Análisis psicométrico de dos versiones de la Connor-Davidson Resilience Scale en estudiantes universitarios peruanos: propuesta del CD-RISC-7

The Connor-Davidson Resilience Scale (CD-RISC) is a resilience measure used worldwide, still there are no validity evidence in Peru. The aim of this paper was to analyze the psychometric properties of the CD-RISC in Peruvian college students (n = 746; 74.5% females; Mage = 19.99 years old). The internal structure was analyzed with confirmatory factor analysis and exploratory structural equation modeling (ESEM). Its relationship with academic self-efficacy and emotional exhaustion measures was also analyzed, and the reliability was estimated. Results show that the brief and unidimensional 7-items model (CD-RISC-7) has more support based on its fit indices, factor loadings, achieving tau-equivalence, and misspecifications absence. In the same way, the CD-RISC-7 has positive and negative relationship with self-efficacy and emotional exhaustion, respectively. Finally, the reliability indices are meritorious. We conclude that the CD-RISC-7 has appropriate psychometric properties.La Connor-Davidson Resilience Scale (CD-RISC) es una de las medidas de resiliencia a nivel mundial, pero no cuenta con evidencias de validez en Perú. El objetivo del presente estudio fue analizar las propiedades psicométricas de la CD-RISC en estudiantes universitarios peruanos (n = 746; 74.5% mujeres; Medad = 19.99 años). La estructura interna del CD-RISC fue analizada con análisis factorial confirmatorio y exploratory structural equation modeling (ESEM), así como su relación con medidas de autoeficacia y agotamiento emocional académico, y la confiabilidad del constructo y puntuaciones. Los resultados muestran que el modelo breve y unidimensional de siete ítems (CD-RISC-7) recibe mayor respaldo considerando los índices de ajuste, magnitud de cargas factoriales, cumplimiento del supuesto de tau-equivalencia y ausencia de malas especificaciones. Asimismo, el CD-RISC-7 se asocia positiva y negativamente con autoeficacia académica y agotamiento emocional, respectivamente. Finalmente, sus indicadores de confiabilidad son meritorios. Se concluye que el CD-RISC-7 cuenta con propiedades psicométricas adecuadas

Biopolymers: Scaffold Applications in Regenerative Medicine

Los biopolímeros se han convertido en un herramienta indispensable para el desarrollo de la medicina regenerativa, su amplio espectro ha permitido la aparición de nuevas técnicas para la generación de andamios de diversos tamaños, formas, con características estructurales únicas capaces de generar e innovar tratamientos nuevos ante enfermedades catastróficas, su aplicación por todas las ramas de investigación como la neurología, endocrinología, en el área cardiovascular, para la reparación de tejidos o donación de órganos ha producido su aplicación como conductores o transportadores de fármacos para lograr una liberación guiada aumentando la efectividad y disminuyendo efectos adversos en el caso de tratamientos contra el cáncer. El objetivo de esta revisión es conocer los fundamentos de la medicina regenerativa, los avances producidos a partir del uso de biopolímeros como una herramienta capaz de desarrollar biomateriales funcionales, tipos, modo de síntesis y aplicabilidad en tratamientos. Esta investigación se realizó a partir de la recopilación de artículos científicos relacionados al área de la salud pública y la aplicación de andamios funcionales como terapia. La funcionalización de andamios radica en la utilización de polímeros biocompatibles capaces de unirse a un sustrato en un ambiente controlado para el desarrollo de una matriz celular, generando la producción de un tejido en específico acorde a las células diana que se han investigado, gracias a esto el posible rechazo ante un injerto producido con las mismas células del paciente permite la aparición de estructuras como vasos sanguíneos u órganos biocompatibles. Este trabajo recapitula la importancia del uso de biopolímeros en la medicina, las técnicas de producción, su estructura, forma y  aplicaciones más importantes para el tratamiento contra enfermedades.Biopolymers have become an indispensable tool for the development of regenerative medicine, their broad spectrum has allowed the emergence of new techniques for the generation of scaffolds of various sizes, shapes, with unique structural characteristics capable of generating and innovating new treatments before catastrophic diseases, its application by all branches of research such as neurology, endocrinology, in the cardiovascular area, for tissue repair or organ donation has produced its application as drug conductors or transporters to achieve a guided release increasing the effectiveness and reducing adverse effects in the case of cancer treatments. The objective of this review is to know the fundamentals of regenerative medicine, the advances produced from the use of biopolymers as a tool capable of developing functional biomaterials, types, synthesis mode and applicability in treatments. This research was carried out from the compilation of scientific articles related to the area of ​​public health and the application of functional scaffolds as therapy. The functionalization of scaffolds lies in the use of biocompatible polymers capable of binding to a substrate in a controlled environment for the development of a cellular matrix, generating the production of a specific tissue according to the target cells that have been investigated, thanks to this the possible rejection of a graft produced with the same cells of the patient allows the appearance of structures such as blood vessels or biocompatible organs. This work recapitulates the importance of the use of biopolymers in medicine, production techniques, their structure, form and most important applications for the treatment against diseases

Evaluating Indoor Positioning Systems in a Shopping Mall: The Lessons Learned From the IPIN 2018 Competition

The Indoor Positioning and Indoor Navigation (IPIN) conference holds an annual competition in which indoor localization systems from different research groups worldwide are evaluated empirically. The objective of this competition is to establish a systematic evaluation methodology with rigorous metrics both for real-time (on-site) and post-processing (off-site) situations, in a realistic environment unfamiliar to the prototype developers. For the IPIN 2018 conference, this competition was held on September 22nd, 2018, in Atlantis, a large shopping mall in Nantes (France). Four competition tracks (two on-site and two off-site) were designed. They consisted of several 1 km routes traversing several floors of the mall. Along these paths, 180 points were topographically surveyed with a 10 cm accuracy, to serve as ground truth landmarks, combining theodolite measurements, differential global navigation satellite system (GNSS) and 3D scanner systems. 34 teams effectively competed. The accuracy score corresponds to the third quartile (75 th percentile) of an error metric that combines the horizontal positioning error and the floor detection. The best results for the on-site tracks showed an accuracy score of 11.70 m (Track 1) and 5.50 m (Track 2), while the best results for the off-site tracks showed an accuracy score of 0.90 m (Track 3) and 1.30 m (Track 4). These results showed that it is possible to obtain high accuracy indoor positioning solutions in large, realistic environments using wearable light-weight sensors without deploying any beacon. This paper describes the organization work of the tracks, analyzes the methodology used to quantify the results, reviews the lessons learned from the competition and discusses its future

Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression

Oral T. gondii infection (30 cysts of 76K strain) induces acute lethal ileitis in sensitive C57BL/6 (B6) mice with increased expression of IL-33 and its receptor ST2 in the ileum. Here we show that IL-33 is involved in ileitis, since absence of IL-33R/ST2 attenuated neutrophilic inflammation and Th1 cytokines upon T. gondii infection with enhanced survival. Blockade of ST2 by neutralizing ST2 antibody in B6 mice conferred partial protection, while rmIL-33 aggravated ileitis. Since IL-22 expression further increased in absence of ST2, we blocked IL-22 by neutralizing antibody, which abrogated protection from acute ileitis in ST2 deficient mice. In conclusion, severe lethal ileitis induced by oral T. gondii infection is attenuated by blockade of ST2 signaling and may be mediated in part by endogenous IL-22

Evaluating indoor positioning systems in a shopping mall : the lessons learned from the IPIN 2018 competition

The Indoor Positioning and Indoor Navigation (IPIN) conference holds an annual competition in which indoor localization systems from different research groups worldwide are evaluated empirically. The objective of this competition is to establish a systematic evaluation methodology with rigorous metrics both for real-time (on-site) and post-processing (off-site) situations, in a realistic environment unfamiliar to the prototype developers. For the IPIN 2018 conference, this competition was held on September 22nd, 2018, in Atlantis, a large shopping mall in Nantes (France). Four competition tracks (two on-site and two off-site) were designed. They consisted of several 1 km routes traversing several floors of the mall. Along these paths, 180 points were topographically surveyed with a 10 cm accuracy, to serve as ground truth landmarks, combining theodolite measurements, differential global navigation satellite system (GNSS) and 3D scanner systems. 34 teams effectively competed. The accuracy score corresponds to the third quartile (75th percentile) of an error metric that combines the horizontal positioning error and the floor detection. The best results for the on-site tracks showed an accuracy score of 11.70 m (Track 1) and 5.50 m (Track 2), while the best results for the off-site tracks showed an accuracy score of 0.90 m (Track 3) and 1.30 m (Track 4). These results showed that it is possible to obtain high accuracy indoor positioning solutions in large, realistic environments using wearable light-weight sensors without deploying any beacon. This paper describes the organization work of the tracks, analyzes the methodology used to quantify the results, reviews the lessons learned from the competition and discusses its future

The IPIN 2019 Indoor Localisation Competition—Description and Results

IPIN 2019 Competition, sixth in a series of IPIN competitions, was held at the CNR Research Area of Pisa (IT), integrated into the program of the IPIN 2019 Conference. It included two on-site real-time Tracks and three off-site Tracks. The four Tracks presented in this paper were set in the same environment, made of two buildings close together for a total usable area of 1000 m 2 outdoors and and 6000 m 2 indoors over three floors, with a total path length exceeding 500 m. IPIN competitions, based on the EvAAL framework, have aimed at comparing the accuracy performance of personal positioning systems in fair and realistic conditions: past editions of the competition were carried in big conference settings, university campuses and a shopping mall. Positioning accuracy is computed while the person carrying the system under test walks at normal walking speed, uses lifts and goes up and down stairs or briefly stops at given points. Results presented here are a showcase of state-of-the-art systems tested side by side in real-world settings as part of the on-site real-time competition Tracks. Results for off-site Tracks allow a detailed and reproducible comparison of the most recent positioning and tracking algorithms in the same environment as the on-site Tracks

Signaling in innate immunity and apicomplexa : role of the adapter protein MyD88 and inflammasome in control of Toxoplasma gondii infection or Cryptosporidium parvum

Les Apicomplexes constituent une vaste famille de parasites protozoaires responsables de nombreuses maladies chez l’Homme et chez les animaux. C’est le cas de Toxoplasma gondii, agent de la toxoplasmose et de Cryptosporidium parvum, responsable de la cryptosporidiose. Ces pathogènes représentent un réel problème de santé publique et vétérinaire. A l’heure actuelle, les seuls moyens de lutte contre ces parasites demeurent la chimiothérapie car il n’existe aucune stratégie prophylactique efficace. L’identification de cibles vaccinales repose sur le décryptage des mécanismes de défense mis en jeux vis-à-vis de ces agents infectieux. Dans le cadre de cette thèse, nos recherches se sont tournées vers l’étude du bras inné de la réponse immunitaire et plus particulièrement vers les voies de signalisation intracellulaires conséquentes de la reconnaissance de ces parasites.No summary availabl

Nanoparticles cellular uptake, trafficking, activation, toxicity and in vitro evaluation

Nanoparticles (NPs) physicochemical properties, such as size, shape, surface chemistry, charge, etc., play a critical role in biological systems interactions, which include NPs' cellular uptake, trafficking, activation, and toxicity. Although nano-bio interactions are multifaceted and complex, their assessment is essential for future therapeutic and diagnostic use since being carriers that deliver specific molecules (i.e., active pharmaceutical ingredients and imaging agents) in intracellular sites. The journey of NPs begins by reaching the plasma membrane and entering the cell mainly through endocytosis. After vesicles pinch off the cell membrane, the intracellular trafficking is mediated by a network of cellular endosomes which direct NPs to the different cellular components. Otherwise, NPs or their contents are released into the cytoplasm. In both cases, NPs can pass undetected or be recognized by the cell leading to a pro or anti-inflammatory response. Indeed, the cell response mostly depends on cell type and NPs physicochemical properties. The principal mechanism by which NPs activate the cell response is RONS production. Other mechanism includes signaling pathways modulation related to metabolic and enzymatic reactions, cell transduction, and immune modulation. Hence, the underlying mechanisms of cellular and subcellular interactions in vitro should be performed to provide insights into NPs' effect. This information helps us to improve their synthesis and design to maximize the clinical benefits while minimizing side effects. Most in vitro tests to evaluate NPs' effect in cells were developed focusing on cell dysfunctions, cytotoxicity, genotoxicity, immunogenicity, and cell death