Co-create with stakeholders : Action research approach in service development

This paper promotes the value of including many stakeholders in service development. The experience of co-creative service development is examined through the lens of action research. Engaging multiple stakeholders in face-to-face, in simultaneous joint activities, from various organisations, with different levels of hierarchy, and dissimilar positions, may increase the diversification through the broadness of the information, knowledge, and experiences, and increase the amount, and quality of the development suggestions. This paper is an attempt to tell the story of action research and how it was applied to increase the understanding of the usefulness of multiple stakeholders in service development. Outcomes of a research project are presented. The paper ends with discussion of the theoretical and practical implications of the conducted researc

Educating the future generation of service innovators in emerging markets: A tale from the land of 100000 lakes

20 páginas. Artículo aceptado.This paper highlights the role of Higher Educations Institutions in educating the future generation of service innovators and their potential contribution to the service industry growth in emerging economies. In this study, first a global view of service innovation programs in HEIs shows the progress of service innovation education. Second, a single case of service innovation program in the land of 100,000 lakes is presented. This case serves as a trigger to consider how to embed service innovation education in emergent economies to strengthen their future innovation capabilities. The study suggests that educational transformations need to take place for this purpose. Download full proceedings http://reser-online.net/?p=108Laurea University of Applied Sciences; Universidad Autónoma Metropolitana (México)

NÄYTTEITÄ MURTOLUVUN KÄSITTEESTÄ ERI AIKAKAUSIEN OPPIKIRJOISSA

Tässä artikkelissa kartoitamme sitä, miten murtoluvun käsitettä on opetettu eräissä 1800–2000-lukujen alaluokkien oppikirjoissa, ja millaisia murtoluvun käsitekuvia tar-kasteluun valituista oppikirjoista välittyy. Osoittautuu, että murtolukua on käsitelty mo-nipuolisesti ja eri tavoin jo 1800-luvun oppikirjoissa ja osa näistä käsittelytavoista on edelleen käytössä. Uuden matematiikan kirjoissa korostuu jonkin verran konseptuaalinen ajattelu, muuten murtolukujen käsittelyä hallitsee laskemisen näkökulma.Tässä artikkelissa kartoitamme sitä, miten murtoluvun käsitettä on opetettu eräissä 1800–2000-lukujen alaluokkien oppikirjoissa, ja millaisia murtoluvun käsitekuvia tar-kasteluun valituista oppikirjoista välittyy. Osoittautuu, että murtolukua on käsitelty mo-nipuolisesti ja eri tavoin jo 1800-luvun oppikirjoissa ja osa näistä käsittelytavoista on edelleen käytössä. Uuden matematiikan kirjoissa korostuu jonkin verran konseptuaalinen ajattelu, muuten murtolukujen käsittelyä hallitsee laskemisen näkökulma

Selvitys palvelukohtaisista asiakastiedoista : Aikuissosiaalityön, toimeentulotuen ja sosiaalisen luototuksen tehtävissä

Sosiaalialan tietoteknologiahanke (2004-2011)Tarkista ajantasaiset määrittelyt osoitteesta:https://thl.fi/fi/web/tiedonhallinta-sosiaali-ja-terveysalalla/tiedonhallinnan-ohjaus/sosiaalihuollon-tiedonhallinta/asiakastietojen-maarittelyt​ tai osoitteesta:sosmeta.thl.fi</a

Targeted Exome Sequencing of Genes Involved in Rare CNVs in Early-Onset Severe Obesity

Context: Rare copy number variants (CNVs) have been associated with the development of severe obesity. However, the potential disease-causing contribution of individual genes within the region of CNVs is often not known.Objective: Screening of rare variants in genes involved in CNVs in Finnish patients with severe early-onset obesity to find candidate genes linked to severe obesity.Methods: Custom-made targeted exome sequencing panel to search for rare (minor allele frequencyPeer reviewe

The solution structure of the amino-terminal domain of human DNA polymerase ε subunit B is homologous to C-domains of AAA+ proteins

DNA polymerases α, δ and ε are large multisubunit complexes that replicate the bulk of the DNA in the eukaryotic cell. In addition to the homologous catalytic subunits, these enzymes possess structurally related B subunits, characterized by a carboxyterminal calcineurin-like and an aminoproximal oligonucleotide/oligosaccharide binding-fold domain. The B subunits also share homology with the exonuclease subunit of archaeal DNA polymerases D. Here, we describe a novel domain specific to the N-terminus of the B subunit of eukaryotic DNA polymerases ε. The N-terminal domain of human DNA polymerases ε (Dpoe2NT) expressed in Escherichia coli was characterized. Circular dichroism studies demonstrated that Dpoe2NT forms a stable, predominantly α-helical structure. The solution structure of Dpoe2NT revealed a domain that consists of a left-handed superhelical bundle. Four helices are arranged in two hairpins and the connecting loops contain short β-strand segments that form a short parallel sheet. DALI searches demonstrated a striking structural similarity of the Dpoe2NT with the α-helical subdomains of ATPase associated with various cellular activity (AAA+) proteins (the C-domain). Like C-domains, Dpoe2NT is rich in charged amino acids. The biased distribution of the charged residues is reflected by a polarization and a considerable dipole moment across the Dpoe2NT. Dpoe2NT represents the first C-domain fold not associated with an AAA+ protein

HILMO Vårdanmälan för socialvården samt hälso- och sjukvården 2013 - Definitioner och anvisningar

Publikationen innehåller anvisningar för datainsamling för år 2013

Low childhood high density lipoprotein cholesterol levels and subsequent risk for chronic inflammatory bowel disease

Background and aims: Several genetic and environmental risk factors have been linked to chronic inflammatory bowel disease (IBD). The incidence of IBD has significantly increased in developed countries during last decades. The aim of the present study was to examine childhood risk factors for subsequent IBD diagnosis in a longitudinal cohort study of children and adolescents. Methods: A Finnish study population consisting of 3551 children and adolescents originally evaluated as part of the Cardiovascular Risk in Young Finns study in 1980. At baseline, participant BMI, insulin, lipid, C-reactive protein and blood pressure levels, socioeconomic position, dietary habits, and physical activity, were evaluated. In addition, information was gathered on rural residency, severe infections, breast feeding, parental smoking and birth weight. Subsequent IBD diagnosis status was evaluated based on nationwide registries on hospitalisations and drug imbursement decisions. Results: Altogether, 49 participants (1.4%) had IBD diagnosed during the 34 years of register follow-up, of which 31 had ulcerative colitis, 12 Crohn's disease and 6 undetermined colitis. In univariate analyses, significant correlations were observed between childhood HDL-cholesterol (risk ratio (95% CI) for 1-SD change (0.58 (0.42-0.79)) and CRP concentrations (1.20 (1.01-1.43)) with IBD. The inverse association between HDL-cholesterol and IBD remained significant (0.57 (0.39-0.82)) in a multivariable model including data on age, sex and CRP. In addition, a weighted genetic z-score of 71 single nucleotide polymorphisms associated with elevated HDL-cholesterol levels was significantly lower in IBD patients, p = 0.01). Conclusion: Low childhood HDL-cholesterol levels are associated with subsequent IBD diagnosis. In addition, a genetic risk score associated with low HDL-cholesterol levels predict later IBD suggesting that HDL-cholesterol metabolism might have a role in the pathogenesis of IBD. (C) 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.Peer reviewe

Longitudinal analysis of risk of non-alcoholic fatty liver disease in adulthood

Background & Aims We aimed to determine how childhood body mass index and metabolic health, along with the change in body mass index between childhood and adulthood, determine the risk of adult non-alcoholic fatty liver disease. Methods Data from 2020 participants aged 3-18 years at baseline, followed up 31 years later, were examined to assess the utility of four childhood metabolic phenotypes (Metabolic Groups I: normal body mass index, no metabolic disturbances; II: normal body mass index, one or more metabolic disturbances; III: overweight/obese, no metabolic disturbances; IV: overweight/obese, one or more metabolic disturbances) and four life-course adiposity phenotypes (Adiposity Group 1: normal child and adult body mass index; 2, high child, normal adult body mass index; 3, normal child body mass index, high adult body mass index; 4, high child and adult body mass index) in predicting adult non-alcoholic fatty liver disease. Results The risk for adult non-alcoholic fatty liver disease was similar across all four groups after adjustment for age, sex, lifestyle factors and adult body mass index. Risk of adult non-alcoholic fatty liver disease was not increased among individuals overweight/obese in childhood but non-obese in adulthood. In contrast, overweight or obese adults, irrespective of their youth body mass index status, had similar to eight-fold to 10-fold increased risk (P <0.001). Conclusions Childhood overweight/obesity, not metabolic health, is associated with increased risk for adult non-alcoholic fatty liver disease. However, the increased risk associated with childhood overweight/obesity can be largely removed by obtaining a normal body mass index by adulthood.Peer reviewe