3,095 research outputs found
Design and advancement status of the Beam Expander Testing X-ray facility (BEaTriX)
The BEaTriX (Beam Expander Testing X-ray facility) project is an X-ray
apparatus under construction at INAF/OAB to generate a broad (200 x 60 mm2),
uniform and low-divergent X-ray beam within a small lab (6 x 15 m2). BEaTriX
will consist of an X-ray source in the focus a grazing incidence paraboloidal
mirror to obtain a parallel beam, followed by a crystal monochromation system
and by an asymmetrically-cut diffracting crystal to perform the beam expansion
to the desired size. Once completed, BEaTriX will be used to directly perform
the quality control of focusing modules of large X-ray optics such as those for
the ATHENA X-ray observatory, based on either Silicon Pore Optics (baseline) or
Slumped Glass Optics (alternative), and will thereby enable a direct quality
control of angular resolution and effective area on a number of mirror modules
in a short time, in full X-ray illumination and without being affected by the
finite distance of the X-ray source. However, since the individual mirror
modules for ATHENA will have an optical quality of 3-4 arcsec HEW or better,
BEaTriX is required to produce a broad beam with divergence below 1-2 arcsec,
and sufficient flux to quickly characterize the PSF of the module without being
significantly affected by statistical uncertainties. Therefore, the optical
components of BEaTriX have to be selected and/or manufactured with excellent
optical properties in order to guarantee the final performance of the system.
In this paper we report the final design of the facility and a detailed
performance simulation.Comment: Accepted paper, pre-print version. The finally published manuscript
can be downloaded from http://dx.doi.org/10.1117/12.223895
Simbol-X Hard X-ray Focusing Mirrors: Results Obtained During the Phase A Study
Simbol-X will push grazing incidence imaging up to 80 keV, providing a strong
improvement both in sensitivity and angular resolution compared to all
instruments that have operated so far above 10 keV. The superb hard X-ray
imaging capability will be guaranteed by a mirror module of 100 electroformed
Nickel shells with a multilayer reflecting coating. Here we will describe the
technogical development and solutions adopted for the fabrication of the mirror
module, that must guarantee an Half Energy Width (HEW) better than 20 arcsec
from 0.5 up to 30 keV and a goal of 40 arcsec at 60 keV. During the phase A,
terminated at the end of 2008, we have developed three engineering models with
two, two and three shells, respectively. The most critical aspects in the
development of the Simbol-X mirrors are i) the production of the 100 mandrels
with very good surface quality within the timeline of the mission; ii) the
replication of shells that must be very thin (a factor of 2 thinner than those
of XMM-Newton) and still have very good image quality up to 80 keV; iii) the
development of an integration process that allows us to integrate these very
thin mirrors maintaining their intrinsic good image quality. The Phase A study
has shown that we can fabricate the mandrels with the needed quality and that
we have developed a valid integration process. The shells that we have produced
so far have a quite good image quality, e.g. HEW <~30 arcsec at 30 keV, and
effective area. However, we still need to make some improvements to reach the
requirements. We will briefly present these results and discuss the possible
improvements that we will investigate during phase B.Comment: 6 pages, 3 figures, invited talk at the conference "2nd International
Simbol-X Symposium", Paris, 2-5 december, 200
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Digitalization and co-creation of healthcare value: A case study in Occupational Health
This paper discusses how digitalization of healthcare empowers stakeholders to interact and co-create value. The literature so far has focused on the benefits of healthcare value co-creation through digital technologies (DTs) from the patients and providers’ perspective. It has viewed patients and providers in isolation focusing on the benefits accruing to the healthcare system but has not shed light upon the role of DT during interactions between stakeholders to co-create healthcare value. To address this gap, this research uses a case of the ‘Occupational Health Adviceline’ (OHA), a DT-enabled Occupational Health (OH) service introduced in England to provide support and advice to Small and Medium Enterprises (SMEs). We draw upon the affordances and S-D Logic concepts to illustrate how technology enables stakeholder (employees, employers, contact centre advisors, and OH nurses) empowerment and allows them to interact and co-create healthcare value. Our contribution lies in illustrating, through the affordances and S-D Logic lenses, how digitalization facilitates value co-creation through empowering stakeholders while providing new forms of visibility management.British Academy / Leverhulme Trust (grant no. SG122331); Knowledge Transfer Leave (Brunel University London)
Playing “hide and seek” with the Mediterranean monk seal: a citizen science dataset reveals its distribution from molecular traces (eDNA)
Animal conservation relies on assessing the distribution and habitat use of species, but for endangered/elusive animals this can prove difficult. The Monk Seal, Monachus monachus, is one of the world's most endangered species of pinniped, and the only one endemic to the Mediterranean Sea. During recent decades, direct observations have been few and scattered, making it difficult to determine its distribution away from the Aegean Sea (core distribution area of the post-decline relict population). This study relies on environmental DNA (eDNA) analysis to detect the presence of the Monk Seal in 135 samples collected in 120 locations of the central/western Mediterranean Sea, spanning about 1500 km longitudinally and 1000 km latitudinally. A recently described species-specific qPCR assay was used on marine-water samples, mostly collected during 2021 by a Citizen Science (CS) project. Positive detections occurred throughout the longitudinal range, including the westernmost surveyed area (Balearic archipelago). The distribution of the positive detections indicated six “hotspots”, mostly overlapping with historical Monk Seal sites, suggesting that habitat-specific characteristics play a fundamental role. We applied single-season occupancy models to correct for detection probability and to assess the importance of site-specific characteristics. The distance from small islets and protected (or access-restricted) areas was correlated negatively with the detection probability. This novel molecular approach, applied here for the first time in an extensive CS study, proved its potential as a tool for monitoring the distribution of this endangered/elusive species
Physical Investigation of the Potentially Hazardous Asteroid (144898) 2004 VD17
In this paper we present the observational campaign carried out at ESO NTT
and VLT in April and May 2006 to investigate the nature and the structure of
the Near Earth Object (144898) 2004 VD17. In spite of a great quantity of
dynamical information, according to which it will have a close approach with
the Earth in the next century, the physical properties of this asteroid are
largely unknown. We performed visible and near--infrared photometry and
spectroscopy, as well as polarimetric observations. Polarimetric and
spectroscopic data allowed us to classify 2004 VD17 as an E-type asteroid. A
good agreement was also found with the spectrum of the aubrite meteorite Mayo
Belwa. On the basis of the polarimetric albedo (p_v=0.45) and of photometric
data, we estimated a diameter of about 320 m and a rotational period of about 2
hours. The analysis of the results obtained by our complete survey have shown
that (144898) 2004 VD17 is a peculiar NEO, since it is close to the breakup
limits for fast rotator asteroids, as defined by Pravec and Harris (2000).
These results suggest that a more robust structure must be expected, as a
fractured monolith or a rubble pile in a "strength regime" (Holsapple 2002).Comment: 32 pages, 7 figure, paper accepted for publication in Icaru
Novel bicistronic lentiviral vectors correct beta-Hexosaminidase deficiency in neural and hematopoietic stem cells and progeny: implications for in vivo and ex vivo gene therapy of GM2 gangliosidosis
The favorable outcome of in vivo and ex vivo gene therapy approaches in several Lysosomal Storage Diseases suggests that these treatment strategies might equally benefit GM2 gangliosidosis. Tay-Sachs and Sandhoff disease (the main forms of GM2 gangliosidosis) result from mutations in either the HEXA or HERB genes encoding, respectively, the alpha- or beta-subunits of the lysosomal beta-Hexosaminidase enzyme. In physiological conditions, alpha- and beta-subunits combine to generate beta-Hexosaminidase A (HexA, alpha beta) and beta-Hexosaminidase B (HexB, 1313). A major impairment to establishing in vivo or ex vivo gene therapy for GM2 gangliosidosis is the need to synthesize the alpha- and beta-subunits at high levels and with the correct stoichiometric ratio, and to safely deliver the therapeutic products to all affected tissues/organs.
Here, we report the generation and in vitro validation of novel bicistronic lentiviral vectors (LVs) encoding for both the murine and human codon optimized Hexa and Hex!) genes. We show that these LVs drive the safe and coordinate expression of the alpha- and beta-subunits, leading to supranormal levels of beta-Hexosaminidase activity with prevalent formation of a functional HexA in SD murine neurons and glia, murine bone marrow-derived hematopoietic stem/progenitor cells (HSPCs), and human SD fibroblasts. The restoration/overexpression of beta-Hexosaminidase leads to the reduction of intracellular GM2 ganglioside storage in transduced and in cross-corrected SD murine neural progeny, indicating that the transgenic enzyme is secreted and functional. Importantly, bicistronic LVs safely and efficiently transduce human neurons/glia and CD34 + HSPCs, which are target and effector cells, respectively, in prospective in vivo and ex vivo GT approaches.
We anticipate that these bicistronic LVs may overcome the current requirement of two vectors co-delivering the alpha- or beta-subunits genes. Careful assessment of the safety and therapeutic potential of these bicistronic LVs in the SD murine model will pave the way to the clinical development of LV-based gene therapy for GM2 gangliosidosis
Identifying Near Earth Object Families
The study of asteroid families has provided tremendous insight into the
forces that sculpted the main belt and continue to drive the collisional and
dynamical evolution of asteroids. The identification of asteroid families
within the NEO population could provide a similar boon to studies of their
formation and interiors. In this study we examine the purported identification
of NEO families by Drummond (2000) and conclude that it is unlikely that they
are anything more than random fluctuations in the distribution of NEO
osculating orbital elements. We arrive at this conclusion after examining the
expected formation rate of NEO families, the identification of NEO groups in
synthetic populations that contain no genetically related NEOs, the orbital
evolution of the largest association identified by Drummond (2000), and the
decoherence of synthetic NEO families intended to reproduce the observed
members of the same association. These studies allowed us to identify a new
criterion that can be used to select real NEO families for further study in
future analyses, based on the ratio of the number of pairs and the size of
strings to the number of objects in an identified association.Comment: Accepted for publication in Icarus. 19 pages including 11 figure
Acute kidney injury and acute kidney disease in high-dose cisplatin-treated head and neck cancer
Background: In locally advanced head and neck squamous cell carcinoma (LA-SCCHN) at least 200mg/m2 (standard dose 300 mg/m2) of cisplatin concomitant with radiotherapy represents the standard of care, both in postoperative and conservative settings. Nevertheless, high dose administration every 3 weeks is often replaced with low dose weekly cisplatin to avoid toxicities like kidney injury, though often failing to reach the therapeutic dose. Our aim was to investigate the incidence of renal impairment in the real-life setting, integrating high dose cisplatin with adequate supportive therapy, and to explore both Acute Kidney Injury (AKI) and Acute Kidney Disease (AKD), a recently described clinical renal syndrome that encompasses functional alterations of the kidney lasting fewer than 3 months. Methods: One hundred and nine consecutive patients affected by LA-SCCHN and treated with at least a cumulative dosage of 200 mg/m2 of cisplatin concomitant with radiotherapy were enrolled in this prospective observational study. Results: AKI was reported in 12.8% of patients, 50% of whom were stage 1 (KDIGO criteria), while 25.7% of the cohort developed AKD. Patients with baseline estimated Glomerular Filtration Rate (eGFR) < 90 ml/min showed a higher incidence of AKD (36.2% vs 17.7%). Hypertension, baseline eGFR, and therapy with Renin-angiotensin-aldosterone system inhibitors proved to be significant factors associated with both AKI and AKD. Conclusion: AKI and AKD are not rare complications of high-dose cisplatin, but an appropriate prevention strategy and accurate monitoring of patients during treatment could lead to a reduction of the burden of these conditions
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