko Mizuguchi
- Iguel Llano
- Ilaria Pattarino
- Ilkay Ceylan
- Imed Chouchene
- Imo Aisiku
- Ingeborg D Welters
- Ingela Nygren
- Irene M Bailey
- IsabelM Serra
- Islem Ouanes
- Istvan Kajtor
- Jack R Richecoeur
- Jacob S Yumha
- Jacques Duranteau
- JadeM Cole
- Jaime E SolisQuesada
- Jakob Gjedsted
- Jan Máca
- Janet S Aguirre
- Jarone Lee
- Jason E Cohen
- Javier Alvarez
- Javier Blanco
- Javier E Salas
- Javier G Alonso
- Javier Hurtado
- Javier Hurtado
- Javier Hurtado
- Jean Dellamonica
- Jean-Daniel Chiche
- Jean-Etienne Herbrecht
- Jean-Michel Arnal
- Jean-Philippe Rigaud
- Jennene J Miller
- Jennifer C Goodson
- Jenny Knoll
- Jens Kraßler
- Jeremy R Beitler
- Jeroen A Schouten
- Jerome Biehler
- Jessica Warren
- Jesús Sánchez-Ballesteros
- Jian Liu
- Jing Kong
- Jing L Liu
- Joan M Lynch
- Joana M Estilita
- Joanna Wessbergh
- Joanne B Robles
- Johan Helleberg
- Johanna E Citalán
- John C Adams
- John Laffey
- John Neal
- John O Shinn Iii
- Jon Bramall
- Jon H Laake
- Jon Henrik Laake
- Jon P Careless
- Jonas Nielsen
- Jonas Nielsen
- JonasI Rosa
- Jonathan Casement
- Jonathan Chelly
- Jonathan M Fierro
- Jonathan Messika
- Jordana S Lemus
- Jordi Mancebo
- Jorge Luis Ranero
- Jorge M Monteiro
- Jorge R Sanchez-Medina
- Joris Vermassen
- Jose A Lorente
- Jose Emmanuel Palo
- Josette Gally
- Juan A Buensuseso
- Juan Alfonso Soler
- Juan Carlos J Sotillo Diaz
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- Suresh Shindhe
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- Sébastien Jochmans
- T John Trinder
- Tadaaki Takada
- Takeshi Ueda
- Tamas Szakmany
- Tao Yu
- Tarek Dendane
- Teresa Honrubia
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thierry Sottiaux
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- Thomas Kander
- Thomas Staudinger
- Tie H Qin
- Tim Wenham
- Tomas P Roser
- Tomaz Mesar
- Tommaso Fossali
- Tomoaki Hashida
- Tomofumi Harasawa
- Tomoyuki Nakamura
- Toni E McKenna
- Toshikazu Abe
- Trevor W Oetting
- Troy S Browne
- Ulrich Strauch
- Ushio Higashijima
- Valeria I Cerrato
- Valerie M BannerGoodspeed
- VallishK Bhardwaj
- Vallverdu P Imma
- Vanessa M Sales
- Vania A Brito
- Varsha Kadaba
- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Schiavone
- Virginie Lemiale
- Vivek Kakar
- Vladimir Cerny
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- YaseenM Arabi
- Yasuaki Ogino
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- YvesD Jarquin-Badiola
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Ángela Algaba
- Ángela González-Salamanca
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/12/2022
- Field of study
Background: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmH2O, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmH2O, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmH2O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. Trial registration Clinicaltrials.gov NCT02010073