エアガン音源による遠距離伝搬特性の解析

MCS(Multi Channel Seismic Survey) is used for purpose of an investigation in a focal region and submarine resource-searching all over the world in recent years. Special vessel for MSC is often also built all over the world. But an environmental protection group shows the suspicion by which a high-power air gun source of MCS has an influence upon ecology of a marine mammal. Therefore the user of MCS is requesting always to watch a marine mammal. So JAMSTEC made a guideline to protect a marine mammal independently. When finding a marine mammal in a watch area, this guideline has decided that an air gun is stopped. But this guideline followed the example of foreign countries. An American researcher was planning a crustal structure investigation in the Hawaii Islands neighborhood jointly with JAMSTEC in 2014. But the opposite of an environmental protection group made them cancel a plan. To check influence to a marine mammal by this research, PE method suitable for long-distance propagation analysis was used. The distribution of the acoustic propagation attenuation and a receiving pulse from the offing in the Hawaii Islands to the Alaska offing were calculated by PE method. The air gun source used for a simulation is loaded into a new research vessel of JAMSTEC "KAIYO". The transmission level is 230dB (re 1μPa/1m), center frequency is 50 Hz band width is about 100 Hz, depth is about 5m.1J4-1, The 36th Symposium on Ultrasonic Electronics (5-7 November 2015, Tsukuba International Congress Center, http://www.use-jp.org/j/) / 第36回超音波エレクトロニクスの基礎と応用に関するシンポジウ

Stem cells in liver regeneration and therapy

The liver has adapted to the inflow of ingested toxins by the evolutionary development of unique regenerative properties and responds to injury or tissue loss by the rapid division of mature cells. Proliferation of the parenchymal cells, i.e. hepatocytes and epithelial cells of the bile duct, is regulated by numerous cytokine/growth-factor-mediated pathways and is synchronised with extracellular matrix degradation and restoration of the vasculature. Resident hepatic stem/progenitor cells have also been identified in small numbers in normal liver and implicated in liver tissue repair. Their putative role in the physiology, pathophysiology and therapy of the liver, however, is not yet precisely known. Hepatic stem/progenitor cells also known as “oval cells” in rodents have been implicated in liver tissue repair, at a time when the capacity for hepatocyte and bile duct replication is exhausted or experimentally inhibited (facultative stem/progenitor cell pool). Although much more has to be learned about the role of stem/progenitor cells in the physiology and pathophysiology of the liver, experimental analysis of the therapeutic value of these cells has been initiated. Transplantation of hepatic stem/progenitor cells or in vivo pharmacological activation of the pool of hepatic stem cells may provide novel modalities for the therapy of liver diseases. In addition, extrahepatic stem cells (e.g. bone marrow cells) are being investigated for their contribution to liver regeneration. Hepatic progenitor cells derived from embryonic stem cells are included in this review, which also discusses future perspectives of stem cell-based therapies for liver diseases

SRM・CRMの観点から考察する商社営業のコンピテンシー

Stem cells have captured the imagination of the general public by their potential as new therapeutic tools in the fight against degenerative diseases. This potential is based on their capability for self-renewal and at the same time for producing progenitor cells that will eventually provide the building blocks for tissue and organ regeneration. These processes are carefully orchestrated in the organism by means of a series of molecular cues. An emerging molecule which is responsible for some of these physiological responses is adrenomedullin, a 52-amino acid regulatory peptide which increases proliferation and regulates cell fate of stem cells of different origins. Adrenomedullin binds to specific membrane receptors in stem cells and induces several intracellular pathways such as those involving cAMP, Akt, or MAPK. Regulation of adrenomedullin levels may help in directing the growth and differentiation of stem cells for applications (e.g., cell therapy) both in vitro and in vivo. © 2012 Elsevier Inc.Peer Reviewe

Flexible Ceramic Film Sensors for Free-Form Devices

Recent technological innovations, such as material printing techniques and surface functionalization, have significantly accelerated the development of new free-form sensors for next-generation flexible, wearable, and three-dimensional electronic devices. Ceramic film sensors, in particular, are in high demand for the production of reliable flexible devices. Various ceramic films can now be formed on plastic substrates through the development of low temperature fabrication processes for ceramic films, such as photocrystallization and transferring methods. Among flexible sensors, strain sensors for precise motion detection and photodetectors for biomonitoring have seen the most research development, but other fundamental sensors for temperature and humidity have also begun to grow. Recently, flexible gas and electrochemical sensors have attracted a lot of attention from a new real-time monitoring application that uses human breath and perspiration to accurately diagnose presymptomatic states. The development of a low-temperature fabrication process of ceramic film sensors and related components will complete the chemically stable and reliable free-form sensing devices by satisfying the demands that can only be addressed by flexible metal and organic components