MIMAC : Detection of low energy recoils for Dark Matter search

The MIMAC project is based on a matrix of Micro Time Projection Chambers (micro-TPC) for Dark Matter search, filled with He3 or CF4 and using ionization and tracks. The first measurement of the energy resolution of this micro-TPC is presented as well as its low thresholdComment: Dark Energy and Dark Matter conference, Lyon : France (2008

MIMAC : a micro-TPC detector for non-baryonic dark matter search

The MIMAC project is multi-chamber detector for Dark Matter search, aiming at measuring both track and ionization with a matrix of micromegas micro-TPC filled with He3 and CF4. Recent experimental results on the first measurements of the Helium quenching factor at low energy (1 keV recoil) are presented.Comment: 7 pages, Proc of Dark Energy and Dark Matter conference, Lyon : France (2008

TRAIL receptor signaling and therapeutic option in bone tumors: the trap of the bone microenvironment

Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) has been reported to specifically induce malignant cell death being relatively nontoxic to normal cells. Since its identification 15 years ago, the antitumor activity and therapeutic value of TRAIL have been extensively studied. Five receptors quickly emerged, two of them being able to induce programmed cell death in tumor cells. This review takes a comprehensive look at this ligand and its receptors, and its potential role in primary bone tumors (osteosarcoma and Ewing's sarcoma) therapy. The main limit of clinical use of TRAIL being the innate or acquired resistance mechanisms, different possibilities to sensitize resistant cells are discussed in this review, together with the impact of bone microenvironment in the regulation of TRAIL activity

CHALLENGES OF DYNAMIC SIMULATION OF HIGH-SPEED ELECTROMAGNETIC VALVES OF GAS DISTRIBUTION DEVICES

High-speed electromagnetic valves of gas distribution devices are used in modern missile and space technology as jet micro-motors of the executive elements of missile stabilization systems, as well as to control the movement of spacecrafts in space. The problem of creating such valves which are simple and reliable in the operation is relevant. In this work, it is proposed at the development and design stage to perform computer modelling of mutually coupled electromechanical processes, such as: distribution of transient electromagnetic field, transients in an electric circuit, and movement of an electromagnet armature. Besides, the calculation of the force with which the compressed gas acts on the corresponding structural elements of the valve is proposed to be performed by solving the system of Navier-Stokes equations. All problems are solved by numerical methods in axisymmetrical formulation with the corresponding initial and boundary conditions. Improvement of the accuracy of electromagnetic calculations and taking into account the movement of the armature of an electromagnet in the process of multiphysics numerical simulation is achieved using so-called tunable elastic meshes. The paper presents a comparative analysis of the numerical results obtained for several designs of electromagnets. The features of the dynamics of high-speed electromagnets of gas distribution valves during on and off operations are analyzed, the corresponding dynamic characteristics calculated using the proposed technique are presented. Быстродействующие электромагнитные клапаны газораспределительных устройств применяются в современной ракетно-космической технике в качестве реактивных микродвигателей исполнительных органов систем стабилизации ракет, а также для управления движением космическими летательными аппаратами в пространстве. Проблема создания простых в эксплуатации и надежных в работе указанных клапанов является актуальной. В настоящей работе предлагается на стадии разработки и проектирования выполнять компьютерное моделирование взаимосвязанных электромеханических процессов, таких как: распределение нестационарного электромагнитного поля, переходные процессы в электрической цепи, движение якоря электромагнита. При этом расчет силы, с которой сжатый газ действует на соответствующие конструктивные элементы клапана, предлагается выполнять путем решения системы уравнений Навье-Стокса. Все задачи решаются численными методами в осесимметричной постановке с соответствующими начальными и граничными условиями. Повышение точности электромагнитных расчетов и учет движения якоря электромагнита в процессе мультифизического численного моделирования достигается благодаря использованию так называемых перестраиваемых упругих сеток. В работе приведен сравнительный анализ численных результатов, полученных для нескольких конструкций электромагнитов. Проанализированы особенности динамики быстродействующих электромагнитов газораспределительных клапанов при выполнении операций включения и отключения, приведены соответствующие динамические характеристики, рассчитанные по предложенной методике.

Ionization Quenching Factor Measurement of Helium 4

The ionization quenching factor (IQF) is defined as the fraction of energy released by a recoil in a medium through ionization compared with its total kinetic energy. At low energies, in the range of a few keV, the ionization produced in a medium falls rapidly and systematic measurements are needed. We report measurements carried out at such low energies as a function of the pressure in He4 at 350, 700, 1000 and 1300 mbar. In order to produce a nucleus moving with a controlled energy in the detection volume, we have developed an Electron Cyclotron Resonance Ion Source (ECRIS) coupled to an ionization chamber by a differential pumping. The quenching factor of He4 has been measured for the first time down to 1 keV recoil energies. An important deviation with respect to the phenomenological calculations has been found allowing an estimation of the scintillation produced in He4 as a function of pressure. The variation of the IQF as a function of the percentage of isobutane, used as quencher, is also presented

Novel recoil nuclei detectors to qualify the AMANDE facility as a Standard for mono-energetic neutron fields

The AMANDE facility at IRSN-Cadarache produces mono-energetic neutron fields from 2 keV to 20 MeV with metrological quality. To be considered as a standard facility, characteristics of neutron field i.e fluence distribution must be well known by a device using absolute measurements. The development of new detector systems allowing a direct measurement of neutron energy and fluence has started in 2006. Using the proton recoil telescope principle with the goal of increase the efficiency, two systems with full localization are studied. A proton recoil telescope using CMOS sensor (CMOS-RPT) is studied for measurements at high energies and the helium 4 gaseous micro-time projection chamber (microTPC He4) will be dedicated to the lowest energies. Simulations of the two systems were performed with the transport Monte Carlo code MCNPX, to choose the components and the geometry, to optimize the efficiency and detection limits of both devices or to estimate performances expected. First preliminary measurements realised in 2008 demonstrated the proof of principle of these novel detectors for neutron metrology.Comment: to appear in Radiation Measurements, Proc. of 24th International Conference on Nuclear Tracks in Solids (Bologna, 1-5 September 2008

Calcifediol is a safe and effective metabolite for raising vitamin D status and improving growth and feed conversion in rainbow trout

The vitamin D endocrine system is required for the transcriptional regulation of a myriad of vertebrate genes including those involved in bone health, growth, nutrient metabolism and immunity. The requirements of salmonids for vitamin D are amongst the highest for any aquaculture species. With nuances, the metabolism of the pre-vitamin cholecalciferol (D3) via calcifediol (25-OH-D3), required to produce the physiologically active hormone calcitriol (1,25-OH-D3) is conserved in fish. The composition of modern aquafeeds, growth in seawater and production challenges, such as disease, may result in the suboptimal biochemical activation of vitamin D hormone in fish. A 91-day experimental feeding trial was used to test the safety and efficacy of calcifediol for the supply of vitamin D to rainbow trout with an initial body weight of 57.6 g. A practical diet containing cholecalciferol within recommended levels (5240 IU) was supplemented with either 69.8, 687 or 6854 μg/kg calcifediol. The efficacy of calcifediol was determined by the assessment of zootechnical performance and the appearance of vitamin D metabolites in the blood. The safety of the dietary interventions was assessed from generic health indices, examination of gross pathologies, hematology, and blood chemistry. Test fish increased body weight at least 5.6-fold to 323.5 g over the experimental feeding period. The supplementation of 687 or 6854 μg/kg calcifediol resulted in significant improvements in growth rate and feed conversion (FCR). Whilst not detectable in control fish, calcifediol increased linearly according to dietary levels in the blood and to a lesser extent in the white muscle. The increases of calcifediol in the blood were accompanied by saturable increases of circulating active vitamin D. At the end of the 91-day feeding period, survival was 100%, no gross pathologies relating to the diets were observed, and health indices, hematology, and blood chemistry, including calcium and phosphorus, were not significantly altered. The supplementation of calcifediol to practical diets containing recommended levels of cholecalciferol improves zootechnical performance and ensures that maximal levels of active vitamin D are present in the blood to meet physiological demands. With a lack of significant effects on health indices, hematology, and blood chemistry, including calcium and phosphorus, the tested high doses of calcifediol are concluded to be safe for salmonids

Robust, tunable, and high purity triggered single photon source at room temperature using a nitrogen-vacancy defect in diamond in an open microcavity

We report progress in the development of tunable room temperature triggered single photon sources based on single nitrogen-vacancy (NV) centres in nanodiamond coupled to open access optical micro-cavities. The feeding of fluorescence from an NV centre into the cavity mode increases the spectral density of the emission and results in an output stream of triggered single photons with spectral line width of order 1 nm, tunable in the range 640 - 700 nm. We record single photon purities exceeding 96% and estimated device efficiencies up to 3%. We compare performance using plano-concave microcavities with radii of curvature from 25 mu m to 4 mu m and show that up to 17% of the total emission is fed into the TEM00 mode. Pulsed Hanbury-Brown Twiss (HBT) interferometry shows that an improvement in single photon purity is facilitated due to the increased spectral density. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License

Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate

Introduction Repair of large bone defects remains a significant clinical challenge. Bone marrow stromal cells (BMSCs), a subset of which is known as bone marrow-derived mesenchymal stem cells, show therapeutic potential for bone regeneration. However, their isolation, expansion and implantation will need to be conducted under good manufacturing practices (GMP) at separate locations. An investigation which mimics this clinical scenario where large bone defects shall be regenerated is required before clinical trials can be initiated. Methods Seven batches of 100 million human ex-vivo expanded BMSCs from five donors were transported fresh in syringes from a GMP facility in Germany to France. BMSCs were mixed with biphasic calcium phosphate (BCP) biomaterial prior to subcutaneous implantation in nude mice. The capacity of BMSCs in unison with BCP to regenerate critical sized cranial bone defects was also evaluated. BMSCs expressing luciferase were used to assess the viability and bio-distribution of implanted cells. In situ hybridization, using the human-specific repetitive Alu sequence, was performed for the identification of human cells in explants. Results Eight weeks after implantation of BMSCs, mineralized bone containing mature bone marrow territories was formed in ectopic sites and in calvaria defects. Significant loss of cell viability was observed by bioluminescence imaging and only 1.5 percent of the initial number of transplanted cells remained after 37 days. After eight weeks, while explants were comprised primarily of host cells, there were also human cells attached along the periphery of BCP and embedded in osteocyte lacunae dispersed throughout the newly formed bone matrix. Conclusions This study demonstrates the safety and efficacy of BMSC/BCP combinations and provides crucial information for the implementation of BMSC therapy for bone regeneration