Epstein-Barr virus: clinical and epidemiological revisits and genetic basis of oncogenesis

Epstein-Barr virus (EBV) is classified as a member in the order herpesvirales, family herpesviridae, subfamily gammaherpesvirinae and the genus lymphocytovirus. The virus is an exclusively human pathogen and thus also termed as human herpesvirus 4 (HHV4). It was the first oncogenic virus recognized and has been incriminated in the causation of tumors of both lymphatic and epithelial nature. It was reported in some previous studies that 95% of the population worldwide are serologically positive to the virus. Clinically, EBV primary infection is almost silent, persisting as a life-long asymptomatic latent infection in B cells although it may be responsible for a transient clinical syndrome called infectious mononucleosis. Following reactivation of the virus from latency due to immunocompromised status, EBV was found to be associated with several tumors. EBV linked to oncogenesis as detected in lymphoid tumors such as Burkitt's lymphoma (BL), Hodgkin's disease (HD), post-transplant lymphoproliferative disorders (PTLD) and T-cell lymphomas (e.g. Peripheral T-cell lymphomas; PTCL and Anaplastic large cell lymphomas; ALCL). It is also linked to epithelial tumors such as nasopharyngeal carcinoma (NPC), gastric carcinomas and oral hairy leukoplakia (OHL). In vitro, EBV many studies have demonstrated its ability to transform B cells into lymphoblastoid cell lines (LCLs). Despite these malignancies showing different clinical and epidemiological patterns when studied, genetic studies have suggested that these EBV- associated transformations were characterized generally by low level of virus gene expression with only the latent virus proteins (LVPs) upregulated in both tumors and LCLs. In this review, we summarize some clinical and epidemiological features of EBV- associated tumors. We also discuss how EBV latent genes may lead to oncogenesis in the different clinical malignancie

Adaptive responses of animals to climate change are most likely insufficient

Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed trait changes are adaptive. Here we reviewed 10,090 abstracts and extracted data from 71 studies reported in 58 relevant publications, to assess quantitatively whether phenotypic trait changes associated with climate change are adaptive in animals. A meta-analysis focussing on birds, the taxon best represented in our dataset, suggests that global warming has not systematically affected morphological traits, but has advanced phenological traits. We demonstrate that these advances are adaptive for some species, but imperfect as evidenced by the observed consistent selection for earlier timing. Application of a theoretical model indicates that the evolutionary load imposed by incomplete adaptive responses to ongoing climate change may already be threatening the persistence of species

Beneficial effects of biochar to contaminated soils on the bioavailability of Cd, Pb and Zn and the biomass production of rapeseed (Brassica napus L.).

The observation of the recent electron neutrino appearance in a muon neutrino beam and the high-precision measurement of the mixing angle $\theta_{13}$ have led to a re-evaluation of the physics potential of the T2K long-baseline neutrino oscillation experiment. Sensitivities are explored for CP violation in neutrinos, non-maximal $\sin^22\theta_{23}$, the octant of $\theta_{23}$, and the mass hierarchy, in addition to the measurements of $\delta_{CP}$, $\sin^2\theta_{23}$, and $\Delta m^2_{32}$, for various combinations of $\nu$-mode and $\bar{\nu}$-mode data-taking. With an exposure of $7.8\times10^{21}$~protons-on-target, T2K can achieve 1-$\sigma$ resolution of 0.050(0.054) on $\sin^2\theta_{23}$ and $0.040(0.045)\times10^{-3}~\rm{eV}^2$ on $\Delta m^2_{32}$ for 100\%(50\%) neutrino beam mode running assuming $\sin^2\theta_{23}=0.5$ and $\Delta m^2_{32} = 2.4\times10^{-3}$ eV$^2$. T2K will have sensitivity to the CP-violating phase $\delta_{\rm{CP}}$ at 90\% C.L. or better over a significant range. For example, if $\sin^22\theta_{23}$ is maximal (i.e $\theta_{23}$=$45^\circ$) the range is $-115^\circ<\delta_{\rm{CP}}<-60^\circ$ for normal hierarchy and $+50^\circ<\delta_{\rm{CP}}<+130^\circ$ for inverted hierarchy. When T2K data is combined with data from the NO$\nu$A experiment, the region of oscillation parameter space where there is sensitivity to observe a non-zero $\delta_{CP}$ is substantially increased compared to if each experiment is analyzed alone.Comment: 40 pages, 27 figures, accepted by PTE

Recent Results from the T2K Experiment

The Tokai to Kamioka (T2K) experiment studies neutrino oscillations using a beam of muon neutrinos produced by an accelerator. The neutrinos travel from J-PARC on the east coast of Japan and are detected 295 kilometers further away in the Super-Kamiokande detector. A complex of near detectors located 280 meters away from the neutrino production target is used to better characterize the neutrino beam and reduce systematic uncertainties. The experiment aims at measuring electronic neutrino appearance (νμ→νe oscillation) to measure the neutrino mixing angle θ13, and muon neutrino disappearance to measure the neutrino mixing angleθ23 and mass splitting |Δm232|. We report here electron neutrino appearance results using three years of data, recorded until the 2012 summer, as well as muon neutrino disappearance results based on the data coming from the first two years of the experiment