Educational and activating activities of seniors in long-term care facilities in the Pilsen Region

Diploma thesis "Educational and activating activities of seniors in long-term care facilities in the Pilsen Region" in the theoretical part is devoted to the definition of old age and related aspects from the biological, psychological and social point of view. The thesis also deals with education and activation of seniors in the context of applied science discipline and organization in the Czech Republic within the framework of lifelong learning. Aspects of educational activities of seniors and specifics of their education and activation are also identified. The thesis also describes the best-known methods and techniques of seniors activation in long-term care facilities. In the empirical part, a questionnaire survey was carried out, in which the respondents were clients of retirement homes and patients of specialized hospital wards providing care to geriatric patients. At the same time, standardized interviews were conducted with workers who organize, secure or participate in activities focused on education and activation of their clients or patients. The aim of the thesis is to characterize aspects of the educational activities of seniors and to identify the specifics of education and activation of seniors in long-term care facilities. Based on an analysis of existing educational activities in...Diplomová práce "Vzdělávací a aktivizační činnosti seniorů v zařízeních dlouhodobé péče v Plzeňském kraji" se v teoretické části věnuje definici stáří a s ním spojenými aspekty z pohledu biologického, psychického i sociálního. Práce se dále věnuje vzdělávání a aktivizací seniorů v kontextu aplikované vědní disciplíny a organizace v České republice v rámci celoživotního učení. Identifikovány jsou také aspekty edukační činnosti seniorů a specifika jejich vzdělávání a aktivizace. V práci jsou také popsány nejznámější metody a techniky aktivizace seniorů v zařízeních dlouhodobé péče. V empirické části bylo realizováno dotazníkové šetření, ve kterém byli respondenti klienti domovů pro seniory a pacienti specializovaných nemocničních oddělení, která poskytují péči geriatrickým pacientům. Zároveň byly uskutečněny standardizované rozhovory s pracovníky, kteří v těchto zařízeních organizují, zabezpečují, případně participují na aktivitách, které jsou zaměřené na vzdělávání a aktivizaci jejich klientů či pacientů. Cílem diplomové práce je na základě analýzy relevantních informačních zdrojů charakterizovat aspekty edukační činnosti seniorů a identifikovat specifika vzdělávání a aktivizace seniorů v zařízeních dlouhodobé péče. Na základě analýzy stávajících edukačních aktivit ve vybraných zařízeních dlouhodobé...Katedra andragogiky a managementu vzděláváníFaculty of EducationPedagogická fakult

Cardiac Pacing Hemodynamics

(CZ) Jediným zavedeným dlouhodobým léčebným postupem klinicky významných bradyarytmií je implantace kardiostimulátoru. Naprostá většina nemocných potřebuje jednu stimulační elektrodu v pravé komoře. Aktivační sekvence komorové svaloviny při pravokomorové stimulaci připomíná stav při bloku levého raménka Tawarova (BLRT). Pokud je podíl stimulovaných cyklů v pravé komoře významný, dojde u 10-20 % nemocných ke vzniku kardiomyopatie navozené stimulací. Příčinnou souvislost se stimulací nepřímo potvrzuje zlepšení subjektivních stesků nemocných i objektivních parametrů funkce levé komory provedením upgrade na srdeční resynchronizační léčbu (CRT - cardiac resynchronization therapy). U nemocných s preexistujícím srdečním selháním a dysfunkcí levé komory srdeční je nejlepší prevencí použití biventrikulární stimulace při léčbě bradyarytmií. U nemocných s normální nebo téměř normální funkcí levé komory srdeční je situace problematičtější. Implantace CRT u všech pacientů, u kterých lze předpokládat vysoký podíl pravokomorové stimulace by ale byla spojena s vysokými náklady, větší zátěží pro implantující a v neposlední řadě by množství časných i pozdních komplikací nevyvážil prospěch z CRT. Přímá stimulace Hisova svazku se jeví být lepší metodou, stále je však úspěšnost jejího zavádění omezená, a ne každý...(EN) Cardiac pacing is the only established treatment method of bradyarrhythmias. Most patients indicated for cardiac pacing need to have one lead implanted in the right ventricle. Activation sequence of the left ventricle during right ventricular pacing resembles the activation sequence in patients with left bundle branch block. When the proportion of paced cycles in the right ventricle reaches significant level, 10-20 % of patients develop pacing induced cardiomyopathy. Direct causal relationship with right ventricular pacing is supported by the improvement of subjective symptoms and objective parameters of the left ventricular function after the upgrade to cardiac resynchronization therapy (CRT). In patients with preexisting heart failure with reduced left ventricular ejection fraction, the best prevention of heart failure worsening is to implant CRT when antibradycardic indication to the right ventricular pacing occurs. In patients with normal or near normal left ventricular function, the situation is more problematic. CRT implantation in all patients with supposed high proportion of right ventricular paced cycles is not only more expensive, but also imposes higher demands on implanting centers and increases the occurrence of immediate as well as long-term complications which do not outweigh...I.interní klinikaLékařská fakulta v PlzniFaculty of Medicine in Pilse

First Updates to the New Theoretical Framework of Technology Start-up Lifecycle Stages

As a result of previous research and the outlined theoretical framework, the concept needs to be further developed, validated, and modified by further research. The technology startup lifecycle is an area that is currently not well-defined. Thanks to further research, this theoretical framework can be developed to a more detailed classification of the stages and their more complex characteristics. Through a collaboration with several technology startups and based on qualitative interviews, we collect relevant data referring to the technology start-up lifecycle. As a result of feedback, we are able to test and develop the theoretical framework, as well as identify other possible directions or approaches. This framework is needed in the next step of research aimed at marketing strategies at a specific stage of the lifecycle of a technology start-up. The outcome of this research is to provide updates to the characteristics of each phase and to suggest directions for further research in this area

Optimization of Lead Placement in the Right Ventricle During Cardiac Resynchronization Therapy. A Simulation Study

[EN] Patients suffering from heart failure and left bundle branch block show electrical ventricular dyssynchrony causing an abnormal blood pumping. Cardiac resynchronization therapy (CRT) is recommended for these patients. Patients with positive therapy response normally present QRS shortening and an increased left ventricle (LV) ejection fraction. However, around one third do not respond favorably. Therefore, optimal location of pacing leads, timing delays between leads and/or choosing related biomarkers is crucial to achieve the best possible degree of ventricular synchrony during CRT application. In this study, computational modeling is used to predict the optimal location and delay of pacing leads to improve CRT response. We use a 3D electrophysiological computational model of the heart and torso to get insight into the changes in the activation patterns obtained when the heart is paced from different regions and for different atrioventricular and interventricular delays. The model represents a heart with left bundle branch block and heart failure, and allows a detailed and accurate analysis of the electrical changes observed simultaneously in the myocardium and in the QRS complex computed in the precordial leads. Computational simulations were performed using a modified version of the O'Hara et al. action potential model, the most recent mathematical model developed for human ventricular electrophysiology. The optimal location for the pacing leads was determined by QRS maximal reduction. Additionally, the influence of Purkinje system on CRT response was assessed and correlation analysis between several parameters of the QRS was made. Simulation results showed that the right ventricle (RV) upper septum near the outflow tract is an alternative location to the RV apical lead. Furthermore, LV endocardial pacing provided better results as compared to epicardial stimulation. Finally, the time to reach the 90% of the QRS area was a good predictor of the instant at which 90% of the ventricular tissue was activated. Thus, the time to reach the 90% of the QRS area is suggested as an additional index to assess CRT effectiveness to improve biventricular synchrony.This work was supported by the Secretaría de Educación Superior, Ciencia, Tecnología e Innovación (SENESCYT) of Ecuador CIBAE-023-2014, the Plan Estatal de Investigación Científica y Técnica y de Innovación 2013 2016 from the Ministerio de Economía, Industria y Competitividad of Spain and Fondo Europeo de Desarrollo Regional (FEDER) DPI2016-75799-R (AEI/FEDER, UE), and by Dirección General de Política Científica de la Generalitat Valenciana (PROMETEU 2016/088).Carpio-Garay, EF.; Gómez García, JF.; Sebastian, R.; López-Pérez, AD.; Castellanos, E.; Almendral, J.; Ferrero De Loma-Osorio, JM.... (2019). Optimization of Lead Placement in the Right Ventricle During Cardiac Resynchronization Therapy. A Simulation Study. Frontiers in Physiology. 10:1-17. https://doi.org/10.3389/fphys.2019.00074S11710Abraham, W. T., Fisher, W. G., Smith, A. L., Delurgio, D. B., Leon, A. R., Loh, E., … Messenger, J. (2002). Cardiac Resynchronization in Chronic Heart Failure. New England Journal of Medicine, 346(24), 1845-1853. doi:10.1056/nejmoa013168Abraham, W. T., Gras, D., Yu, C. M., Guzzo, L., & Gupta, M. S. (2010). Rationale and design of a randomized clinical trial to assess the safety and efficacy of frequent optimization of cardiac resynchronization therapy: The Frequent Optimization Study Using the QuickOpt Method (FREEDOM) trial. American Heart Journal, 159(6), 944-948.e1. doi:10.1016/j.ahj.2010.02.034Ai, X., & Pogwizd, S. M. (2005). Connexin 43 Downregulation and Dephosphorylation in Nonischemic Heart Failure Is Associated With Enhanced Colocalized Protein Phosphatase Type 2A. Circulation Research, 96(1), 54-63. doi:10.1161/01.res.0000152325.07495.5aAkar, F. G., Nass, R. D., Hahn, S., Cingolani, E., Shah, M., Hesketh, G. G., … Tomaselli, G. F. (2007). Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. American Journal of Physiology-Heart and Circulatory Physiology, 293(2), H1223-H1230. doi:10.1152/ajpheart.00079.2007ARBELO, E., TOLOSANA, J. M., TRUCCO, E., PENELA, D., BORRÀS, R., DOLTRA, A., … MONT, L. (2013). Fusion-Optimized Intervals (FOI): A New Method to Achieve the Narrowest QRS for Optimization of the AV and VV Intervals in Patients Undergoing Cardiac Resynchronization Therapy. Journal of Cardiovascular Electrophysiology, 25(3), 283-292. doi:10.1111/jce.12322Auricchio, A., Fantoni, C., Regoli, F., Carbucicchio, C., Goette, A., Geller, C., … Klein, H. (2004). Characterization of Left Ventricular Activation in Patients With Heart Failure and Left Bundle-Branch Block. Circulation, 109(9), 1133-1139. doi:10.1161/01.cir.0000118502.91105.f6Auricchio, A., Klein, H., Tockman, B., Sack, S., Stellbrink, C., Neuzner, J., … Spinelli, J. (1999). Transvenous biventricular pacing for heart failure: can the obstacles be overcome? The American Journal of Cardiology, 83(5), 136-142. doi:10.1016/s0002-9149(98)01015-7Barber, F., García-Fernández, I., Lozano, M., & Sebastian, R. (2018). Automatic estimation of Purkinje-Myocardial junction hot-spots from noisy endocardial samples: A simulation study. International Journal for Numerical Methods in Biomedical Engineering, 34(7), e2988. doi:10.1002/cnm.2988Barold, S. S., Ilercil, A., & Herweg, B. (2008). Echocardiographic optimization of the atrioventricular and interventricular intervals during cardiac resynchronization. Europace, 10(Supplement 3), iii88-iii95. doi:10.1093/europace/eun220Bertaglia, E., Migliore, F., Baritussio, A., De Simone, A., Reggiani, A., Pecora, D., … Stabile, G. (2017). Stricter criteria for left bundle branch block diagnosis do not improve response to CRT. Pacing and Clinical Electrophysiology, 40(7), 850-856. doi:10.1111/pace.13104Bertini, M., Ziacchi, M., Biffi, M., Martignani, C., Saporito, D., Valzania, C., … Boriani, G. (2008). Interventricular Delay Interval Optimization in Cardiac Resynchronization Therapy Guided by Echocardiography Versus Guided by Electrocardiographic QRS Interval Width. The American Journal of Cardiology, 102(10), 1373-1377. doi:10.1016/j.amjcard.2008.07.015BLEEKER, G. B., SCHALIJ, M. J., MOLHOEK, S. G., VERWEY, H. F., HOLMAN, E. R., BOERSMA, E., … BAX, J. J. (2004). Relationship Between QRS Duration and Left Ventricular Dyssynchrony in Patients with End-Stage Heart Failure. Journal of Cardiovascular Electrophysiology, 15(5), 544-549. doi:10.1046/j.1540-8167.2004.03604.xBonakdar, H. R., Jorat, M. V., Fazelifar, A. F., Alizadeh, A., Givtaj, N., Sameie, N., … Haghjoo, M. (2009). Prediction of response to cardiac resynchronization therapy using simple electrocardiographic and echocardiographic tools. Europace, 11(10), 1330-1337. doi:10.1093/europace/eup258Bordachar, P., Derval, N., Ploux, S., Garrigue, S., Ritter, P., Haissaguerre, M., & Jaïs, P. (2010). Left Ventricular Endocardial Stimulation for Severe Heart Failure. Journal of the American College of Cardiology, 56(10), 747-753. doi:10.1016/j.jacc.2010.04.038Boukens, B. J., Rivaud, M. R., Rentschler, S., & Coronel, R. (2014). Misinterpretation of the mouse ECG: ‘musing the waves ofMus musculus’. The Journal of Physiology, 592(21), 4613-4626. doi:10.1113/jphysiol.2014.279380Bradley, C. P., Pullan, A. J., & Hunter, P. J. (1997). Geometric modeling of the human torso using cubic hermite elements. Annals of Biomedical Engineering, 25(1), 96-111. doi:10.1007/bf027385422013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy. (2013). European Heart Journal, 34(29), 2281-2329. doi:10.1093/eurheartj/eht150Brugada, J., Brachmann, J., Delnoy, P. P., Padeletti, L., Reynolds, D., Ritter, P., … Singh, J. P. (2014). Automatic Optimization of Cardiac Resynchronization Therapy Using SonR—Rationale and Design of the Clinical Trial of the SonRtip Lead and Automatic AV-VV Optimization Algorithm in the Paradym RF SonR CRT-D (RESPOND CRT) Trial. American Heart Journal, 167(4), 429-436. doi:10.1016/j.ahj.2013.12.007Cano, O., Osca, J., Sancho-Tello, M.-J., Sánchez, J. M., Ortiz, V., Castro, J. E., … Olagüe, J. (2010). Comparison of Effectiveness of Right Ventricular Septal Pacing Versus Right Ventricular Apical Pacing. The American Journal of Cardiology, 105(10), 1426-1432. doi:10.1016/j.amjcard.2010.01.004Cazeau, S., Leclercq, C., Lavergne, T., Walker, S., Varma, C., Linde, C., … Daubert, J.-C. (2001). Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction Delay. New England Journal of Medicine, 344(12), 873-880. doi:10.1056/nejm200103223441202Chung, E. S., Leon, A. R., Tavazzi, L., Sun, J.-P., Nihoyannopoulos, P., Merlino, J., … Murillo, J. (2008). Results of the Predictors of Response to CRT (PROSPECT) Trial. Circulation, 117(20), 2608-2616. doi:10.1161/circulationaha.107.743120ClelandJ. G. F. DaubertJ.-C. ErdmannE. FreemantleN. GrasD. KappenbergerL. The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure.2005Coppola, G., Ciaramitaro, G., Stabile, G., DOnofrio, A., Palmisano, P., Carità, P., … Corrado, E. (2016). Magnitude of QRS duration reduction after biventricular pacing identifies responders to cardiac resynchronization therapy. International Journal of Cardiology, 221, 450-455. doi:10.1016/j.ijcard.2016.06.203Coronel, R., Wilders, R., Verkerk, A. O., Wiegerinck, R. F., Benoist, D., & Bernus, O. (2013). Electrophysiological changes in heart failure and their implications for arrhythmogenesis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1832(12), 2432-2441. doi:10.1016/j.bbadis.2013.04.002Crozier, A., Blazevic, B., Lamata, P., Plank, G., Ginks, M., Duckett, S., … Niederer, S. A. (2016). The relative role of patient physiology and device optimisation in cardiac resynchronisation therapy: A computational modelling study. Journal of Molecular and Cellular Cardiology, 96, 93-100. doi:10.1016/j.yjmcc.2015.10.026Da Costa, A., Gabriel, L., Romeyer-Bouchard, C., Géraldine, B., Gate-Martinet, A., Laurence, B., … Isaaz, K. (2013). Focus on right ventricular outflow tract septal pacing. Archives of Cardiovascular Diseases, 106(6-7), 394-403. doi:10.1016/j.acvd.2012.08.005De Pooter, J., El Haddad, M., Timmers, L., Van Heuverswyn, F., Jordaens, L., Duytschaever, M., & Stroobandt, R. (2015). Different Methods to Measure QRS Duration in CRT Patients: Impact on the Predictive Value of QRS Duration Parameters. Annals of Noninvasive Electrocardiology, 21(3), 305-315. doi:10.1111/anec.12313Derval, N., Steendijk, P., Gula, L. J., Deplagne, A., Laborderie, J., Sacher, F., … Jaïs, P. (2010). Optimizing Hemodynamics in Heart Failure Patients by Systematic Screening of Left Ventricular Pacing Sites. Journal of the American College of Cardiology, 55(6), 566-575. doi:10.1016/j.jacc.2009.08.045DeskR. WilliamsL. HealthK. Characteristics and Distribution of M Cells in Arterially.1998Dou, J., Xia, L., Deng, D., Zang, Y., Shou, G., Bustos, C., … Crozier, S. (2012). A Study of Mechanical Optimization Strategy for Cardiac Resynchronization Therapy Based on an Electromechanical Model. Computational and Mathematical Methods in Medicine, 2012, 1-13. doi:10.1155/2012/948781DURRER, D., VAN DAM, R. T., FREUD, G. E., JANSE, M. J., MEIJLER, F. L., & ARZBAECHER, R. C. (1970). Total Excitation of the Isolated Human Heart. Circulation, 41(6), 899-912. doi:10.1161/01.cir.41.6.899Dutta, S., Mincholé, A., Quinn, T. A., & Rodriguez, B. (2017). Electrophysiological properties of computational human ventricular cell action potential models under acute ischemic conditions. Progress in Biophysics and Molecular Biology, 129, 40-52. doi:10.1016/j.pbiomolbio.2017.02.007Elhakam Elzoghby, I. A., Attia, I., Azab, A. E., & Hammouda, M. (2017). Impact of Cardiac Resynchronization Therapy on Heart Failure Patients: Experience from One Center. Archives of Medicine, 09(04). doi:10.21767/1989-5216.1000232Ferrer, A., Sebastián, R., Sánchez-Quintana, D., Rodríguez, J. F., Godoy, E. J., Martínez, L., & Saiz, J. (2015). Detailed Anatomical and Electrophysiological Models of Human Atria and Torso for the Simulation of Atrial Activation. PLOS ONE, 10(11), e0141573. doi:10.1371/journal.pone.0141573FLEVARI, P., LEFTHERIOTIS, D., FOUNTOULAKI, K., PANOU, F., RIGOPOULOS, A. G., PARASKEVAIDIS, I., & KREMASTINOS, D. T. (2009). Long-Term Nonoutflow Septal Versus Apical Right Ventricular Pacing: Relation to Left Ventricular Dyssynchrony. Pacing and Clinical Electrophysiology, 32(3), 354-362. doi:10.1111/j.1540-8159.2008.02244.xGRAS, D., GUPTA, M. S., BOULOGNE, E., GUZZO, L., & ABRAHAM, W. T. (2009). Optimization of AV and VV Delays in the Real-World CRT Patient Population: An International Survey on Current Clinical Practice. Pacing and Clinical Electrophysiology, 32, S236-S239. doi:10.1111/j.1540-8159.2008.02294.xGreenbaum, R. A., Ho, S. Y., Gibson, D. G., Becker, A. E., & Anderson, R. H. (1981). Left ventricular fibre architecture in man. Heart, 45(3), 248-263. doi:10.1136/hrt.45.3.248Guo, T., Li, R., Zhang, L., Luo, Z., Zhao, L., Yang, J., … Hua, B. (2015). Biventricular Pacing With Ventricular Fusion by Intrinsic Activation in Cardiac Resynchronization Therapy. International Heart Journal, 56(3), 293-297. doi:10.1536/ihj.14-260Gurev, V., Constantino, J., Rice, J. J., & Trayanova, N. A. (2010). Distribution of Electromechanical Delay in the Heart: Insights from a Three-Dimensional Electromechanical Model. Biophysical Journal, 99(3), 745-754. doi:10.1016/j.bpj.2010.05.028Heidenreich, E. A., Ferrero, J. M., Doblaré, M., & Rodríguez, J. F. (2010). Adaptive Macro Finite Elements for the Numerical Solution of Monodomain Equations in Cardiac Electrophysiology. Annals of Biomedical Engineering, 38(7), 2331-2345. doi:10.1007/s10439-010-9997-2Huang, W., Su, L., Wu, S., Xu, L., Xiao, F., Zhou, X., & Ellenbogen, K. A. (2017). A Novel Pacing Strategy With Low and Stable Output: Pacing the Left Bundle Branch Immediately Beyond the Conduction Block. Canadian Journal of Cardiology, 33(12), 1736.e1-1736.e3. doi:10.1016/j.cjca.2017.09.013Keller, D. U. J., Weber, F. M., Seemann, G., & Dössel, O. (2010). Ranking the Influence of Tissue Conductivities on Forward-Calculated ECGs. IEEE Transactions on Biomedical Engineering, 57(7), 1568-1576. doi:10.1109/tbme.2010.2046485Krum, H., Lemke, B., Birnie, D., Lee, K. L.-F., Aonuma, K., Starling, R. C., … Martin, D. (2012). A novel algorithm for individualized cardiac resynchronization therapy: Rationale and design of the adaptive cardiac resynchronization therapy trial. American Heart Journal, 163(5), 747-752.e1. doi:10.1016/j.ahj.2012.02.007Leclercq, C., Sadoul, N., Mont, L., Defaye, P., Osca, J., Mouton, E., … Fernandez-Lozano, I. (2015). Comparison of right ventricular septal pacing and right ventricular apical pacing in patients receiving cardiac resynchronization therapy defibrillators: the SEPTAL CRT Study. European Heart Journal, 37(5), 473-483. doi:10.1093/eurheartj/ehv422LEE, A. W. C., CROZIER, A., HYDE, E. R., LAMATA, P., TRUONG, M., SOHAL, M., … NIEDERER, S. (2017). Biophysical Modeling to Determine the Optimization of Left Ventricular Pacing Site and AV/VV Delays in the Acute and Chronic Phase of Cardiac Resynchronization Therapy. Journal of Cardiovascular Electrophysiology, 28(2), 208-215. doi:10.1111/jce.13134Lee, A. W. C., Costa, C. M., Strocchi, M., Rinaldi, C. A., & Niederer, S. A. (2018). Computational Modeling for Cardiac Resynchronization Therapy. Journal of Cardiovascular Translational Research, 11(2), 92-108. doi:10.1007/s12265-017-9779-4Lee, H., Park, J.-H., Seo, I., Park, S.-H., & Kim, S. (2014). Improved application of the electrophoretic tissue clearing technology, CLARITY, to intact solid organs including brain, pancreas, liver, kidney, lung, and intestine. BMC Developmental Biology, 14(1). doi:10.1186/s12861-014-0048-3Linde, C., Ellenbogen, K., & McAlister, F. A. (2012). Cardiac resynchronization therapy (CRT): Clinical trials, guidelines, and target populations. Heart Rhythm, 9(8), S3-S13. doi:10.1016/j.hrthm.2012.04.026Lopez-Perez, A., Sebastian, R., & Ferrero, J. M. (2015). Three-dimensional cardiac computational modelling: methods, features and applications. BioMedical Engineering OnLine, 14(1). doi:10.1186/s12938-015-0033-5Mafi Rad, M., Blaauw, Y., Dinh, T., Pison, L., Crijns, H. J., Prinzen, F. W., & Vernooy, K. (2014). Different regions of latest electrical activation during left bundle-branch block and right ventricular pacing in cardiac resynchronization therapy patients determined by coronary venous electro-anatomic mapping. European Journal of Heart Failure, 16(11), 1214-1222. doi:10.1002/ejhf.178Miri, R., Graf, I. M., & Dossel, O. (2009). Efficiency of Timing Delays and Electrode Positions in Optimization of Biventricular Pacing: A Simulation Study. IEEE Transactions on Biomedical Engineering, 56(11), 2573-2582. doi:10.1109/tbme.2009.2027692Miri, R., Reumann, M., Farina, D., & Dössel, O. (2009). Concurrent optimization of timing delays and electrode positioning in biventricular pacing based on a computer heart model assuming 17 left ventricular segments. Biomedizinische Technik/Biomedical Engineering, 54(2), 55-65. doi:10.1515/bmt.2009.013Miri, R., Reumann, M., Keller, D. U. J., Farina, D., & Dossel, O. (2008). Comparison of the electrophysiologically based optimization methods with different pacing parameters in patient undergoing resynchronization treatment. 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. doi:10.1109/iembs.2008.4649513MOLHOEK, S. G., BAX, J. J., BOERSMA, E., ERVEN, L. V., BOOTSMA, M., STEENDIJK, P., … SCHALIJ, M. J. (2004). QRS Duration and Shortening to Predict Clinical Response to Cardiac Resynchronization Therapy in Patients with End‐Stage Heart Failure. Pacing and Clinical Electrophysiology, 27(3), 308-313. doi:10.1111/j.1540-8159.2004.00433.xMora, M. T., Ferrero, J. M., Romero, L., & Trenor, B. (2017). Sensitivity analysis revealing the effect of modulating ionic mechanisms on calcium dynamics in simulated human heart failure. PLOS ONE, 12(11), e0187739. doi:10.1371/journal.pone.0187739MUTO, C., OTTAVIANO, L., CANCIELLO, M., CARRERAS, G., CALVANESE, R., ASCIONE, L., … TUCCILLO, B. (2007). Effect of Pacing the Right Ventricular Mid-Septum Tract in Patients with Permanent Atrial Fibrillation and Low Ejection Fraction. Journal of Cardiovascular Electrophysiology, 18(10), 1032-1036. doi:10.1111/j.1540-8167.2007.00914.xO’Hara, T., Virág, L., Varró, A., & Rudy, Y. (2011). Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation. PLoS Computational Biology, 7(5), e1002061. doi:10.1371/journal.pcbi.1002061Passini, E., Mincholé, A., Coppini, R., Cerbai, E., Rodriguez, B., Severi, S., & Bueno-Orovio, A. (2016). Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 96, 72-81. doi:10.1016/j.yjmcc.2015.09.003Pitzalis, M. V., Iacoviello, M., Romito, R., Massari, F., Rizzon, B., Luzzi, G., … Rizzon, P. (2002). Cardiac resynchronization therapy tailored by echocardiographic evaluation of ventricular asynchrony. Journal of the American College of Cardiology, 40(9), 1615-1622. doi:10.1016/s0735-1097(02)02337-9Pluijmert, M., Bovendeerd, P. H. M., Lumens, J., Vernooy, K., Prinzen, F. W., & Delhaas, T. (2016). New insights from a computational model on the relation between pacing site and CRT response. EP Europace, 18(suppl_4), iv94-iv103. doi:10.1093/europace/euw355Potse, M., Dube, B., Richer, J., Vinet, A., & Gulrajani, R. M. (2006). A Comparison of Monodomain and Bidomain Reaction-Diffusion Models for Action Potential Propagation in the Human Heart. IEEE Transactions on Biomedical Engineering, 53(12), 2425-2435. doi:10.1109/tbme.2006.880875Potse, M., Krause, D., Bacharova, L., Krause, R., Prinzen, F. W., & Auricchio, A. (2012). Similarities and differences between electrocardiogram signs of left bundle-branch block and left-ventricular uncoupling. Europace, 14(suppl 5), v33-v39. doi:10.1093/europace/eus272Prassl, A. J., Kickinger, F., Ahammer, H., Grau, V., Schneider, J. E., Hofer, E., … Plank, G. (2009). Automatically Generated, Anatomically Accurate Meshes for Cardiac Electrophysiology Problems. IEEE Transactions on Biomedical Engineering, 56(5), 1318-1330. doi:10.1109/tbme.2009.2014243PRINZEN, F. W., & PESCHAR, M. (2002). Relation Between the Pacing Induced Sequence of Activation and Left Ventricular Pump Function in Animals. Pacing and Clinical Electrophysiology, 25(4), 484-498. doi:10.1046/j.1460-9592.2002.00484.xVan Deursen, C., van Geldorp, I. E., Rademakers, L. M., van Hunnik, A., Kuiper, M., Klersy, C., … Prinzen, F. W. (2009). Left Ventricular Endocardial Pacing Improves Resynchronization Therapy in Canine Left Bundle-Branch Hearts. Circulation: Arrhythmia and Electrophysiology, 2(5), 580-587. doi:10.1161/circep.108.846022Prinzen, F. W., Vernooy, K., Lumens, J., & Auricchio, A. (2017). Physiology of Cardiac Pacing and Resynchronization. Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy, 213-248. doi:10.1016/b978-0-323-37804-8.00007-9Rickard, J., Karim, M., Baranowski, B., Cantillon, D., Spragg, D., Tang, W. H. W., … Varma, N. (2017). Effect of PR interval prolongation on long-term outcomes in patients with left bundle branch block vs non–left bundle branch block morphologies undergoing cardiac resynchronization therapy. Heart Rhythm, 14(10), 1523-1528. doi:10.1016/j.hrthm.2017.05.028Romero, D., Sebastian, R., Bijnens, B. H., Zimmerman, V., Boyle, P. M., Vigmond, E. J., & Frangi, A. F. (2010). Effects of the Purkinje

Utilization of Nanocomposites in the Present-Day PVC Production Practice

Na základě zadání byla provedena literární a patentová rešerše o využití nanokompozitní technologie při výrobě polyvinylchloriduBasing on the task input I made a literar and patent research on the utilization of nanocomposite technology in the polyvinylchloride productionÚstav polymerních materiálůDokončená práce s úspěšnou obhajobo

Analysis of net inflation development in the Czech republic

Autor v práci sleduje vývoj čisté inflace v české ekonomice. Shrnuje hlavní příčiny včetně měnové a fiskální politiky ČR.Dokončená práce s úspěšnou obhajobo

Sport as a business activity

Cílem této bakalářské práce je charakterizovat vybrané sportovní odvětví, jako podnikatelskou činnost v České republice. V teoretické části jsou objasněny pojmy k vybranému tématu a praktická část se zabývá seznámením s daným sportovním klubem a jeho finančním hospodařením. Závěrem jsou zpracovány vlastní návrhy a doporučená zlepšení dané problematiky.The aim of this work is to characterize the selected sports industry as a business activity in the Czech Republic. In the theoretical part the concepts are explained to a selected topic and a practical part deals with the introduction to the sports club and its financial management. Finally, custom designs are processed and recommended improvements of the issue.Ústav podnikové ekonomiky a managementuPředstavení sportovního klubu, druhy příjmů sportovního klubu, výdaje klubu, výsledky. Otázky vedoucího práce: Myslíte si, že sloučením české a slovenské fotbalové ligy se zlepší příjmy fotbalového klubu SK Slavia Praha? Jakými dalšími opatřeními byste zlepšil příjmy fotbalového klubu SK Slavia Praha? Jaká je nejčastější právní forma sportovních klubů

Management and Operation of Sports Club VK Příbram

The object of this work is to analyze the current situation, evaluation and follow up proposals to improve the management and control of a professional volleyball club VK Příbram. The theoretical part describes the background related to the issue, the practical part is focused on the analysis of the organizational structure, management and operation of the club