11 research outputs found
Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry
- Author
- Abdelsayed A.A. (Abeer Abeer)
- Acosta A. (Adriana)
- Adams H. (Heath)
- Agostinho J. (João)
- Agostoni P. (Piergiuseppe)
- Airò E. (Edoardo)
- Al Dalaan A. (Abdullah)
- Alexandre M. (Myriam)
- Alexeeva D.E. (Dalyana Eduardovna)
- Alfetlawi M. (Monthir)
- Almagro R.M. (Raúl Menor)
- Alonso L.P. (Lecue Pilar)
- Altraja A. (Alan)
- Andreassen A.K. (Arne K.)
- Anton L. (Ly)
- Argiento P. (Paola)
- Arjona J.J. (Josefa Jiménez)
- Asencio I. (Isabel)
- Atas H. (Halil)
- Avdeev S.N. (Sergey Nikolaevich)
- Avilés F.F. (Francisco Fernandez)
- Badagliacca R. (Roberto)
- Baptista R. (Rui)
- Barberá J.A. (Joan A.)
- Barry L. (Lisa)
- Bartfay S.-E. (Sven-Erik)
- Batalina M.V. (Marina Vadimovna)
- Bauleo C. (Carolina)
- Blanco I. (Isabel)
- Bohacekova M. (Marcela)
- Boogaard H. (H.)
- Boomars K.A.T. (Karin)
- Boonstra A. (Anco)
- Bosio M. (Martin)
- Bruno N. (Noemi)
- Bukatova I.F. (Irina Fedorovna)
- Camacho R.C. (Rafael Conde)
- Campo F. (Felipe)
- Caneva J. (Jorge)
- Capinha M. (Marta)
- Cardoso T. (Tania)
- Castro G. (Graça)
- Cheng C.-C. (Chin-Chang)
- Chu C.Y. (Chun Yuan)
- Church C. (Colin)
- Cifrián Martínez J.M. (José Manuel)
- Conte L. (Luca)
- Correra A. (Anna)
- Corris P. (Paul)
- Costa S. (Serena)
- Cottin V. (Vincent)
- Coutinho D. (Daniel)
- Cresci C. (Chiara)
- Cuesta V.M. (Victor Mora)
- Cárdenas S.L. (Salvador López)
- D'Alto M. (Michele)
- D'Armini A.M. (Andrea Maria)
- De La Pava S. (Sebastian)
- De Luca A. (Anna)
- De Pauw M. (Michel)
- Delcroix M. (Marion)
- Deleo S. (Sabino)
- Di Marco G.M. (Giovanni Maria)
- Diez M. (Mirta)
- Dwyer N. (Nathan)
- Egenlauf B. (Benjamin)
- Elias T. (Teresa)
- Escribano Subías P. (Pilar)
- Espinha M. (Mafalda)
- Evrard P. (Patrick)
- Ewert R. (Ralf)
- Fanaridis M. (Michail)
- Farina S. (Stefania)
- Farkasova I. (Iveta)
- Farruggio S. (Silvia)
- Feenstra J. (John)
- Feistmantl L.-T. (Lisa-Theresa)
- Fernandez D.I. (David Iturbe)
- Filippov E.V. (Evgeny Vladimirovich)
- Fong M.-C. (Man-Cai)
- Gaine S. (Sean)
- Galgano G. (Giuseppe)
- Gall H. (Henning)
- Galyavich A.S. (Albert Sarvatovich)
- Garcea A. (Alessio)
- Garcia A. (Alberto)
- Garcia P. (Paula)
- García S.A. (Salvador Alcaraz)
- Gasche-Soccal P. (Paola)
- Georgopoulos D. (Dimitrios)
- Gerhardt F. (Felix)
- Ghofrani H.A.
- Giannakoulas G. (George)
- Gomez Sanchez M.-A. (Miguel-Angel)
- Gomez J.E. (Juan Esteban)
- Grazioli V. (Valentina)
- Grimminger J. (Jan)
- Gruenberger M. (Margarethe)
- Grünig E. (Ekkehard)
- Guiot J. (Julien)
- Halank M. (Michael)
- Hanta I. (Ismail)
- Harbaum L. (Lars)
- Hegya D.V. (Daria Viktorovna)
- Helmersen D.S. (Douglas S.)
- Ho W.-J. (Wan-Jing)
- Hoeper M.M. (Marius M.)
- Hsu C.-H. (Chih-Hsin)
- Hsu P.-C. (Po-Chao)
- Hsu T.-S. (Tsu-Shiu)
- Huang C.-L. (Chien-Lung)
- Huang W.-C. (Wei-Chun)
- Huang W.-P. (Wen-Pin)
- Huber C. (Charlotte)
- Humbert M.
- Hung C.-S. (Chi-Sheng)
- Ivanov K.I. (Kyundyul Ivanovich)
- Jansa P. (Pavel)
- Jara L. (Luis)
- Karvounis H.I.
- Keogh A. (Anne)
- Klose H. (Hans)
- Klotsche J. (Jens)
- Knoop-Busch S. (Susanne)
- Kolomeytseva T.M. (Tatyana Mikhaylovna)
- Konstantinides S. (Stavros)
- Kotlyar E. (Eugene)
- Kotsia A. (Anna)
- Kramer T. (Tilmann)
- Kulka C. (Christine)
- Kuo P.-H. (Ping-Hung)
- Kuo S.-H. (Shu-Hung)
- Lador F. (Frédéric)
- Lai W.-T. (Wen-Ter)
- Lang I. (Irene)
- Lange T.J. (Tobias J.)
- Langleben D. (David)
- Lavender M. (Melanie)
- Lema C. (Camila)
- Lin J.-L. (Jiunn-Lee)
- Lin T.-H. (Tsung-Hsien)
- Lin Y.-H. (Yen-Hung)
- Lombardi F. (Francesco)
- Londoño A. (Alejandro)
- Lopez M. (Manuel)
- Lopez R. (Raquel)
- Louis R. (Renaud)
- Loureiro M.J. (Maria José)
- Lunardi C. (Claudio)
- Löffler-Ragg J. (Judith)
- Mackenzie M. (Michele)
- Mager J. (J.)
- Maldonado L. (Lorena)
- Manzi G. (Giovanna)
- Marinho A. (António)
- Marrero F.L. (Fernando León)
- Martinez W. (William)
- Martinez-Meñaca A. (Amaya)
- Martins Jesus S.M. (Susana Maria)
- Martynyuk T.V. (Tamila Vitalievna)
- Massola G. (Giulia)
- Mehta S. (Sanjay)
- Meier C. (Christian)
- Melatini L. (Luciano)
- Mellemkjaer S. (Soren)
- Michalis L.K. (Lampros)
- Mielniczuk L.M. (Lisa M.)
- Minson R. (Robert)
- Mitrouska I. (Ioanna)
- Mouratoglou S. (Sofia)
- Mulè M. (Massimiliano)
- Mutlu B. (Bülent)
- Naldi M. (Marco)
- Ndreu R. (Rudina)
- Newnham M. (Michael)
- Ng B. (Benjamin)
- Nielsen-Kudsk J.E. (Jens Erik)
- Nikolaevich B.A. (Bykov Aleksander)
- Nolde A. (Anna)
- Noël-Savina E. (Elise)
- Okumus G. (Gulfer)
- Oliveira A. (Ana)
- Olzik I. (Ilona)
- Ongen G. (Gul)
- Oqueka T. (Tim)
- Orozco-Levi M. (Mauricio)
- Otero R. (Remedios)
- Paciocco G. (Giuseppe)
- Pane F. (Federico)
- Pappas A. (Athanasios)
- Pappas K. (Konstantinos)
- Pavlickova I. (Ivana)
- Pavlova O.B. (Olga Borisovna)
- Peacock A. (Andrew)
- Pepke-Zaba J. (Joanna)
- Pesci A. (Alberto)
- Petruzzi M. (Mario)
- Peñate G.P. (Gregorio Pérez)
- Picariello C. (Claudio)
- Piccari L. (Lucilla)
- Pin M. (Maurizio)
- Pitsiou G. (Georgia)
- Pittrow D. (David)
- Platonov D.Y. (Dmitry Yurievich)
- Poscia R. (Roberto)
- Prediletto R. (Renato)
- Proudman S. (Susanna)
- Quezada C.A. (Carlos Andres)
- Reesink H.J. (Herre)
- Reeves G. (Glenn)
- Regotta S. (Sabine)
- Repolho D. (Débora)
- Rocha A. (Andreia)
- Rochat T. (Thierry)
- Rodríguez P.V. (Patricia Villanueva)
- Roman A. (Antonio)
- Roncon L. (Loris)
- Rosenkranz S. (Stephan)
- Rozas S.F. (Sonia Fernandez)
- Rundqvist B. (Bengt)
- Sadushi-Kolici R. (Roela)
- Sakkijha H. (Hussam)
- Saleemi S. (Sarferaz)
- Sardella L. (Luca)
- Schulz C. (Christian)
- Schwarz E.I. (Esther Irene)
- Sciortino A. (Antonio)
- Sebastian L. (Laura)
- Shearman N. (Nicole)
- Shiang T. (Teresa)
- Simon M. (Marcel)
- Simonneau G. (Gérald)
- Sitbon O. (Olivier)
- Skripkina E.S. (Elena Sergeevna)
- Snijder R.
- Sourla E. (Evdokia)
- Sousa J. (Joana)
- Speich R. (Rudolf)
- Stanopoulos I. (Ioannis)
- Steele P. (Peter)
- Steringer-Mascherbauer R. (Regina)
- Stevens W. (Wendy)
- Su H.-M. (Ho-Ming)
- Sung S.-H. (Shih-Hsien)
- Söderberg S. (Stefan)
- Talavera M.L. (Maria Lujan)
- Tania G. (Gonçalves)
- Tayler S. (Susanne)
- Tilea I. (Ioana)
- Toorn L.M. (Leon) van den
- Torricelli E. (Elena)
- Toshner M. (Mark)
- Tovar P.P. (Patricia Parada)
- Tregubova A.V. (Anna Viktorovna)
- Tsangaris I. (Iraklis)
- Tsareva N.A. (Natalia Anatolievna)
- Tuhay G. (Graciela)
- Têtu L. (Laurent)
- Ulrich S. (Silvia)
- Un Z. (Zeynep)
- Vachiéry J.-L. (Jean-Luc)
- Valkovicova T. (Tatiana)
- Vannucchi V. (Vieri)
- Vasankari T. (Tuija)
- Vihinen T. (Tapani)
- Vizza C.D. (Carmine Dario)
- Vonk Noordegraaf A. (Anton)
- Voon W.-C. (Wen-Chol)
- Vulcano N. (Norberto)
- Wang W.-H. (Wen-Hwa)
- Weheba I. (Ihab)
- Williams E. (Evgenia)
- Wirtz G. (Gil)
- Wirtz H. (Hubert)
- Wodlin P. (Peter)
- Wu C.-K. (Cho-Kai)
- Wu S.-H. (Shu-Hao)
- Yakovleva O.E. (Olga Eduardovna)
- Yen H.-W. (Hsueh-Wei)
- Yih-Jer Wu J. (Jacob)
- Yotti R. (Raquel)
- Zvereva T.N. (Tatyana Nikolaevna)
- Šimková I. (Iveta)
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/03/2021
- Field of study
Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- A. Mohammed Kalakwa
- A. Nemer Ayoub
- Abantanga Francis A.
- Abatli Safa' Jamal
- Abbas Wisam
- Abbo Olivier
- Abdelbaqi Reem
- Abdelhady Dina Sobhy
- Abdelhafez Mohammad Omar Mohammad
- Abdelhamid Sultan S.
- Abdelmaksoud Sherif
- Abdelmoumen Roua
- Abdelmutalib Fakereldeen
- Abdul-Mumin Alhassan
- Abduljawad Fatima Mousa
- Abdullah Fizan
- Abdullah Mohd Yusof bin
- Abdulraheem Nurudeen
- Abdulrahman Alaa
- Abdulsalam Moruf Adekunle
- Abdunomonovich Dekhkonboev Avazjon
- Aboelela Ahmed
- Abouheba Mohamed
- Abrahamsson Kate
- Abrunhosa Matias Marcia
- Abu-Nejmah Fawzi
- Abuajaila Abdulsalam
- Abuattaya Adham Ashraf
- Abubakar Auwal M
- Abueideh Ahmad
- Abuhayyeh Husam Aldean
- Abuhlega Ma'aly A.
- Abukhalaf Sadi
- Abumunshar Ali Abdelhay
- Acuna Gaston
- Adams Stephen
- Adamu Sani
- Adanan Mohd Fitri Shukri bin Mohamed
- Adawi Ihda
- Adawi Samer
- Adawy Ahmad
- Ade-Ajayi Niyi
- Adegboyega Rilwan
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adhiwidjaja Cathline Freya
- Adofo-Ansong Nana
- Agboola Titiloye Hannah
- Agelebe Efeturi
- Aguilar Aguilar Faye
- Aguilar Gargurevich Prince Pamela
- Aguirre-Lopez Pastor
- Agulham Miguel Angelo
- Ahmad Hira
- Ahmad Zahidah Adlynee Haji
- Ahmed Hazem
- Ahmed Mahmoud Abdelfattah
- Ajai Olalekan Temitope
- Ajao Emmanuel Akinlabi
- Ajiboye Olalekan S.
- Ajrami Yara
- Ajwa Ahmad Elian Abu
- Akan M. Eren
- Akhbari Melika
- Akhter Nadeem
- Akova Fatih
- Al-Attar Hala M.
- Al-Halbouni Layana
- Al-Mamun Abdullah
- Al-Mayoof Ali Farooq
- Al-Momani Hashem M.
- Al-Mouakeh Ahmad
- Al-Rayyes Maisara
- Al-saleem Hasan Subhi Hasan Abu
- Al-Salhi Ashraf Ayman
- Al-Shwaikh Samar H.
- Al-Slaibi Ibrahim
- Al-Taher Raed Nael
- Al-Taher Raed Nael
- Al-Tammam Hiba
- Alakaloko Felix
- Alamrain Abdulwhhab Ayman Abu
- Alanguia Chipana Cathy Lee
- Alattas Khalid
- Alberto Carlos
- Albozidi Aya
- Alcántara Elvyn
- ALDIRAWI MOHAMMED A. M.
- Alebbini Mohanad Mutasem
- Alfoghi Mabroka
- Algabri Hayder Nadhim Obaid
- Alglaib Mohammed Meftah
- Alhamid Ahmad
- Alhamid Aos
- Alhassan Priscilla
- Ali Hassan
- Ali Karim Osamy
- Ali Liza
- Ali Mansour
- Alijla Sharif
- Alijla Sharif S.
- Aliwisat Ahmad Hasan
- Aljaboo Hajir
- Aljadidi Wesal Omar F. Saied
- Aljarad Ziad
- Alkareem Raghad mohammad abdu
- Almada Suad Ahmed
- Almadhoun Walaa
- Almasri Murad
- Almeida Aguiar Arthur
- Almeida Giovana
- Almengar Inas
- Almohamady Hisham
- Almosaibli Mohammad
- Almusleh Tasneem Fathi Hasan
- Alnaeri Ali
- Alnahhal Khaled
- Alonso Verónica
- Alosta Hasan Mustafa
- Alqarajeh Firas
- Alqor Mohammad Omar Ibrahim
- Alsaadi Nijmeh Nasser
- Alsaggaf Ameen
- Alsaied Amer
- Alser Mohammed
- Alser Osaid H.
- Alshaikhkhalil Haya Abdulnasser Ali
- Alshehri Abdullah
- Altaweel Ahmed
- Altın Merve
- Altokhais Tariq
- Altomi Mohamed
- Alturki Fahad
- Alvarado Zelada Jackelyne
- Alves Dutra da Silva Érika
- Alwadia Soha Marwan Salem
- Alwaggaa Nouriyah Ali
- Alzamari Ainaa Ata Mohammad
- Alzate Gallego Edgar
- Alzeer Asmahan Mohammad Suliman
- Alzerei Sulaiman T.
- Alzraikat Sayel H.
- Alzubair Afnan
- Alzughayyar Tareq Z.
- Amad Mohamed
- Amado Fernando
- Amaechi Chukwubinyelum
- Amah Christopher Chim
- Amarin Justin Z.
- Amarin Marzouq
- Ambriz-González Gabriela
- Ameh Emmanuel
- Amjad Muhammad Bin
- Amoabin Afua Amoabin
- Anatole Nzanzu
- Anatole Nzanzu Kipata
- Anaya Dominguez Marlene
- Anaya Firas
- Andrade Jerhy
- Andreussi Lorna
- Anicama Elias Rocio
- Annajjar Mohammad hasan
- Anntinea Jessmine
- Antunes Amanda
- Antunez-Mora Alexandra
- Anyomih Theophilus Teddy Kojo
- Anzelewicz Stefan
- Apaza Leon Jose Luis
- Appeadu-Mensah William
- Arabiat Esraa
- Arafa Mohamed Ahmed
- Arafat Hasan
- Aragão Liliana
- Arancibia Gutiérrez Elsa
- Aranda Sánchez Cristian Irela
- Arar Ahmad Samih
- Arauco Jenny
- Arbab Hana
- Arboleda Jenny
- Aremo Anuoluwapo
- Arnadóttir Helena
- Arnaud Alexis P
- Arnold Marion
- Arnoletto Lucia Beatriz
- Arrmali Saddam
- Arrmalli Lina Ali
- Arshad Muhammad
- Arthur Felicity
- Arul Suren
- Ashour Dina Ayman
- Ashour Yara shareef
- Aslan Yakup
- Aspirot Ann
- Assi Ahmadfateh
- Assi Muath Abdelrahem Fuad
- Astudillo Miguel
- Atatri Yazid yousef mahmoud
- Atta Ahmed
- Attia Alaa Mobarak
- Avile Romina
- Avolio Luigi
- Awad Hadeel
- Aydin Emrah
- Aykut Merve
- Ayque Rosas Fernando
- Aziz Dayang Anita Abdul
- Ba'baa' Basheer
- Badr Helmy
- Baertschiger Reto
- Bagbio Dominic
- Bah Abdoulie
- Bai Qiang
- Bai Yu Zuo
- Baistrocchi Valentina
- Bakar Ainal Huda Abu
- Baker Wisam
- Ballouhey Quentin
- Balousha Abrar ghassan
- Bamanga Ahmed
- Baniowda Muath A. M.
- Bao Xiaozhou
- Barauskas Vidmantas
- Barbosa Patricia Reis
- Baseggio Natalia
- Bashir Fatma
- Bashir Muhammad Kashif
- Bassan Gonçalves Paulo César
- Bataineh Ziad A.
- Batal Mohammad Mohannad
- Bazozi Hana Milad
- Beasley Spencer
- Becker Karin
- Belmino Gadelha Aluísio Augusto
- Benaskeur Yousra-Imane
- Beres Alana
- Berková Klára
- Bernaus Marianela
- Berrocal Anaya Waldo
- Berzanskis Mindaugas
- Beshtawi Doha mustafa saleh
- Beşir Ahmet
- Bianchin Ezequiel
- Bibas Fatma
- Biber Elna
- Bischoff Cristiano
- Bismarck Sylvester von
- Blain Otilia Eva
- Blanc Thomas
- Blazquez-Gomez Eva
- Bobadilla Morales Lucina
- Bode Christopher
- Bonnard Arnaud
- Boonthai Ampaipan
- Borbonet Daniel
- Bouhadiba Nordeen
- Bowder Alex
- Bracho Blanchet Eduardo
- Bradshaw Kate
- Bragagnini Paolo
- Brahmamdam Pavan
- Bravo Mauro Nicolas
- Bright Benedict Paul
- Brito Quevedo Luz Mery
- Broch Aline
- Brolin Santis Isolan Paola Maria
- Brunero Marco
- Bruxel Carla Luisa
- Bsisu Isam
- Bucaram Elena
- Bueno Mazzuca Rafael
- Bueno Motter Sarah
- Bujarimin Ahmad Shafiee bin
- Bulnes Mendizabal David
- Burks Stephen S.
- Burns Kate
- Butler Marilyn
- Bvulani Bruce
- C. Nwosu David
- Caamal Lorenzo Juvencio
- Calancea Calin
- Calderon Moore Antonio
- Calderón Arancibia José Alfredo
- Calistus Nwachukwu
- Cama Jitoko
- Camamra Kajali
- Cameron Fraser
- Camp Lauren
- Canözer Ali
- Caouette-Laberge Louise
- Cardenas Alva Loreley Raquel
- Cardenas Ruiz Velasco Juan Jose
- Carrasco Ana Lucia
- Carrasco-Ortega Cesar
- Carrillo Isabel
- Casado Francis Tanise
- Casal Beloy Isabel
- Caseb Paloma
- Casquero Victor
- Castañeda Espinosa Sergio
- Castaño Avila Daniela
- Castedo Camacho Fabiola Ruth
- Cavaiuolo Silvia
- Cañapataña Sahuanay Veronica Raquel
- Cepeda Rodrigo
- Cesur İlknur Banlı
- Chan Jonathan
- Chang Jeremy
- Charras Maria Delia
- Chaudary Ali Raza
- Chaudhry Muhammad Amjad
- Chauhan Nirav
- Chavez Galvez Patricia
- Chen Lulu
- Chen Rui
- Cheung Maija
- Chipalavela Rossana Francisco
- Chiriboga Elena
- Chitiavi Soita Wycliffe
- Chitnis Milind
- Cho Seok Hyeon
- Choo Candy SC
- Chukwu Isaac
- Chukwuemeka Anyanwu Lofty-John
- Chung Jae Hee
- Cletus Cyril
- Coghill Griffin
- Collins Nwokoro
- Colombo de Holanda Felipe
- Contreras Carla Sofia
- Coon John
- Cordonnier Annelien
- Cornelli Fabio
- Cornwall Hannah
- Corona C. Rivera Jorge Román
- Corona Rivera Alfredo
- Correa Leite Mila Torii
- Correa Armandou
- Correa Catalina
- Corrêa Costa Eduardo
- Cosoreanu Vlad
- Costas-Chavarri Ainhoa
- Cripovich Alejandrina
- Cunningham Aaron
- Czauderna Piotr
- Cáceres Aucatoma Freud
- Cárdenas Barón José de Jesús
- Cömert Hatice Sonay Yalçın
- da Silva Augusto Maria Lucia
- Dagilytė Rūta
- Dahman Nesrine Ben Hadj
- Dajia Wang
- Dalek Noor Fa'izatul Rahil Ambok
- Dallegre Maria Belen
- Dalloul Hisham
- Damiani Andrea
- Dammagh Nagham Mohammed Al
- Dania Bouguermouh
- Darras Osama Majed
- Darwish Ahmed S
- Darwish Ammar
- Dass Anthony
- Dassonville Martine
- Davenport Kate
- David Kuria
- Davies Justine
- Davis Jenna Kylene
- de Assis Silva Murilo
- de Azevedo Belesa Flavia
- de Campos Vieira Abib Simone
- de Deus Passos Leles Kamila
- de Guzman Johann
- de Souza Santos Ferreira Mariana
- Dedeke Florence
- Defago Victor Hugo
- Defert Coralie
- Delefortrie Thomas
- Delforge Xavier
- Delft Dirk von
- Delgado Malaga Florangel Patricia
- Delgado Quinteros Edgar Fernando
- Dellenmark Blom Michaela
- Dendusic Nejra
- Derbew Miliard
- Derks Terry
- Deya Corazone
- Deyab Abdelaziz
- Di Siervi Oscar
- Diaz Castañeda Flor de Maria
- Diaz Echegaray Marlene
- Diaz Gomez Jose Manuel
- Diaz Leon Cesar
- Dieudonné Lemfuka
- Dimatatac Doris Mae
- Djordjevic Ivona
- Dogar Sohail
- Doheim Mohamed Fahmy
- Dominguez Danny
- Donglai Hu
- Dornellas do Nascimento Suely
- dos Santos Dias André Iván Bradley
- Dosselman Luke J.
- Douiri Abdel
- Drah Weam
- Dube Andile Maqhawe
- Duchesne Camille
- Duggan Eileen
- Duote Cai
- Dure Carolina
- Dávila Perez Roberto
- Ebeido Annan
- Egbuchulem Ifeanyichukwu Kelvin
- Ejinkeonye Eze Chukwuemeka
- Ekenze Sebastian Okwuchukwu
- Ekwunife Okechukwu Hyginus
- El-Ghazaly Mohammed
- Elassall Gena Mohamed Hamed
- Elayeb Abdallah
- Elebute Olumide Abiodun
- Elewaily Mohamed
- Elfiky Mahmoud
- Elgammudi Mala
- Elghazaly Shrouk Mahmoud
- Elhadi Ahmed
- Elhadi Muhammed
- Elhajjaji Yasmine Ali
- Elhattab Ahmad
- Elisante Joseph
- Elkaloush Abdullahn Abdousalam
- Elkhazmi Ebtesam Othman Abdulsalam
- Elmenam Mohamed Abd
- Elmzyyen Aya Mahmoud
- Elrais Safa Abdal
- Elsadek Menan Ahmed
- Elsaied Adham
- Elshaer Omar Adly
- Elsherbiny Mohamed
- Elsiraffy Omar Ossama
- Elstad Maria
- Elzohiri Mohamed
- Elzowawi Fathi
- Emam Omar Sameh
- Emil Sherif
- Enbaya Manal Ben
- Ensar Nicholas
- Erdem Melisa
- Eren Elif
- Ergenekon Ebru
- Eroğlu Egemen
- Erturk Nazile
- Erçin Seçil
- Eshkabilov Shukurali
- Espineda Beda
- Essa Tarek Mohamed
- Essamilghi Kamila Almabrouk Mohammed
- Ezidiegwu Ugochukwu S
- Ezomike Uchechukwu Obiora
- Faboya Omolara Moronkeji
- Fachin Camila
- Fadhle Muhamed Jassim
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- Zanellato Josiane Bernartt
- Zarwawi Ahmad Zulhisyam bin
- Zea-Salazar Luis Enrique
- Zeinelabdeen Ali
- Zhao Xiaoxia
- Zhu Jianming
- Zhu Libin
- Zidan Mazen
- Zivanovic Dragoljub
- Zottis Barcelos Fabricio
- Zreeg Dafer abdulhakim . S.
- Zurikat Rajai O.
- Zvizdic Nada
- Zvizdic Zlatan
- Çekiç Bahanur
- Çelik Müge
- Özçelik Zerrin
- Şeref Kıvanç
- Šafus Antonín
- Škvařil Jan
- Štichhauer Radek
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Summary
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally.
Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies
have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of
the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income
countries globally, and identified factors associated with mortality.
Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to
hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis,
exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a
minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical
status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary
intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause,
in-hospital mortality for all conditions combined and each condition individually, stratified by country income status.
We did a complete case analysis.
Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital
diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal
malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome
countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male.
Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3).
Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income
countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups).
Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome
countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries;
p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients
combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11],
p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20
[1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention
(ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety
checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed
(ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of
parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65
[0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality.
Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome,
middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will
be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger
than 5 years by 2030
Major histocompatibility class I antigenic peptides derived from translation of pre-mRNAs generate immune tolerance
- Author
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 01/01/2023
- Field of study
Antigenic peptides derived from introns are presented on major histocompatibility (MHC) class I molecules, but how these peptides are produced is poorly understood. Here, we show that an MHC class I epitope (SL8) sequence inserted in the second intron of the β-globin gene in a C57BL/6 mouse (HBB) generates immune tolerance. Introduction of SL8-specific CD8+ T cells derived from OT-1 transgenic mice resulted in a threefold increase in OT-1 T cell proliferation in HBB animals, as compared to wild-type animals. The growth of MCA sarcoma cells expressing the intron-derived SL8 epitope was suppressed in wild-type animals compared to HBB mice. The β-globin pre-mRNA was detected in the light polysomal fraction, and introducing stop codons identified a non-AUG initiation site between +228 and +255 nts upstream of the SL8. Isolation of ribosome footprints confirmed translation initiation within this 27 nt sequence. Furthermore, treatment with splicing inhibitor shifts the translation of the pre-mRNA to monosomal fractions and results in an increase of intron-derived peptide substrate as shown by polysome profiling and cell imaging. These results show that non-AUG-initiated translation of pre-mRNAs generates peptides for MHC class I immune tolerance and helps explain why alternative tissue-specific splicing is tolerated by the immune system
Surgical site infection after gastrointestinal surgery in children : an international, multicentre, prospective cohort study
- Author
- A A Essam
- A B Jayathilake
- Abbas Chabok
- Abd Elkhalek Sallam
- Abdalla Gamal Saad
- Abdelaziz Abdelaal
- Abdelaziz Elhendawy
- Abdelkader Belkouchi
- Abdelmalek Hrora
- Abdelrahman Adelshone
- Abdelrahman Assal
- Abdelrahman Geuoshy
- Abdelrahman Soliman
- Abdelrhman Kz Darwish
- Abdul Rehman Alvi
- Abdulaziz Altwijri
- Abdullah Altamimi
- Abdullah Hashim
- Abdulmalik Altaf
- Abdulrahman Abdel-Aty
- Abdulrasheed Nasir
- Abdulrazzaq Lawal
- Abdulshafi Khaled AbdRabou
- Abdurrahaman Sheshe
- Abdussemiu Abdurrazzaaq
- Abeer Esam
- Abhishek Sharma
- Abiboye Yifieyeh
- Abobaker Younis
- Abrar Nawawi
- Adam Boggon
- Adam Gyedu
- Ade Waterman
- Adedapo Osinowo
- Adedeji Fatuga
- Adel Albiety
- Adel B Hassanein
- Adel Denewer
- Ademola Adebanjo
- Ademola Adeyeye
- Ademola Popoola
- Adesina Adedeji
- Adesoji O Ademuyiwa
- Adewale Adeniyi
- Adewale O Adisa
- Adham Tarek
- Adomas Ladukas
- Adrian Palma
- Adrienne Ho
- Afifatun Hasanah
- Afizah Salleh
- Afnan Abdelfatah
- Afnan Altamimi
- Afnan Altamini
- Agazi Fitsum
- Agboola Taiwo
- Ahed Ghaben
- Ahmad Abdel Razaq Al Rafati
- Ahmad Aboelkassem Ibrahem
- Ahmad Ashour
- Ahmad Ashour
- Ahmad Bakr
- Ahmad Bani-Sadar
- Ahmad Bin Adnan
- Ahmad Gudal
- Ahmad Hasan
- Ahmad Khaled Sabe
- Ahmad Khoja
- Ahmad Qaissieh
- Ahmad Sabe
- Ahmad Saber Sleem
- Ahmad Sakr
- Ahmad Shalabi
- Ahmad Uzair Qureshi
- Ahmed Aamer
- Ahmed Abd El-Sameea
- Ahmed Abd Elmoen Elhusseiny
- Ahmed Adamu
- Ahmed Al-Bahrani
- Ahmed Alghamdi
- Ahmed Ali
- Ahmed Alkhatib
- Ahmed Altibi
- Ahmed Alzahrani
- Ahmed Ata
- Ahmed Dahy
- Ahmed El Kashash
- Ahmed El-Sehily
- Ahmed Essam
- Ahmed Farag
- Ahmed Gad
- Ahmed Ghanem
- Ahmed Hossam Eldin Fouad Rida
- Ahmed Ismail
- Ahmed M Rashed
- Ahmed Magdy
- Ahmed Mahmoud Abdelraouf
- Ahmed Mohamed Ibrahim
- Ahmed Moustafa
- Ahmed Rabeih Mohammed
- Ahmed Rabie Mohamed
- Ahmed Raza
- Ahmed Said Badr
- Ahmed Shahine
- Ahmed Sheta
- Ahmed Soliman
- Ahmed Tarek Abdelbaset Hassan
- Ahmed W Shamsedine
- Ahmed Zaki
- Ahmed Zaki Eldeeb
- Ahmed Zohair
- Ahmedali M Kandil
- Ahmedglal Elnagar
- Ahmet Murat Pektaş
- Aia Mehdi
- Aida Suarez
- Aidan Haslegrave
- Ainhoa Costas-Chavarri
- Aized Raza Shahbaz
- Akin Olaolorun
- Akinlabi Ajao
- Al Faifi Jubran
- Ala Shamasneh
- Alaa Al-Buhaisi
- Alaa Bowabsak
- Alaa El Jamassi
- Alaa Elazab
- Alaa Elhadad
- Alaa Fergany
- Alaa Shaheen
- Alaba Adesina
- Alberto Miyar de León
- Alberto Realis Luc
- Alejandro Matheu
- Alemayehu Ginbo Bedada
- Alessandro Favero
- Alex Makupe
- Alex Reece-Smith
- Alexander Canta Calua
- Alexander Smedley
- Alexandra Gerosa
- Alexia Farrugia
- Alexis Arnaud
- Alexis Pierre Arnaud
- Alfio Alessandro Russo
- Alfredo Gulielmi
- Ali Ababneh
- Ali Abo El Dahab
- Ali Adam
- Ali Guner
- Ali Khan Niazi
- Ali Mussad
- Aliaksandr Filatau
- Aliang Latif
- Alibeth Andres Baquero Suarez
- Alice Murray
- Alina Robledo-Rabanal
- Aline Broch
- Alissa Gübeli
- Alistair Rocke
- Aliyu Ndajiwo
- Alphonse Zeta Mutabazi
- Alvaro Enrique Mendoza Beleño
- Alvin Ee Zhiun Cheah
- Aly Abd-Elrazek
- Aly Sanad
- Alyaa Halim Elgendy
- Amal Ibrahim
- Amany Eldosouky Mohammed
- Amar Kourdouli
- Amgad Al Meligy
- Amina Abdelhamid
- Aminah Hanum Haji Abdul Majid
- Aminu Mohammad
- Amir Ait Kaci
- Amira Elsawy
- Amira Hassan Bekhet
- Amira Reda
- Amjad Abu Qumbos
- Amjad Elmashala
- Ammar Gado
- Amna Mamdouh Mohamed
- Amna Mohamed
- Amr Ahmed Saleh
- Amr Hassaan
- Amr Hossameldin
- Amreen Faruq
- Amro Aglan
- Ana Lucia Contreras-Vergara
- Ana Maria Sandoval Barrantes
- Anahita Mansuri
- Anan Rady Abdelazeam
- Anass Majbar
- Anastasios Stefanopoulos
- Anders Thorell
- Andre L Mihaljevic
- Andre Navarro
- Andrea Armellini
- Andrea Belli
- Andrea Bondurri
- Andrea Craus-Miguel
- Andrea Natili
- Andrea Ruzzenente
- Andrea Simioni
- Andreass Haloho
- Andrejus Subocius
- Andrew Kirby
- Andrey Litvin
- Andrius Burmistrovas
- Angel David Pérez Rojas
- Angela Dell
- Angela Mazzella
- Angelica Genoveva Vergara Mejia
- Angeline Charles
- Angelo Antoniozzi
- Angelo Benevento
- Angelos Tselos
- Anil Kaul
- Anil Semiz
- Ankur Bhatnagar
- Anmar Homeida
- Anna Jeffery
- Anna Lasek
- Anna Maffioli
- Anna Rinaldi
- Anna Verbeek
- Annalisa Lo Conte
- Annamaria Bigaran
- Annisa Dewi Fitriana Mukin
- Antanas Gulbinas
- Antanas Zadoroznas
- Anthonius Santoso Rulie
- Anthony Ajiboye
- Anthony Avoka
- Anthony Chuk-Him Lai
- Anthony Davor
- Anthony Sander
- Antoinette Bediako-Bowan
- Antonella La Brocca
- Antonio Nocito
- Antonio Picardo
- Antonio Ramos-De la Medina
- Antonio Taddei
- Anwar Atiyeh
- Anyomih Theophilus Teddy Kojo
- April Camilla Roslani
- Aram Abdelhaq
- Arazzelly Del Pilar Paucar
- Arcangelo Picciariello
- Arestis Sokratous
- Arezo Kanani
- Ari Leppäniemi
- Ariadne L'Heveder
- Arianna Birindelli
- Arij Ibrahim
- Arjun Paramasivan
- Arlindawati Suyadi
- Armando José Román Velásquez
- Arnav Agarwal
- Aroub Alkaaki
- Arturas Vaicius
- Arvin Khamajeet
- Arvo Reinsoo
- Arwa Abouzaid
- Arwa Elfarargy
- Arwa Ibrahim
- Arwa Mohamed
- Asad Choudhry
- Asaf Kedar
- Asdaq Ahmed
- Aseel Alnusairat
- Aseel Hamarshi
- Aseel Musleh
- Ashish Gupta
- Ashish Minocha
- Ashraf Maghrabi
- Ashrafun Nessa
- Ashrarur Rahman Mitul
- Ashwath Bandi
- Asmaa Rezq
- Asmaa Salah
- Asnel Dorismé
- Aspasia Papailia
- Astrid Leusink
- Ataa Ahmed
- Athanasia Bamicha
- Athar Abbas
- Athirah Zulkifli
- Athula Tennakoon
- Attia Attia
- Audrey Clarissa
- Audrius Dulskas
- Audrius Parseliunas
- Augusto Zani
- Aurel Mironescu
- Aurel Sandu Mironescu
- Aurelien Scalabre
- Aurora Mariani
- Aurore Haffreingue
- Aurore Thollot
- Awais Raza
- Aya Abdelfatah Ibraheem
- Aya Adel Elsharkawy
- Aya El-Sawy
- Aya Firwana
- Aya Hammad
- Aya Mohamed Fathy
- Aya Reda
- Aya Yehia Ata
- Ayah Hamdan
- Ayat Hassaan
- Ayman And Taher
- Ayman Salman
- Ayman Shwky
- Azher Herebat
- Babajide Adenekan
- Babatunde Odeyemi
- Badr Eldin Adel
- Badreldin Adel Tawfik
- Bahadir Emre Baki
- Bahar Busra Ozkan
- Bakeer Mohamed
- Basant Kumar
- Bashir Bello
- Basma Mahmoud
- Basmah Alhassan
- Bassant Mowafy
- Beatrice Brunoni
- Behrad Barmayehvar
- Belen Sanchez
- Benogreît Parmentier
- Berk Baris Ozmen
- Berna Buse Kobal
- Bernard Limoges
- Bernhard Wolf
- Bertrand Dousset
- Besmir Grizhja
- Bettina Lieske
- Betty Maillot
- Bogdan Diaconescu
- Britta Dedekind
- Bruno Noukpozounkou
- Busra Murutoglu
- Bárbara Málaga
- Calogero Iacono
- Calvin Eng
- Cameron Fairfield
- Camila Sanchez Samaniego
- Camilla Cona
- Can Adiyaman
- Carla Soldevila-Verdeguer
- Carlo Corbellini
- Carlos Nsengiyumva
- Carlos Paz Galvez
- Carly Bisset
- Carmen Capito
- Carmen Fernández
- Carmen García Bernardo
- Carmina Diaz Zorrilla
- Carolina Guzmán Dueñas
- Caroluce K Musyoka
- Catherine A Shaw
- Catrin Jones
- Catrin Morgan
- Cecile Muller
- Cecilia Costa
- Cedar Andress
- Celeste Caliman
- Celeste Del Basso
- Cesar Miranda
- Cesar Razuri
- Cezar Ciubotaru
- Chali Chibuye
- Challine Alexandre
- Charlene Tan
- Charles Dally
- Chaymae Benyaiche
- Cheewei Gan
- Chelise Currow
- Chelsea Deane
- Chetan Khatri
- Chi Chung Foo
- Chi Ying Jacquelyn Fok
- Chia Kong
- Chimwemwe Kwatiwani
- Chingwan Yip
- Chloe Roy
- Choon Seng Chong
- Chouikh Taieb
- Choy Ling Tan
- Chris Bode
- Christel Leanne Almanon
- Christian Lari Coompson
- Christina Panteli
- Christine Mizzi
- Christoforos Ferousis
- Christopher Owen
- Christopher Smith
- Christos Agalianos
- Christos Anthoulakis
- Christos Barkolias
- Chu-Ann Chai
- Chui Yee Wong
- Cicilia Viany Evajelista
- Ciskje Zarb
- Citra Dewi Mohd Ali
- Claire Sharpin
- Clare Skerritt
- Claudia Reali
- Claudio Arcudi
- Claudio Gabriel Fermani
- Clement Onuoha
- Colombani Jean-Francois
- Cornelius Mukuzunga
- Corrado Bottini
- Cristina Fernandes
- Cristina Pineño-Flores
- Crystal Yern Nee Chow
- Céline Grosos
- D C Grobler
- Damir Ljuhar
- Dana Jaradat
- Daniel Cox
- Daniel Frey
- Daniel Hamill
- Daniela Magri
- Daniele Angelieri
- Daniele Gui
- Danilo Herrera Cruz
- Danjuma Sale
- Dansou Gaspard Gbessi
- Dario Andreotti
- David Ambrona-Zafra
- David Bunting
- David Evans
- David Ewart Henshall
- David Merlini
- David Monterroso Cohen
- Davide De Boni
- Davide Rossi
- Dayang Nita Abdul Aziz
- Dayson Kumwenda
- Debkumar Chowdhury
- Deborah Chiesa
- Deborah Saraste
- Deimante Mikuckyte
- Deividas Dragatas
- Demi Gray
- Deniz Mutlu
- Dennis Oswald
- Dharminder Dhillon
- Diaaaldin Zahran
- Diana Sanchez
- Dickson Bandoh
- Diego Antezana
- Diego Coletta
- Diego Romani
- Diego Sasia
- Dieudonne Duhoranenayo
- Dima Nassif
- Dimitri Aristotle Raptis
- Dimitrios Balalis
- Dimitrios K Manatakis
- Dimitrios Korkolis
- Dimitrios Kyziridis
- Dimitrios Lytras
- Dimitrios Papageorgiou
- Dimitrios Sfougaris
- Dina Al-Marakby
- Dina Faizatur Rahmah
- Dina Fouad
- Dina Gamal
- Dina Tarek
- Dion Morton
- Djifid Morel Seto
- Dmitri Nepogodiev
- Dmitri Raptis
- Doaa Gamil
- Doaa Hasan
- Doaa Hasanain
- Doaa Maher Abdelrouf
- Domenica Pata
- Dominic Townsend
- Donal B O'Connor
- Donatas Danys
- Donatas Venskutonis
- Dorota Radkowiak
- Dorothy Kufeji
- Dovilè Majauskyté
- Durvesh Lacthman Jethwani
- Dush Iyer
- Dushyant Iyer
- Dzianis Khokha
- Dzmitry Paulouski
- Ebenezer Takyi Atkins
- Echaieb Anis
- Edgar Domini
- Edvard Grisin
- Edvinas Dainius
- Eimear Monaghan
- Eirik Kjus Aahlin
- Ekin Arslan
- Ekow Mensah
- Elaine Borg
- Elena Goldin
- Elena Muzio
- Elena Vendramin
- Elena Zdanyte Sruogiene
- Eleonora Ciccioli
- Eliana Kalakouti
- Elio Jovine
- Elisa Contreras
- Elisa Francone
- Elisabeth Hall
- Elisabeth Jensen
- Elissa Rifhan Mohd Basir
- Elizabeth Evans
- Elke Reunis
- Ella Teasdale
- Elliot Akoto
- Elodie Haraux
- Eloy Espin-Basany
- Elsa Robert
- Elsayed Ali
- Emad Abdallah
- Emad Al-Dakka
- Eman Abd Al Raouf
- Eman Abdelmageed
- Eman Abuqwaider
- Eman Elwy
- Eman Emara
- Eman Hashad
- Eman Ibrahim
- Eman Magdy
- Eman Magdy Hegazy
- Eman Mahmoud Abdulhakeem
- Eman Mohamed Ibrahim
- Eman Mohamed Morshedy
- Eman Rashad
- Eman Yahya Mansor
- Emeka Nwabuoku
- Emilia de Luca
- Emilio Dijan
- Emin Kose
- Emmanuel Acquah
- Emmanuel Akatibo
- Emmanuel Barrios
- Enas Alaloul
- Enisburak Gül
- Enkhbat Dashnyam
- Enoch Dagoe
- Enoch Tackie
- Enrique Esteban
- Eric Ackom
- Eric Etchill
- Eric Kofi Appiah
- Erick Samuel Florez Farfan
- Erik Hervieux
- Erik Schadde
- Erika Vicario
- Erikas Laugzemys
- Ernest Yemalin Stephane Ahounou
- Eslam Ezzat
- Esraa Abd Elkhalek
- Esraa Abdalmageed Kasem
- Esraa Alm Eldeen
- Esraa El Halawany
- Esraa El-Gizawy
- Esraa El-Taher
- Esraa Gamal
- Esraa Samir Elbanby
- Esraay Zakaria
- Esther Ferrero
- Esther Hg Park
- Ethar Hany
- Etienne Courboin
- Eu Xian Lee
- Eugenio Morandi
- Eunice Zuling Ter
- Evangelos Voulgaris
- Evelina Slapelyte
- Ewen Griffiths
- Ewen M Harrison
- Eyad Khalifah
- Fabrizio Aquilino
- Fahd Abdel Sabour
- Faisal Idris
- Faith Qi Hui Leong
- Fanjandrainy Rasoaherinomenjanahary
- Farah Mahmoud Ali
- Farhana Iftekhar
- Farhat Din
- Farrag Sayed
- Fatai Balogun
- Fatema Al Bastawis
- Fatema Asi
- Fathy Sroor
- Fatima Baluch
- Fatima Sena-Ruiz
- Faustin Ntirenganya
- Fawzia Abdellatif Elsherif
- Fawzy Mohamed
- Fayez Elian Al Barrawi
- Fazlin Noor
- Federica Bianco
- Federica Falaschi
- Federico Coccolini
- Felipe Zapata
- Felix Alakaloko
- Felix Lee
- Feng Yih Chai
- Ferdy Iskandar
- Fernande Djivoh
- Fernando Espinoza
- Ferry Fitriya Ayu Andika
- Fidelis Jacklyn Adella
- Finaritra Casimir Fleur Prudence Rahantasoa
- Fitjerald Henry
- Flip du Plooy
- Florence Dedey
- Francesca Steccanella
- Francesco Pata
- Francesco Riente
- Francesco Ruben Giardino
- Francesco Selvaggi
- Francis Abantanga
- Francis Dossou
- Francisca Wong
- Francois-Coridon Helene
- Frank Anderson
- Frank Enoch Gyamfi
- Frank Owusu
- Françoise Schmitt
- Fraser Cohen
- Fraser Cullen
- Fred Hodonou
- Frederick Du Toit
- Frederick Stourton
- Fredrik Wogensen
- Fridiz Saravia
- Gabriel Pardo
- Gabriela Elisa Nita
- Gabriela Werder
- Gaetano Gallo
- Gaetano Luglio
- Galaleldin Abdelazim
- Gandau Naa Barnabas
- Garba Samson
- Gareth Chilton
- Gareth Irwin
- Gehad Tawfik
- Genoveffa Balducci
- George Christian Manrique Sila
- George Ihediwa
- Georges Azzie
- Georgette Marie Camilleri
- Georgios Gemenetzis
- Georgios Gkiokas
- Georgios Karabelias
- Georgios Kyrou
- Georgios Peros
- Georgios Tzikos
- Gerardo Perrotta
- Germain Ahlonsou
- Gezim Galiqi
- Ghada Elhoseny
- Ghada Saied Nagy
- Ghiath Al Saied
- Giacomo Pata
- Gianfranco Cocorullo
- Gianluca Curletti
- Gianluca Pagano
- Gianluca Pellino
- Gianmaria Confalonieri
- Gianpiero Gravante
- Giedrius Lauzikas
- Giles Bond-Smith
- Gintaras Simutis
- Giorgio Vasquez
- Giovanni Landolfo
- Giovanni Lazzari
- Giovanni Pascale
- Giovanni Pesenti
- Giuliano Borda-Luque
- Giuseppe Clerico
- Giuseppe Rotunno
- Giuseppe Salamone
- Giuseppe Sammarco
- GlobalSurg Collaborative: Aneel Bhangu
- Greg Padmore
- Gregorio Tugnoli
- Greta Wood
- Greta Žiubrytė
- Grzegorz Zuk
- Guillaume Podevin
- Guillermo Sanchez Rosenberg
- Guled M Jama
- Guo Liang Yong
- Gurpreet Singh Banipal
- Gustavo Miguel Machain Vega
- Gustavo Recinos
- Gustavo Rodolfo Pertersen Servin
- Haaris A Shiwani
- Hadeel Al-Farram
- Hager Abdul Aziz Amin
- Hager Abdulaziz
- Haidar Hajeh
- Hakeem Ayomi Sanni
- Hala Saad
- Halil Alis
- Halima Aliyu
- Haluk Cem Çakaloğlu
- Hamza Asumah
- Hanaan Caydiid
- Hanan Adel Saad
- Hani Natalie
- Hannah Sarafilovic
- Hasbi Maulana Arsyad
- Haya Tahboub
- Hayam Ahmed
- Hazmi Dwinanda Nurqistan
- Heather Bougard
- Heba Baraka
- Heba Gamal
- Hector Shibao Miyasato
- Helena Franco
- Helmut Alfredo Segovia Lohse
- Hend Abdel Gawad Shakshouk
- Hend Kandil
- Hend Mahmoud
- Henri Kotobi
- Henry Mendel
- Herlin Karismaningtyas
- Hesham Magdy
- Hesham Mohammed Bakry
- Hesham Mohammed Bakry
- Hew D Torrance
- Hian Ee Heng
- Hildur Thorarinsdottir
- Hogea Mircea
- Hong Yee Wong
- Hoong-Yin Chong
- Hope Edem Kofi Kordorwu
- Hope Glover-Addy
- Hosni Khairy Salem
- Hossam Elfeki
- Hossam Emadeldin
- Houda Bachri
- Hui Lim
- Hussein Mohammed
- Hussien Ahmed
- Hyunjin Jeon
- Iason-Antonios Papaskarlatos
- Ibrahem Abdelmotaleb
- Ibrahim Al-Slaibi
- Ibrahim Rakha
- Ibrahim Raza
- Ida Björklund
- Idelso Vasquez
- Ignatius Liew
- Ihab Hassan
- Ihdaa Adawi
- Ilkan Tansoker
- Ilkay Halicioglu
- Iloba Njokanma
- Immacolata Iannone
- Ioannis Kyriazanos
- Ioannis Mykoniatis
- Ioannis Patoulias
- Ioannis Valioulis
- Ionut Negoi
- Ipek Sapci
- Irene Montes
- Irene Ortega
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- Volkan Ozben
- Vu Thanh Hien Le
- Vytautas Gaižauskas
- Vytautas Lipnickas
- Wadah Ali
- Wai Cheong Soon
- Wai Him Lam
- Wairimu Ndegwa
- Waleed Thabet
- Walter Ruiz Panez
- Wan Nurul 'Ain Wan Mohd Nasir
- Ward Hamsho
- Wasim Dar
- Wedyan Alhazmi
- Weihei Dao
- Wennweoi Goh
- Wifanto Saditya Jeo
- Wiktor Rutkowski
- William Appeadu-Mensah
- William Bonney
- William English
- Willy Alcca Ticona
- Xavier Delforge
- Xianelle Rodriguez
- Xinwei Low
- Xue Wei Chan
- Ya Theng Neo
- Yacoubou Imorou Souaibou
- Yahaya Ukwenya
- Yahya Salama
- Yasmin Elfouly
- Yasmin Soliman
- Ye Ru Chin
- Yee Wen Tan
- Yehia Zakaria
- Yi Koon Tan
- Yi Ting Mok
- Yih Jeng Cheong
- Yiing Yee Gan
- Yishan Der
- Yomna Allam
- Yomna Hosny Asar
- Yong Yong Tew
- Yoshan Moodley
- Yousef Abuowda
- Ysabel Esthefany Alejos Bermúdez
- Yucel Cengiz
- Yuk Hong Eric Cheung
- Yuksel Altinel
- Yun Lin Ang
- Yung Kok Ng
- Yuri Macchitella
- Zahra Jaffry
- Zain Ali Khan
- Zainab Iftikhar
- Zakaria Rob
- Zhan Herr Ng
- Zi Hao Sam
- Zigmantas Urniežius
- Zilvinas Dambrauskas
- Zineb Bentounsi
- Zygimantas Tverskis
- Ömer Faruk Toto
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Introduction Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings. Methods A multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI). Results Of 1159 children across 181 hospitals in 51 countries, 523 (45 center dot 1%) children were from high HDI, 397 (34 center dot 2%) from middle HDI and 239 (20 center dot 6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12 center dot 8% (51/397) in middle HDI and 24 center dot 7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI. Conclusion The odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.Peer reviewe
Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry
- Author
- Abdelsayed Abeer Abeer
- Acosta Adriana
- Adams Heath
- Agostinho João
- Agostoni Piergiuseppe
- Airò Edoardo
- Al Dalaan Abdullah
- Alexandre Myriam
- Alexeeva Dalyana Eduardovna
- Alfetlawi Monthir
- Almagro Raúl Menor
- Alonso Lecue Pilar
- Altraja Alan
- Andreassen Arne K.
- Anton Ly
- Argiento Paola
- Arjona Josefa Jiménez
- Asencio Isabel
- Atas Halil
- Avdeev Sergey Nikolaevich
- Avilés Francisco Fernandez
- Badagliacca Roberto
- Baptista Rui
- Barberá Joan A.
- Barry Lisa
- Bartfay Sven-Erik
- Batalina Marina Vadimovna
- Bauleo Carolina
- Blanco Isabel
- Bohacekova Marcela
- Boogaard H.
- Boomars Karin
- Boonstra Anco
- Bosio Martin
- Bruno Noemi
- Bukatova Irina Fedorovna
- Camacho Rafael Conde
- Campo Felipe
- Caneva Jorge
- Capinha Marta
- Cardoso Tania
- Castro Graça
- Cheng Chin-Chang
- Chu Chun Yuan
- Church Colin
- Cifrián Martínez José Manuel
- Conte Luca
- Correra Anna
- Corris Paul
- Costa Serena
- Cottin Vincent
- Coutinho Daniel
- Cresci Chiara
- Cuesta Victor Mora
- Cárdenas Salvador López
- D'Alto Michele
- D'Armini Andrea Maria
- De La Pava Sebastian
- De Luca Anna
- De Pauw Michel
- Delcroix Marion
- Deleo Sabino
- Di Marco Giovanni Maria
- Diez Mirta
- Dwyer Nathan
- Egenlauf Benjamin
- Elias Teresa
- Escribano Subias Pilar
- Espinha Mafalda
- Evrard Patrick
- Ewert Ralf
- Fanaridis Michail
- Farina Stefania
- Farkasova Iveta
- Farruggio Silvia
- Feenstra John
- Feistmantl Lisa-Theresa
- Fernandez David Iturbe
- Filippov Evgeny Vladimirovich
- Fong Man-Cai
- Gaine Sean
- Galgano Giuseppe
- Gall Henning
- Galyavich Albert Sarvatovich
- Garcea Alessio
- Garcia Alberto
- Garcia Paula
- García Salvador Alcaraz
- Gasche-Soccal Paola
- Georgopoulos Dimitrios
- Gerhardt Felix
- Ghofrani Hossein-Ardeschir
- Giannakoulas George
- Gomez Sanchez Miguel-Angel
- Gomez Juan Esteban
- Grazioli Valentina
- Grimminger Jan
- Gruenberger Margarethe
- Grünig Ekkehard
- Guiot Julien
- Halank Michael
- Hanta Ismail
- Harbaum Lars
- Hegya Daria Viktorovna
- Helmersen Douglas S.
- Ho Wan-Jing
- Hoeper Marius M.
- Hsu Chih-Hsin
- Hsu Po-Chao
- Hsu Tsu-Shiu
- Huang Chien-Lung
- Huang Wei-Chun
- Huang Wen-Pin
- Huber Charlotte
- Humbert Marc
- Hung Chi-Sheng
- Ivanov Kyundyul Ivanovich
- Jansa Pavel
- Jara Luis
- Karvounis Haralambos
- Keogh Anne
- Klose Hans
- Klotsche Jens
- Knoop-Busch Susanne
- Kolomeytseva Tatyana Mikhaylovna
- Konstantinides Stavros
- Kotlyar Eugene
- Kotsia Anna
- Kramer Tilmann
- Kulka Christine
- Kuo Ping-Hung
- Kuo Shu-Hung
- Lador Frédéric
- Lai Wen-Ter
- Lang Irene
- Lange Tobias J.
- Langleben David
- Lavender Melanie
- Lema Camila
- Lin Jiunn-Lee
- Lin Tsung-Hsien
- Lin Yen-Hung
- Lombardi Francesco
- Londoño Alejandro
- Lopez Manuel
- Lopez Raquel
- Louis Renaud
- Loureiro Maria José
- Lunardi Claudio
- Löffler-Ragg Judith
- Mackenzie Michele
- Mager J.
- Maldonado Lorena
- Manzi Giovanna
- Marinho António
- Marrero Fernando León
- Martinez William
- Martinez-Meñaca Amaya
- Martins Jesus Susana Maria
- Martynyuk Tamila Vitalievna
- Massola Giulia
- Mehta Sanjay
- Meier Christian
- Melatini Luciano
- Mellemkjaer Soren
- Michalis Lampros
- Mielniczuk Lisa M.
- Minson Robert
- Mitrouska Ioanna
- Mouratoglou Sofia
- Mulè Massimiliano
- Mutlu Bülent
- Naldi Marco
- Ndreu Rudina
- Newnham Michael
- Ng Benjamin
- Nielsen-Kudsk Jens Erik
- Nikolaevich Bykov Aleksander
- Nolde Anna
- Noël-Savina Elise
- Okumus Gulfer
- Oliveira Ana
- Olzik Ilona
- Ongen Gul
- Oqueka Tim
- Orozco-Levi Mauricio
- Otero Remedios
- Paciocco Giuseppe
- Pane Federico
- Pappas Athanasios
- Pappas Konstantinos
- Pavlickova Ivana
- Pavlova Olga Borisovna
- Peacock Andrew
- Pepke-Zaba Joanna
- Pesci Alberto
- Petruzzi Mario
- Peñate Gregorio Pérez
- Picariello Claudio
- Piccari Lucilla
- Pin Maurizio
- Pitsiou Georgia
- Pittrow David
- Platonov Dmitry Yurievich
- Poscia Roberto
- Prediletto Renato
- Proudman Susanna
- Quezada Carlos Andres
- Reesink H.
- Reeves Glenn
- Regotta Sabine
- Repolho Débora
- Rocha Andreia
- Rochat Thierry
- Rodríguez Patricia Villanueva
- Roman Antonio
- Roncon Loris
- Rosenkranz Stephan
- Rozas Sonia Fernandez
- Rundqvist Bengt
- Sadushi-Kolici Roela
- Sakkijha Hussam
- Saleemi Sarferaz
- Sardella Luca
- Schulz Christian
- Schwarz Esther Irene
- Sciortino Antonio
- Sebastian Laura
- Shearman Nicole
- Shiang Teresa
- Simon Marcel
- Simonneau Gérald
- Sitbon Olivier
- Skripkina Elena Sergeevna
- Snijder Repke J.
- Sourla Evdokia
- Sousa Joana
- Speich Rudolf
- Stanopoulos Ioannis
- Steele Peter
- Steringer-Mascherbauer Regina
- Stevens Wendy
- Su Ho-Ming
- Sung Shih-Hsien
- Söderberg Stefan
- Talavera Maria Lujan
- Tania Gonçalves
- Tayler Susanne
- Tilea Ioana
- Torricelli Elena
- Toshner Mark
- Tovar Patricia Parada
- Tregubova Anna Viktorovna
- Tsangaris Iraklis
- Tsareva Natalia Anatolievna
- Tuhay Graciela
- Têtu Laurent
- Ulrich Silvia
- Un Zeynep
- Un Zeynep
- Vachiéry Jean-Luc
- Valkovicova Tatiana
- van den Toorn Leon M.
- Vannucchi Vieri
- Vasankari Tuija
- Vihinen Tapani
- Vizza Carmine Dario
- Vonk-Noordegraaf A.
- Voon Wen-Chol
- Vulcano Norberto
- Wang Wen-Hwa
- Weheba Ihab
- Williams Evgenia
- Wirtz Gil
- Wirtz Hubert
- Wodlin Peter
- Wu Cho-Kai
- Wu Shu-Hao
- Yakovleva Olga Eduardovna
- Yen Hsueh-Wei
- Yih-Jer Wu Jacob
- Yotti Raquel
- Zvereva Tatyana Nikolaevna
- Šimková Iveta
- Publication venue
- W B SAUNDERS CO LTD
- Publication date
- 01/01/2021
- Field of study
Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase 3 randomized trials. The EXPosurE Registry RiociguaT in patients with pulmonary hypertension (EXPERT) study was designed to monitor the long-term safety of riociguat in clinical practice. Methods: EXPERT was an international, multicenter, prospective, uncontrolled, non-interventional cohort study of patients treated with riociguat. Patients were followed for at least 1 year and up to 4 years from enrollment or until 30 days after stopping riociguat treatment. Primary safety outcomes were adverse events (AEs) and serious adverse events (SAEs) coded using Medical Dictionary for Regulatory Activities preferred terms and System Organ Classes version 21.0, collected during routine clinic visits and collated via case report forms. Results: In total, 956 patients with CTEPH were included in the analysis. The most common AEs in these patients were peripheral edema/edema (11.7%), dizziness (7.5%), right ventricular (RV)/cardiac failure (7.7%), and pneumonia (5.0%). The most common SAEs were RV/cardiac failure (7.4%), pneumonia (4.1%), dyspnea (3.6%), and syncope (2.5%). Exposure-adjusted rates of hemoptysis/pulmonary hemorrhage and hypotension were low and comparable to those in the long-term extension study of riociguat (Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate Cyclase-Stimulator Trial [CHEST-2]). Conclusion: Data from EXPERT show that in patients with CTEPH, the safety of riociguat in routine practice was consistent with the known safety profile of the drug, and no new safety concerns were identified
Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry
- Author
- Abdelsayed Abeer Abeer
- Acosta Adriana
- Adams Heath
- Agostinho João
- Agostoni Piergiuseppe
- Airò Edoardo
- Al Dalaan Abdullah
- Alexandre Myriam
- Alexeeva Dalyana Eduardovna
- Alfetlawi Monthir
- Almagro Raúl Menor
- Alonso Lecue Pilar
- Altraja Alan
- Andreassen Arne
- Anton Ly
- Argiento Paola
- Arjona Josefa Jiménez
- Asencio Isabel
- Atas Halil
- Avdeev Sergey Nikolaevich
- Avilés Francisco Fernandez
- Badagliacca Roberto
- Baptista Rui
- Barberà Joan
- Barry Lisa
- Bartfay Sven-Erik
- Batalina Marina Vadimovna
- Bauleo Carolina
- Blanco Isabel
- Bohacekova Marcela
- Boogaard H.
- Boomars Karin
- Boonstra Anco
- Bosio Martin
- Bruno Noemi
- Bukatova Irina Fedorovna
- Camacho Rafael Conde
- Campo Felipe
- Caneva Jorge
- Capinha Marta
- Cardoso Tania
- Castro Graça
- Cheng Chin-Chang
- Chu Chun Yuan
- Church Colin
- Cifrián Martínez José Manuel
- Conte Luca
- Correra Anna
- Corris Paul
- Costa Serena
- Cottin Vincent
- Coutinho Daniel
- Cresci Chiara
- Cuesta Victor Mora
- Cárdenas Salvador López
- d'Alto Michele
- d'Armini Andrea Maria
- de la Pava Sebastian
- de Luca Anna
- de Pauw Michel
- Delcroix Marion
- Deleo Sabino
- Di Marco Giovanni Maria
- Diez Mirta
- Dwyer Nathan
- Egenlauf Benjamin
- Elias Teresa
- Escribano Subias Pilar
- Espinha Mafalda
- Evrard Patrick
- Ewert Ralf
- Fanaridis Michail
- Farina Stefania
- Farkasova Iveta
- Farruggio Silvia
- Feenstra John
- Feistmantl Lisa-Theresa
- Fernandez David Iturbe
- Filippov Evgeny Vladimirovich
- Fong Man-Cai
- Gaine Sean
- Galgano Giuseppe
- Gall Henning
- Galyavich Albert Sarvatovich
- Garcea Alessio
- Garcia Alberto
- Garcia Paula
- García Salvador Alcaraz
- Gasche-Soccal Paola
- Georgopoulos Dimitrios
- Gerhardt Felix
- Ghofrani Hossein-Ardeschir
- Giannakoulas George
- Gomez Sanchez Miguel-Angel
- Gomez Juan Esteban
- Grazioli Valentina
- Grimminger Jan
- Gruenberger Margarethe
- Grünig Ekkehard
- Guiot Julien
- Halank Michael
- Hanta Ismail
- Harbaum Lars
- Hegya Daria Viktorovna
- Helmersen Douglas
- Ho Wan-Jing
- Hoeper Marius
- Hsu Chih-Hsin
- Hsu Po-Chao
- Hsu Tsu-Shiu
- Huang Chien-Lung
- Huang Wei-Chun
- Huang Wen-Pin
- Huber Charlotte
- Humbert Marc
- Hung Chi-Sheng
- Ivanov Kyundyul Ivanovich
- Jansa Pavel
- Jara Luis
- Karvounis Haralambos
- Keogh Anne
- Klose Hans
- Klotsche Jens
- Knoop-Busch Susanne
- Kolomeytseva Tatyana Mikhaylovna
- Konstantinides Stavros
- Kotlyar Eugene
- Kotsia Anna
- Kramer Tilmann
- Kulka Christine
- Kuo Ping-Hung
- Kuo Shu-Hung
- Lador Frédéric
- Lai Wen-Ter
- Lang Irene
- Lange Tobias
- Langleben David
- Lavender Melanie
- Lema Camila
- Lin Jiunn-Lee
- Lin Tsung-Hsien
- Lin Yen-Hung
- Lombardi Francesco
- Londoño Alejandro
- Lopez Manuel
- Lopez Raquel
- Louis Renaud
- Loureiro Maria José
- Lunardi Claudio
- Löffler-Ragg Judith
- Mackenzie Michele
- Mager J.
- Maldonado Lorena
- Manzi Giovanna
- Marinho António
- Marrero Fernando León
- Martinez William
- Martinez-Meñaca Amaya
- Martins Jesus Susana Maria
- Martynyuk Tamila Vitalievna
- Massola Giulia
- Mehta Sanjay
- Meier Christian
- Melatini Luciano
- Mellemkjaer Soren
- Michalis Lampros
- Mielniczuk Lisa
- Minson Robert
- Mitrouska Ioanna
- Mouratoglou Sofia
- Mulè Massimiliano
- Mutlu Bülent
- Naldi Marco
- Ndreu Rudina
- Newnham Michael
- Ng Benjamin
- Nielsen-Kudsk Jens Erik
- Nikolaevich Bykov Aleksander
- Nolde Anna
- Noël-Savina Elise
- Okumus Gulfer
- Oliveira Ana
- Olzik Ilona
- Ongen Gul
- Oqueka Tim
- Orozco-Levi Mauricio
- Otero Remedios
- Paciocco Giuseppe
- Pane Federico
- Pappas Athanasios
- Pappas Konstantinos
- Pavlickova Ivana
- Pavlova Olga Borisovna
- Peacock Andrew
- Pepke-Zaba Joanna
- Pesci Alberto
- Petruzzi Mario
- Peñate Gregorio Pérez
- Picariello Claudio
- Piccari Lucilla
- Pin Maurizio
- Pitsiou Georgia
- Pittrow David
- Platonov Dmitry Yurievich
- Poscia Roberto
- Prediletto Renato
- Proudman Susanna
- Quezada Carlos Andres
- Reesink H.
- Reeves Glenn
- Regotta Sabine
- Repolho Débora
- Rocha Andreia
- Rochat Thierry
- Rodríguez Patricia Villanueva
- Roman Antonio
- Roncon Loris
- Rosenkranz Stephan
- Rozas Sonia Fernandez
- Rundqvist Bengt
- Sadushi-Kolici Roela
- Sakkijha Hussam
- Saleemi Sarferaz
- Sardella Luca
- Schulz Christian
- Schwarz Esther Irene
- Sciortino Antonio
- Sebastian Laura
- Shearman Nicole
- Shiang Teresa
- Simon Marcel
- Simonneau Gérald
- Sitbon Olivier
- Skripkina Elena Sergeevna
- Snijder Repke
- Sourla Evdokia
- Sousa Joana
- Speich Rudolf
- Stanopoulos Ioannis
- Steele Peter
- Steringer-Mascherbauer Regina
- Stevens Wendy
- Su Ho-Ming
- Sung Shih-Hsien
- Söderberg Stefan
- Talavera Maria Lujan
- Tania Gonçalves
- Tayler Susanne
- Tilea Ioana
- Torricelli Elena
- Toshner Mark
- Tovar Patricia Parada
- Tregubova Anna Viktorovna
- Tsangaris Iraklis
- Tsareva Natalia Anatolievna
- Tuhay Graciela
- Têtu Laurent
- Ulrich Silvia
- Un Zeynep
- Vachiéry Jean-Luc
- Valkovicova Tatiana
- van den Toorn Leon
- Vannucchi Vieri
- Vasankari Tuija
- Vihinen Tapani
- Vizza Carmine Dario
- Vonk-Noordegraaf A.
- Voon Wen-Chol
- Vulcano Norberto
- Wang Wen-Hwa
- Weheba Ihab
- Williams Evgenia
- Wirtz Gil
- Wirtz Hubert
- Wodlin Peter
- Wu Cho-Kai
- Wu Shu-Hao
- Yakovleva Olga Eduardovna
- Yen Hsueh-Wei
- Yih-Jer Wu Jacob
- Yotti Raquel
- Zvereva Tatyana Nikolaevna
- Šimková Iveta
- Publication venue
- Elsevier
- Publication date
- 01/02/2021
- Field of study
International audienc
Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry
- Author
- Abdelsayed Abeer Abeer
- Acosta Adriana
- Adams Heath
- Agostinho João
- Agostoni Piergiuseppe
- Airò Edoardo
- Al Dalaan Abdullah
- Alexandre Myriam
- Alexeeva Dalyana Eduardovna
- Alfetlawi Monthir
- Almagro Raúl Menor
- Alonso Lecue Pilar
- Altraja Alan
- Andreassen Arne
- Anton Ly
- Argiento Paola
- Arjona Josefa Jiménez
- Asencio Isabel
- Atas Halil
- Avdeev Sergey Nikolaevich
- Avilés Francisco Fernandez
- Badagliacca Roberto
- Baptista Rui
- Barberá Joan
- Barry Lisa
- Bartfay Sven-Erik
- Batalina Marina Vadimovna
- Bauleo Carolina
- Blanco Isabel
- Bohacekova Marcela
- Boogaard H.
- Boomars Karin
- Boonstra Anco
- Bosio Martin
- Bruno Noemi
- Bukatova Irina Fedorovna
- Camacho Rafael Conde
- Campo Felipe
- Caneva Jorge
- Capinha Marta
- Cardoso Tania
- Castro Graça
- Cheng Chin-Chang
- Chu Chun Yuan
- Church Colin
- Cifrián Martínez José Manuel
- Conte Luca
- Correra Anna
- Corris Paul
- Costa Serena
- Cottin Vincent
- Coutinho Daniel
- Cresci Chiara
- Cuesta Victor Mora
- Cárdenas Salvador López
- d'Alto Michele
- d'Armini Andrea Maria
- de la Pava Sebastian
- de Luca Anna
- de Pauw Michel
- Delcroix Marion
- Deleo Sabino
- Di Marco Giovanni Maria
- Diez Mirta
- Dwyer Nathan
- Egenlauf Benjamin
- Elias Teresa
- Escribano Subias Pilar
- Espinha Mafalda
- Evrard Patrick
- Ewert Ralf
- Fanaridis Michail
- Farina Stefania
- Farkasova Iveta
- Farruggio Silvia
- Feenstra John
- Feistmantl Lisa-Theresa
- Fernandez David Iturbe
- Filippov Evgeny Vladimirovich
- Fong Man-Cai
- Gaine Sean
- Galgano Giuseppe
- Gall Henning
- Galyavich Albert Sarvatovich
- Garcea Alessio
- Garcia Alberto
- Garcia Paula
- García Salvador Alcaraz
- Gasche-Soccal Paola
- Georgopoulos Dimitrios
- Gerhardt Felix
- Ghofrani Hossein-Ardeschir
- Giannakoulas George
- Gomez Sanchez Miguel-Angel
- Gomez Juan Esteban
- Grazioli Valentina
- Grimminger Jan
- Gruenberger Margarethe
- Grünig Ekkehard
- Guiot Julien
- Halank Michael
- Hanta Ismail
- Harbaum Lars
- Hegya Daria Viktorovna
- Helmersen Douglas
- Ho Wan-Jing
- Hoeper Marius
- Hsu Chih-Hsin
- Hsu Po-Chao
- Hsu Tsu-Shiu
- Huang Chien-Lung
- Huang Wei-Chun
- Huang Wen-Pin
- Huber Charlotte
- Humbert Marc
- Hung Chi-Sheng
- Ivanov Kyundyul Ivanovich
- Jansa Pavel
- Jara Luis
- Karvounis Haralambos
- Keogh Anne
- Klose Hans
- Klotsche Jens
- Knoop-Busch Susanne
- Kolomeytseva Tatyana Mikhaylovna
- Konstantinides Stavros
- Kotlyar Eugene
- Kotsia Anna
- Kramer Tilmann
- Kulka Christine
- Kuo Ping-Hung
- Kuo Shu-Hung
- Lador Frédéric
- Lai Wen-Ter
- Lang Irene
- Lange Tobias
- Langleben David
- Lavender Melanie
- Lema Camila
- Lin Jiunn-Lee
- Lin Tsung-Hsien
- Lin Yen-Hung
- Lombardi Francesco
- Londoño Alejandro
- Lopez Manuel
- Lopez Raquel
- Louis Renaud
- Loureiro Maria José
- Lunardi Claudio
- Löffler-Ragg Judith
- Mackenzie Michele
- Mager J.
- Maldonado Lorena
- Manzi Giovanna
- Marinho António
- Marrero Fernando León
- Martinez William
- Martinez-Meñaca Amaya
- Martins Jesus Susana Maria
- Martynyuk Tamila Vitalievna
- Massola Giulia
- Mehta Sanjay
- Meier Christian
- Melatini Luciano
- Mellemkjaer Soren
- Michalis Lampros
- Mielniczuk Lisa
- Minson Robert
- Mitrouska Ioanna
- Mouratoglou Sofia
- Mulè Massimiliano
- Mutlu Bülent
- Naldi Marco
- Ndreu Rudina
- Newnham Michael
- Ng Benjamin
- Nielsen-Kudsk Jens Erik
- Nikolaevich Bykov Aleksander
- Nolde Anna
- Noël-Savina Elise
- Okumus Gulfer
- Oliveira Ana
- Olzik Ilona
- Ongen Gul
- Oqueka Tim
- Orozco-Levi Mauricio
- Otero Remedios
- Paciocco Giuseppe
- Pane Federico
- Pappas Athanasios
- Pappas Konstantinos
- Pavlickova Ivana
- Pavlova Olga Borisovna
- Peacock Andrew
- Pepke-Zaba Joanna
- Pesci Alberto
- Petruzzi Mario
- Peñate Gregorio Pérez
- Picariello Claudio
- Piccari Lucilla
- Pin Maurizio
- Pitsiou Georgia
- Pittrow David
- Platonov Dmitry Yurievich
- Poscia Roberto
- Prediletto Renato
- Proudman Susanna
- Quezada Carlos Andres
- Reesink H.
- Reeves Glenn
- Regotta Sabine
- Repolho Débora
- Rocha Andreia
- Rochat Thierry
- Rodríguez Patricia Villanueva
- Roman Antonio
- Roncon Loris
- Rosenkranz Stephan
- Rozas Sonia Fernandez
- Rundqvist Bengt
- Sadushi-Kolici Roela
- Sakkijha Hussam
- Saleemi Sarferaz
- Sardella Luca
- Schulz Christian
- Schwarz Esther Irene
- Sciortino Antonio
- Sebastian Laura
- Shearman Nicole
- Shiang Teresa
- Simon Marcel
- Simonneau Gérald
- Sitbon Olivier
- Skripkina Elena Sergeevna
- Snijder Repke
- Sourla Evdokia
- Sousa Joana
- Speich Rudolf
- Stanopoulos Ioannis
- Steele Peter
- Steringer-Mascherbauer Regina
- Stevens Wendy
- Su Ho-Ming
- Sung Shih-Hsien
- Söderberg Stefan
- Talavera Maria Lujan
- Tania Gonçalves
- Tayler Susanne
- Tilea Ioana
- Torricelli Elena
- Toshner Mark
- Tovar Patricia Parada
- Tregubova Anna Viktorovna
- Tsangaris Iraklis
- Tsareva Natalia Anatolievna
- Tuhay Graciela
- Têtu Laurent
- Ulrich Silvia
- Un Zeynep
- Un Zeynep
- Vachiéry Jean-Luc
- Valkovicova Tatiana
- van den Toorn Leon
- Vannucchi Vieri
- Vasankari Tuija
- Vihinen Tapani
- Vizza Carmine Dario
- Vonk-Noordegraaf A.
- Voon Wen-Chol
- Vulcano Norberto
- Wang Wen-Hwa
- Weheba Ihab
- Williams Evgenia
- Wirtz Gil
- Wirtz Hubert
- Wodlin Peter
- Wu Cho-Kai
- Wu Shu-Hao
- Yakovleva Olga Eduardovna
- Yen Hsueh-Wei
- Yih-Jer Wu Jacob
- Yotti Raquel
- Zvereva Tatyana Nikolaevna
- Šimková Iveta
- Publication venue
- Elsevier
- Publication date
- 01/03/2021
- Field of study
International audienc
Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry
- Author
- Abdelsayed Abeer Abeer
- Acosta Adriana
- Adams Heath
- Agostinho João
- Agostoni Piergiuseppe
- Airò Edoardo
- Al Dalaan Abdullah
- Alexandre Myriam
- Alexeeva Dalyana Eduardovna
- Alfetlawi Monthir
- Almagro Raúl Menor
- Alonso Lecue Pilar
- Altraja Alan
- Andreassen Arne K.
- Anton Ly
- Argiento Paola
- Arjona Josefa Jiménez
- Asencio Isabel
- Atas Halil
- Avdeev Sergey Nikolaevich
- Avilés Francisco Fernandez
- Badagliacca Roberto
- Baptista Rui
- Barberà Joan A.
- Barry Lisa
- Bartfay Sven-Erik
- Batalina Marina Vadimovna
- Bauleo Carolina
- Blanco Isabel
- Bohacekova Marcela
- Boogaard H.
- Boomars Karin
- Boonstra Anco
- Bosio Martin
- Bruno Noemi
- Bukatova Irina Fedorovna
- Camacho Rafael Conde
- Campo Felipe
- Caneva Jorge
- Capinha Marta
- Cardoso Tania
- Castro Graça
- Cheng Chin-Chang
- Chu Chun Yuan
- Church Colin
- Cifrián Martínez José Manuel
- Conte Luca
- Correra Anna
- Corris Paul
- Costa Serena
- Cottin Vincent
- Coutinho Daniel
- Cresci Chiara
- Cuesta Victor Mora
- Cárdenas Salvador López
- D'Alto Michele
- D'Armini Andrea Maria
- De La Pava Sebastian
- De Luca Anna
- De Pauw Michel
- Delcroix Marion
- Deleo Sabino
- Di Marco Giovanni Maria
- Diez Mirta
- Dwyer Nathan
- Egenlauf Benjamin
- Elias Teresa
- Escribano Subias Pilar
- Espinha Mafalda
- Evrard Patrick
- Ewert Ralf
- Fanaridis Michail
- Farina Stefania
- Farkasova Iveta
- Farruggio Silvia
- Feenstra John
- Feistmantl Lisa-Theresa
- Fernandez David Iturbe
- Filippov Evgeny Vladimirovich
- Fong Man-Cai
- Gaine Sean
- Galgano Giuseppe
- Gall Henning
- Galyavich Albert Sarvatovich
- Garcea Alessio
- Garcia Alberto
- Garcia Paula
- García Salvador Alcaraz
- Gasche-Soccal Paola
- Georgopoulos Dimitrios
- Gerhardt Felix
- Ghofrani Hossein-Ardeschir
- Giannakoulas George
- Gomez Sanchez Miguel-Angel
- Gomez Juan Esteban
- Grazioli Valentina
- Grimminger Jan
- Gruenberger Margarethe
- Grünig Ekkehard
- Guiot Julien
- Halank Michael
- Hanta Ismail
- Harbaum Lars
- Hegya Daria Viktorovna
- Helmersen Douglas S.
- Ho Wan-Jing
- Hoeper Marius M.
- Hsu Chih-Hsin
- Hsu Po-Chao
- Hsu Tsu-Shiu
- Huang Chien-Lung
- Huang Wei-Chun
- Huang Wen-Pin
- Huber Charlotte
- Humbert Marc
- Hung Chi-Sheng
- Ivanov Kyundyul Ivanovich
- Jansa Pavel
- Jara Luis
- Karvounis Haralambos
- Keogh Anne
- Klose Hans
- Klotsche Jens
- Knoop-Busch Susanne
- Kolomeytseva Tatyana Mikhaylovna
- Konstantinides Stavros
- Kotlyar Eugene
- Kotsia Anna
- Kramer Tilmann
- Kulka Christine
- Kuo Ping-Hung
- Kuo Shu-Hung
- Lador Frédéric
- Lai Wen-Ter
- Lang Irene
- Lange Tobias J.
- Langleben David
- Lavender Melanie
- Lema Camila
- Lin Jiunn-Lee
- Lin Tsung-Hsien
- Lin Yen-Hung
- Lombardi Francesco
- Londoño Alejandro
- Lopez Manuel
- Lopez Raquel
- Louis Renaud
- Loureiro Maria José
- Lunardi Claudio
- Löffler-Ragg Judith
- Mackenzie Michele
- Mager J.
- Maldonado Lorena
- Manzi Giovanna
- Marinho António
- Marrero Fernando León
- Martinez William
- Martinez-Meñaca Amaya
- Martins Jesus Susana Maria
- Martynyuk Tamila Vitalievna
- Massola Giulia
- Mehta Sanjay
- Meier Christian
- Melatini Luciano
- Mellemkjaer Soren
- Michalis Lampros
- Mielniczuk Lisa M.
- Minson Robert
- Mitrouska Ioanna
- Mouratoglou Sofia
- Mulè Massimiliano
- Mutlu Bülent
- Naldi Marco
- Ndreu Rudina
- Newnham Michael
- Ng Benjamin
- Nielsen-Kudsk Jens Erik
- Nikolaevich Bykov Aleksander
- Nolde Anna
- Noël-Savina Elise
- Okumus Gulfer
- Oliveira Ana
- Olzik Ilona
- Ongen Gul
- Oqueka Tim
- Orozco-Levi Mauricio
- Otero Remedios
- Paciocco Giuseppe
- Pane Federico
- Pappas Athanasios
- Pappas Konstantinos
- Pavlickova Ivana
- Pavlova Olga Borisovna
- Peacock Andrew
- Pepke-Zaba Joanna
- Pesci Alberto
- Petruzzi Mario
- Peñate Gregorio Pérez
- Picariello Claudio
- Piccari Lucilla
- Pin Maurizio
- Pitsiou Georgia
- Pittrow David
- Platonov Dmitry Yurievich
- Poscia Roberto
- Prediletto Renato
- Proudman Susanna
- Quezada Carlos Andres
- Reesink H.
- Reeves Glenn
- Regotta Sabine
- Repolho Débora
- Rocha Andreia
- Rochat Thierry
- Rodríguez Patricia Villanueva
- Roman Antonio
- Roncon Loris
- Rosenkranz Stephan
- Rozas Sonia Fernandez
- Rundqvist Bengt
- Sadushi-Kolici Roela
- Sakkijha Hussam
- Saleemi Sarferaz
- Sardella Luca
- Schulz Christian
- Schwarz Esther Irene
- Sciortino Antonio
- Sebastian Laura
- Shearman Nicole
- Shiang Teresa
- Simon Marcel
- Simonneau Gérald
- Sitbon Olivier
- Skripkina Elena Sergeevna
- Snijder Repke J.
- Sourla Evdokia
- Sousa Joana
- Speich Rudolf
- Stanopoulos Ioannis
- Steele Peter
- Steringer-Mascherbauer Regina
- Stevens Wendy
- Su Ho-Ming
- Sung Shih-Hsien
- Söderberg Stefan
- Talavera Maria Lujan
- Tania Gonçalves
- Tayler Susanne
- Tilea Ioana
- Torricelli Elena
- Toshner Mark
- Tovar Patricia Parada
- Tregubova Anna Viktorovna
- Tsangaris Iraklis
- Tsareva Natalia Anatolievna
- Tuhay Graciela
- Têtu Laurent
- Ulrich Silvia
- Un Zeynep
- Vachiéry Jean-Luc
- Valkovicova Tatiana
- van den Toorn Leon M.
- Vannucchi Vieri
- Vasankari Tuija
- Vihinen Tapani
- Vizza Carmine Dario
- Vonk-Noordegraaf A.
- Voon Wen-Chol
- Vulcano Norberto
- Wang Wen-Hwa
- Weheba Ihab
- Williams Evgenia
- Wirtz Gil
- Wirtz Hubert
- Wodlin Peter
- Wu Cho-Kai
- Wu Shu-Hao
- Yakovleva Olga Eduardovna
- Yen Hsueh-Wei
- Yih-Jer Wu Jacob
- Yotti Raquel
- Zvereva Tatyana Nikolaevna
- Šimková Iveta
- Publication venue
- W B SAUNDERS CO LTD
- Publication date
- 01/01/2021
- Field of study
Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension following Phase 3 randomized trials. The EXPosurE Registry RiociguaT in patients with pulmonary hypertension (EXPERT) study was designed to monitor the long-term safety of riociguat in clinical practice. Methods: EXPERT was an international, multicenter, prospective, uncontrolled, non-interventional cohort study of patients treated with riociguat. Patients were followed for at least 1 year and up to 4 years from enrollment or until 30 days after stopping riociguat treatment. Primary safety outcomes were adverse events (AEs) and serious adverse events (SAEs) coded using Medical Dictionary for Regulatory Activities preferred terms and System Organ Classes version 21.0, collected during routine clinic visits (usually every 3-6 months) and collated via case report forms. Results: In total, 326 patients with PAH were included in the analysis. The most common AEs in these patients were dizziness (11.7%), right ventricular (RV)/cardiac failure (10.7%), edema/peripheral edema (10.7%), diarrhea (8.6%), dyspnea (8.0%), and cough (7.7%). The most common SAEs were RV/cardiac failure (10.1%), pneumonia (6.1%), dyspnea (4.0%), and syncope (3.4%). The exposure-adjusted rate of hemoptysis/pulmonary hemorrhage was 2.5 events per 100 patient-years. Conclusion: Final data from EXPERT show that in patients with PAH, the safety of riociguat in clinical practice was consistent with clinical trials, with no new safety concerns identified and a lower exposure-adjusted rate of hemoptysis/pulmonary hemorrhage than in the long-term extension of the Phase 3 trial in PAH
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdağ Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
- Ashour Firas
- Ashoushan Hana
- Ashraf Ahmed
- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
- Banglani Muntaha
- Bani Hani Farah
- Bani hani Mohammad
- Bani hani Zeina
- Baniowda Muath
- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
- Barati Nastaran
- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
- Barghuthi Lutfi
- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- Beltrán de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
- Ben Saoud Abdulsalam Ali
- Bengur Fuat Baris
- Benkabbou Amine
- Benke Marton
- Benyaiche Chaymae
- Bergeat Damien
- Bernstein Mitchell
- Beshtawi Doha
- Besli Sevval
- Beuran Mircea
- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
- Bingham Janne
- Bird Jonathan
- Birindelli Arianna
- Birks Sarah
- Birutis Justas
- Björklund Ida
- Blackman Brighid
- Blackwell James
- Blanco-Colino Ruth
- Blok Robin
- Blomme Nina
- Blomqvist Malin
- Blunnie Eimear
- Bnhameida Sondos
- Boddy Alex
- Bodur Muhammed Selim
- Boereboom Catherine
- Bogusevicius Algirdas
- Bolzonaro Elisa
- Bonavina Luigi
- Bondurri Andrea
- Bonghaseh Divine Tim
- Bono Lorenzo
- Borda-Luque Giuliano
- Borg Elaine
- Borghi Felice
- Borham Hala
- Borowski David W
- Bortolasi Luca
- Bosch Marina
- Bosire Fridah
- Bossi Daniela
- Botes Azel
- Bouaziz Hanen
- Bougard Heather
- Boutall Adam
- Boutros Marylise
- Bouzaiene Hatem
- Boyce Stephen
- Boyd-Carson Hannah
- Boyle Connor
- Braccio Bartolomeo
- Bradulskis Saulius
- Brata Santi Yuanita
- Bratu Matei Razvan
- Brito Diana
- Brocklehurst Peter
- Brooker Ethan
- Brooks Savannah
- Brown James
- Bruce Eilidh
- Bsisu Isam
- Bua Emmanuel
- Bucci Luigi
- Budd Gabrielle
- Budzyński Andrzej
- Budzyński Piotr
- Bujda Michele
- Bulaya Anadi
- Bullock Cameron
- Burger Sule
- Burgu Gökçen
- Burke Daniel
- Burman Shivang
- Bury Pawel
- Busuttil Zachary
- Butt Eman
- Buxant Frederic
- Buzaite Kristina
- C S Archana
- Caballero Díaz Yurena
- Cabrera Rivera Paulo Andrés
- Cagigas Fernandez Carmen
- Calik Adnan
- Calleja Thomas
- Camelo Saul
- Camilo Correa Juan
- Caminsky Natasha
- Cammarata Francesco
- Campagnaro Tommaso
- Campanella Sofia
- Campanelli Michela
- Campo Veronica
- Campos Costa Filipa
- Campos Maite
- Candas Altinbas Bahar
- Canic Renata
- Canonica Claudia
- Canonico Silvestro
- Canotilho Rita
- Cansana Bernalynn Eris
- Capote Hugo
- Capunge Ines
- Carballo Federico
- Cardia Roberto
- Cardoso Louro Hugo
- Cardoso Diogo
- Cardoso Vasco
- Carella Marcella
- Carlini Massimo
- Carrano Francesco Maria
- Carrington Emma Victoria
- Caruso Emanuele
- Carvalho Ana Cristina
- Carvalho Lúcia
- Carvalho Márcia
- Carvello Michele Maria
- Castaldi Antonio
- Castanedo Bezanilla Sonia
- Castilla Moreno Miguel Angel
- Castillo Arrascue José Neiser
- Castillo Barbosa Andrea Carolina
- Castro López Elizabeth Victoria
- Castro Ernes John
- Castro Luis
- Catarino Santos Sara
- Cañete Joannes Paul
- Ceballos André
- Celebioglu Fuat
- Celentano Valerio
- Cenal Ulukan
- Cengiz Yucel
- Cervone Carmela
- Cesleviciene Ieva
- Cesna Vaidotas
- Chabok Abbas
- Chachaima Mar Jorge Emerson
- Chacòn-Herrera Patricia
- Chaggar Gurpreet
- Chamberlain Carla
- Chambers Alice
- Chan Claudia
- Chan Erick
- Chandler Julia
- Chandrasinghe Pramodh
- Chang Ern Ng
- Chanousi Iris
- Chantalat Elodie
- Chapman Gavin
- Charalabopoulos Alexandros
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- Winter Des
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- Wogensen Fredrik
- Wondoh Paul M.
- Wong Florence
- Wong Hsu Ven
- Wong Jane J
- Wong Jeremy
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- Wong Michael Pak-Kai
- Wong Sui-Weng
- Wong Tsz Lun Ernest
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- Woon-Shoo-Tong Xiao-Ming Sarah
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- Xanthopoulou Georgia
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- Yaghi Yasmine
- Yahia Mohamed Ali Mohamed
- Yakushkina Al'ona
- Yalçinkaya Ali
- Yang P Zichu
- Yanikoğlu Erkan
- Yanni Fady
- Yates Charlotte
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- Yeşilsancak Merve
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- Yildiz Alp
- Yilmaz Duygu
- Yip Ching Wan
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- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
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- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research
Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries
- Author
- A.A. Essam
- A.B. Jayathilake
- Abbas Chabok
- Abd Elkhalek Sallam
- Abdalla Gamal Saad
- Abdelaziz Abdelaal
- Abdelaziz Elhendawy
- Abdelkader Belkouchi
- Abdelmalek Hrora
- Abdelrahman Adelshone
- Abdelrahman Assal
- Abdelrahman Geuoshy
- Abdelrahman Soliman
- Abdelrhman K.Z. Darwish
- Abdul Rehman Alvi
- Abdulaziz Altwijri
- Abdullah Altamimi
- Abdullah Hashim
- Abdulmalik Altaf
- Abdulrahman Abdel-Aty
- Abdulrasheed Nasir
- Abdulrazzaq Lawal
- Abdulshafi Khaled Abdrabou
- Abdurrahaman Sheshe
- Abdussemiu Abdurrazzaaq
- Abeer Esam
- Abhishek Sharma
- Abiboye Yifieyeh
- Abobaker Younis
- Abrar Nawawi
- Adam Boggon
- Adam Gyedu
- Ade Waterman
- Adedapo Osinowo
- Adedeji Fatuga
- Adel Albiety
- Adel B. Hassanein
- Adel Denewar
- Ademola Adebanjo
- Ademola Adeyeye
- Ademola Adeyeye
- Ademola Popoola
- Adesina Adedeji
- Adesoji Ademuyiwa
- Adesoji O. Ademuyiwa
- Adesoji O. Ademuyiwa
- Adesoji O. Ademuyiwa
- Adesoji O. Ademuyiwa
- Adewale Adeniyi
- Adewale O. Adisa
- Adham Tarek
- Adomas Ladukas
- Adrian Palma
- Adrienne Ho
- Afifatun Hasanah
- Afizah Salleh
- Afnan Abdelfatah
- Afnan Altamimi
- Afnan Altamini
- Agazi Fitsum
- Agboola Taiwo
- Ahed Ghaben
- Ahmad Abdel Razaq Al Rafati
- Ahmad Aboelkassem Ibrahem
- Ahmad Ashour
- Ahmad Ashour
- Ahmad Bakr
- Ahmad Bani-Sadar
- Ahmad Bin Adnan
- Ahmad Gudal
- Ahmad Gudal
- Ahmad Hasan
- Ahmad Khaled Sabe
- Ahmad Khoja
- Ahmad Qaissieh
- Ahmad Sabe
- Ahmad Saber Sleem
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- Ahmad Shalabi
- Ahmad Uzair Qureshi
- Ahmad Uzair Qureshi
- Ahmed Aamer
- Ahmed Abd Elmoen Elhusseiny
- Ahmed Abd Elsameea
- Ahmed Adamu
- Ahmed Al-Bahrani
- Ahmed Al-Khatib
- Ahmed Alghamdi
- Ahmed Ali
- Ahmed Altibi
- Ahmed Alzahrani
- Ahmed Ata
- Ahmed Dahy
- Ahmed El Kashash
- Ahmed El-Sehily
- Ahmed Essam
- Ahmed Farag
- Ahmed Gad
- Ahmed Ghanem
- Ahmed Hossam Eldin Fouad Rida
- Ahmed Ismail
- Ahmed M. Rashed
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- Ahmed Mahmoud Abdelraouf
- Ahmed mohamed Ibrahim
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- Ahmed Rabeih Mohammed
- Ahmed Rabie Mohamed
- Ahmed Raza
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- Alex Makupe
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- Silvia Basilicò
- Silvia Boni
- Silvia De Franciscis
- Simon Cole
- Simon Paterson-Brown
- Simon Stock
- Simona Kasputyte
- Simone Conci
- Simone Sandler
- Simone Targa
- Sinem Yolcu
- Sir Young Yam
- Siti Mohd Desa Asilah
- Siti Nur Alia Kamarulzamil
- Sivesh K. Kamarajah
- Sobhana Iftekhar Tani
- Soha Abushamleh
- Sohaila Elmihy
- Sondos Turkustani
- Sophian Hmila
- Stavros Parasyris
- Stefan Zammit
- Stefano Berti
- Stefano Giuliani
- Stefano M.M. Basso
- Sten Saar
- Stephanie Hiu-wai Kwok
- Stephanie Van Straten
- Stephen Kache
- Stephen Knight
- Stephen O'Neill
- Stephen Tabiri
- Stephen Tabiri
- Stephen Tabiri
- Stephen Tabiri
- Steponas Petrikenas
- Stuart J. Fergusson
- Stuart J. Fergusson
- Styliani Parpoudi
- Stylianos Germanos
- Suhhuey Yap
- Sukrit Suresh
- Sule Burger
- Suleiman Baba
- Sunil Kumar
- Sunil Kumar
- Suraj Kadiwar
- Suraya Bahar
- Susan Aviles
- Susan McGarvie
- Susan Wndy Mathew
- Suzanne Kershaw
- Svetlana Doris Brincat
- Swapnil Roy
- Syed Abdul Wahhab Eusoffee Wan Ali
- Syed Asaat Ul Razi
- Sylvia Kamya
- Sylvie Mochet
- Syrine Rekhis
- T. Ariani Widiastini
- T.W.C. Mak
- Taha Yusufali
- Taher
- Taher Al-Taher
- Taiwo Lawal
- Talar Vartanoglu
- Tamara Diaz Vico
- Tanzeela Gala
- Tanzeela Gala
- Tara Grima
- Tarek Ezzat
- Tariq Alhammali
- Tasneem Idress
- Tasnia Hamid Kanta
- Tatsiana Shachykava
- Tebian Hassanein Ahmed Ali
- Tewodros Worku
- Thamer Nouh
- Thandinkosi Madiba
- Tharindra Dissanayake
- Thays Brunelli Pugliesi
- Thea Dimech
- Thelma Tembo
- Theodore Pezas
- Theodosios Theodosopoulos
- Therese Duane
- Thierry Alihonou
- Thomas Feidantsis
- Thomas Kidd
- Thomas M. Drake
- Thomas M. Drake
- Thomas Mann
- Thomas Olagboyega Olajide
- Thomas Pinkney
- Thomas Pinkney
- Thomas Prudhomme
- Thomas Tetens Moe
- Tien Seng Bryan Lee
- Tina Gaarder
- Tobias Schuetz
- Todisoa Emmanuella Christina Tolotra
- Tolg Cecilia
- Tom Abbott
- Tom Arthur
- Tomas Abaliksta
- Tomas Jankus
- Tomas Poskus
- Tomas Poskus
- Tomas Poškus
- Tomas Urbonas
- Tommaso Bocchetti
- Tommaso Campagnaro
- Tommaso Fontana
- Toqa Khafagy
- Torhild Veen
- Tracy E. Roberts
- Tsz-Yan Katie Chan
- Tuan Nur'Azmah Tuan Mat
- Tunde Sholadoye
- Turgut Bora Cengiz
- Tyler Rouse
- Tzu-Ling Chen
- Uday Muddebihal
- Umar Muktar
- Umberto Tedeschi
- Umme Salma
- Usama Hantour
- Uttaran Datta
- Vahit Mutlu
- Valdemaras Jotautas
- Valeria Andriola
- Vanessa Msosa
- Vanessa Msosa
- Vania Guglielmo
- Vania Silvestri
- Vasileios Kalles
- Vasileios Kalles
- Vasiliki Soulou
- Vassilis Kalles
- Vedatcan Işler
- Veeranna Shatkar
- Venerand Barendegere
- Veronica Lazzari
- Vicky Jennings
- Victor Dassah
- Victor Etwire
- Victor Kong
- Victor Nwinee
- Vijaid Upadhyaya
- Viktorija Nevieraite
- Ville Sallinen
- Vincas Jonas Banaitis
- Virginia Jiménez Carneros
- Virginia Ramos Pérez
- Viviana Sollazzo
- Vladimir Khokha
- Volkan Ozben
- Vu Thanh Hien Le
- Vytautas Gaižauskas
- Vytautas Lipnickas
- Wadah Ali
- Wai Cheong Soon
- Wai Him Lam
- Wairimu Ndegwa
- Waleed Thabet
- Walter Ruiz Panez
- Wan Nurul 'Ain Wan Mohd Nasir
- Ward Hamsho
- Wasim Dar
- Wedyan Alhazmi
- Weihei Dao
- Wennweoi Goh
- Wifanto Saditya Jeo
- Wiktor Rutkowski
- William Appeadu-Mensah
- William Bonney
- William English
- Willy Alcca Ticona
- Xavier Delforge
- Xianelle Rodriguez
- Xinwei Low
- Xue Wei Chan
- Ya Theng Neo
- Yacoubou Imorou Souaibou
- Yahaya Ukwenya
- Yahya Salama
- Yakubu Momohsani Adinoyi
- Yasmin Elfouly
- Yasmin Soliman
- Ye Ru Chin
- Yee Wen Tan
- Yehia Zakaria
- Yi Koon Tan
- Yi Ting Mok
- Yih Jeng Cheong
- Yiing Yee Gan
- Yishan Der
- Yomna Allam
- Yomna Hosny Asar
- Yong Yong Tew
- Yong Yong Tew
- Yoshan Moodley
- Yousef Abuowda
- Ysabel Esthefany Alejos Bermúdez
- Yucel Cengiz
- Yucel Cengiz
- Yuk Hong Eric Cheung
- Yuksel Altinel
- Yuksel Altinel
- Yun Lin Ang
- Yung Kok Ng
- Yuri Macchitella
- Zahra Jaffry
- Zain Ali Khan
- Zainab Iftikhar
- Zakaria Rob
- Zhan Herr Ng
- Zi Hao Sam
- Zigmantas Urniežius
- Zilvinas Dambrauskas
- Zineb Bentounsi
- Zygimantas Tverskis
- Ömer Faruk Toto
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/09/2023
- Field of study
Background: This study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods: Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ().Results:HighFiO2maybecost−effective(cheaperandeffective).InNigeria,theaveragecostforhighFiO2was216 compared with 222forlowFiO2leadingtoa −6 (95% confidence interval [CI]: −13to −1) difference in costs. In India, the average cost for high FiO2 was 184comparedwith195 for low FiO2 leading to a −11(9515 to −6)differenceincosts.InSouthAfrica,theaveragecostforhighFiO2was1164 compared with 1257forlowFiO2leadingtoa −93 (95% CI: −132to −65) difference in costs. The high FiO2 arm had few SSIs, 7.33% compared with 8.38% for low FiO2, leading to a −1.05 (95% CI: −1.14 to −0.90) percentage point reduction in SSIs. Conclusion: High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this