The importance of forecasting regional wind power ramping: a case study for the UK

In recent years there has been a significant change in the distribution of wind farms in Great Britain, with a trend towards very large offshore farms clustered together in zones. However, there are concerns these clusters could produce large ramping events on time scales of less than 6 hours as local meteorological phenomena simultaneously impact the production of several farms. This paper presents generation data from the wind farms in the Thames Estuary (the largest cluster in the world) for 2014 and quantifies the high frequency power ramps. Based on a case study of a ramping event which occurred on 3rd November 2014, we show that due to the large capacity of the cluster, a localised ramp can have a significant impact on the cost of balancing the power system on a national level if it is not captured by the forecast of the system operator. The planned construction of larger offshore wind zones will exacerbate this problem. Consequently, there is a need for accurate regional wind power forecasts to minimise the costs of managing the system. This study shows that state-of-the-art high resolution forecast models have capacity to provide valuable information to mitigate this impact

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

Recent data implicate elevated transforming growth factor-β (TGFβ) signalling in BRAF inhibitor drug-resistance mechanisms, but the potential for targeting TGFβ signalling in cases of advanced melanoma has not been investigated. We show that mutant BRAFV600E confers an intrinsic dependence on TGFβ/TGFβ receptor 1 (TGFBR1) signalling for clonogenicity of murine melanocytes. Pharmacological inhibition of the TGFBR1 blocked the clonogenicity of human mutant BRAF melanoma cells through SMAD4-independent inhibition of mitosis, and also inhibited metastasis in xenografted zebrafish. When investigating the therapeutic potential of combining inhibitors of mutant BRAF and TGFBR1, we noted that unexpectedly, low-dose PLX-4720 (a vemurafenib analogue) promoted proliferation of drug-naïve melanoma cells. Pharmacological or pharmacogenetic inhibition of TGFBR1 blocked growth promotion and phosphorylation of SRC, which is frequently associated with vemurafenib-resistance mechanisms. Importantly, vemurafenib-resistant patient derived cells retained sensitivity to TGFBR1 inhibition, suggesting that TGFBR1 could be targeted therapeutically to combat the development of vemurafenib drug-resistance

Exploring uncertainty of trends in the North Pacific Jet position

It has been difficult to establish trends in the observed jet streams, despite modelling studies suggesting they will move polewards in a warming world. While this is partly due to biases between the models and observations, we propose that another uncertainty is rooted in the choice of statistic used to determine the 'jet latitude', one measure used to quantify the jet position. We use seven different jet latitude statistics, four climate reanalysis products, and CMIP6 simulations to assess the relative importance of different uncertainties associated with lower-tropospheric North Pacific Jet (NPJ) trends. Our results show a statistically significant poleward trend in the observed winter NPJ across all reanalyses and using all jet latitude statistics. The magnitude of this trend is most sensitive to the choice of statistic. Furthermore, we find that the NPJ shifts poleward in Autumn under high emission scenarios, which is robust to the choice of jet statistic

Detection of Lassa Virus, Mali

To determine whether Lassa virus was circulating in southern Mali, we tested samples from small mammals from 3 villages, including Soromba, where in 2009 a British citizen probably contracted a lethal Lassa virus infection. We report the isolation and genetic characterization of Lassa virus from an area previously unknown for Lassa fever

The Lantern Vol. 67, No. 2, Spring 2000

• Dearest Yarn-Spinner • My Poem, This Tongue In Your Eye • 15th & Rodman • Vision • Linguistics • Casting Cartesian Shadows • On the Defensive • Sea Sick but Still Docked • Urban Dreams • Wolf of the Steppes • Josephine • Happy Birthday to Me • I Have Never Been to Africa • Pa-pou • Onion[s] • Intimacy • Three Trick Pony • Blazer • In My Tea • Emmaless • Dreamcatcher • Repetition • With the Turn of the Reel • Fault Lines • The Shrink Is In • The dancE • Exam • Another Post-Apocalyptic Christmas • The Circumstances of My Prolonged Depressionhttps://digitalcommons.ursinus.edu/lantern/1156/thumbnail.jp

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy.

Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead