Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of binary black hole coalescences confidently observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include the effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that have already been identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total source-frame mass M > 70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz emitted gravitational-wave frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place a conservative upper limit for the merger rate density of high-mass binaries with eccentricities 0 < e ≤ 0.3 at 16.9 Gpc−3 yr−1 at the 90% confidence level

Plot size and experimental unit relationship in exploratory experiments Relação do tamanho ótimo de parcela com o tamanho da unidade básica nos ensaios em brancos

Quality of field experiments data dependent upon adequate experimental design. This study investigated the relationship between the size of the basic unit for exploratory experiments and the optimum plot size, and the experiment precision with potato crop. Tuber yield of 24 rows, 144 mounds, were used to arrange experimental units of one, two, three, four, six, eight and 12 mounds. Tuber yield data of different mounds were used to arrange plot sizes with different numbers of basic units. The model CV(x)=A/X B was adjusted, in which CV(x) was the coefficient of variation among plots with different numbers of basic units. Optimum plot size was estimated with the modified maximum curvature method of the function CV(x)=A/X B, allowing completely random design. Experimental precision was estimated though the Hatheway method for different experimental arrangements. Based upon the modification of the maximum curvature method, for a fixed total experimental area, experimental unit size of potato initial experiments affects optimum plot size estimations with the same experimental precision and variable number of treatments.<br>A qualificação dos dados de experimentos de campo é obtida, em grande parte, pela escolha adequada do delineamento experimental. Este estudo foi realizado com o objetivo de investigar a relação do tamanho da unidade básica de ensaios em branco com o tamanho de parcela e com a precisão de experimentos com a cultura de batata. Os dados da produção de tubérculos de batata, obtidos de 24 linhas com 144 covas, foram usados para planejar unidades básicas (UB) de 1, 2, 3, 4, 6, 8 e 12 covas. Com os valores da produção das UB de diferentes tamanhos foram planejadas parcelas de diferentes números de UB. Foi ajustado o modelo CV(x)=A/X B, em que CV(x) é o coeficiente de variação entre as parcelas com X UB de tamanho. A estimativa do tamanho ótimo de parcela foi procedida pelo método da máxima curvatura modificada da função CV(x)=A/X B, considerando o delineamento inteiramente ao acaso, e a precisão foi estimada pelo método de Hatheway para diferentes configurações do delineamento experimental. Concluiu-se que o tamanho da unidade básica, usada nos ensaios em branco com batata, afeta a estimativa do tamanho ótimo de parcela pelo método da máxima curvatura modificada, sem alterar a precisão experimental, independente do número de tratamentos, mantendo fixa a área total do experimento

Size and form of plots for the culture of the Italian pumpkin in plastic greenhouse Tamanho e forma de parcelas para a cultura da abóbora italiana cultivada em estufa plástica

Quality control is the guaranty that experimental error is kept under acceptable levels, and the definition of the proper size and form of experimental plots ensures acurate experimental planning. This paper aims to determine the proper plot size and shape for the culture of the Italian pumpkin in protected environments. Two experiments were set in plastic green house in distinct crop seasons: either Summer-Fall or Winter-Spring season. The experiment comprised eight, 23-m long lines with 20 plants each, and fruit weight was considered the main performance parameter. Estimates of best plots size and shape were obtained by the maximum curvature, variance comparison and Hatheway methods. The plot size and shape varied according to the season and the ideal size and shape, according to the maximum curvature and Hatheway methods, to the Summer-Fall and Winter-Spring seasons, were eight plants (4 <FONT FACE=Symbol>&acute;</FONT> 2 plot) and four plants (2 <FONT FACE=Symbol>&acute;</FONT> 2 plot), respectively.<br>Na experimentação é de fundamental importância o controle de qualidade, fazendo com que o erro experimental apresente-se em níveis aceitáveis e, uma das formas desse controle, é a definição do tamanho e forma ótimos de parcela, no planejamento experimental. Determinou-se o tamanho e a forma ideais de parcela, para a cultura da abóbora italiana, em experimentos realizados sob ambientes protegidos, avaliando-se o rendimento acumulado da fitomassa dos frutos. Foram conduzidos dois experimentos em estufa plástica, modelo arco pampeano, durante o ano de 2001, em duas épocas de cultivo, um na estação sazonal verão-outono e outro na estação sazonal inverno-primavera. Os experimentos foram constituídos de oito fileiras de 20m de comprimento, sendo que, em cada uma delas, foram alocadas 20 plantas. As estimativas do tamanho e da forma de parcela foram obtidas pelos métodos da máxima curvatura, da comparação das variâncias e de Hatheway. As estimativas do tamanho e da forma da parcela variaram conforme a estação sazonal e o tamanho e a forma ideais, segundo os métodos da máxima curvatura e de Hatheway, para as estações sazonais verão-outono e inverno-primavera, foram de oito (quatro no comprimento e duas na largura) e quatro plantas (duas no comprimento e duas na largura), respectivamente