126 research outputs found

    Community structure of pelagic copepods in the eastern tropical Pacific Ocean during summer and autumn.

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    The Eastern Tropical Pacific Ocean (ETPO) is a region of interest for commercial fisheries but is subject to high oceanographic variability, which affects primary and secondary production. Because pelagic copepods contribute significantly to secondary productivity, they were investigated to examine community structure variation both temporally and spatially. Zooplankton samples were collected from August to December 2003 using a bongo net (333 µm in mesh size). Ninety-six zooplankton samples were analysed, recording 94 copepod species from orders Calanoida, Cyclopoida, Harpacticoida and Poecilostomatoida. The study area could be divided into six geographical zones based on the numerically dominant species. The oceanographic conditions were relatively stable during summer and autumn. Total copepod abundance was higher (47,096 to 62,681 ind.100 m-3) in stations near the coast, mostly in southern Baja California and the Gulf of Tehuantepec; the lowest densities were recorded towards the study area's oceanic regions. Similarly, ecological diversity was higher in zones influenced by tropical mass waters. The biogeographical affinity of copepod species was dominated by tropical species (75.5%), whereas subtropical and temperate species were far less abundant (15.7 and 8.6%, respectively).Versión del editor0,708

    Helping pregraduate students reach deep understanding of the second law of thermodynamics

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    Pregraduate students often have low success expectations toward their thermodynamics courses, which are often considered too abstract and remarkably difficult to understand. For this reason, they may not even try to reach any level of comprehension while settling for reproducing mathematical calculations and memorizing definitions to pass the exams. Traditional lectures on thermodynamics, focusing on mathematical deductions while neglecting the qualitative characterization of the concepts behind the equations, do not help in this respect. Aiming at a change in the teaching practice and focused on the second law of thermodynamics, the main goals of this work are to characterize the way of reasoning of the expert; to present a review on the most important learning difficulties encountered by students and categorize them into three groups: the disregard of qualitative understanding, the inherent conceptual difficulties, and those related to the students’ previous knowledge; and to propose some suitable teaching practices to assist instructors in this difficult but rewarding task

    Alignment of galaxy spins in the vicinity of voids

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    We provide limits on the alignment of galaxy orientations with the direction to the void center for galaxies lying near the edges of voids. We locate spherical voids in volume limited samples of galaxies from the Sloan Digital Sky Survey using the HB inspired void finder and investigate the orientation of (color selected) spiral galaxies that are nearly edge-on or face-on. In contrast with previous literature, we find no statistical evidence for departure from random orientations. Expressed in terms of the parameter c, introduced by Lee & Pen to describe the strength of such an alignment, we find that c<0.11(0.13) at 95% (99.7%) confidence limit within a context of a toy model that assumes a perfectly spherical voids with sharp boundaries.Comment: 8 pages, 4 figures; v2 discussion expanded, references fixed, matches version accepted by JCA

    Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide

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    Reactive oxygen and nitrogen species have been implicated in the loss of skeletal muscle mass and function that occurs during aging. Nitric oxide (NO) and superoxide are generated by skeletal muscle and where these are generated in proximity their chemical reaction to form peroxynitrite can compete with the superoxide dismutation to hydrogen peroxide. Changes in NO availability may therefore theoretically modify superoxide and peroxynitrite activities in tissues, but published data are contradictory regarding aging effects on muscle NO availability. We hypothesised that an age-related increase in NO generation might increase peroxynitrite generation in muscles from old mice, leading to an increased nitration of muscle proteins and decreased superoxide availability. This was examined using fluorescent probes and an isolated fiber preparation to examine NO content and superoxide in the cytosol and mitochondria of muscle fibers from adult and old mice both at rest and following contractile activity. We also examined the 3-nitrotyrosine (3-NT) and peroxiredoxin 5 (Prx5) content of muscles from mice as markers of peroxynitrite activity. Data indicate that a substantial age-related increase in NO levels occurred in muscle fibers during contractile activity and this was associated with an increase in muscle eNOS. Muscle proteins from old mice also showed an increased 3-NT content. Inhibition of NOS indicated that NO decreased superoxide bioavailability in muscle mitochondria, although this effect was not age related. Thus increased NO in muscles of old mice was associated with an increased 3-NT content that may potentially contribute to age-related degenerative changes in skeletal muscle

    The Position of High Frequency Waves with Respect to the Granulation Pattern

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    High frequency velocity oscillations were observed in the spectral lines Fe I 543.45nm and 543.29nm, using 2D spectroscopy with a Fabry- Perot and speckle reconstruction, at the VTT in Tenerife. We investigate the radial component of waves with frequencies in the range 8 - 22mHz in the internetwork, network and a pore. We find that the occurrence of waves do not show any preference on location and are equally distributed over down-flows and up-flows, regardless of the activity of the observed area in the line of Fe I 543.45nm. The waves observed in the lower formed line of Fe I 543.29nm seem to appear preferentially over down-flows.Comment: Article has 12 pages and 7 images. It is accepted in Solar Physics Journa

    Recessive dystrophic epidermolysis bullosa: the origin of the c.6527insC mutation in the Spanish population

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    This work was supported by grants from the Spanish Ministry of Science and Innovation (MICINN) (SAF2007-61019 and SAF 2010-16976), INTRA ⁄08 ⁄714.1 and INTRA ⁄09 ⁄758 from the Biomedical Network Research Centre on Rare Diseases (CIBERER) and S2010 ⁄BMD-2420 (CELLCAM) from Comunidad de Madrid

    Magnetic field diagnostics and spatio-temporal variability of the solar transition region

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    Magnetic field diagnostics of the transition region from the chromosphere to the corona faces us with the problem that one has to apply extreme UV spectro-polarimetry. While for coronal diagnostic techniques already exist through infrared coronagraphy above the limb and radio observations on the disk, for the transition region one has to investigate extreme UV observations. However, so far the success of such observations has been limited, but there are various projects to get spectro-polarimetric data in the extreme UV in the near future. Therefore it is timely to study the polarimetric signals we can expect for such observations through realistic forward modeling. We employ a 3D MHD forward model of the solar corona and synthesize the Stokes I and Stokes V profiles of C IV 1548 A. A signal well above 0.001 in Stokes V can be expected, even when integrating for several minutes in order to reach the required signal-to-noise ratio, despite the fact that the intensity in the model is rapidly changing (just as in observations). Often this variability of the intensity is used as an argument against transition region magnetic diagnostics which requires exposure times of minutes. However, the magnetic field is evolving much slower than the intensity, and thus when integrating in time the degree of (circular) polarization remains rather constant. Our study shows the feasibility to measure the transition region magnetic field, if a polarimetric accuracy on the order of 0.001 can be reached, which we can expect from planned instrumentation.Comment: Accepted for publication in Solar Physics (4.Mar.2013), 19 pages, 9 figure

    Global methylome scores correlate with histological subtypes of colorectal carcinoma and show different associations with common clinical and molecular features

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    Background. The typical methylation patterns associated with cancer are hypermethylation at gene promoters and global genome hypomethylation. Aberrant CpG island hypermethylation at promoter regions and global genome hypomethylation have not been associated with histological colorectal carcinomas (CRC) subsets. Using Illumina’s 450 k Infinium Human Methylation beadchip, the methylome of 82 CRCs were analyzed, comprising different histological subtypes: 40 serrated adenocarcinomas (SAC), 32 conventional carcinomas (CC) and 10 CRCs showing histological and molecular features of microsatellite instability (hmMSI‐H), and, additionally, 35 normal adjacent mucosae. Scores reflecting the overall methylation at 250 bp, 1 kb and 2 kb from the transcription starting site (TSS) were studied. Results. SAC has an intermediate methylation pattern between CC and hmMSI‐H for the three genome locations. In addition, the shift from promoter hypermethylation to genomic hypomethylation occurs at a small sequence between 250 bp and 1 Kb from the gene TSS, and an asymmetric distribution of methylation was observed between both sides of the CpG islands (N vs. S shores). Conclusion. These findings show that different histological subtypes of CRC have a particular global methylation pattern depending on sequence distance to TSS and highlight the so far underestimated importance of CpGs aberrantly hypomethylated in the clinical phenotype of CRCs.This work was supported by two grants from Instituto de Salud Carlos III, Ministerio de Sanidad, Spain and FEDER funds (refs: PI12-1232, PI18-0144) and another from the European Union’s Horizon 2020 research and innovation program (ref. 848098

    Numerical resolution of the hyperbolic heat equation using smoothed mathematical functions instead of Heaviside and Dirac delta distributions

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    The hyperbolic bioheat equation (HBE) has been used to model heating applications involving very short power pulses. This equation includes two mathematical distributions (Heaviside and Delta) which have to be necessarily substituted for smoothed mathematical functions when the HBE is solved by numerical methods. This study focuses on which type of smoothed functions would be suitable for this purpose, i.e. those which would provide solutions similar to those obtained analytically from the original Heaviside and Delta distributions. The logistic function was considered as a substitute for the Heaviside function, while its derivative and the probabilistic Gaussian function were considered as substitutes for the Delta distribution. We also considered polynomial interpolation functions, in particular, the families of smoothed functions with continuous second derivative without overshoot used by COMSOL Multiphysics. All the smoothed functions were used to solve the HBE by the Finite Element Method (COMSOL Multiphysics), and the solutions were compared to those obtained analytically from the original Heaviside and Delta distributions. The results showed that only the COMSOL smoothed functions provide a numerical solution almost identical to the analytical one. Finally, we demonstrated mathematically that in order to find a suitable smoothed function (f) that must adequately substitute any mathematical distribution (D) in the HBE, the difference D - f must have compact support. (c) 2013 Elsevier Ltd. All rights reserved.This work received financial support from the Spanish "Plan Nacional de I + D + I del Ministerio de Ciencia e Innovacion" Grant No. TEC2011-27133-C02-01 and from Universitat Politenica de Valencia (PAID-06-11 Ref. 1988). V. Romero Garcia is grateful for the support of "Programa de Contratos Post-Doctorales con Movilidad UPV del Campus de Excelencia (CEI-01-11)" and FEDER Project MAT2009-09438.Rivera Ortun, MJ.; Trujillo Guillen, M.; Romero García, V.; López Molina, JA.; Berjano Zanón, E. (2013). Numerical resolution of the hyperbolic heat equation using smoothed mathematical functions instead of Heaviside and Dirac delta distributions. International Communications in Heat and Mass Transfer. 46:7-12. https://doi.org/10.1016/j.icheatmasstransfer.2013.05.017S7124
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