Comparison of ferric carboxymaltose and iron sucrose for treatment of iron deficiency anemia in pregnancy at tertiary care centre, Western India

Background: Iron deficiency anemia is the most common haematological health problem among pregnant women but can be prevented by effective measure. The study aimed to evaluate the efficacy and safety of intravenous ferric carboxymaltose (FCM) in comparison with intravenous Iron sucrose (IS) for treatment of iron deficiency anemia in pregnancy. Methods: A prospective interventional comparative study was conducted from (June 2021-June 2022) at a tertiary care hospital. Pregnant women diagnosed with moderate to severe iron deficiency anaemia were screened for the study. One hundred patients were randomized to receive either intravenous FCM or IS. Treatment effectiveness was assessed by repeat Haemoglobin (Hb) and RBC indices measurement after 4 weeks of completion of therapy. Safety was assessed by analysis of adverse drug reactions during infusion and 2 hours after infusion. Results: Mean rise in Hb at 4 weeks was significantly higher in FCM group (1.67±0.47 Vs 1.07±0.25; p<0.0001) as compared to IS group.  There was also rise in other biochemical parameters like MCV and MCHC in both groups. Numbers of visits were significantly less in FCM group. No serious adverse events were noted in either group. Conclusions: Intravenous ferric carboxymaltose is more effective and safer as compared to intravenous iron sucrose in the management of anemia during pregnancy. It has advantage to administer large dose in single sitting which reduce overall cost of therapy and hence will lead to better compliance in community setting

Freezing induces an increase in leaf spectral transmittance of forest understorey and alpine forbs

Evergreen plants growing at high latitudes or high elevations may experience freezing events in their photosynthetic tissues. Freezing events can have physical and physiological effects on the leaves which alter leaf optical properties affecting remote and proximal sensing parameters. We froze leaves of six alpine plant species (Soldanella alpina, Ranunculus kuepferi, Luzula nutans, Gentiana acaulis, Geum montanum, and Centaurea uniflora) and three evergreen forest understorey species (Hepatica nobilis, Fragaria vesca and Oxalis acetosella), and assessed their spectral transmittance and optically measured pigments, as well as photochemical efficiency of photosystem II (PSII) as an indicator of freezing damage. Upon freezing, leaves of all the species transmitted more photosynthetically active radiation (PAR) and some species had increased ultraviolet-A (UV-A) transmittance. These differences were less pronounced in alpine than in understorey species, which may be related to higher chlorophyll degradation, visible as reduced leaf chlorophyll content upon freezing in the latter species. Among these understorey forbs, the thin leaves of O. acetosella displayed the largest reduction in chlorophyll (−79%). This study provides insights into how freezing changes the leaf optical properties of wild plants which could be used to set a baseline for upscaling optical reflectance data from remote sensing. Changes in leaf transmittance may also serve to indicate photosynthetic sufficiency and physiological tolerance of freezing events, but experimental research is required to establish this functional association.Peer reviewe

Alpine forbs rely on different photoprotective strategies during spring snowmelt

Snowmelt in alpine ecosystems brings ample water, and together with above-freezing temperatures, initiates plant growth. In this scenario, rapid activation of photosynthesis is essential for a successful life-history strategy. But, strong solar radiation in late spring enhances the risk of photodamage, particularly before photosynthesis is fully functional. We compared the photoprotective strategy of five alpine forbs: one geophyte not particularly specialised in subnival life (Crocus albiflorus) and four wintergreens differing in their degree of adaptation to subnival life, from least to most specialised: Gentiana acaulis, Geum montanum, Homogyne alpina and Soldanella alpina. We used distance to the edge of snow patches as a proxy to study time-dependent changes after melting. We postulated that the photoprotective response of snowbed specialists would be stronger than of more-generalist alpine meadow species. F-v/F-m was relatively low across wintergreens and even lower in the geophyte C. albiflorus. This species also had the largest xanthophyll-cycle pool and lowest tocopherol and flavonoid glycoside contents. After snow melting, all the species progressively activated ETR, but particularly the intermediate snowbed species G. acaulis and G. montanum. The photoprotective responses after snowmelt were idiosyncratic: G. montanum rapidly accumulated xanthophyll-cycle pigments, tocopherol and flavonoid glycosides; while S. alpina showed the largest increase in plastochromanol-8 and chlorophyll contents and the greatest changes in optical properties. Climate warming scenarios might shift the snowmelt date and consequently alter the effectiveness of photoprotection mechanisms, potentially changing the fitness outcome of the different strategies adopted by alpine forbs.Peer reviewe

Rare Case of Isolated Right Sided Dilated Cardiomyopathy

In dilated cardiomyopathies biventricular involvement is the usual case though left ventricular dysfunction is more apparent. In RVDCM, as the name suggests right ventricle is solely involved and left ventricular function is normal. The other causes of right heart failure are tricuspid valve disease (infective endocarditis, rheumatic, Ebsteins anomaly), right ventricular infarction and rarely pulmonary regurgitation without pulmonary hypertension. The diagnosis was made on echocardiography which revealed dilated, hypokinetic right ventricle, with normal left ventricular dimensions and ejection fraction and no evidence of pulmonary artery hypertension with normal pulmonary artery size and normal pulmonary valve with dilated right ventricle outflow trac

Hypertrophic cardiomyopathy: in a search of its own identity

Hypertrophic cardiomyopathy (HCM) is a genetic disorder characterized by left ventricular hypertrophy not explained by secondary causes, and a non-dilated left ventricle with preserved or increased ejection fraction. It is commonly asymmetric with most severe hypertrophy involving the basal interventricular septum.. The histologic features of HCM are myocyte hypertrophy and disarray, as well as interstitial fibrosis. The hypertrophy is associated with left ventricular diastolic dysfunction. Left ventricular outflow tract obstruction is present at rest in about one third of the patients, and can be provoked in another third. HCM is also an important cause of sudden cardiac death, particularly in adolescents and young adults. Nonsustained ventricular tachycardia, syncope, a family history of sudden cardiac death, and severe cardiac hypertrophy are major risk factors for sudden cardiac death.incidence being 30 % and the cause of cardiac death is LVOT obstruction,increased oxygen of thick myocardium with compromised coronary circulation and intractable ventricular tachycardia. Mutations in over a dozen genes encoding sarcomere-associated proteins cause HCM. MYH7 and MYBPC3, encoding β-myosin heavy chain and myosin binding protein C, respectively, are the two most common genes involved, together accounting for about 50% of the HCM families. Mutations in genes responsible for storage diseases cause a phenotype like HCM (genocopy or phenocopy). The routine applications of genetic testing and preclinical identification of family members represents an important advance. In genetic study HCM is associated with HLA DRW4

UV-screening and springtime recovery of photosynthetic capacity in leaves of Vaccinium vitis-idaea above and below the snow pack

Evergreen plants in boreal biomes undergo seasonal hardening and dehardening adjusting their photosynthetic capacity and photopmtection; acclimating to seasonal changes in temperature and irradiance. Leaf epidermal ultraviolet (UV)-screening by flavonols responds to solar radiation, perceived in part through increased ultraviolet-B (UV-B) radiation, and is a candidate trait to provide cross-photoprotection. At Hyytiala Forestry Station, central Finland, we examined whether the accumulation of flavonols was higher in leaves of Vaccinium vitis-idaea L. growing above the snowpack compared with those below the snowpack. We found that leaves exposed to colder temperatures and higher solar radiation towards the top of hummocks suffered greater photoinhibition than those at the base of hummocks. Epidermal UV-screening was highest in upper-hummock leaves, particularly during winter when lower leaves were beneath the snowpack. There was also a negative relationship between indices of flavonols and anthocyanins across all leaves suggesting fine-tuning of flavonoid composition for screening vs. antioxidant activity in response to temperature and irradiance. However, the positive correlation between the maximum quantum yield of photosystem II photochemistry (F-v/F-m) and flavonol accumulation in upper hummock leaves during dehardening did not confer on them any greater cross-protection than would be expected from the general relationship of F-v/F-m with temperature and irradiance (throughout the hummocks). Irrespective of timing of snow-melt, photosynthesis fully recovered in all leaves, suggesting that V. vills-idaea has the potential to exploit the continuing trend for longer growing seasons in central Finland without incurring significant impairment from reduced duration of snow cover.Peer reviewe

Ultraviolet radiation accelerates photodegradation under controlled conditions but slows the decomposition of senescent leaves from forest stands in southern Finland

Depending on the environment, sunlight can positively or negatively affect litter decomposition, through the ensemble of direct and indirect processes constituting photodegradation. Which of these processes predominate depends on the ecosystem studied and on the spectral composition of sunlight received. To examine the relevance of photodegradation for litter decomposition in forest understoreys, we filtered ultraviolet radiation (UV) and blue light from leaves of Fagus sylvatica and Bettda pendula at two different stages of senescence in both a controlled-environment experiment and outdoors in four different forest stands (Picea abies, Pagus sylvatica, Acer platanoides, Betula pendula). Controlling for leaf orientation and initial differences in leaf chlorophyll and flavonol concentrations; we measured mass loss at the end of each experiment and characterised the phenolic profile of the leaf litter following photodegradation. In most forest stands, less mass was lost from decomposing leaves that received solar UV radiation compared with those under UV-attenuating filters, while in the controlled environment UV-A radiation either slightly accelerated or had no significant effect on photodegradation, according to species identity. Only a few individual phenolic compounds were affected by our different filter treatments, but photodegradation did affect the phenolic profile. We can conclude that photodegradation has a small stand- and species-specific effect on the decomposition of surface leaf litter in forest understoreys during the winter following leaf fall in southern Finland. Photodegradation was wavelength-dependent and modulated by the canopy species filtering sunlight and likely creating different combinations of spectral composition, moisture, temperature and snowpack characteristics.Peer reviewe

Green Chemistry for the Development of Eco-Friendly Products

In today’s world, it has become necessary to shift towards a more eco-friendly and sustainable approach in the industrial field to reduce pollution and stop toxic chemicals from entering the environment. Green chemistry is an emerging concept that can be utilized to assist with these environmental issues. To ensure this concept is employed to its full potential, further study on the best practices and challenges of implementation are required.Green Chemistry for the Development of Eco-Friendly Products discusses the main objective of green chemistry and how it can redefine and modify manufacturing processes and products in order to decrease hazards to human health. The book also considers key concepts of green chemistry, such as the need to make better use of available resources for the development of a chemical process. Covering critical topics such as bioplastics, waste, and hydrogen law, this reference work is ideal for chemists, business owners, environmentalists, policymakers, academicians, scholars, reВ современном мире стало необходимым перейти к более экологичному и устойчивому подходу в промышленной сфере, чтобы уменьшить загрязнение и предотвратить попадание токсичных химических веществ в окружающую среду. Зеленая химия - это новая концепция, которая может быть использована для решения этих экологических проблем. Для обеспечения того, чтобы эта концепция использовалась в полной мере, требуется дальнейшее изучение передовой практики и проблем, связанных с внедрением. В "Зеленой химии для разработки экологически чистых продуктов" обсуждается основная цель "зеленой химии" и то, как она может переопределить и модифицировать производственные процессы и продукты, чтобы уменьшить опасность для здоровья человека. В книге также рассматриваются ключевые концепции "зеленой химии", такие как необходимость более эффективного использования имеющихся ресурсов для разработки химического процесса. Этот справочник, охватывающий такие важные темы, как биопластики, отходы и водородное законодательство, идеально подходит

EcoScale MCR sustainability to impart rapid access to pyrrolo[1,2-b]pyrazoles scaffolds assisted by recyclable HClO4•SiO2 heterogeneous catalytic system

1218-1222Present work elicits an account of synthesizing a new series of pyrrolo[1,2-b]pyrazole scaffolds involving multi component reaction (MCR) strategy, assisted by silica-supported perchloric acid HClO4ꞏSiO2 as the heterogeneous catalyst. It embraces methyl 2-cyano-2-(phenyldiazenyl)acetate as the key precursor. The reusability of the catalyst up to five synthetic cycles is the value-added advantage of the protocol. Moreover, feasibility of the strategy has been endorsed on the basis of EcoScale values in the sustainable limits. Structural corroboration of all the newly synthesized compounds and catalyst have been ascertained by different spectro analytical data viz., IR, 1H NMR, mass, XRD, TG/DTA and FE-SEM