266 research outputs found
Space- and Time-Efficient Algorithm for Maintaining Dense Subgraphs on One-Pass Dynamic Streams
While in many graph mining applications it is crucial to handle a stream of
updates efficiently in terms of {\em both} time and space, not much was known
about achieving such type of algorithm. In this paper we study this issue for a
problem which lies at the core of many graph mining applications called {\em
densest subgraph problem}. We develop an algorithm that achieves time- and
space-efficiency for this problem simultaneously. It is one of the first of its
kind for graph problems to the best of our knowledge.
In a graph , the "density" of a subgraph induced by a subset of
nodes is defined as , where is the set of
edges in with both endpoints in . In the densest subgraph problem, the
goal is to find a subset of nodes that maximizes the density of the
corresponding induced subgraph. For any , we present a dynamic
algorithm that, with high probability, maintains a -approximation
to the densest subgraph problem under a sequence of edge insertions and
deletions in a graph with nodes. It uses space, and has an
amortized update time of and a query time of . Here,
hides a O(\poly\log_{1+\epsilon} n) term. The approximation ratio
can be improved to at the cost of increasing the query time to
. It can be extended to a -approximation
sublinear-time algorithm and a distributed-streaming algorithm. Our algorithm
is the first streaming algorithm that can maintain the densest subgraph in {\em
one pass}. The previously best algorithm in this setting required
passes [Bahmani, Kumar and Vassilvitskii, VLDB'12]. The space required by our
algorithm is tight up to a polylogarithmic factor.Comment: A preliminary version of this paper appeared in STOC 201
UNA MIRADA A TRAVÉS DE LAS MACROALGAS: Una lupa sumergida bajo los mares antárticos, recopilando y compartiendo el conocimiento sobre las macroalgas.
Bajo el mar antártico se esconde una vida única adaptada a condiciones extremas de temperatura y luz. Las macroalgas antárticas desempeñan un papel fundamental en la producción de oxígeno y en la absorción de dióxido de carbono de la atmósfera, contribuyendo a regular el clima global. Estas importantes productoras primarias son auténticas ingenieras del ecosistema marino, crean y modifican los hábitats y proveen refugio y protección a una variedad de organismos marinos. Se presentan aquí las diferentes líneas de investigación desarrolladas en Caleta Potter, un ecosistema marino antártico costero seriamente afectado por los fenómenos asociados al cambio global
miR-17-5p regulates endocytic trafficking through targeting TBC1D2/ Armus
miRNA cluster miR-17-92 is known as oncomir-1 due to its potent oncogenic function. miR-17-92 is a polycistronic cluster that encodes 6 miRNAs, and can both facilitate and inhibit cell proliferation. Known targets of miRNAs encoded by this cluster are largely regulators of cell cycle progression and apoptosis. Here, we show that miRNAs encoded by this cluster and sharing the seed sequence of miR-17 exert their influence on one of the most essential cellular processes – endocytic trafficking. By mRNA expression analysis we identified that regulation of endocytic trafficking by miR-17 can potentially be achieved by targeting of a number of trafficking regulators. We have thoroughly validated TBC1D2/Armus, a GAP of Rab7 GTPase, as a novel target of miR-17. Our study reveals regulation of endocytic trafficking as a novel function of miR-17, which might act cooperatively with other functions of miR-17 and related miRNAs in health and disease
Nature of Sonoluminescence: Noble Gas Radiation Excited by Hot Electrons in "Cold" Water
We show that strong electric fields occurring in water near the surface of
collapsing gas bubbles because of the flexoelectric effect can provoke dynamic
electric breakdown in a micron-size region near the bubble and consider the
scenario of the SBSL. The scenario is: (i) at the last stage of incomplete
collapse of the bubble the gradient of pressure in water near the bubble
surface has such a value and sign that the electric field arising from the
flexoelectric effect exceeds the threshold field of the dynamic electrical
breakdown of water and is directed to the bubble center; (ii) mobile electrons
are generated because of thermal ionization of water molecules near the bubble
surface; (iii) these electrons are accelerated in ''cold'' water by the strong
electric fields; (iv) these hot electrons transfer noble gas atoms dissolved in
water to high-energy excited states and optical transitions between these
states produce SBSL UV flashes in the trasparency window of water; (v) the
breakdown can be repeated several times and the power and duration of the UV
flash are determined by the multiplicity of the breakdowns. The SBSL spectrum
is found to resemble a black-body spectrum where temperature is given by the
effective temperature of the hot electrons. The pulse energy and some other
characteristics of the SBSL are found to be in agreement with the experimental
data when realistic estimations are made.Comment: 11 pages (RevTex), 1 figure (.ps
Approximating Mexican highways with slime mould
Plasmodium of Physarum polycephalum is a single cell visible by unaided eye.
During its foraging behavior the cell spans spatially distributed sources of
nutrients with a protoplasmic network. Geometrical structure of the
protoplasmic networks allows the plasmodium to optimize transport of nutrients
between remote parts of its body. Assuming major Mexican cities are sources of
nutrients how much structure of Physarum protoplasmic network correspond to
structure of Mexican Federal highway network? To find an answer undertook a
series of laboratory experiments with living Physarum polycephalum. We
represent geographical locations of major cities by oat flakes, place a piece
of plasmodium in Mexico city area, record the plasmodium's foraging behavior
and extract topology of nutrient transport networks. Results of our experiments
show that the protoplasmic network formed by Physarum is isomorphic, subject to
limitations imposed, to a network of principle highways. Ideas and results of
the paper may contribute towards future developments in bio-inspired road
planning
Sonoluminescence as a QED vacuum effect. I: The Physical Scenario
Several years ago Schwinger proposed a physical mechanism for
sonoluminescence in terms of changes in the properties of the
quantum-electrodynamic (QED) vacuum state. This mechanism is most often phrased
in terms of changes in the Casimir Energy: changes in the distribution of
zero-point energies and has recently been the subject of considerable
controversy. The present paper further develops this quantum-vacuum approach to
sonoluminescence: We calculate Bogolubov coefficients relating the QED vacuum
states in the presence of a homogeneous medium of changing dielectric constant.
In this way we derive an estimate for the spectrum, number of photons, and
total energy emitted. We emphasize the importance of rapid spatio-temporal
changes in refractive indices, and the delicate sensitivity of the emitted
radiation to the precise dependence of the refractive index as a function of
wavenumber, pressure, temperature, and noble gas admixture. Although the
physics of the dynamical Casimir effect is a universal phenomenon of QED,
specific experimental features are encoded in the condensed matter physics
controlling the details of the refractive index. This calculation places rather
tight constraints on the possibility of using the dynamical Casimir effect as
an explanation for sonoluminescence, and we are hopeful that this scenario will
soon be amenable to direct experimental probes. In a companion paper we discuss
the technical complications due to finite-size effects, but for reasons of
clarity in this paper we confine attention to bulk effects.Comment: 25 pages, LaTeX 209, ReV-TeX 3.2, eight figures. Minor revisions:
Typos fixed, references updated, minor changes in numerical estimates, minor
changes in some figure
An objective comparison of cell-tracking algorithms
We present a combined report on the results of three editions of the Cell Tracking Challenge, an ongoing initiative aimed at promoting the development and objective evaluation of cell segmentation and tracking algorithms. With 21 participating algorithms and a data repository consisting of 13 data sets from various microscopy modalities, the challenge displays today's state-of-the-art methodology in the field. We analyzed the challenge results using performance measures for segmentation and tracking that rank all participating methods. We also analyzed the performance of all of the algorithms in terms of biological measures and practical usability. Although some methods scored high in all technical aspects, none obtained fully correct solutions. We found that methods that either take prior information into account using learning strategies or analyze cells in a global spatiotemporal video context performed better than other methods under the segmentation and tracking scenarios included in the challenge
HP1β-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs
Joule-heating Effects In the Amorphous Fe40ni40b20 Alloy
The effects of Joule heating on the amorphous Fe40Ni40B20 alloy are investigated by measuring the time behavior of the electrical resistance of ribbon strips during such a treatment. The structural transformations occurring in subsequent stages of the process are studied by means of x-ray-diffraction, differential-scanning-calorimetry, and magnetic-permeability measurements. A continuous evolution from a fully amorphous to a fully crystalline structure may be followed. The crystallization mechanisms observed in Joule-heated samples differ from the ones occurring under conventional heating conditions. The electrical resistance displays a bump in the course of Joule heating. A quantitative model relating such a bump to the extra heat released to the sample by fast crystallization is proposed and discussed
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