Ampliación en altura de edificación existente entre medianeras : Puerto de Sagunto (Valencia)

Convenios con empresa. Este proyecto de seguimiento de obra se divide en las siguientes partes: estudio y análisis del proyecto, control de calidad, diario de obra, programación y seguimiento económico de la obra, seguridad y saludAsensi Vives, V. (2011). Ampliación en altura de edificación existente entre medianeras : Puerto de Sagunto (Valencia). http://hdl.handle.net/10251/12471.Archivo delegad

Accelerating statistical texture analysis with an FPGA-DSP hybrid architecture

Nowadays, most image processing systems are implemented using either MMX-optimized software libraries or, when time requirements are limited, expensive high performance DSP-based boards. In this paper we present a texture analysis co-processor concept that permits the efficient hardware implementation of statistical feature extraction, and hardware-software codesign to achieve high-performance low-cost solutions. We propose a hybrid architecture based on FPGA chips, for massive data processing, and digital signal processor (DSP) for floating-point computations. In our preliminary trials with test images, we achieved sufficient performance improvements to handle a wide range of real-time applications

Distance Measurement Error in Time-of-Flight Sensors Due to Shot Noise

Unlike other noise sources, which can be reduced or eliminated by different signal processing techniques, shot noise is an ever-present noise component in any imaging system. In this paper, we present an in-depth study of the impact of shot noise on time-of-flight sensors in terms of the error introduced in the distance estimation. The paper addresses the effect of parameters, such as the size of the photosensor, the background and signal power or the integration time, and the resulting design trade-offs. The study is demonstrated with different numerical examples, which show that, in general, the phase shift determination technique with two background measurements approach is the most suitable for pixel arrays of large resolutionThis work has been partially funded by Spanish government Project TEC2012-38921-C02-02 MINECO(FEDER) and by the Xunta de Galicia with EM2013/038 and EM2014/012, AE CITIUS(CN2012/151, (FEDER)) and GPC2013/040 (FEDER)S

Real time architectures for the scale Invariant feature transform algorithm

Feature extraction in digital image processing is a very intensive task for a CPU. In order to achieve real time image throughputs, hardware parallelism must be exploited. The speed-up of the system is constrained by the degree of parallelism of the implementation and this one at the same time, by programmable device size and the power dissipation. In this work, issues related to the synthesis of the Scale-Invariant Feature Transform (SIFT) algorithm on a FPGA to obtain target processing rates faster than 50 frames per second for VGA images, are analyzed. In order to increase the speedup of the algorithm, the work includes the analysis of feasible simplifications of the algorithm for a tracking application and the results are synthesized on an FPGA.This work has been partially funded by Spanish government projects TEC2015-66878-C3-2-R (MINECO/FEDER, UE) and TEC2015- 66878-C3-3-R (MINECO/FEDER, UE)

Ultrathin a-Si:H/Oxide transparent solar cells exhibiting UV-Blue selective-like absorption

This is the peer reviewed version of the following article: Lopez-Garcia, A. [et al.]. Ultrathin a-Si:H/Oxide transparent solar cells exhibiting UV-Blue selective-like absorption. "Solar RRL", April 2023, which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1002/solr.202200928. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.Herein, the fabrication of transparent solar cells based on nanometric (8 and30 nm) intrinsic hydrogenated amorphous siliconfilms (a-Si:H) and using oxidethinfilms as transparent carrier selective contacts are reported. The ultrathindevices present photovoltaic effect and high average visible transmittance (AVT).Additionally, they display a shifted spectral response toward short wavelengths.Glass/fluorine-doped tin oxide (FTO)/aluminum-doped zinc oxide (AZO)/a-Si:H/MoO3/indium tin oxide (ITO) prototypes are shown, presenting AVT=35% andphotovoltaic conversion efficiency (PCE)=2% for a device with a 30 nm a-Si:Hfilm. This yields a light utilization efficiency (LUE) of 0.7%, a record up to this datefor inorganic oxide-based transparent solar cells. For devices including an 8 nma-Si:Hfilm, the AVT reaches 66% with a PCE=0.6% (LUE=0.4%). These highAVT values are comparable or even superior in some cases to those achieved forpure oxide devices. Thesefindings confirm the potential of the proposedarchitectures for the development of highly transparent energy harvesters asfunctional components in building-integrated photovoltaics (BIPV), agrophoto-voltaics (APV), sensors and other low-power devices. In addition, these devicesare fabricated with earth-abundant materials and with up-scalable techniquesthat can allow for a feasible implementation.Peer ReviewedPostprint (published version

Choice of the initial antiretroviral treatment for HIV-positive individuals in the era of integrase inhibitors

BACKGROUND: We aimed to describe the most frequently prescribed initial antiretroviral therapy (ART) regimens in recent years in HIV-positive persons in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) and to investigate factors associated with the choice of each regimen. METHODS: We analyzed initial ART regimens prescribed in adults participating in CoRIS from 2014 to 2017. Only regimens prescribed in >5% of patients were considered. We used multivariable multinomial regression to estimate Relative Risk Ratios (RRRs) for the association between sociodemographic and clinical characteristics and the choice of the initial regimen. RESULTS: Among 2874 participants, abacavir(ABC)/lamivudine(3TC)/dolutegavir(DTG) was the most frequently prescribed regimen (32.1%), followed by tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)/elvitegravir(EVG)/cobicistat(COBI) (14.9%), TDF/FTC/rilpivirine (RPV) (14.0%), tenofovir alafenamide (TAF)/FTC/EVG/COBI (13.7%), TDF/FTC+DTG (10.0%), TDF/FTC+darunavir/ritonavir or darunavir/cobicistat (bDRV) (9.8%) and TDF/FTC+raltegravir (RAL) (5.6%). Compared with ABC/3TC/DTG, starting TDF/FTC/RPV was less likely in patients with CD4100.000 copies/mL. TDF/FTC+DTG was more frequent in those with CD4100.000 copies/mL. TDF/FTC+RAL and TDF/FTC+bDRV were also more frequent among patients with CD4<200 cells//μL and with transmission categories other than men who have sex with men. Compared with ABC/3TC/DTG, the prescription of other initial ART regimens decreased from 2014-2015 to 2016-2017 with the exception of TDF/FTC+DTG. Differences in the choice of the initial ART regimen were observed by hospitals' location. CONCLUSIONS: The choice of initial ART regimens is consistent with Spanish guidelines' recommendations, but is also clearly influenced by physician's perception based on patient's clinical and sociodemographic variables and by the prescribing hospital location.The RIS cohort (CoRIS) is supported by the Instituto de Salud Carlos III through the Red Temática de Investigación Cooperativa en Sida (RD06/006, RD12/0017/0018 and RD16/0002/0006) as part of the Plan Nacional I+D+i and cofinanced by ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER). This study was funded by ViiV Healthcare. ViiV Healthcare was given the opportunity to review a preliminary version of this manuscript for factual accuracy. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors are solely responsible for final content and interpretation of the results.S

Expression profiling of chromatin-modifying enzymes and global DNA methylation in CD4+ T cells from patients with chronic HIV infection at different HIV control and progression states

Abstract Background Integration of human immunodeficiency virus type 1 (HIV-1) into the host genome causes global disruption of the chromatin environment. The abundance level of various chromatin-modifying enzymes produces these alterations and affects both the provirus and cellular gene expression. Here, we investigated potential changes in enzyme expression and global DNA methylation in chronically infected individuals with HIV-1 and compared these changes with non-HIV infected individuals. We also evaluated the effect of viral replication and degree of disease progression over these changes. Results Individuals with HIV-1 had a significant surge in the expression of DNA and histone methyltransferases (DNMT3A and DNMT3B, SETDB1, SUV39H1) compared with non-infected individuals, with the exception of PRMT6, which was downregulated. Some histone deacetylases (HDAC2 and HDAC3) were also upregulated in patients with HIV. Among individuals with HIV-1 with various degrees of progression and HIV control, the group of treated patients with undetectable viremia showed greater differences with the other two groups (untreated HIV-1 controllers and non-controllers). These latter two groups exhibited a similar behavior between them. Of interest, the overexpression of genes that associate with viral protein Tat (such as SETDB1 along with DNMT3A and HDAC1, and SIRT-1) was more prevalent in treated patients. We also observed elevated levels of global DNA methylation in individuals with HIV-1 in an inverse correlation with the CD4/CD8 ratio. Conclusions The current study shows an increase in chromatin-modifying enzymes and remodelers and in global DNA methylation in patients with chronic HIV-1 infection, modulated by various levels of viral control and progression

Mortality due to non-AIDS-defining cancers among people living with HIV in Spain over 18 years of follow-up

Purpose: Our aim was to describe non-AIDS-defining cancer (NADC) mortality among people living with HIV (PLWH), to compare it with that of the general population, and to assess potential risk factors. Methods: We included antiretroviral-naive PLWH from the multicentre CoRIS cohort (2004-2021). We estimated mortality rates and standardised mortality ratios (SMRs). We used cause-specific Cox models to identify risk factors. Results: Among 17,978 PLWH, NADC caused 21% of all deaths observed during the follow-up. Mortality rate due to NADC was 1.58 (95%CI 1.36, 1.83) × 1000 person-years and lung and liver were the most frequent cancer-related causes of death. PLWH had 79% excess NADC mortality risk compared to the general population with the highest SMR found for Hodgkin lymphoma, anal and liver cancers. The SMRs decreased with age and were the highest in age groups under 50 years. The most important prognostic factor was low CD4 count, followed by smoking, viral hepatitis and HIV transmission through heterosexual contact or injection drug use. Conclusion: Non-AIDS cancers are an important cause of death among PLWH. The excess mortality related to certain malignancies and the association with immunodeficiency, smoking, and coinfections highlights the need for early detection and treatment of cancer in this population.Purpose: Our aim was to describe non-AIDS-defining cancer (NADC) mortality among people living with HIV (PLWH), to compare it with that of the general population, and to assess potential risk factors. Methods: We included antiretroviral-naive PLWH from the multicentre CoRIS cohort (2004-2021). We estimated mortality rates and standardised mortality ratios (SMRs). We used cause-specific Cox models to identify risk factors. Results: Among 17,978 PLWH, NADC caused 21% of all deaths observed during the follow-up. Mortality rate due to NADC was 1.58 (95%CI 1.36, 1.83) × 1000 person-years and lung and liver were the most frequent cancer-related causes of death. PLWH had 79% excess NADC mortality risk compared to the general population with the highest SMR found for Hodgkin lymphoma, anal and liver cancers. The SMRs decreased with age and were the highest in age groups under 50 years. The most important prognostic factor was low CD4 count, followed by smoking, viral hepatitis and HIV transmission through heterosexual contact or injection drug use. Conclusion: Non-AIDS cancers are an important cause of death among PLWH. The excess mortality related to certain malignancies and the association with immunodeficiency, smoking, and coinfections highlights the need for early detection and treatment of cancer in this population.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This research was supported by CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB21/13/00091), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU, the Gilead Scholarship Program for Biomedical Research (GLD19_00106) and the ISCIII- Miguel Servet CP19CIII—00002 contract.S