Exile Vol. XXII No. 1

PROSE Dust by Katie Tight 4-13 The Masculine Cure by Elizabeth Thomas 14-19 The Rats Still Sleep At Night by Wolfgang Borchert (translated from the German by Eric Fridman) 20-22 Largo for a Pelican by Morgan Wills 23-25 Role by Anne Tomfohrde 26-29 Goody Two-Shoes Meets the Cincinnati Kid by Kim McMullen 30-38 In the Final Analysis (Psychological or Otherwise): A Review of Carl Jung\u27s Theory of Art by Issa Christian Halabi 39-42 POETRY Here by Fayad Jamis (translated from the Spanish by Joseph R. deArmas) 44 No. 236 by Dawn Patnode 45 No. 237 by Dawn Patnode 46 In my Room by Ulf Miehe 47 Saturday Night Lament by Woodrow Jones 48-49 Basho\u27s Hut by Lenore Mayhew 50 From a Train: Ireland by Kim McMullen 51 Suggested by One Hundred Years Of Solitude by Martin Cloran 52 (to L. Martynov) by Yevgeny Yevtushenko 53 At Sea by Paul Bennett 54 Words In A Line by Lawrence Weber 55 a leave-taking by Debra Allbery 56 untitled by Alison Orleans 57 As The Water Whittles in Colour by Lawrence Weber 58-59 Falconsong or Falcon Song by The Man from Kurenben (translated from the German by John Kessler) 60 POUND Introduction 62 Response from Hugh Kenner 63 Response from Mary de Rachewiltz 64 The Cantos: The Vision of Ezra Pound by William McNaughton 65-78 CONTRIBUORS 79-80 Cover sketch by Lisa Rope Pound Photograph Courtesy of Bill McNaughto

Exile Vol. XXIII no. 1

PROSE The White Butterfly by Dalton Trevisan (translated from the Portugese by Alexis Levitin) 5-6 Natural Selection by Anne Tomfohrde 7-14 Stuck a Feather in His Cap... (for Boo) by Tim Cockey 15-18 An Act of Violence by William McNaughton 19-22 Shall We Now Praise Famous Men? by Lawrence Weber 23-24 POETRY Wake by Dawn Patnode 26 Pebble by Lenore Mayhew 27 Bien: yo respeto... by José Mártí 28 Yes: I respect by José Mártí (translated from the Spanish by Joan Straub) 29 untitled by Mary Schloss 30 Nursing Home by Tim Cockey 31 Maia by Betsy Sloan 32 untitled by Loranna Franz 33 Momento Num Cafe by Manuel Banderia 34 Moment in a Café by Manuel Banderia (translated from the Portoguese by Alexis Levitin) 35 Pleiades by Dawn Patnode 36-37 untitled by Sharon Singleton 39 Travel by Libby Thomas 40 untitled by José Pretlow 41 Melancolía by Rubén Darío 42 Melancholy by Rubén Darío (translated from the Spanish by Joan Straub) 43 Lake Shore Drive by Alison Orleans 44 Repudiation by Tona Dickerson 45 Auvers 1889 by Dawn Patnode 47 Retreat by Deb Allbery 48 An Illusion Of Dancing Figures by Lawrence Weber 50-58 Cloud by Lenore Mayhew 59 ESSAYS Climbing \u27earth\u27s undying monument\u27 by Richard H. Soaper, Jr. 61-71 A Program for the American Land by Lindy Davies 72-77 Kerouac and His Critics (For Amy) by John Kralik 80-82 Cover photograph from a late nineteenth century glass negative found in an Ohio antique shop and used with the permission of its owner

Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease

An important paradigm in evolutionary genetics is that of a delicate balance between genetic variants that favorably boost host control of infection but which may unfavorably increase susceptibility to autoimmune disease. Here, we investigated whether patients with psoriasis, a common immune-mediated disease of the skin, are enriched for genetic variants that limit the ability of HIV-1 virus to replicate after infection. We analyzed the HLA class I and class II alleles of 1,727 Caucasian psoriasis cases and 3,581 controls and found that psoriasis patients are significantly more likely than controls to have gene variants that are protective against HIV-1 disease. This includes several HLA class I alleles associated with HIV-1 control; amino acid residues at HLA-B positions 67, 70, and 97 that mediate HIV-1 peptide binding; and the deletion polymorphism rs67384697 associated with high surface expression of HLA-C. We also found that the compound genotype KIR3DS1 plus HLA-B Bw4-80I, which respectively encode a natural killer cell activating receptor and its putative ligand, significantly increased psoriasis susceptibility. This compound genotype has also been associated with delay of progression to AIDS. Together, our results suggest that genetic variants that contribute to anti-viral immunity may predispose to the development of psoriasis