377 research outputs found
Infrared Spectroscopy of Symbiotic Stars. IV. V2116 Ophiuchi/GX 1+4, The Neutron Star Symbiotic
We have computed, based on 17 infrared radial velocities, the first set of
orbital elements for the M giant in the symbiotic binary V2116 Ophiuchi. The
giant's companion is a neutron star, the bright X-ray source GX 1+4. We find an
orbital period of 1161 days by far the longest of any known X-ray binary. The
orbit has a modest eccentricity of 0.10 with an orbital circularization time of
less than 10^6 years. The large mass function of the orbit significantly
restricts the mass of the M giant. Adopting a neutron-star mass of 1.35M(Sun),
the maximum mass of the M giant is 1.22M(Sun), making it the less massive star.
Derived abundances indicate a slightly subsolar metallicity. Carbon and
nitrogen are in the expected ratio resulting from the red-giant first dredge-up
phase. The lack of O-17 suggests that the M-giant has a mass less than
1.3M(Sun), consistent with our maximum mass. The red giant radius is 103R(Sun),
much smaller than the estimated Roche lobe radius. Thus, the mass loss of the
red giant is via a stellar wind. Although the M giant companion to the neutron
star has a mass similar to the late-type star in low-mass X-ray binaries, its
near-solar abundances and apparent runaway velocity are not fully consistent
with the properties of this class of stars.Comment: In press to The Astrophysical Journal (10 April 2006 issue). 23 page
Full Genome Characterisation of Bluetongue Virus Serotype 6 from the Netherlands 2008 and Comparison to Other Field and Vaccine Strains
In mid September 2008, clinical signs of bluetongue (particularly coronitis) were observed in cows on three different farms in eastern Netherlands (Luttenberg, Heeten, and Barchem), two of which had been vaccinated with an inactivated BTV-8 vaccine (during May-June 2008). Bluetongue virus (BTV) infection was also detected on a fourth farm (Oldenzaal) in the same area while testing for export. BTV RNA was subsequently identified by real time RT-PCR targeting genome-segment (Seg-) 10, in blood samples from each farm. The virus was isolated from the Heeten sample (IAH “dsRNA virus reference collection” [dsRNA-VRC] isolate number NET2008/05) and typed as BTV-6 by RT-PCR targeting Seg-2. Sequencing confirmed the virus type, showing an identical Seg-2 sequence to that of the South African BTV-6 live-vaccine-strain. Although most of the other genome segments also showed very high levels of identity to the BTV-6 vaccine (99.7 to 100%), Seg-10 showed greatest identity (98.4%) to the BTV-2 vaccine (RSAvvv2/02), indicating that NET2008/05 had acquired a different Seg-10 by reassortment. Although Seg-7 from NET2008/05 was also most closely related to the BTV-6 vaccine (99.7/100% nt/aa identity), the Seg-7 sequence derived from the blood sample of the same animal (NET2008/06) was identical to that of the Netherlands BTV-8 (NET2006/04 and NET2007/01). This indicates that the blood contained two different Seg-7 sequences, one of which (from the BTV-6 vaccine) was selected during virus isolation in cell-culture. The predominance of the BTV-8 Seg-7 in the blood sample suggests that the virus was in the process of reassorting with the northern field strain of BTV-8. Two genome segments of the virus showed significant differences from the BTV-6 vaccine, indicating that they had been acquired by reassortment event with BTV-8, and another unknown parental-strain. However, the route by which BTV-6 and BTV-8 entered northern Europe was not established
Astrometric orbits of SB9 stars
Hipparcos Intermediate Astrometric Data (IAD) have been used to derive
astrometric orbital elements for spectroscopic binaries from the newly released
Ninth Catalogue of Spectroscopic Binary Orbits (SB9). Among the 1374 binaries
from SB9 which have an HIP entry, 282 have detectable orbital astrometric
motion (at the 5% significance level). Among those, only 70 have astrometric
orbital elements that are reliably determined (according to specific
statistical tests discussed in the paper), and for the first time for 20
systems, representing a 10% increase relative to the 235 DMSA/O systems already
present in the Hipparcos Double and Multiple Systems Annex.
The detection of the astrometric orbital motion when the Hipparcos IAD are
supplemented by the spectroscopic orbital elements is close to 100% for
binaries with only one visible component, provided that the period is in the 50
- 1000 d range and the parallax is larger than 5 mas. This result is an
interesting testbed to guide the choice of algorithms and statistical tests to
be used in the search for astrometric binaries during the forthcoming ESA Gaia
mission.
Finally, orbital inclinations provided by the present analysis have been used
to derive several astrophysical quantities. For instance, 29 among the 70
systems with reliable astrometric orbital elements involve main sequence stars
for which the companion mass could be derived. Some interesting conclusions may
be drawn from this new set of stellar masses, like the enigmatic nature of the
companion to the Hyades F dwarf HIP 20935. This system has a mass ratio of 0.98
but the companion remains elusive.Comment: Astronomy & Astrophysics, in press (16 pages, 12 figures); also
available at http://www.astro.ulb.ac.be/Html/ps.html#Astrometr
Catalog of Galactic Beta Cephei Stars
We present an extensive and up-to-date catalog of Galactic Beta Cephei stars.
This catalog is intended to give a comprehensive overview of observational
characteristics of all known Beta Cephei stars. 93 stars could be confirmed to
be Beta Cephei stars. For some stars we re-analyzed published data or conducted
our own analyses. 61 stars were rejected from the final Beta Cephei list, and
77 stars are suspected to be Beta Cephei stars. A list of critically selected
pulsation frequencies for confirmed Beta Cephei stars is also presented. We
analyze the Beta Cephei stars as a group, such as the distributions of their
spectral types, projected rotational velocities, radial velocities, pulsation
periods, and Galactic coordinates. We confirm that the majority of these stars
are multiperiodic pulsators. We show that, besides two exceptions, the Beta
Cephei stars with high pulsation amplitudes are slow rotators. We construct a
theoretical HR diagram that suggests that almost all 93 Beta Cephei stars are
MS objects. We discuss the observational boundaries of Beta Cephei pulsation
and their physical parameters. We corroborate that the excited pulsation modes
are near to the radial fundamental mode in frequency and we show that the mass
distribution of the stars peaks at 12 solar masses. We point out that the
theoretical instability strip of the Beta Cephei stars is filled neither at the
cool nor at the hot end and attempt to explain this observation
Pharmacological and rAAV Gene Therapy Rescue of Visual Functions in a Blind Mouse Model of Leber Congenital Amaurosis
BACKGROUND: Leber congenital amaurosis (LCA), a heterogeneous early-onset retinal dystrophy, accounts for ~15% of inherited congenital blindness. One cause of LCA is loss of the enzyme lecithin:retinol acyl transferase (LRAT), which is required for regeneration of the visual photopigment in the retina. METHODS AND FINDINGS: An animal model of LCA, the Lrat (−/−) mouse, recapitulates clinical features of the human disease. Here, we report that two interventions—intraocular gene therapy and oral pharmacologic treatment with novel retinoid compounds—each restore retinal function to Lrat (−/−) mice. Gene therapy using intraocular injection of recombinant adeno-associated virus carrying the Lrat gene successfully restored electroretinographic responses to ~50% of wild-type levels (p < 0.05 versus wild-type and knockout controls), and pupillary light responses (PLRs) of Lrat (−/−) mice increased ~2.5 log units (p < 0.05). Pharmacological intervention with orally administered pro-drugs 9-cis-retinyl acetate and 9-cis-retinyl succinate (which chemically bypass the LRAT-catalyzed step in chromophore regeneration) also caused long-lasting restoration of retinal function in LRAT-deficient mice and increased ERG response from ~5% of wild-type levels in Lrat (−/−) mice to ~50% of wild-type levels in treated Lrat (−/−) mice (p < 0.05 versus wild-type and knockout controls). The interventions produced markedly increased levels of visual pigment from undetectable levels to 600 pmoles per eye in retinoid treated mice, and ~1,000-fold improvements in PLR and electroretinogram sensitivity. The techniques were complementary when combined. CONCLUSION: Intraocular gene therapy and pharmacologic bypass provide highly effective and complementary means for restoring retinal function in this animal model of human hereditary blindness. These complementary methods offer hope of developing treatment to restore vision in humans with certain forms of hereditary congenital blindness
Effects of phosphorus and drought stresses on dry matter and phosphorus allocation in wheat
Structure and contents of a new geomorphological GIS database linked to a geomorphological map — With an example from Liden, central Sweden
Further Defining Spectral Type "Y" and Exploring the Low-mass End of the Field Brown Dwarf Mass Function
We present the discovery of another seven Y dwarfs from the Wide-field
Infrared Survey Explorer (WISE). Using these objects, as well as the first six
WISE Y dwarf discoveries from Cushing et al., we further explore the transition
between spectral types T and Y. We find that the T/Y boundary roughly coincides
with the spot where the J-H colors of brown dwarfs, as predicted by models,
turn back to the red. Moreover, we use preliminary trigonometric parallax
measurements to show that the T/Y boundary may also correspond to the point at
which the absolute H (1.6 um) and W2 (4.6 um) magnitudes plummet. We use these
discoveries and their preliminary distances to place them in the larger context
of the Solar Neighborhood. We present a table that updates the entire stellar
and substellar constituency within 8 parsecs of the Sun, and we show that the
current census has hydrogen-burning stars outnumbering brown dwarfs by roughly
a factor of six. This factor will decrease with time as more brown dwarfs are
identified within this volume, but unless there is a vast reservoir of cold
brown dwarfs invisible to WISE, the final space density of brown dwarfs is
still expected to fall well below that of stars. We also use these new Y dwarf
discoveries, along with newly discovered T dwarfs from WISE, to investigate the
field substellar mass function. We find that the overall space density of
late-T and early-Y dwarfs matches that from simulations describing the mass
function as a power law with slope -0.5 < alpha < 0.0; however, a power-law may
provide a poor fit to the observed object counts as a function of spectral type
because there are tantalizing hints that the number of brown dwarfs continues
to rise from late-T to early-Y. More detailed monitoring and characterization
of these Y dwarfs, along with dedicated searches aimed at identifying more
examples, are certainly required.Comment: 91 pages, 15 figures, accepted for publication in The Astrophysical
Journa
Apoptosis and proliferation in the trigeminal placode
The neurogenic trigeminal placode develops from the crescent-shaped panplacodal primordium which delineates the neural plate anteriorly. We show that, in Tupaia belangeri, the trigeminal placode is represented by a field of focal ectodermal thickenings which over time changes positions from as far rostral as the level of the forebrain to as far caudal as opposite rhombomere 3. Delamination proceeds rostrocaudally from the ectoderm adjacent to the rostral midbrain, and contributes neurons to the trigeminal ganglion as well as to the ciliary ganglion/oculomotor complex. Proliferative events are centered on the field prior to the peak of delamination. They are preceded, paralleled and, finally, outnumbered by apoptotic events which proceed rostrocaudally from non-delaminating to delaminating parts of the field. Apoptosis persists upon regression of the placode, thereby exhibiting a massive “wedge” of apoptotic cells which includes the postulated position of the “ventrolateral postoptic placode” (Lee et al. in Dev Biol 263:176–190, 2003), merges with groups of lens-associated apoptotic cells, and disappears upon lens detachment. In conjunction with earlier work (Washausen et al. in Dev Biol 278:86–102, 2005) our findings suggest that apoptosis contributes repeatedly to the disintegration of the panplacodal primordium, to the elimination of subsets of premigratory placodal neuroblasts, and to the regression of placodes
Targeting Cx43 and N-Cadherin, Which Are Abnormally Upregulated in Venous Leg Ulcers, Influences Migration, Adhesion and Activation of Rho GTPases
Venous leg ulcers can be very hard to heal and represent a significant medical need with no effective therapeutic treatment currently available
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