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A novel NGS library preparation method to characterize native termini of fragmented DNA.
Biological and chemical DNA fragmentation generates DNA molecules with a variety of termini, including blunt ends and single-stranded overhangs. We have developed a Next Generation Sequencing (NGS) assay, XACTLY, to interrogate the termini of fragmented DNA, information traditionally lost in standard NGS library preparation methods. Here we describe the XACTLY method, showcase its sensitivity and specificity, and demonstrate its utility in in vitro experiments. The XACTLY assay is able to report relative abundances of all lengths and types (5' and 3') of single-stranded overhangs, if present, on each DNA fragment with an overall accuracy between 80-90%. In addition, XACTLY retains the sequence of each native DNA molecule after fragmentation and can capture the genomic landscape of cleavage events at single nucleotide resolution. The XACTLY assay can be applied as a novel research and discovery tool for fragmentation analyses and in cell-free DNA
Why Incorporating a Platform-Intermediary can Increase Crowdsourceesâ Engagement - Case-Study Based Insights
While the crowdsourcerâs job is to encourage valuable contributions and sustained commitment in a cost- effective manner, it seems as if the primary attention of management and research is still centered on the evaluation of contributions rather than the crowd. As many crowd- sourcers lack the resources to successfully execute such projects, crowdsourcing intermediaries play an increas- ingly important role. First studies dealt with internal management challenges of incorporating an intermediary. However, the issue of how intermediaries influence crowdsourceesâ psychological and behavioral responses, further referred to as engagement, has not been addressed yet. Consequently, two leading research questions guide this paper: (1) How can the engagement process of crowdsourcees be conceptualized? (2) How and why do crowdsourcing intermediaries impact crowdsourceesâ engagement? This study extends existing knowledge by offering IS-researchers a process perspective on engage- ment and exploring the underlying mechanisms and IT- enabled stimuli that foster value-creation in a mediated and non-mediated setting. A theoretical process model is first conceptualized and then explored with insights from two common cases in the growing field of crowd testing. By triangulating platform and interview data, initial proposi- tions concerning the role of specific stimuli and the inter- mediary within the engagement process are derived. It is proposed that crowdsourcing enterprises, incorporating intermediaries, have the potential to generate a desired engagement state when perceived stimuli under their con- trol belong to the so-called group of ââgame changersââ and ââvalue addersââ, while the intermediary controls mainly âârisk factorsââ for absorbing negative experiences. Apart from the theoretical relevance of studying mediated engagement processes and explaining voluntary use and participation in a socio-technical system, findings support decisions on how to effectively incorporate platform intermediaries
Magma Ascent along a Major Terrane Boundary: Crustal Contamination and Magma Mixing at the Drumadoon Intrusive Complex, Isle of Arran, Scotland
The composite intrusions of Drumadoon and An Cumhann crop out on the SE coast of the Isle of Arran, Scotland and form part of the larger British and Irish Palaeogene Igneous Province, a subset of the North Atlantic Igneous Province. The intrusions (shallow-level dykes and sills) comprise a central quartz-feldspar-phyric rhyolite flanked by xenocryst-bearing basaltic andesite, with an intermediate zone of dark quartz-feldspar-phyric dacite. New geochemical data provide information on the evolution of the component magmas and their relationships with each other, as well as their interaction with the crust through which they travelled. During shallow-crustal emplacement, the end-member magmas mixed. Isotopic evidence shows that both magmas were contaminated by the crust prior to mixing; the basaltic andesite magma preserves some evidence of contamination within the lower crust, whereas the rhyolite mainly records upper-crustal contamination. The Highland Boundary Fault divides Arran into two distinct terranes, the Neoproterozoic to Early Palaeozoic Grampian Terrane to the north and the Palaeozoic Midland Valley Terrane to the south. The Drumadoon Complex lies within the Midland Valley Terrane but its isotopic signatures indicate almost exclusive involvement of Grampian Terrane crust. Therefore, although the magmas originated at depth on the northern side of the Highland Boundary Fault, they have crossed this boundary during their evolution, probably just prior to emplacemen
Influence of Humidity on Ultraviolet Injury
High humidity enhances the injurious effect of ultraviolet radiation. This was demonstrated in experiments in which hairless mice were irradiated with Westinghouse FS-40-T-12 sunlamps while maintained in an environmental chamber allowing controlled conditions of relative humidity and temperature. Hairless mice given 10 MED (minimal erythemal dose) while maintained at 80% relative humidity had markedly greater exfoliation, crusting, and erosion of skin than did mice maintained at 5% and 10% relative humidity. Animals kept at 50% humidity had damage intermediate to those kept at high and low humidity. These morphologic observations were confirmed histologically.Additionally, water immersion enhances ultraviolet injury. Animals immersed in water for 6 hr prior to irradiation with 3 MED had more damage than animals irradiated but not immersed. Similarly, albino rabbits irradiated with 300 nm radiation from a xenon arc grating monochrometer had lower erythemal energy requirements on that part of their skin that had been hydrated with wet packs compared to nonhydrated skin
Controlled Irradiative Formation of Penitentes
Spike-shaped structures are produced by light-driven ablation in very
different contexts. Penitentes 1-4 m high are common on Andean glaciers, where
their formation changes glacier dynamics and hydrology. Laser ablation can
produce cones 10-100 microns high with a variety of proposed applications in
materials science. We report the first laboratory generation of
centimeter-scale snow and ice penitentes. Systematically varying conditions
allows identification of the essential parameters controlling the formation of
ablation structures. We demonstrate that penitente initiation and coarsening
requires cold temperatures, so that ablation leads to sublimation rather than
melting. Once penitentes have formed, further growth of height can occur by
melting. The penitentes intially appear as small structures (3 mm high) and
grow by coarsening to 1-5 cm high. Our results are an important step towards
understanding and controlling ablation morphologies.Comment: Accepted for publication in Physical Review Letter
Petrogenesis of the Loch BĂ ring-dyke and Centre 3 granites, Isle of Mull, Scotland
The project was supported by Science Foundation Ireland (SFI), the Royal Irish Academy (RIA) and by the Swedish Research Council (VR). Open Access funding provided by Uppsala University.The Loch BĂ ring-dyke and the associated Centre 3 granites represent the main events of the final phase of activity at the Palaeogene Mull igneous complex. The Loch BĂ ring-dyke is one of the best exposed ring-intrusions in the world and records intense interaction between rhyolitic and basaltic magma. To reconstruct the evolutionary history of the Centre 3 magmas, we present new major- and trace-element, and new Sr isotope data as well as the first Nd and Pb isotope data for the felsic and mafic components of the Loch BĂ intrusion and associated Centre 3 granites. We also report new Sr, Nd and Pb isotope data for the various crustal compositions from the region, including Moine and Dalradian metasedimentary rocks, Lewisian gneiss, and Iona Group metasediments. Isotope data for the Loch BĂ rhyolite (87Sr/86Sri = 0.716) imply a considerable contribution of local Moine-type metasedimentary crust (87Sr/86Sr = 0.717â0.736), whereas Loch BĂ mafic inclusions (87Sr/86Sri = 0.704â0.707) are closer to established mantle values, implying that felsic melts of dominantly crustal origin mixed with newly arriving basalt. The Centre 3 microgranites (87Sr/86Sri = 0.709â0.716), are less intensely affected by crustal assimilation relative to the Loch BĂĄ rhyolite. Pb-isotope data confirm incorporation of Moine metasediments within the Centre 3 granites. Remarkably, the combined SrâNdâPb data indicate that Centre 3 magmas record no detectable interaction with underlying deep Lewisian gneiss basement, in contrast to Centre 1 and 2 lithologies. This implies that Centre 3 magmas ascended through previously depleted or insulated feeding channels into upper-crustal reservoirs where they resided within and interacted with fertile Moine-type upper crust prior to eruption or final emplacement.Publisher PDFPeer reviewe
Dissipative chaotic scattering
We show that weak dissipation, typical in realistic situations, can have a
metamorphic consequence on nonhyperbolic chaotic scattering in the sense that
the physically important particle-decay law is altered, no matter how small the
amount of dissipation. As a result, the previous conclusion about the unity of
the fractal dimension of the set of singularities in scattering functions, a
major claim about nonhyperbolic chaotic scattering, may not be observable.Comment: 4 pages, 2 figures, revte
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