Potential and mass-matrix in gauged N=4 supergravity

We discuss the potential and mass-matrix of gauged N=4 matter coupled supergravity for the case of six matter multiplets, extending previous work by considering the dependence on all scalars. We consider all semi-simple gauge groups and analyse the potential and its first and second derivatives in the origin of the scalar manifold. Although we find in a number of cases an extremum with a positive cosmological constant, these are not stable under fluctuations of all scalar fields.Comment: 28 pages, LaTe

Einstein Brane-Worlds In 5D Gauged Supergravity

We study, in the context of five dimensional N=2 gauged supergravity with vector and hypermultiplets, curved domain wall solutions with worldvolumes given by four dimensional Einstein manifolds. For a choice of the projection condition on the Killing spinors of the BPS solutions, first order differential equations governing the flow of the scalars are derived. With these equations, we analyze the equations of motion and determine conditions under which gauged supergravity theories may admit Einstein domain wall solutions.Comment: Correcting Equation (3.29) and all changes following from this correction including some conclusion

Mapping the Potential Risk of Mycetoma Infection in Sudan and South Sudan Using Ecological Niche Modeling

In 2013, the World Health Organization (WHO) recognized mycetoma as one of the neglected tropical conditions due to the efforts of the mycetoma consortium. This same consortium formulated knowledge gaps that require further research. On

General Brane Geometries from Scalar Potentials: Gauged Supergravities and Accelerating Universes

We find broad classes of solutions to the field equations for d-dimensional gravity coupled to an antisymmetric tensor of arbitrary rank and a scalar field with non-vanishing potential. Our construction generates these configurations from the solution of a single nonlinear ordinary differential equation, whose form depends on the scalar potential. For an exponential potential we find solutions corresponding to brane geometries, generalizing the black p-branes and S-branes known for the case of vanishing potential. These geometries are singular at the origin with up to two (regular) horizons. Their asymptotic behaviour depends on the parameters of the model. When the singularity has negative tension or the cosmological constant is positive we find time-dependent configurations describing accelerating universes. Special cases give explicit brane geometries for (compact and non-compact) gauged supergravities in various dimensions, as well as for massive 10D supergravity, and we discuss their interrelation. Some examples lift to give new solutions to 10D supergravity. Limiting cases with a domain wall structure preserve part of the supersymmetries of the vacuum. We also consider more general potentials, including sums of exponentials. Exact solutions are found for these with up to three horizons, having potentially interesting cosmological interpretation. We give several additional examples which illustrate the power of our techniques.Comment: 54 pages, 6 figures. Uses JHEP3. Published versio

Supermembranes and Super Matrix Models

We review recent developments in the theory of supermembranes and their relation to matrix models.Comment: Invited lecture presented at the Corfu Workshop, September 20 - 26, 1998, of the TMR Project "Quantum Aspects of Gauge Theories, Supersymmetry and Unification" (ERBFMRXCT96-0045), to appear in the proceedings. Latex 41 p

Coupled oscillators as models of phantom and scalar field cosmologies

We study a toy model for phantom cosmology recently introduced in the literature and consisting of two oscillators, one of which carries negative kinetic energy. The results are compared with the exact phase space picture obtained for similar dynamical systems describing, respectively, a massive canonical scalar field conformally coupled to the spacetime curvature, and a conformally coupled massive phantom. Finally, the dynamical system describing exactly a minimally coupled phantom is studied and compared with the toy model.Comment: 18 pages, LaTeX, to appear in Physical Review

Accelerating Universes in String Theory via Field Redefinition

We study cosmological solutions in the effective heterotic string theory with $\alpha'$-correction terms in string frame. It is pointed out that the effective theory has an ambiguity via field redefinition and we analyze generalized effective theories due to this ambiguity. We restrict our analysis to the effective theories which give equations of motion of second order in the derivatives, just as "Galileon" field theory. This class of effective actions contains two free coupling constants. We find de Sitter solutions as well as the power-law expanding universes in our four-dimensional Einstein frame. The accelerated expanding universes are always the attractors in the present dynamical system.Comment: 22 pages, 3 figures, some additional formulae adde

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC

Recent work has demonstrated that nonstimulatory endogenous peptides can enhance T cell recognition of antigen, but MHCI- and MHCII-restricted systems have generated very different results. MHCII-restricted TCRs need to interact with the nonstimulatory peptide–MHC (pMHC), showing peptide specificity for activation enhancers or coagonists. In contrast, the MHCI-restricted cells studied to date show no such peptide specificity for coagonists, suggesting that CD8 binding to noncognate MHCI is more important. Here we show how this dichotomy can be resolved by varying CD8 and TCR binding to agonist and coagonists coupled with computer simulations, and we identify two distinct mechanisms by which CD8 influences the peptide specificity of coagonism. Mechanism 1 identifies the requirement of CD8 binding to noncognate ligand and suggests a direct relationship between the magnitude of coagonism and CD8 affinity for coagonist pMHCI. Mechanism 2 describes how the affinity of CD8 for agonist pMHCI changes the requirement for specific coagonist peptides. MHCs that bind CD8 strongly were tolerant of all or most peptides as coagonists, but weaker CD8-binding MHCs required stronger TCR binding to coagonist, limiting the potential coagonist peptides. These findings in MHCI systems also explain peptide-specific coagonism in MHCII-restricted cells, as CD4–MHCII interaction is generally weaker than CD8–MHCI.National Institutes of Health (U.S.). Pioneer Awar

Do soil fertilization and forest canopy foliage affect the growth and photosynthesis of Amazonian saplings?

Most Amazonian soils are highly weathered and poor in nutrients. Therefore, photosynthesis and plant growth should positively respond to the addition of mineral nutrients. Surprisingly, no study has been carried out in situ in the central Amazon to address this issue for juvenile trees. The objective of this study was to determine how photosynthetic rates and growth of tree saplings respond to the addition of mineral nutrients, to the variation in leaf area index of the forest canopy, and to changes in soil water content associated with rainfall seasonality. We assessed the effect of adding a slow-release fertilizer. We determined plant growth from 2010 to 2012 and gas exchange in the wet and dry season of 2012. Rainfall seasonality led to variations in soil water content, but it did not affect sapling growth or leaf gas exchange parameters. Although soil amendment increased phosphorus content by 60 %, neither plant growth nor the photosynthetic parameters were influenced by the addition of mineral nutrients. However, photosynthetic rates and growth of saplings decreased as the forest canopy became denser. Even when Amazonian soils are poor in nutrients, photosynthesis and sapling growth are more responsive to slight variations in light availability in the forest understory than to the availability of nutrients. Therefore, the response of saplings to future increases in atmospheric [CO2] will not be limited by the availability of mineral nutrients in the soil