Comparative efficacy of hospital disinfectants against nosocomial infection pathogens

Background: Due to the increasing rate of hospital-acquired infections, it is essential to select appropriate disinfectant agents. In this study, the efficacy of hospital disinfectants against nosocomial infection pathogens was compared. Methods: High level disinfectants (Steranios 2, Deconex HLDPA, and Microzed Quatenol) were tested for their antibacterial effects by determining their minimum inhibitory (MIC) and minimum bactericidal concentrations (MBC) against Enterococcus faecalis ATCC 29212 and Burkholderia cepacia ATCC 10673. Results: E. faecalis, as gram-positive bacterium, was more susceptible to high level disinfectants compared to gram-negative B.cepacia. The MIC = MBC values of 2 Steranios, Deconex HLDPA and Microzed Quatenol against E. faecalis and B.cepacia were 0.31, 9.77, 2.2 mg/L and 9.8, 78.13, 70.31 mg/L, respectively. Conclusions: According to the findings of this study, the most effective disinfectants against both E. faecalis and B.cepacia were Steranios 2, Microzed Quatenol, and Deconex HLDPA in order. Considering the importance of these bacterial strains in healthcare-associated infections, the use of these effective disinfectants is recommended in the hospitals. © 2020 The Author(s)

Comparative efficacy of hospital disinfectants against nosocomial infection pathogens

Background: Due to the increasing rate of hospital-acquired infections, it is essential to select appropriate disinfectant agents. In this study, the efficacy of hospital disinfectants against nosocomial infection pathogens was compared. Methods: High level disinfectants (Steranios 2, Deconex HLDPA, and Microzed Quatenol) were tested for their antibacterial effects by determining their minimum inhibitory (MIC) and minimum bactericidal concentrations (MBC) against Enterococcus faecalis ATCC 29212 and Burkholderia cepacia ATCC 10673. Results: E. faecalis, as gram-positive bacterium, was more susceptible to high level disinfectants compared to gram-negative B.cepacia. The MIC = MBC values of 2 Steranios, Deconex HLDPA and Microzed Quatenol against E. faecalis and B.cepacia were 0.31, 9.77, 2.2 mg/L and 9.8, 78.13, 70.31 mg/L, respectively. Conclusions: According to the findings of this study, the most effective disinfectants against both E. faecalis and B.cepacia were Steranios 2, Microzed Quatenol, and Deconex HLDPA in order. Considering the importance of these bacterial strains in healthcare-associated infections, the use of these effective disinfectants is recommended in the hospitals. © 2020 The Author(s)

Embedding of L�Arginine into graphene oxide (GO) for endotoxin removal from water: Modeling and optimization approach

Endotoxin, also called lipopolysaccharides (LPS), has strong biological effects, even at a very low concentration in humans. In this study, surface functionalization of graphene oxide (GO) with L�Arginine amino acid was successfully prepared using epichlorohydrin as a coupling agent (GO�EPI�L�Arg) for endotoxin removal from water. Characterization of Novel GO�EPI�L�Arg was confirmed by an analytical technique. The model was optimized using response surface methodology (RSM) via various input parameters. The effect of concomitant anions was also investigated to establish and simulate competitive endotoxin adsorption in real hemodialysis water supply. The pH and endotoxin concentration had an antagonistic effect on the quadratic model. The endotoxin adsorption process was better fitted by pseudo-second-order model with Qmax value of 139.47 EU/mg, while the equilibrium followed the Langmuir isotherm with the maximum monolayer adsorption capacity of 154.85 EU/mg. The coefficient of determination (R2=0.9761), non�significant lack of fit (p > 0.05), and p�value with low probability (<5.596 � 10�11) revealed a regression model with a good fit with input variables. The GO�EPI�L�Arg nanocomposite could be regenerated more than four times based on their adsorption-desorption cycles, with a slight loss in adsorption capacity. The results suggested that the GO�EPI�L�Arg can be applied as an effective adsorbent for endotoxin removal from water. © 2020 Elsevier B.V