13 research outputs found
Flawed Evidence Should Not Derail Sound Policy: The Case Remains Strong for Population-Wide Sodium Reduction
Epidemiologic Data on the Relationships of Caloric Intake, Energy Balance, and Weight Gain Over the Life Span With Longevity and Morbidity
Lack of Impact of a Comprehensive Intervention on Hypertension in the Primary Care Setting
Predictive Value for the Rural Chinese Population of the Framingham Hypertension Risk Model: Results From Liaoning Province
The Long-Term Effects of Lifestyle Change on Blood Pressure: One-Year Follow-Up of the ENCORE Study
Effect of Low vs. High Dietary Sodium on Blood Pressure Levels in a Normotensive Indo-Asian Population
The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials
Modulation of the BP Response to Diet by Genes in the Renin-Angiotensin System and the Adrenergic Nervous System
BACKGROUND: Essential hypertension results from the interaction of several genetic and environmental factors. Identification of genetic factors that modulate blood pressure (BP) response to interventions can lead to improved strategies for prevention and control. The purpose of this study was to identify genes that modulate BP response to dietary interventions. METHODS: We used data and samples collected in two randomized feeding studies to determine the extent to which genetic architecture is associated with the effect on BP of sodium intake and the Dietary approaches to Stop Hypertension (DASH) dietary pattern. Participants in both trials were adults with above-optimal BP or unmedicated stage 1 hypertension. Genomic DNa was typed for several candidate genes. RESULTS: The effect of sodium intake on BP differed by genotype at the angiotensinogen, β2-adrenergic receptor, and kallikrein loci. The effect of DASH dietary pattern on BP differed by genotype at the β2-adrenergic receptor locus. CONCLUSIONS: These findings have implications for understanding the mechanism(s) through which diet affects BP, the heterogeneity of these effects, and the extent to which dietary interventions can modulate genetic predisposition