Kaposi sarcoma coexisting with new onset diabetes mellitus in a 42-year old KIDNEY TRANSPLANT RECIPIENT: A CASE REPORT

Renal allograft recipients develop several complications such as infections and neoplasms. New onset diabetes mellitus is a common transplant complication but rarely coexist with Kaposi sarcoma. Case report: We report the case of a 42-year-old banker who presented with polyuria, polydipsia, polyphagia, weight loss and dark spots in the lower limbs 8 months after he had received a live-related kidney transplant in India. He is not a known diabetic and had no family history of diabetes mellitus. His post-transplant immunosuppressive drugs included Myfortic® (mycophenolate), tacrolimus and prednisolone. At presentation he was wasted, dehydrated and afebrile, with multiple hyperpigmented nodules and plaques in both his lower limbs. Random blood glucose was 38mmol/l, had 2+ glucosuria and no ketones. Biopsy of skin lesions showed features of Kaposi sarcoma. A diagnosis of post-transplant diabetes mellitus and Kaposi sarcoma was made. His treatment included soluble insulin and antibiotics. Tacrolimus was changed to sirolimus and mycophenolate was reduced to 360mg twice daily. Conclusion: Coexistence of diabetes mellitus and karposi sarcoma occurs rarely among kidney transplant recipients. Evaluation of transplant recipient who developed diabetes for malignancies such as karposi sarcoma will improve patient and graft survival

A novel model for solar radiation prediction

Energy for fulfilling basic community/individual needs has come to constitute the first article of expectation in all contemporary societies. The exploitation of renewables notably solar in electricity generation has brought relief to the fulfilment of energy demand especially among susceptible communities. In this paper yearly minimum solar radiation of Kano (12.05°N; 08.2°E; altitude 472.5 m; 3 air density 1.1705 kg/m3) for 46 years is used to generate a prediction model that fits the data using autoregressive moving average (ARMA) and a new model termed autoregressive moving average process (ARMAP). Comparison between the ARMA and ARMAP models showed a tremendous improve in the sum of square error reduction between the actual data and the forecasted data by 47%

Effect of Dietary Replacement of Maize with Yam and Irish potato peel meals on the Growth and Economic Performance of Growing Rabbits

An eight-week feeding trial was conducted to investigate the effect of feeding yam and irish potato peel meals on the growth performance and economic analysis of cross-bred (Dutch x New Zealand white) growing rabbits aged between five to seven weeks. Thirty rabbits were randomly allocated to six dietary treatments with five rabbits per treatment. Diets 1, 2, 3, 4, 5 and 6 contained 100% maize, 50% maize and 50% yam peel meal, 50% maize and 50% irish potato peel meal, 50% yam peel meal and 50% irish potato peel meal, 100% yam peel meal and 100% irish potato peel meal, respectively. The response showed that the growth parameters were not significantly (P>0.05) different among the treatment groups except mean final body weight which was significantly (P>0.05) different. The mean final body weight of rabbits fed T3 diet (50% maize and 50% irish potato peel meal) was significantly (P< 0.05) higher than those fed T2 (50% maize and 50% yam peel meal) and T6 (100% irish potato peel meal) diets, but were similar (P>0.05) to other diets. However, the lowest mean final body weight was obtained in rabbits fed T6 (100% irish potato peel meal) diet. The cost per kg feed decreased progressively as the levels of yam and irish potato peel meals increased in the diets. The cost per kg gain also declined from  ₦ 249.59 in T1 (100% maize) to ₦ 181.95 in T4 (50% yam peel meal and 50% irish potato peel meal), which showed the best cost per kg weight gain. The study demonstrated that the yam and irish potato peel meals can replace maize up to 100% as energy source for growing rabbits without adverse effect on performance.Keywords: Growth Performance, Yam and Irish Potato peel meals, Economic Analysi

Anti Bacterial Activity of Ethanolic Extract of Zingiber Officinale and Pipper Nigrum against Some Clinical Isolates

Ethanolic extract of Zingiber officinale and Pipper nigrum were evaluated by testing in vitro antimicrobial activity on clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Escherichia coli, and proteus specie using Agar diffusion method. Proteus specie showed sensitivity to Z. officinale at disc concentration range of 50 to 800µg/ml, Staphylococcus aureus also showed sensitivity to z. officinale at concentration of 100 to 800 µg/ml and Klebsiella pneumonia showed sensitivity at disc concentration of 100 to 800 µg/ml likewise proteus specie showed sensitivity to p. nigrum at disc concentration range of 100 to 800µg/ml and staphylococcus aureus also showed sensitivity to p. nigrum at disc concentration range of 100 to 800µg/ml. However, the Ethanolic extract of z. officinale and p. nigrum showed no lethal or inhibitory effects on Pseudomonas aeruginosa and Escherichia coli at all concentration. The observed minimum inhibitory concentration (MIC) of the Ethanolic extraction for proteus species, Staphylococcus aureus and Klebsiella pneumonia were 50, 100,200µglml respectively for Z. officinale, while for P. nigrum, the minimum inhibitory concentration (MIC) were 100 and 200µg/ml for Proteus specie and staphylococcus aureus respectively. The extracts were further subjected to phytochemical tests for the presence of secondary metabolites using standard procedures. The results of phytochemical screening indicated the presence of alkaloids, Flavonoid, reducing sugar, saponins and steroids in Z. officinale, and alkaloids, Flavonoid, saponins, steroids and tannin in P. nigrum. This indicates that both Z. officinale and piper nigrum has the potential for the production of drugs against pathogenic organisms

Optical and structural properties of rice husk silicate incorporated borotellurite glasses doped with erbium oxide nanoparticles

A system of erbium oxide nanoparticles doped rice-husk-silicate borotellurite glasses with compositional formula, {[(TeO2)0.7 (B2O3)0.3]0.8 (SiO2)0.2}1−y (Er2O3 NPs)y with y = 0.01, 0.02, 0.03, 0.04 and 0.05 was fabricated using the method of melt-quenching. Various characterizations and measurement techniques such as density and molar volume, X-ray diffraction, Fourier transform infrared, transmission electron microscopy and UV–Vis spectroscopy were carried out to study the structural, morphological and optical properties of the fabricated glasses. The density values for the glasses increased from 4.1900 to 4.6003 g cm−3 with the addition of 1% to 5% of Er2O3 NPs in the glass structure. The increase can be ascribed to increase in the overall molar weight of the glass caused by the higher molecular weight of erbium. The microstructural nature revealed in the glass morphological evidence of nanoparticle agglomerations in the glasses. From the UV–Vis spectra both direct and indirect energy band gap decreased with Er2O3 NPs increased 0.01 to 0.02 mol and then increased thereafter up to 0.05 mol%. The refractive index was found to be high, in the range of 2.6050 to 2.6794, metallization criterion ranged from 0.3268 to 0.3414 which according to Berwal et al. (J Mol Struct 1127:636–644, 2017), is an indication that the glass has good optical non-linearity and also suggests the glass has good potential for non-linear optical application. The molar polarizability ranged from 7.7041 to 7.4515 Å3 while the optical transmission coefficient values ranged from 0.6551 to 0.6691. The high refractive index, good metallization criterion, polarizability and transmission coefficient values suggest that the erbium oxide nanoparticles doped Rice husk silicate borotellurite glasses studied has some good potential for optical fibre amplifier application

Responses of haptoglobin and serum amyloid A in goats inoculated intradermally with C. pseudotuberculosis and mycolic acid extract immunogen

Haptoglobin (Hp) and Serum Amyloid A (SAA) are a group of blood proteins whose concentrations in animals can be influenced by infection, inflammation, surgical trauma or stress. Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis (CLA), and Mycolic acid is a virulent factor extracted from C. pseudotuberculosis. There is a dearth of sufficient evidence on the clinical implication of MAs on the responses of Hp and SAA in goats. Therefore, this study was conducted to evaluate the potential effects of Mycolic acid (MAs) and C. pseudotuberculosis on the responses of Hp and SAA in female goats. A total of 12 healthy female goats was divided into three groups; A, B and C each comprising of 4 goats and managed for a period of three months. Group (A) was inoculated with 2 mL of sterile phosphate buffered saline (as a negative control group) intradermally, while group (B) and (C) were inoculated intradermally with 2 ml each of mycolic acid and 1‏ × 109 cfu of active C. pseudotuberculosis respectively. The result of the study showed that the Hp concentration in goats inoculated with C. pseudotuberculosis was significantly increased up to 7-fold (1.17 ± 0.17 ng/L) while MAs showed a 3-fold increased (0.83 ± 0.01 ng/L) compared with the control. Whereas SAA concentration in C. pseudotuberculosis and MAs groups showed a significant 3-fold (17.85 ± 0.91 pg/mL) and 2-fold (10.97 ± 0.71 pg/mL) increased compared with the control. This study concludes that inoculation of C. pseudotuberculosis and MAs have significant effects on Hp and SAA levels, which indicates that MAs could have a role in the pathogenesis of caseous lymphadenitis

Comparative Study of Local Mining Methods and Assay of Cassiterite with other Alluvial Mineral Deposits in Kuru-Jantar, Plateau State, Nigeria

This research attempt to investigate and compare the local mining methods of cassiterite in Kuru-Jantar with the view to determine the mean recovery per day using statistical approach, separating the valuable minerals through the gravity and magnetic techniques, determine the grade of cassiterite (tin oxide) with the aid of volumetric and energy dispersive x-ray florescence (XRF) analyses; and determine the percentage composition of metals in cassiterite as well as its associate ores with the aid of (XRF). Sub-surface (lotto) and surface (Hand paddock) mining methods were carried out and the respective recovery from each of the method was subjected to processing, sampling and assaying to determine the quantity, quality (grade) and expected smelter-yield. The mean recoveries per day are 14.48 and 11.28 kg/day for lotto and paddock mining methods respectively. The burretting differential obtained for the lotto and paddock methods are 18.80 – 19.80 and 18.80 – 19.30 respectively while their respective percentage tin metal burretted are 90.40 – 97.83 and 92.51 – 97.80 %. The recoveries from the magnetic and gravity separations are 10.91 kg and 9.06 kg for lotto and paddock methods respectively. The XRF analysis gave 68.69 and 66.462 % Sn respectively for the lotto and paddock while the assaying of other associate minerals are 40.4 % Nb; 26.5 % Fe; 22.3 % Ti; 2.5 % Ta; 2.3 % Sn; and 5.1 % W for the paddock and 37.6 % Nb; 24.8 % Fe; 21.5 % Ti; 2.3% Ta; 5.8 % Sn; and 4.9 % W for lotto. It can be observed that the lotto mining method has the highest recovery per day and hence, gives better recovery than paddock mining method. Lotto mining was found to yield higher grade tin-ore concentrate than the hand paddock mining method in both volumetric and XRF analyses but hand paddock gives higher quantity and more associate minerals. It was also found out that the lotto method is more risky and life threatening than paddock mining while the paddock mining practices render more danger to environment than the lotto mining