Evidence-based implementation practices applied to the intensive treatment of eating disorders: Summary of research and illustration of principles using a case example

Implementation of evidence‐based practices (EBPs) in intensive treatment settings poses a major challenge in the field of psychology. This is particularly true for eating disorder (ED) treatment, where multidisciplinary care is provided to a severe and complex patient population; almost no data exist concerning best practices in these settings. We summarize the research on EBP implementation science organized by existing frameworks and illustrate how these practices may be applied using a case example. We describe the recent successful implementation of EBPs in a community‐based intensive ED treatment network, which recently adapted and implemented transdiagnostic, empirically supported treatment for emotional disorders across its system of residential and day‐hospital programs. The research summary, implementation frameworks, and case example may inform future efforts to implement evidence‐based practice in intensive treatment settings.Published versio

Photon Pair Generation in Silicon Micro-Ring Resonator with Reverse Bias Enhancement

Photon sources are fundamental components for any quantum photonic technology. The ability to generate high count-rate and low-noise correlated photon pairs via spontaneous parametric down-conversion using bulk crystals has been the cornerstone of modern quantum optics. However, future practical quantum technologies will require a scalable integration approach, and waveguide-based photon sources with high-count rate and low-noise characteristics will be an essential part of chip-based quantum technologies. Here, we demonstrate photon pair generation through spontaneous four-wave mixing in a silicon micro-ring resonator, reporting a maximum coincidence-to-accidental (CAR) ratio of 602 (+-) 37, and a maximum photon pair generation rate of 123 MHz (+-) 11 KHz. To overcome free-carrier related performance degradations we have investigated reverse biased p-i-n structures, demonstrating an improvement in the pair generation rate by a factor of up to 2, with negligible impact on CAR.Comment: 5 pages, 3 figure

Planning, implementation and scientific goals of the Studies of Emissions and Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys (SEAC4RS) field mission

The Studies of Emissions and Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys (SEAC4RS) field mission based at Ellington Field, Texas, during August and September 2013 employed the most comprehensive airborne payload to date to investigate atmospheric composition over North America. The NASA ER-2, DC-8, and SPEC Inc. Learjet flew 57 science flights from the surface to 20 km. The ER-2 employed seven remote sensing instruments as a satellite surrogate and eight in situ instruments. The DC-8 employed 23 in situ and five remote sensing instruments for radiation, chemistry, and microphysics. The Learjet used 11 instruments to explore cloud microphysics. SEAC4RS launched numerous balloons, augmented AErosol RObotic NETwork, and collaborated with many existing ground measurement sites. Flights investigating convection included close coordination of all three aircraft. Coordinated DC-8 and ER-2 flights investigated the optical properties of aerosols, the influence of aerosols on clouds, and the performance of new instruments for satellite measurements of clouds and aerosols. ER-2 sorties sampled stratospheric injections of water vapor and other chemicals by local and distant convection. DC-8 flights studied seasonally evolving chemistry in the Southeastern U.S., atmospheric chemistry with lower emissions of NOx and SO2 than in previous decades, isoprene chemistry under high and low NOx conditions at different locations, organic aerosols, air pollution near Houston and in petroleum fields, smoke from wildfires in western forests and from agricultural fires in the Mississippi Valley, and the ways in which the chemistry in the boundary layer and the upper troposphere were influenced by vertical transport in convective clouds

Rotating Convection in an Anisotropic System

We study the stability of patterns arising in rotating convection in weakly anisotropic systems using a modified Swift-Hohenberg equation. The anisotropy, either an endogenous characteristic of the system or induced by external forcing, can stabilize periodic rolls in the K\"uppers-Lortz chaotic regime. For the particular case of rotating convection with time-modulated rotation where recently, in experiment, chiral patterns have been observed in otherwise K\"uppers-Lortz-unstable regimes, we show how the underlying base-flow breaks the isotropy, thereby affecting the linear growth-rate of convection rolls in such a way as to stabilize spirals and targets. Throughout we compare analytical results to numerical simulations of the Swift-Hohenberg equation

The Missing Luminous Blue Variables and the Bistability Jump

We discuss an interesting feature of the distribution of luminous blue variables on the H-R diagram, and we propose a connection with the bistability jump in the winds of early-type supergiants. There appears to be a deficiency of quiescent LBVs on the S Dor instability strip at luminosities between log L/Lsun = 5.6 and 5.8. The upper boundary, is also where the temperature-dependent S Dor instability strip intersects the bistability jump at about 21,000 K. Due to increased opacity, winds of early-type supergiants are slower and denser on the cool side of the bistability jump, and we postulate that this may trigger optically-thick winds that inhibit quiescent LBVs from residing there. We conduct numerical simulations of radiation-driven winds for a range of temperatures, masses, and velocity laws at log L/Lsun=5.7 to see what effect the bistability jump should have. We find that for relatively low stellar masses the increase in wind density at the bistability jump leads to the formation of a modest to strong pseudo photosphere -- enough to make an early B-type star appear as a yellow hypergiant. Thus, the proposed mechanism will be most relevant for LBVs that are post-red supergiants. Yellow hypergiants like IRC+10420 and rho Cas occupy the same luminosity range as the ``missing'' LBVs, and show apparent temperature variations at constant luminosity. If these yellow hypergiants do eventually become Wolf-Rayet stars, we speculate that they may skip the normal LBV phase, at least as far as their apparent positions on the HR diagram are concerned.Comment: 20 pages, 4 figs, accepted by Ap

Manipulating the quantum information of the radial modes of trapped ions: Linear phononics, entanglement generation, quantum state transmission and non-locality tests

We present a detailed study on the possibility of manipulating quantum information encoded in the "radial" modes of arrays of trapped ions (i.e., in the ions' oscillations orthogonal to the trap's main axis). In such systems, because of the tightness of transverse confinement, the radial modes pertaining to different ions can be addressed individually. In the first part of the paper we show that, if local control of the radial trapping frequencies is available, any linear optical and squeezing operation on the locally defined modes - on single as well as on many modes - can be reproduced by manipulating the frequencies. Then, we proceed to describe schemes apt to generate unprecedented degrees of bipartite and multipartite continuous variable entanglement under realistic noisy working conditions, and even restricting only to a global control of the trapping frequencies. Furthermore, we consider the transmission of the quantum information encoded in the radial modes along the array of ions, and show it to be possible to a remarkable degree of accuracy, for both finite-dimensional and continuous variable quantum states. Finally, as an application, we show that the states which can be generated in this setting allow for the violation of multipartite non-locality tests, by feasible displaced parity measurements. Such a demonstration would be a first test of quantum non-locality for "massive" degrees of freedom (i.e., for degrees of freedom describing the motion of massive particles).Comment: 21 pages; this paper, presenting a far more extensive and detailed analysis, completely supersedes arXiv:0708.085

Risk maps for range expansion of the Lyme disease vector, Ixodes scapularis, in Canada now and with climate change

<p>Abstract</p> <p>Background</p> <p>Lyme disease is the commonest vector-borne zoonosis in the temperate world, and an emerging infectious disease in Canada due to expansion of the geographic range of the tick vector <it>Ixodes scapularis</it>. Studies suggest that climate change will accelerate Lyme disease emergence by enhancing climatic suitability for <it>I. scapularis</it>. Risk maps will help to meet the public health challenge of Lyme disease by allowing targeting of surveillance and intervention activities.</p> <p>Results</p> <p>A risk map for possible Lyme endemicity was created using a simple risk algorithm for occurrence of <it>I. scapularis </it>populations. The algorithm was calculated for each census sub-division in central and eastern Canada from interpolated output of a temperature-driven simulation model of <it>I. scapularis </it>populations and an index of tick immigration. The latter was calculated from estimates of tick dispersion distances by migratory birds and recent knowledge of the current geographic range of endemic <it>I. scapularis </it>populations. The index of tick immigration closely predicted passive surveillance data on <it>I. scapularis </it>occurrence, and the risk algorithm was a significant predictor of the occurrence of <it>I. scapularis </it>populations in a prospective field study. Risk maps for <it>I. scapularis </it>occurrence in Canada under future projected climate (in the 2020s, 2050s and 2080s) were produced using temperature output from the Canadian Coupled Global Climate Model 2 with greenhouse gas emission scenario enforcing '<it>A2</it>' of the Intergovernmental Panel on Climate Change.</p> <p>Conclusion</p> <p>We have prepared risk maps for the occurrence of <it>I. scapularis </it>in eastern and central Canada under current and future projected climate. Validation of the risk maps provides some confidence that they provide a useful first step in predicting the occurrence of <it>I. scapularis </it>populations, and directing public health objectives in minimizing risk from Lyme disease. Further field studies are needed, however, to continue validation and refinement of the risk maps.</p

De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development

Bosma arhinia microphthalmia syndrome (BAMS) is an extremely rare and striking condition characterized by complete absence of the nose with or without ocular defects. We report here that missense mutations in the epigenetic regulator SMCHD1 mapping to the extended ATPase domain of the encoded protein cause BAMS in all 14 cases studied. All mutations were de novo where parental DNA was available. Biochemical tests and in vivo assays in Xenopus laevis embryos suggest that these mutations may behave as gain-of-function alleles. This finding is in contrast to the loss-of-function mutations in SMCHD1 that have been associated with facioscapulohumeral muscular dystrophy (FSHD) type 2. Our results establish SMCHD1 as a key player in nasal development and provide biochemical insight into its enzymatic function that may be exploited for development of therapeutics for FSHD