Toward Sustainable Environmental Quality: Priority Research Questions for Asia

Environmental and human health challenges are pronounced in Asia, an exceptionally diverse and complex region where influences of global megatrends are extensive and numerous stresses to environmental quality exist. Identifying priorities necessary to engage grand challenges can be facilitated through horizon scanning exercises, and to this end we identified and examined 23 priority research questions needed to advance toward more sustainable environmental quality in Asia, as part of the Global Horizon Scanning Project. Advances in environmental toxicology, environmental chemistry, biological monitoring, and risk‐assessment methodologies are necessary to address the adverse impacts of environmental stressors on ecosystem services and biodiversity, with Asia being home to numerous biodiversity hotspots. Intersections of the food–energy–water nexus are profound in Asia; innovative and aggressive technologies are necessary to provide clean water, ensure food safety, and stimulate energy efficiency, while improving ecological integrity and addressing legacy and emerging threats to public health and the environment, particularly with increased aquaculture production. Asia is the largest chemical‐producing continent globally. Accordingly, sustainable and green chemistry and engineering present decided opportunities to stimulate innovation and realize a number of the United Nations Sustainable Development Goals. Engaging the priority research questions identified herein will require transdisciplinary coordination through existing and nontraditional partnerships within and among countries and sectors. Answering these questions will not be easy but is necessary to achieve more sustainable environmental quality in Asia. Environ Toxicol Chem 2020;39:1485–1505. © 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC

Fuzzy logic control of exothermic batch process

Thermal runaway of exothermic reaction, especially with batch chemical plants, is a critical issue because it can affect production quantity and quality, causes profit loss, and in worst case can threaten the safety of workers and lead to plant accident. The conventional PID controller which is usually used in many industries needs to be operated under supervision in order to perform the temperature control well. In this work, Mamdani type fuzzy logic controller is proposed to track an optimal reference temperature profile. Both process model and proposed controller are simulated using MATLAB. The results show the designed fuzzy logic controller is well-performed in set point tracking and able to cope with the simulated disturbance condition

Optimization of yeast fermentation process using genetic algorithm

This paper proposes genetic algorithm (GA) to optimize the productivity of yeast fermentation process. The proposed optimizer aims to maximize yeast productivity while minimizing the by-product of ethanol. Various initial glucose concentrations will affect yeast productivity and influence the performance of yeast fermentation. Yeast has relatively high ethanol production as compared with other microorganisms. Since the excessive ethanol formation in the yeast fermentation process will have a negative impact on quality of the product, it is needed to optimize glucose feeding rate at optimal level for maximizing the yeast productivity. The conventional open-loop feeding system is inadequate to minimize the growth of by-product as the system will not regulate the glucose feeding rate based on the instant needs. Thus, GA is proposed to optimize the glucose feeding profile based on the instant concentration of yeast, glucose, oxygen and ethanol inside the fermentation tank. The results show the proposed GA can obtain a higher yield production of 95.3% as compared to the conventional open-loop system with 92.5% yield production. The results reveal that the optimal glucose feeding rate using GA is achieved satisfyingly and successfully

Q-learning-based controller for fed-batch yeast fermentation

Industrial fed-batch yeast fermentation process is a typical nonlinear dynamic process that requires good control technique and monitoring to optimize the yeast production. This chapter explores the applicability of Q-learning in determining the feed flow rate in a fed-batch yeast fermentation process to achieve multiobjectives optimization. However, to develop such control system, the complex nature of the yeast metabolism that will affect the system stability has to be considered. Q-learning is well known for its interactive properties with the process environment and is suitable for the learning of system dynamic. Therefore, the utilization and performance of Q-learning to seek for the optimal gain for the controller is studied in this chapter. Meanwhile, the performance of Q-learning under the process disturbance is also tested. © Springer Science+Business Media New York 2013

Genetic-algorithm-based optimisation for exothermic batch process

The aim of this chapter is to optimise the productivity of an exothermic batch process, by maximising the production of the desired product while minimising the undesired by-product. During the process, heat is liberated when the reactants are mixed together. The exothermic behaviour causes the reaction to become unstable and consequently poses safety issues. In the industries, a dual-mode controller is used to control the process temperature according to a predetermined optimal reference temperature profile. However, the predetermined optimal reference profile is not able to limit the production of the undesired by-product. Hence, this work proposed a genetic-algorithm-based controller to optimise the batch productivity without referring to any optimal reference profile. From the simulation results, the proposed algorithm is able to improve the production of the desired product and reduce the production of the undesired by-product by 15.3 and 34.4 %, respectively. As a conclusion, the genetic-algorithm-based optimisation performs better in raw materials utilisation as compared to the predetermined optimal temperature profile method

Control of exothermic batch process using multivariable genetic algorithm

The aim of this research is to control the reactor temperature of an exothermic batch process. During the process, large amount of heat will be released rapidly when the reactants are mixed together. The exothermic behaviour causes the reaction to become unstable and consequently poses safety concern to the plant personnel. In practice, heat is needed to speed up the reaction rate so that the overall process cycle time can be reduced whereas the cooling is employed to cool down the reactor in order to reduce excessive heat. Hence, this paper proposes genetic algorithm (GA) to control the process temperature with a predetermined temperature profile. GA exploits the probabilistic search method to optimise the specific objective function based on the evolutionary principle. Simulation assessment of the GA has been carried out using a benchmark exothermic batch process model. The results show that GA is able to control the reactor temperature effectively

Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H2O2-induced oxidative stress in neonatal rat cardiac myocytes.

The Mdm2 ubiquitin ligase is an important regulator of p53 abundance and p53-dependent apoptosis. Mdm2 expression is frequently regulated by a p53 Mdm2 autoregulatory loop whereby p53 stimulates Mdm2 expression and hence its own degradation. Although extensively studied in cell lines, relatively little is known about Mdm2 expression in heart where oxidative stress (exacerbated during ischemia-reperfusion) is an important pro-apoptotic stimulus. We demonstrate that Mdm2 transcript and protein expression are induced by oxidative stress (0.2 mm H(2)O(2)) in neonatal rat cardiac myocytes. In other cells, constitutive Mdm2 expression is regulated by the P1 promoter (5' to exon 1), with inducible expression regulated by the P2 promoter (in intron 1). In myocytes, H(2)O(2) increased Mdm2 expression from the P2 promoter, which contains two p53-response elements (REs), one AP-1 RE, and two Ets REs. H(2)O(2) did not detectably increase expression of p53 mRNA or protein but did increase expression of several AP-1 transcription factors. H(2)O(2) increased binding of AP-1 proteins (c-Jun, JunB, JunD, c-Fos, FosB, and Fra-1) to an Mdm2 AP-1 oligodeoxynucleotide probe, and chromatin immunoprecipitation assays showed it increased binding of c-Jun or JunB to the P2 AP-1 RE. Finally, antisense oligonucleotide-mediated reduction of H(2)O(2)-induced Mdm2 expression increased caspase 3 activation. Thus, increased Mdm2 expression is associated with transactivation at the P2 AP-1 RE (rather than the p53 or Ets REs), and Mdm2 induction potentially represents a cardioprotective response to oxidative stress

Satori 2018

The Satori is a student literary publication that expresses the artistic spirit of the students of Winona State University. Student poetry, prose, and graphic art are published in the Satori every spring since 1970. The Satori 2018 editors are Sajda Omar (Editor-in-Chief), Kylie Hoff, Keyanna Hultman, Audrey Sitte, Elyse Hoffmann. Art Director and Designer by Elyse Hoffmann. The 2018 Faculty advisor is Dr. Elizabeth Oness, Professor of English.https://openriver.winona.edu/satori/1012/thumbnail.jp

A Scoping Review of Frailty and Acute Care in Middle-Aged and Older Individuals with Recommendations for Future Research

There is general agreement that frailty is a state of heightened vulnerability to stressors arising from impairments in multiple systems leading to declines in homeostatic reserve and resiliency, but unresolved issues persist about its detection, underlying pathophysiology, and relationship with aging, disability, and multimorbidity. A particularly challenging area is the relationship between frailty and hospitalization. Based on the deliberations of a 2014 Canadian expert consultation meeting and a scoping review of the relevant literature between 2005 and 2015, this discussion paper presents a review of the current state of knowledge on frailty in the acute care setting, including its prevalence and ability to both predict the occurrence and outcomes of hospitalization. The examination of the available evidence highlighted a number of specific clinical and research topics requiring additional study. We conclude with a series of consensus recommendations regarding future research priorities in this important area

BOB CAT: a Large-Scale Review and Delphi Consensus for Management of Barrett’s Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia

OBJECTIVES: Barrett’s esophagus (BE) is a common premalignant lesion for which surveillance is recommended. This strategy is limited by considerable variations in clinical practice. We conducted an international, multidisciplinary, systematic search and evidence-based review of BE and provided consensus recommendations for clinical use in patients with nondysplastic, indefinite, and low-grade dysplasia (LGD). METHODS: We defined the scope, proposed statements, and searched electronic databases, yielding 20,558 publications that were screened, selected online, and formed the evidence base. We used a Delphi consensus process, with an 80% agreement threshold, using GRADE (Grading of Recommendations Assessment, Development and Evaluation) to categorize the quality of evidence and strength of recommendations. RESULTS: In total, 80% of respondents agreed with 55 of 127 statements in the final voting rounds. Population endoscopic screening is not recommended and screening should target only very high-risk cases of males aged over 60 years with chronic uncontrolled reflux. A new international definition of BE was agreed upon. For any degree of dysplasia, at least two specialist gastrointestinal (GI) pathologists are required. Risk factors for cancer include male gender, length of BE, and central obesity. Endoscopic resection should be used for visible, nodular areas. Surveillance is not recommended for <5 years of life expectancy. Management strategies for indefinite dysplasia (IND) and LGD were identified, including a de-escalation strategy for lower-risk patients and escalation to intervention with follow-up for higher-risk patients. CONCLUSIONS: In this uniquely large consensus process in gastroenterology, we made key clinical recommendations for the escalation/de-escalation of BE in clinical practice. We made strong recommendations for the prioritization of future research