Beardsley Movement in the Russian Silver Age Culture

The article dwells on the phenomenon of Russian Beardsleism, which was formed by the influence of the works and personality of the English graphic artist Aubrey Beardsley on the Russian intellectual society at the turn of the 19th – 20th centuries. Being the brightest representative of English aestheticism and Art Nouveau, Aubrey Beardsley became a champion of the ideas of new art for Russia. In his homeland, Aubrey Beardsley managed to make a real revolution in the field of illustration and book graphics, separating them into independent elements of creativity and raising the art of graphics to a completely new, unprecedently high level. No less revolutionary was the behavior of the artist — Aubrey Beardsley turned his life into art, postulating innovative aesthetic and philosophical aspirations by his very appearance. The worth of his personality was undoubtedly comparable to the worth of his works, and one became inseparable from the other. Thus, the very image of Aubrey Beardsley became a symbol of the Art Nouveau era, containing a lot of complex concepts. Therefore, no wonder that the sphere of influence of this master in Russia was extremely wide — not limited only to the field of graphics, it extended from new artistic methods up to the lifestyle and demeanor. The significance of Beardsleism in the Russian artistic life of the turn of the centuries is also indicated by its scope — the most prominent figures of the Silver Age, such as S. Diaghilev, L. Bakst, N. Feofilaktov, and rather obscure A. Silin, A. Arapov and M. Durnov — both those and others experienced a significant influence of Aubrey Beardsley on their works and life

Development and Study of Hard-Facing Materials on the Base of Heat-Resisting High-Hardness Steels for Plasma-Jet Hard- Facing in Shielding-Doping Nitrogen Atmosphere

The authors develop hard-facing materials on the base of heat-resisting highhardness steels for plasma-jet hard-facing in nitrogen atmosphere for manufacturing parts of mining and metallurgic equipment which significantly simplify the production process and effect a saving when producing bimetallic parts and tools

Metamorphosis of plasma turbulence-shear flow dynamics through a transcritical bifurcation

The structural properties of an economical model for a confined plasma turbulence governor are investigated through bifurcation and stability analyses. A close relationship is demonstrated between the underlying bifurcation framework of the model and typical behavior associated with low- to high-confinement transitions such as shear flow stabilization of turbulence and oscillatory collective action. In particular, the analysis evinces two types of discontinuous transition that are qualitatively distinct. One involves classical hysteresis, governed by viscous dissipation. The other is intrinsically oscillatory and non-hysteretic, and thus provides a model for the so-called dithering transitions that are frequently observed. This metamorphosis, or transformation, of the system dynamics is an important late side-effect of symmetry-breaking, which manifests as an unusual non-symmetric transcritical bifurcation induced by a significant shear flow drive.Comment: 17 pages, revtex text, 9 figures comprised of 16 postscript files. Submitted to Phys. Rev.

Direct and inverse pumping in flows with homogeneous and non-homogeneous swirl

The conditions in which meridional recirculations appear in swirling flows above a fixed wall are analysed. In the classical Bodew\"adt problem, where the swirl tends towards an aysmptotic value away from the wall, the well-known "tea-cup effect" drives a flow away from the plate at the centre of the vortex. Simple dimensional arguments applied to a single vortex show that if the intensity of the swirl decreases away from the wall, the sense of the recirculation can be inverted, and that the associated flow rate scales with the swirl gradient. Only if the flow is quasi-2D, does the classical tea-cup effect take place. This basic theory is confirmed by numerical simulations of a square array of steady, electrically driven vortices. Experiments in the turbulent regimes of the same configuration reveal that these mechanisms are active in the average flow and in its fluctuating part. The mechanisms singled out in this letter provide an explanation for previously observed phenomena in electrolyte flows. They also put forward a possible mechanism for the generation of helicity in flows close to two-dimensionality, which plays a key role in the transition between 2D and 3D turbulence

The laminar-turbulent transition in a fibre laser

Studying the transition from a linearly stable coherent laminar state to a highly disordered state of turbulence is conceptually and technically challenging, and of great interest because all pipe and channel flows are of that type. In optics, understanding how a system loses coherence, as spatial size or the strength of excitation increases, is a fundamental problem of practical importance. Here, we report our studies of a fibre laser that operates in both laminar and turbulent regimes. We show that the laminar phase is analogous to a one-dimensional coherent condensate and the onset of turbulence is due to the loss of spatial coherence. Our investigations suggest that the laminar-turbulent transition in the laser is due to condensate destruction by clustering dark and grey solitons. This finding could prove valuable for the design of coherent optical devices as well as systems operating far from thermodynamic equilibrium

Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition

Glioblastoma multiforme (GBM) are resistant to TNFα-induced apoptosis and blockade of TNFα-induced NF-κB activation sensitizes glioma cells to apoptosis. As Casein kinase-2 (CK2) induces aberrant NF-κB activation and as we observed elevated CK2 levels in GBM tumors, we investigated the potential of CK2 inhibitors (CK2-Is) - DRB and Apigenin in sensitizing glioma cells to TNFα-induced apoptosis. CK2-Is and CK2 small interfering RNA (siRNA) reduced glioma cell viability, inhibited TNFα-mediated NF-κB activation, and sensitized cell to TNFα-induced apoptosis. Importantly, CK2-Is activated p53 function in wild-type but not in p53 mutant cells. Activation of p53 function involved its increased transcriptional activation, DNA-binding ability, increased expression of p53 target genes associated with cell cycle progression and apoptosis. Moreover, CK2-Is decreased telomerase activity and increased senescence in a p53-dependent manner. Apoptotic gene profiling indicated that CK2-Is differentially affect p53 and TNFα targets in p53 wild-type and mutant glioma cells. CK2-I decreased MDM2-p53 association and p53 ubiquitination to enhance p53 levels. Interestingly, CK2-Is downregulated SIRT1 activity and over-expression of SIRT1 decreased p53 transcriptional activity and rescued cells from CK2-I-induced apoptosis. This ability of CK2-Is to sensitize glioma to TNFα-induced death via multiple mechanisms involving abrogation of NF-κB activation, reactivation of wild-type p53 function and SIRT1 inhibition warrants investigation

p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner

Background: The tumor suppressor p53 is an important regulator that controls various cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 facilitates cell differentiation, whereas others claim that it suppresses differentiation. Therefore, it is critical to evaluate whether this inconsistency represents an authentic differential p53 activity manifested in the various differentiation programs. Methodology/Principal Findings: To clarify this important issue, we conducted a comparative study of several mesenchymal differentiation programs. The effects of p53 knockdown or enhanced activity were analyzed in mouse and human mesenchymal cells, representing various stages of several differentiation programs. We found that p53 downregulated the expression of master differentiation-inducing transcription factors, thereby inhibiting osteogenic, adipogenic and smooth muscle differentiation of multiple mesenchymal cell types. In contrast, p53 is essential for skeletal muscle differentiation and osteogenic re-programming of skeletal muscle committed cells. Conclusions: These comparative studies suggest that, depending on the specific cell type and the specific differentiatio

Development of the SIOPE DIPG network, registry and imaging repository : a collaborative effort to optimize research into a rare and lethal disease

Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It is therefore time for international collaboration in DIPG research, to provide new hope for children, parents and medical professionals fighting DIPG. In a first step towards collaboration, in 2011, a network of biologists and clinicians working in the field of DIPG was established within the European Society for Paediatric Oncology (SIOPE) Brain Tumour Group: the SIOPE DIPG Network. By bringing together biomedical professionals and parents as patient representatives, several collaborative DIPG-related projects have been realized. With help from experts in the fields of information technology, and legal advisors, an international, web-based comprehensive database was developed, The SIOPE DIPG Registry and Imaging Repository, to centrally collect data of DIPG patients. As for April 2016, clinical data as well as MR-scans of 694 patients have been entered into the SIOPE DIPG Registry/Imaging Repository. The median progression free survival is 6.0 months (95% Confidence Interval (CI) 5.6-6.4 months) and the median overall survival is 11.0 months (95% CI 10.5-11.5 months). At two and five years post-diagnosis, 10 and 2% of patients are alive, respectively. The establishment of the SIOPE DIPG Network and SIOPE DIPG Registry means a paradigm shift towards collaborative research into DIPG. This is seen as an essential first step towards understanding the disease, improving care and (ultimately) cure for children with DIPG.Peer reviewe