Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides

A series of new 4-(3-(4-substitutedphenyl)-3a, 4-dihydro-3H-indeno[1,2-c] pyrazol-2-yl) benzenesulfonamides (7-12) was synthesized starting from 2-(4-substitutedbenzylidene)-2,3-dihydro-1H-inden-1-one (1-6) and 4-hydrazinobenzenesulfonamide. The substituted benzaldehydes from which the key intermediate was prepared by introducing 2- or 4-substituents such as fluorine, hydroxy, methoxy, or the 3,4,5-trimethoxy moieties. The compounds were tested for their cytotoxicity, tumor-specificity and potential as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The 3,4,5-trimethoxy and the 4-hydroxy derivatives showed interesting cytotoxic activities, which may be crucial for further anti-tumor activity studies, whereas some of these sulfonamides strongly inhibited both human (h) cytosolic isoforms hCA I and II

Evaluation of aerodynamic profile with a variable curvature

Застосування адаптивного крила в сучасних конструкціях літака є одним з ефективних рішень, що даютє змогу поліпшити характеристики літального апарату на режимах зльоту та посадки. Існуючі конструкції адаптивних крил досить складні, що утрудняє їх реалізацію в малорозмірних безпілотних літальних апаратах. У статті запропонований варіант реалізації адаптивного крила з механічною деформацією нижньої поверхні. Проведено оцінку характеру змін аеродинамічних параметрів профілю в залежності від кривизни нижньої поверхні і точності її формування.The using of adaptive wing structures in modern aircraft is the one with effective solutions that improve takeoff and landing performance of the aircraft. Existing designs of adaptive wings are quite complicated, making them difficult to implement in small unmanned aircrafts. Knowledge of the laws and methods of changing the shape of the profile is an important and urgent topic of research in the design of adaptive wing. At the same time, the trend of development of unmanned vehicles requires a search for new technical solutions to realize the benefits of adaptive wing. One embodiment of the adaptive wing is a wing with variable camber. Changing the camber allows you to adjust the picture of the pressure distribution on the wing, and thus adjust the values of the aerodynamic forces and moments. This article suggests to introduce change profile curvature by mechanical deformation of the bottom surface. The aim of work is the evaluation of the character of changes of aerodynamic profile settings depending on the curvature of the bottom surface and the accuracy of its formation. Also analyzed the possibility of using adaptive wing of this type in the construction of small UAVs. As a result of the research was defined the optimal range of the relative concavity of the profile and value of the lift coefficient of variation in this case. Also, based on the assessment of the impact the accuracy of the formation of the aerodynamic profile of the wing, it was determined that having three break points of the bottom surface, we can obtain the range of variation of the lift coefficient close to the calculated theoretical value. This fact suggests that such an adaptive wing can be realized on small aircraft. Actual direction for further research, the lower profile with a deformable surface, it is possible to use it for lateral control planes.Применение адаптивного крыла в современных конструкциях самолета является одним с эффективных решений позволяющих улучшить взлетно-посадочные характеристики летательного аппарата. Существующие конструкции адаптивных крыл достаточно сложны, что затрудняет их реализацию в малоразмерных беспилотных летательных аппаратах. В статье предложен вариант реализации адаптивного крыла с механической деформацией нижней поверхности. Проведена оценка характера изменений аэродинамических параметров профиля в зависимости от кривизны нижней поверхности и точности ее формирования