Exploring Operational Flexibility of Active Distribution Networks with Low Observability

Power electronic interfaced devices progressively enable the increasing provision of flexible operational actions in distribution networks. The feasible flexibility these devices can effectively provide requires estimation and quantification so the network operators can plan operations close to real-time. Existing approaches estimating the distribution network flexibility require the full observability of the system, meaning topological and state knowledge. However, the assumption of full observability is unrealistic and represents a barrier to system operators' adaptation. This paper proposes a definition of the distribution network flexibility problem that considers the limited observability in real-time operation. A critical review and assessment of the most prominent approaches are done based on the proposed definition. This assessment showcases the limitations and benefits of existing approaches for estimating flexibility with low observability. A case study on the CIGRE MV distribution system highlights the drawbacks brought by low observability.Comment: This paper has been accepted to the IEEE Belgrade Powertech 2023. It has 6 pages, 4 figures, and 2 table

MEASURED LEAKAGE AND ROTORDYNAMIC-COEFFICIENTS FOR THE FOLLOWING LIQUID ANNULAR SEALS: (A) SMOOTH-ROTOR/GROOVED-STATOR, AND (B) GROOVED-ROTOR/SMOOTH-STATOR

LectureTest results are presented and compared for the following annular pump seal geometries: (a) a smooth-rotor/circumferentially-grooved stator (SR/GS) and (b) a smooth-stator/circumferentially-grooved rotor (GR/SS). The GR/SS seal’s geometry and operating conditions are representative of electrical submersible pumps (ESPs) as used for oil recovery. The SR/GS seals’ nominal dimensions are identical with the GR/SS seal except for the reversed groove locations. Test results include static and rotordynamic data at speeds ω of 2, 4, 6 krpm for the SR/GS and 2, 4, 6, 8 krpm for the GR/SS seal. Both seals have axial pressure drops Δ of 2.1, 4.1, 6.2, 8.3 bars, a length-to-diameter ratio / of 0.5, and a minimum radial clearance of 203 μm. They employ 15 circumferential grooves with a length , and depth of 1.52 mm, which are equally spaced with a land length of 1.52 mm. Results are presented for centered conditions. Three different inlet-fluid pre-rotation inserts are used upstream of the test seals to create a range of inlet preswirl ratios. A Pitot tube is used to measure the circumferential velocity at one location immediately upstream of the test seals. The test fluid is ISOVG2 oil @ 46 °C.The GR/SS seal leaks about 10% more than the SR/GS seal. Generally, direct stiffness (Kxx, Kyy) values for both designs have low magnitudes that drop with increasing ω. The GR/SS seals’ Kxx, Kyy values dropped more rapidly and were negative at 6 krpm. For the SR/GS seals, Kyy was negative at 6 krpm, but Kxx was still positive. With either design, instability issues are as likely to arise because of negative direct stiffness that pulls down a pump’s critical speed versus directly destabilizing Kxy, Kyx coefficients. In the same operating conditions, the Kxy, Kyx coefficients’ magnitudes are ~2.5 times larger for GR/SS seals than for SR/GS seals --- significantly more destabilizing. Under the same conditions, the SR/GS seal has slightly more direct damping than the GR/SS seal. Direct virtual mass coefficients are about 20% larger for the SR/GS seals, inducing a lower critical speed.Whirl frequency ratio (WFR) combines the effects of the cross-coupled stiffness, direct damping, and cross-coupled mass terms and provides the best measure for comparing the two seal designs’ stability characteristics. Overall, the GR/SS seal WFR values are about three times higher than the comparable values for SR/GS seals --- much less stable. Effective swirl brakes that could sharply drop the seals’ inlet preswirl would be helpful for the GR/SS seal out to 4 krpm and helpful for the SR/GS seal out to 6 krpm

Visual evoked potentials in offspring born to mothers with overweight, obesity and gestational diabetes

Overweight, obesity, and gestational diabetes (GD) during pregnancy may negatively affect neurodevelopment in the offspring. However, the mechanisms are unclear and objective measures of neurodevelopment in infancy are scarce. We hypothesized that these maternal metabolic pathologies impair cortical visual evoked potentials (cVEPs), a proxy for visual and neuronal maturity. At 3 months of age, visual acuity was significantly poorer in offspring born to GD mothers. At 18 months of age, there were no differences in visual acuity but infants born to GD mothers had significantly longer latencies of cVEPs when measured at 15', and 30' of arc. The group differences at 30' remained significant after confounder adjustment (mean [SD] 121.0 [16.0] vs. 112.6 [7.6] ms in controls, p = 0.007) and the most prolonged latencies were observed in offspring to GD mothers with concurrent overweight (128.9 [26.9] ms, p = 0.002) and obesity (118.5 [5.1] ms, p = 0.020). Infants born to mothers with GD, particularly those with concurrent overweight or obesity, have prolonged latencies of visual evoked potentials at 18 months of age, suggesting that this maternal metabolic profile have a long lasting, non-optimal, effect on infants brain development.This work was supported by Spanish Ministry of Innovation and Science. Junta de AndalucõÂa: Excellence Projects (P06-CTS-02341 [to CC]); Spanish Ministry of Education (Grant no. SB2010- 0025 [to CC]); Spanish Ministry of Economy and Competitiveness (BFU2012-40254- C03-01 [to CC]); Abbott Laboratories, Granada, Spain; Henning and Johan Throne-Holst's foundation (Post Doc scholarship [to SKB])

Análisis de seguridad y productividad del suministro de energía eléctrica en el sistema eléctrico de Nicaragua en el periodo comprendido desde el año 2010 hasta el 2018

El propósito de este estudio fue el de estudiar la seguridad y productividad del suministro de energía eléctrica en el sistema eléctrico de Nicaragua en el periodo desde el año 2010 hasta el 2018 utilizando el Indicador Stirling, indicador margen de reserva, indicador pérdida del mayor generador, el indicador de concentración de mercado y herramienta metodológica de análisis envolvente de datos (DEA) y los índices de Malmquist. Se estudió el comportamiento del sector energético de Nicaragua, en el periodo 2005 – 2013. Como resultado del indicador Stirling se obtuvo, que Nicaragua en estos momentos cuenta con seguridad en el sistema eléctrico, Del indicador margen de reserva se obtuvo como resultado, que el nivel de seguridad desde el punto de evaluación de este indicador el sistema cuenta con la suficiente seguridad como para no incurrir en afectaciones a los consumidores finales, Como resultado del indicador pérdida del mayor generador (LU), concluye en que se posee un sistema seguro. Por otra parte, El índice de concentración de mercado mostro que Nicaragua no posee un mercado energético competitivo. En la evaluación de productividad del uso de recursos energéticos se encontró que solo el uso de biomasa presenta un ritmo promedio anual de crecimiento de productividad

Reciprocal Tripartite Interactions between the Aedes aegypti Midgut Microbiota, Innate Immune System and Dengue Virus Influences Vector Competence

Dengue virus is one of the most important arboviral pathogens and the causative agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. It is transmitted between humans by the mosquitoes Aedes aegypti and Aedes albopictus, and at least 2.5 billion people are at daily risk of infection. During their lifecycle, mosquitoes are exposed to a variety of microbes, some of which are needed for their successful development into adulthood. However, recent studies have suggested that the adult mosquito's midgut microflora is critical in influencing the transmission of human pathogens. In this study we assessed the reciprocal interactions between the mosquito's midgut microbiota and dengue virus infection that are, to a large extent, mediated by the mosquito's innate immune system. We observed a marked decrease in susceptibility to dengue virus infection when mosquitoes harbored certain field-derived bacterial isolates in their midgut. Transcript abundance analysis of selected antimicrobial peptide genes suggested that the mosquito's microbiota elicits a basal immune activity that appears to act against dengue virus infection. Conversely, the elicitation of the mosquito immune response by dengue virus infection itself influences the microbial load of the mosquito midgut. In sum, we show that the mosquito's microbiota influences dengue virus infection of the mosquito, which in turn activates its antibacterial responses

A crowdsourcing database for the copy-number variation of the Spanish population

Background: Despite being a very common type of genetic variation, the distribution of copy-number variations (CNVs) in the population is still poorly understood. The knowledge of the genetic variability, especially at the level of the local population, is a critical factor for distinguishing pathogenic from non-pathogenic variation in the discovery of new disease variants. Results: Here, we present the SPAnish Copy Number Alterations Collaborative Server (SPACNACS), which currently contains copy number variation profiles obtained from more than 400 genomes and exomes of unrelated Spanish individuals. By means of a collaborative crowdsourcing effort whole genome and whole exome sequencing data, produced by local genomic projects and for other purposes, is continuously collected. Once checked both, the Spanish ancestry and the lack of kinship with other individuals in the SPACNACS, the CNVs are inferred for these sequences and they are used to populate the database. A web interface allows querying the database with different filters that include ICD10 upper categories. This allows discarding samples from the disease under study and obtaining pseudo-control CNV profiles from the local population. We also show here additional studies on the local impact of CNVs in some phenotypes and on pharmacogenomic variants. SPACNACS can be accessed at: http://csvs.clinbioinfosspa.es/spacnacs/. Conclusion: SPACNACS facilitates disease gene discovery by providing detailed information of the local variability of the population and exemplifies how to reuse genomic data produced for other purposes to build a local reference database

Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information

Genome-wide association studies have generated an increasing number of common genetic variants associated with neurological and psychiatric disease risk. An improved understanding of the genetic control of gene expression in human brain is vital considering this is the likely modus operandum for many causal variants. However, human brain sampling complexities limit the explanatory power of brain-related expression quantitative trait loci (eQTL) and allele-specific expression (ASE) signals. We address this, using paired genomic and transcriptomic data from putamen and substantia nigra from 117 human brains, interrogating regulation at different RNA processing stages and uncovering novel transcripts. We identify disease-relevant regulatory loci, find that splicing eQTLs are enriched for regulatory information of neuron-specific genes, that ASEs provide cell-specific regulatory information with evidence for cellular specificity, and that incomplete annotation of the brain transcriptome limits interpretation of risk loci for neuropsychiatric disease. This resource of regulatory data is accessible through our web server, http://braineacv2.inf.um.es/

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

Background Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's disease. Methods We did a meta-analysis of 17 datasets from Parkinson's disease GWAS available from European ancestry samples to nominate novel loci for disease risk. These datasets incorporated all available data. We then used these data to estimate heritable risk and develop predictive models of this heritability. We also used large gene expression and methylation resources to examine possible functional consequences as well as tissue, cell type, and biological pathway enrichments for the identified risk factors. Additionally, we examined shared genetic risk between Parkinson's disease and other phenotypes of interest via genetic correlations followed by Mendelian randomisation. Findings Between Oct 1, 2017, and Aug 9, 2018, we analysed 7·8 million single nucleotide polymorphisms in 37 688 cases, 18 618 UK Biobank proxy-cases (ie, individuals who do not have Parkinson's disease but have a first degree relative that does), and 1·4 million controls. We identified 90 independent genome-wide significant risk signals across 78 genomic regions, including 38 novel independent risk signals in 37 loci. These 90 variants explained 16–36% of the heritable risk of Parkinson's disease depending on prevalence. Integrating methylation and expression data within a Mendelian randomisation framework identified putatively associated genes at 70 risk signals underlying GWAS loci for follow-up functional studies. Tissue-specific expression enrichment analyses suggested Parkinson's disease loci were heavily brain-enriched, with specific neuronal cell types being implicated from single cell data. We found significant genetic correlations with brain volumes (false discovery rate-adjusted p=0·0035 for intracranial volume, p=0·024 for putamen volume), smoking status (p=0·024), and educational attainment (p=0·038). Mendelian randomisation between cognitive performance and Parkinson's disease risk showed a robust association (p=8·00 × 10−7). Interpretation These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, to the best of our knowledge, by revealing many additional Parkinson's disease risk loci, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified. These associations derived from European ancestry datasets will need to be followed-up with more diverse data. Funding The National Institute on Aging at the National Institutes of Health (USA), The Michael J Fox Foundation, and The Parkinson's Foundation (see appendix for full list of funding sources)

Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset

Mitochondrial dysfunction has been implicated in the etiology of monogenic Parkinson’s disease (PD). Yet the role that mitochondrial processes play in the most common form of the disease; sporadic PD, is yet to be fully established. Here, we comprehensively assessed the role of mitochondrial function-associated genes in sporadic PD by leveraging improvements in the scale and analysis of PD GWAS data with recent advances in our understanding of the genetics of mitochondrial disease. We calculated a mitochondrial-specific polygenic risk score (PRS) and showed that cumulative small effect variants within both our primary and secondary gene lists are significantly associated with increased PD risk. We further reported that the PRS of the secondary mitochondrial gene list was significantly associated with later age at onset. Finally, to identify possible functional genomic associations we implemented Mendelian randomization, which showed that 14 of these mitochondrial functionassociated genes showed functional consequence associated with PD risk. Further analysis suggested that the 14 identified genes are not only involved in mitophagy, but implicate new mitochondrial processes. Our data suggests that therapeutics targeting mitochondrial bioenergetics and proteostasis pathways distinct from mitophagy could be beneficial to treating the early stage of PD