119 research outputs found

    Dynamic Analysis of MRE Embedded Sandwich Plate Using FEM

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    AbstractMagnetorheological elastomers (MRE) are class of smart materials, whose stiffness and damping characteristics can be changed by applying external magnetic field. In this work three layered rectangular plate is considered where top and bottom layers are made up of aluminium layers and middle layer is MRE material to study free vibration characteristics of the system. With help of Lagrange principle and finite element method (FEM), the governing equation of motion is derived. Natural frequencies and modal loss factors of MRE cored sandwich plate is obtained for different core and constraining layer thickness by using modal strain energy method (MSE) for different magnetic fields. This work will find applications in active reduction of vibrations by applying magnetic field

    ANALYSIS OF COMPLEX CHROMOSOMAL ABNORMALITIES IN A CASE OF MULTIPLE MYELOMA USING SPECTRAL KARYOTYPING

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    Objective: It was proposed to determine the chromosomal abnormalities in a 49-year-old male patient with multiple myeloma (MM) employing both conventional and advanced molecular cytogenetic techniques.Methods: GTG-banding and spectral karyotyping (SKY) on fixed metaphases obtained from LPS-stimulated bone marrow cells and interphase fluorescence in situ hybridization (iFISH) on unsorted marrow cells were carried out to identify genetic markers of prognostic significance.Results: The abnormal chromosomes observed through conventional cytogenetics could be resolved with SKY technique. The translocation t(4;14) (p16;q32) indicating FGFR3/IGH fusion and deletion of 13q14.3 was noticed using iFISH. The genetic abnormalities confirmed a poor prognostic outcome in the patient who died within 6 months of diagnosis.Conclusion: This report emphasizes the need for multicolor FISH techniques besides iFISH to resolve complex abnormalities and to identify cryptic aberrations of importance in risk stratification of MM patients

    Shaping Demand and Practices to Improve Family Health Outcomes: Findings from a Quantitative Survey, Volume 3: Bihar

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    This report provides findings of a study undertaken to generate comprehensive information on eight target behaviors that have direct bearing on family health in rural Bihar. Behaviors include: 1) Increasing the proportion of deliveries that occur in a facility and mothers who have access to basic emergency obstetric care; 2) Increasing the proportion of safe deliveries at home; 3) Increasing the uptake of preventive postnatal-care services for newborns and mothers; 4) Increasing the practice of skin-to-skin care/Kangaroo Mother Care for newborns; 5) Increasing the practice of early and exclusive breastfeeding of infants during the first six months of life; 6) Increasing the proportion of children (6–23 months) who receive appropriate complementary feeding; 7) Increasing the uptake of postpartum family planning methods to adequately space births; 8) Increasing the rate of compliance for recommended schedules of child immunization. Objectives were to: assess the present status of each of the behavior targets, identify the key barriers and facilitating factors to the adoption of these health behaviors, suggest how findings could be utilized for developing a BCC comprehensive strategy. This study generated information that could be used to develop a comprehensive communication strategy

    A study of localisation in dual-phase high-strength steels under dynamic loading using digital image correlation and FE analysis

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    Tensile tests were conducted on dual-phase high-strength steel in a Split-Hopkinson Tension Bar at a strain-rate in the range of 150-600/s and in a servo-hydraulic testing machine at a strain-rate between 10-3 and 100/s. A novel specimen design was utilized for the Hopkinson bar tests of this sheet material. Digital image correlation was used together with high-speed photography to study strain localisation in the tensile specimens at high rates of strain. By using digital image correlation, it is possible to obtain in-plane displacement and strain fields during non-uniform deformation of the gauge section, and accordingly the strains associated with diffuse and localised necking may be determined. The full-field measurements in high strain-rate tests reveal that strain localisation started even before the maximum load was attained in the specimen. An elasto-viscoplastic constitutive model is used to predict the observed stress-strain behaviour and strain localisation for the dual-phase steel. Numerical simulations of dynamic tensile tests were performed using the non-linear explicit FE code LS-DYNA. Simulations were done with shell (plane stress) and brick elements. Good correlation between experiments and numerical predictions was achieved, in terms of engineering stress-strain behaviour, deformed geometry and strain fields. However, mesh density plays a role in the localisation of deformation in numerical simulations, particularly for the shell element analysis

    The Role of β-Arrestin Proteins in Organization of Signaling and Regulation of the AT1 Angiotensin Receptor

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    AT1 angiotensin receptor plays important physiological and pathophysiological roles in the cardiovascular system. Renin-angiotensin system represents a target system for drugs acting at different levels. The main effects of ATR1 stimulation involve activation of Gq proteins and subsequent IP3, DAG, and calcium signaling. It has become evident in recent years that besides the well-known G protein pathways, AT1R also activates a parallel signaling pathway through β-arrestins. β-arrestins were originally described as proteins that desensitize G protein-coupled receptors, but they can also mediate receptor internalization and G protein-independent signaling. AT1R is one of the most studied receptors, which was used to unravel the newly recognized β-arrestin-mediated pathways. β-arrestin-mediated signaling has become one of the most studied topics in recent years in molecular pharmacology and the modulation of these pathways of the AT1R might offer new therapeutic opportunities in the near future. In this paper, we review the recent advances in the field of β-arrestin signaling of the AT1R, emphasizing its role in cardiovascular regulation and heart failure
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