The swift unravelling: party system change and de-institutionalization in Greece during the crisis

The chapter offers a detailed discussion of the radical transformation of the Greek party system since the beginning of the economic crisis in the country in early 2010. By comparing the Greek party system before and after the onset of the crisis, the argument is put forth that the Greek party system has transformed rapidly and profoundly on most meaningful dimensions: the number of parties and the overall fragmentation of the system, the degree of electoral volatility, the type of governments, the dimensions and logic of party competition, the degree of polarization, the reintroduction of centrifugal dynamics and, generally, the degree of institutionalization of the party system. On many of these dimensions, the economic crisis arguably acted as a catalyst, pushing the Greek party system to make a sudden leap towards the same direction that other Western parties also moved, albeit in more gradual, incremental steps.info:eu-repo/semantics/acceptedVersio

Losers of globalization, losers in representation? The impact of education on unequal policy representation in Europe

The article focuses on the impact of education on policy representation. It examines degrees of congruence between political elites and citizens on policy preferences across different policy issues, trying to discern whether there is a representation gap between the so-called “winners” and “losers” of globalization in Europe as captured via the proxy measure of educational attainment. Additionally, we examine whether this representation gap, as well as overall levels of congruence, are affected by contextual factors related to the economy and the ideological orientation of governments. Using data from the 2014 European Election Studies and the 2014 Chapel Hill Expert Survey, our findings largely confirm the existence of a representation gap along educational lines. Contextual factors related to the economy present weak or no direct and moderating effects whereas ideologically left-leaning governments accentuate, for the most part, the representation gap between individuals of low and high educational attainment.info:eu-repo/semantics/publishedVersio

Advanced Modalizing Problems

I present an internal problem for David Lewis’s genuine modal realism. My aim is to show that his analysis of modality is inconsistent with his metaphysics. I consider several ways of modifying the Lewisian analysis of modality, but argue that none are successful. I argue that the problem also affects theories related to genuine modal realism, including the stage theory of persistence and modal fictionalism

IQ in children with autism spectrum disorders: data from the Special Needs and Autism Project (SNAP)

Background Autism spectrum disorder (ASD) was once considered to be highly associated with intellectual disability and to show a characteristic IQ profile, with strengths in performance over verbal abilities and a distinctive pattern of ‘peaks’ and ‘troughs’ at the subtest level. However, there are few data from epidemiological studies. Method Comprehensive clinical assessments were conducted with 156 children aged 10–14 years [mean (s.d.)=11.7 (0.9)], seen as part of an epidemiological study (81 childhood autism, 75 other ASD). A sample weighting procedure enabled us to estimate characteristics of the total ASD population. Results Of the 75 children with ASD, 55% had an intellectual disability (IQIQ>85) but only 3% were of above average intelligence (IQ>115). There was some evidence for a clinically significant Performance/Verbal IQ (PIQ/VIQ) discrepancy but discrepant verbal versus performance skills were not associated with a particular pattern of symptoms, as has been reported previously. There was mixed evidence of a characteristic subtest profile: whereas some previously reported patterns were supported (e.g. poor Comprehension), others were not (e.g. no ‘peak’ in Block Design). Adaptive skills were significantly lower than IQ and were associated with severity of early social impairment and also IQ. Conclusions In this epidemiological sample, ASD was less strongly associated with intellectual disability than traditionally held and there was only limited evidence of a distinctive IQ profile. Adaptive outcome was significantly impaired even for those children of average intelligence

ID1 and ID3 Regulate the Self-Renewal Capacity of Human Colon Cancer-Initiating Cells through p21

SummaryThere is increasing evidence that some cancers are hierarchically organized, sustained by a relatively rare population of cancer-initiating cells (C-ICs). Although the capacity to initiate tumors upon serial transplantation is a hallmark of all C-ICs, little is known about the genes that control this process. Here, we establish that ID1 and ID3 function together to govern colon cancer-initiating cell (CC-IC) self-renewal through cell-cycle restriction driven by the cell-cycle inhibitor p21. Regulation of p21 by ID1 and ID3 is a central mechanism preventing the accumulation of excess DNA damage and subsequent functional exhaustion of CC-ICs. Additionally, silencing of ID1 and ID3 increases sensitivity of CC-ICs to the chemotherapeutic agent oxaliplatin, linking tumor initiation function with chemotherapy resistance

Brief Report: The Use of WAIS-III in Adults with HFA and Asperger Syndrome

The WAIS III was administered to 16 adults with high functioning autism (HFA) and 27 adults with Asperger syndrome. Differences between Verbal Intelligence (VIQ) and Performance Intelligence (PIQ) were not found. Processing Speed problems in people with HFA appeared. At the subtest level, the Asperger syndrome group performed weak on Digit Span. Comprehension and Block Design were relative strengths. In the HFA group, performance on Digit-Symbol Coding and Symbol Search was relatively poor. Strengths were found on Information and Matrix Reasoning. The results suggest that the VIQ-PIQ difference cannot distinguish between HFA and Asperger syndrome. WAIS III Factor Scale and Subtest patterning provides a more valid indicator

Ovarian follicular cells have innate immune capabilities that modulate their endocrine function

Oestrogens are pivotal in ovarian follicular growth, development and function, with fundamental roles in steroidogenesis, nurturing the oocyte and ovulation. Infections with bacteria such as Escherichia coli cause infertility in mammals at least in part by perturbing ovarian follicle function, characterised by suppression of oestradiol production. Ovarian follicle granulosa cells produce oestradiol by aromatisation of androstenedione from the theca cells, under the regulation of gonadotrophins such as FSH. Many of the effects of E. coli are mediated by its surface molecule lipopolysaccharide (LPS) binding to the Toll-like receptor-4 (TLR4), CD14, MD-2 receptor complex on immune cells, but immune cells are not present inside ovarian follicles. The present study tested the hypothesis that granulosa cells express the TLR4 complex and LPS directly perturbs their secretion of oestradiol. Granulosa cells from recruited or dominant follicles are exposed to LPS in vivo and when they were cultured in the absence of immune cell contamination in vitro they produced less oestradiol when challenged with LPS, although theca cell androstenedione production was unchanged. The suppression of oestradiol production by LPS was associated with down-regulation of transcripts for aromatase in granulosa cells, and did not affect cell survival. Furthermore, these cells expressed TLR4, CD14 and MD-2 transcripts throughout the key stages of follicle growth and development. It appears that granulosa cells have an immune capability to detect bacterial infection, which perturbs follicle steroidogenesis, and this is a likely mechanism by which ovarian follicle growth and function is perturbed during bacterial infection

Performance analysis of multi-hop framed ALOHA systems with virtual antenna arrays

We consider a multi-hop virtual multiple-input-multiple-output system, which uses the framed ALOHA technique to select the radio resource at each hop. In this scenario, the source, destination and relaying nodes cooperate with neighboring devices to exploit spatial diversity by means of the concept of virtual antenna array. We investigate both the optimum number of slots per frame in the slotted structure and once the source-destination distance is fixed, the impact of the number of hops on the system performance. A comparison with deterministic, centralized re-use strategies is also presented. Outage probability, average throughput, and energy efficiency are the metrics used to evaluate the performance. Two approximated mathematical expressions are given for the outage probability, which represent lower bounds for the exact metric derived in the paper