Adaptive neural reward processing during anticipation and receipt of monetary rewards in mindfulness meditators

Reward seeking is ubiquitous and adaptive in humans. But excessive reward seeking behavior, such as chasing monetary rewards, may lead to diminished subjective well-being. This study examined whether individuals trained in mindfulness meditation show neural evidence of lower susceptibility to monetary rewards. Seventy-eight participants (34 meditators, 44 matched controls) completed the monetary incentive delay task while undergoing functional magnetic resonance imaging. The groups performed equally on the task, but meditators showed lower neural activations in the caudate nucleus during reward anticipation, and elevated bilateral posterior insula activation during reward anticipation. Meditators also evidenced reduced activations in the ventromedial prefrontal cortex during reward receipt compared with controls. Connectivity parameters between the right caudate and bilateral anterior insula were attenuated in meditators during incentive anticipation. In summary, brain regions involved in reward processingboth during reward anticipation and receipt of rewardresponded differently in mindfulness meditators than in nonmeditators, indicating that the former are less susceptible to monetary incentives

Contextual bias and insulation against bias during aesthetic rating. The roles of VMPFC and DLPFC in neural valuation

The scientific study of aesthetic experience through the examination of the neural correlates of sensory and motor responses works of art and to other visual images has thrived during the last decade. The neural substrate of embodied responses to works of art, and to visual images more generally, has been the object of much attention. This research, however, has tended to sidestep the question of aesthetic preference and rating, and the neural correlates of contextual influences on such ratings. Responses in the domain of perception–action coupling have provided useful and important evidence for the role of somatic and emotional responses in viewers’ engagement with works of art. Nevertheless, the degree to which they form the basis of evaluation, ranking, and even judgment remains unclear. In this chapter we concentrate on the respective roles of the ventromedial prefrontal cortex (VMPFC) and the dorsolateral prefrontal cortex (DLPFC) during aesthetic evaluation, particularly the aesthetic evaluation of visual works of art. Activity in these areas is modulated by external contextual pressures on viewing. The roles of ACC, hippocampal and striatal connections in the process of rating and evaluating works of visual art, and the relationship between expert and non-expert responses, are also discussed

Cognitive framing modulates emotional processing through dorsolateral prefrontal cortex and ventrolateral prefrontal cortex networks: A functional magnetic resonance imaging study

Introduction: In this study, we show new evidence for the role of ventrolateral prefrontal cortex-dorsolateral prefrontal cortex (VLPFC-DLPFC) networks in the cognitive framing of emotional processing. Method: We displayed neutral and aversive images described as having been sourced from artistic material to one cohort of subjects (i.e., the art-frame group; n = 19), while identical images, this time identified as having been sourced from documentary material (i.e., the doc-frame group; n = 20) were shown to a separate cohort. Results: Using functional magnetic resonance imaging (fMRI), we employed a linear parametric model showing that relative to the doc-frame group the art-frame group exhibited a modulation of amygdala activity in response to aversive images. The attenuated amygdala activity in the art-frame group supported our hypothesis that reduced amygdala activity was driven by top-down DLPFC inhibition of limbic responses. A psychophysiological interaction (PPI) analysis demonstrated that VLPFC activity correlated with amygdala activity in the art-frame group, but not in the docframe group for the contrast [Aversive > Neutral]. Conclusion: The role of the VLPFC in cognitive control suggests the hypothesis that it alongside DLPFC insulates against embodied emotional responses by inhibiting automatic affective responses

Dynamics of Warm-Absorbing Gas in Seyfert Galaxies: NGC 5548

A hydromagnetic (MHD) wind from a clumpy molecular accretion disk is invoked to explain observations of warm absorbing (WA) gas in UVX from Sy galaxies. This paper focuses on two issues: (1) compatibility of kinematics and dynamics of MHD wind with the observed properties of WAs; and (2) relationship between the UVX absorptions. We provide an in-depth comparison between the MHD model and the Sy 1 galaxy NGC 5548, which at high spectral resolution exhibits a number of discrete UV absorption components. We find that: (1) the total column densities of Ovii, Oviii and H, are reproduced by constraining the UV ion column densities of Civ and Nv in each component to lie within a factor of 2 of their observed values and optimizing over the possible sets of component ionization states and Civ column densities; (2) the WA exists in the outer part of the wind and is not a continuation of the flow in the BLR; and (3) the WA extends in radial and polar directions and is ionization-stratified. X-ray absorption is found to be heavily biased towards smaller r, and UV absorption originates at larger distances from the central continuum source. We show that the discrete absorption components along the line-of-sight are intrinsically clumpy. Density differences between kinematic components result in a range of ionization and recombination timescales. We further test the applicability of the MHD wind to WAs in general, by constructing a quasi-continuous flow model, and extending it to arbitrary aspect angles. We estimate the fraction of Sy 1s having detectable WAs with larger Ovii column density than Oviii, and the range of total H column densities. We also find that the ratio of Ovii to Oviii optical depths can serve as a new diagnostic of AGN aspect angle.Comment: Latex, 8 postscript figures. Astrophysical Journal, 536, June 10, in pres

Progress in understanding Blazars from BeppoSAX observations

Results obtained with BeppoSAX observations of blazars within various collaborative programs are presented. The spectral similarity "paradigm", whereby the spectral energy distributions of blazars follow a sequence, leading to a unified view of the whole population, is briefly illustrated. We concentrate on recent observations of flares and associated spectral variability for three objects at the "blue" end of the spectral sequence, namely PKS 2155-304, Mkn 421 and Mkn 501. The results are discussed in terms of a general analytic synchrotron self-Compton interpretation of the overall spectrum. The physical parameters of the quasi-stationary emission region can be derived with some confidence, while the variability mechanism(s) must be complex.Comment: 10 pages, 8 figures, to be published in the Proceedings of the 32nd COSPAR Meeting, Nagoya, 12-19 July 199

Observing the gas temperature drop in the high-density nucleus of L 1544

Abridged: The thermal structure of a starless core is crucial for our understanding of the physics in these objects and hence for our understanding of star formation. Theory predicts a gas temperature drop in the inner 5000 AU of these objects, but there has been little observational proof of this. We performed VLA observations of the NH3 (1,1) and (2,2) transitions towards the pre-stellar core L 1544 in order to measure the temperature gradient between the high density core nucleus and the surrounding core envelope. Our VLA observation for the first time provide measurements of gas temperature in a core with a resolution smaller than 1000 AU. We have also obtained high resolution Plateau de Bure observations of the 110 GHz 111-101 para-NH2D line in order to further constrain the physical parameters of the high density nucleus. We have estimated the temperature gradient using a model of the source to fit our data in the u,v plane. We find that indeed the temperature decreases toward the core nucleus from 12 K down to 5.5 K resulting in an increase of a factor of 50% in the estimated density of the core from the dust continuum if compared with the estimates done with constant temperature of 8.75 K. We also found a remarkably high abundance of deuterated ammonia with respect to the ammonia abundance (50%+-20%), which proves the persistence of nitrogen bearing molecules at very high densities (2e6 cm-3) and shows that high-resolution observations yield higher deuteration values than single-dish observations. Our analysis of the NH3 and NH2D kinematic fields shows a decrease of specific angular momentum from the large scales to the small scales.Comment: 12 pages, 6 figures. Accepted for publication by A&

Synchrotron and inverse-Compton emission from blazar jets I: a uniform conical jet model

In the first of a series of papers investigating emission from blazar jets from radio to high-energy {\gamma}-rays, we revisit the class of models where the jet has a uniform conical ballistic structure. We argue that by using simple developments of these models, in the context of new multi-frequency data extending to gamma-ray energies, valuable insights may be obtained into the properties that fully realistic models must ultimately have. In this paper we consider the synchrotron and synchrotron-self-Compton emission from the jet, modelling the recent simultaneous multi-wavelength observations of BL Lac. This is the first time these components have been fitted simultaneously for a blazar using a conical jet model. In the model we evolve the electron population dynamically along the jet taking into account the synchrotron and inverse-Compton losses. The inverse-Compton emission is calculated using the Klein-Nishina cross section and a relativistic transformation into the jet frame, and we explicitly show the seed photon population. We integrate synchrotron opacity along the line of sight through the jet plasma, taking into account the emission and opacity of each section of the jet. In agreement with previous studies of radio emission, we find that a conical jet model which conserves magnetic energy produces the characteristic blazar flat radio spectrum, however, we do not require any fine-tuning of the model to achieve this. Of particular note, in our model fit to BL Lac--which at ~10^37W is a relatively low jet-power source--we find no requirement for significant re-acceleration within the jet to explain the observed spectrum.Comment: 11 pages, 6 figures, accepted for publication in MNRA

Tetraphenyl­arsonium cis-bis­[1,2-bis­(tri­fluoro­meth­yl)ethene-1,2-dithiol­ato]platinate(II)

In the title compound, (C24H20As)[Pt(C4F6S2)2], the cation lies on a twofold rotation axis while the anion has crystallographic inversion symmetry. The PtII ion is in a slightly distorted square-planar coordination environment. The F atoms of both unique –CF3 groups are disordered over two sets of sites, the ratios of refined occupancies being 0.677 (15):0.323 (15) and 0.640 (16):0.360 (16). The crystal structure is the first to date of a monoanionic [Pt(tfd)2]− species [tfd is 1,2-bis­(trifluoro­meth­yl)ethene-1,2-dithiol­ate] with a non-redox-active cation

Research and Education in Computational Science and Engineering

Over the past two decades the field of computational science and engineering (CSE) has penetrated both basic and applied research in academia, industry, and laboratories to advance discovery, optimize systems, support decision-makers, and educate the scientific and engineering workforce. Informed by centuries of theory and experiment, CSE performs computational experiments to answer questions that neither theory nor experiment alone is equipped to answer. CSE provides scientists and engineers of all persuasions with algorithmic inventions and software systems that transcend disciplines and scales. Carried on a wave of digital technology, CSE brings the power of parallelism to bear on troves of data. Mathematics-based advanced computing has become a prevalent means of discovery and innovation in essentially all areas of science, engineering, technology, and society; and the CSE community is at the core of this transformation. However, a combination of disruptive developments---including the architectural complexity of extreme-scale computing, the data revolution that engulfs the planet, and the specialization required to follow the applications to new frontiers---is redefining the scope and reach of the CSE endeavor. This report describes the rapid expansion of CSE and the challenges to sustaining its bold advances. The report also presents strategies and directions for CSE research and education for the next decade.Comment: Major revision, to appear in SIAM Revie